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Cat. No.: HY-W1130334

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Thalidomide-O-PNB ester

Thalidomide-O-PNB ester is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Thalidomide-O-PNB ester can be linked to a target protein ligand via a linker to form a PROTAC.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₁H₁₅N₃O₉
분자량:453.36

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (242 KB)

Thalidomide-O-PNB ester Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- IC₅₀ & Target
- In Vitro
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Biological Activity

제품 설명

IC₅₀ & Target

Cereblon

All Ligands for E3 Ligase Isoforms :

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 453.36
화학식 C₂₁H₁₅N₃O₉
SMILES

O=C1CCC(C(N1)=O)N2C(C3=C(C(OCC(OC4=CC=C([N+]([O-])=O)C=C4)=O)=CC=C3)C2=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.