country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-181289

Copy Link Print Information

SelDeg51

SelDeg51 is a selective FKBP51 PROTAC degrader with a K_d value of 18 nM and a D_max of 90%. SelDeg51 induces proteasomal degradation of FKBP51 via the FKBP51:SelDeg51:VCB ternary complex and reactivates the glucocorticoid receptor signaling pathway. SelDeg51 can be used for research on stress-related mental disorders, chronic pain, and obesity.
(Pink: Target protein ligand; Blue: VHL ligand (HY-125905); Black: linker).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3036372-80-9
화학식: C₇₂H₉₁FN₈O₁₄S
분자량:1343.60

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

SelDeg51 Chemical Structure

CAS No.: 3036372-80-9

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

SelDeg51 is a selective FKBP51 PROTAC degrader with a K_d value of 18 nM and a D_max of 90%. SelDeg51 induces proteasomal degradation of FKBP51 via the FKBP51:SelDeg51:VCB ternary complex and reactivates the glucocorticoid receptor signaling pathway. SelDeg51 can be used for research on stress-related mental disorders, chronic pain, and obesity^[1]. (Pink: Target protein ligand; Blue: VHL ligand (HY-125905); Black: linker).

IC₅₀ & Target

^[1]

VHL	FKBP51 18 nM (Kd)

All PROTACs Isoforms :

In Vitro

SelDeg51 (0.6-10 μM; 0-48 h) degrades FKBP51 in a time-dependent and reversible manner in HEK293T cells, with high selectivity for FKBP12^[1].
SelDeg51 (250 nM) enhances Dexamethasone (HY-14648)-induced expression of endogenous glucocorticoid receptor target genes GILZ and FKBP5 in A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HEK293T cells
Concentration:

1 μM
Incubation Time:

0, 2, 4, 6, 8, 24 and 48 h
Result:

Reduced FKBP51 protein levels.
Did not affact FKBP12 protein levels.

Chemical Information

CAS No. 3036372-80-9
분자량 1343.60
화학식 C₇₂H₉₁FN₈O₁₄S
SMILES

O=C(N1CCCC[C@H]1C(O[C@H](CCC2=CC(OC)=C(OC)C=C2)C3=CC=C(OCC4=CN(CCCOC5=C(CNC([C@@H]6C[C@@H](O)CN6C([C@H](C(C)(C)C)NC(C7(CC7)F)=O)=O)=O)C=CC(C8=C(C)N=CS8)=C5)N=N4)C=C3)=O)[C@H](C9=CC(OC)=C(OC)C(OC)=C9)C%10CCCCC%10
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Geiger TM, et al. Discovery of a Potent Proteolysis Targeting Chimera Enables Targeting the Scaffolding Functions of FK506-Binding Protein 51 (FKBP51). Angew Chem Int Ed Engl. 2024;63(3):e202309706. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

SelDeg51

All PROTACs Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

SelDeg51 Related Classifications

HY-181289 Related Classifications

Bioz

Keywords

Your Recently Viewed Products

IC₅₀ & Target