Tecaginlimab
Based on 1 Customer Validation
Tecaginlimab (BNT-312) is a Fc-inert bispecific antibody for dual targeting and conditional stimulation of CD40 and 4-1BB. Tecaginlimab can enhance priming and reactivation of tumor-specific immunity.
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- Purity: 99.00%
- CAS No.: 2253891-70-0
- 분자량:145.098 kDa
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG1 kappa
Human
|
CD40 |
4-1BB |
Tecaginlimab binds to recombinant human CD40 and 4-1BB with affinities of 1.0 nM and 0.17 nM, respectively[1].
Tecaginlimab (0.001-1 µg/mL; 5 d) induces dendritic cell (DC) maturation in vitro[1].
Tecaginlimab (0.2 µg/mL; 10-15 d) enhances T-cell activation in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
P27512-1 & Q07011
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Loaded Tecaginlimab on AHC2 biosensor, can bind 4-1BB/TNFRSF9 Protein, Human (HEK293, His, HY-P70678) with an affinity constant of 5.270E-11 M as determined in BLI assay. -
Flow Cytometry analysis of Raji cells labelling CD40 (red) with Tecaginlimab (HY-P99572). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS No. 2253891-70-0
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Appearance Liquid
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분자량 145.098 kDa
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Color Colorless to light yellow
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SMILES
[Tecaginlimab]
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Synonyms
BNT-312; DuoBody-CD40x-4-1BB; GEN1042
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선적
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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Data Sheet (256 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)