Tristin
Based on 1 Customer Validation
Tristin is a PTP1B inhibitor (IC50=21.2 μM) with antioxidant and antifungal activities. Tristin inhibits lipid peroxidation and NO production in LPS-stimulated macrophages, and also exhibits activity against a variety of phytopathogenic fungi. Tristin is also able to inhibit cancer cell proliferation. Tristin can be used in the research of diseases associated with phytopathogenic fungal infection, leukemia, type 2 diabetes and inflammatory responses.
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- Purity: 99.26%
- CAS No.: 139101-67-0
- 화학식: C15H16O4
- 분자량:260.29
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보관:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>10 μM
Compound: 20
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Cytotoxicity against human A549 cells assessed as decrease in cell viability after 6 days by MTT assay
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 6 days by MTT assay
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[PMID: 27310249] |
| HeLa | IC50 |
>10 μM
Compound: 20
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Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 6 days by MTT assay
Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 6 days by MTT assay
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[PMID: 27310249] |
| HL-60 | IC50 |
29.06 μM
Compound: 4
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Anti-cancer activity against human HL-60 cells
Anti-cancer activity against human HL-60 cells
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[PMID: 32711292] |
| MCF7 | IC50 |
>10 μM
Compound: 20
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Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 6 days by MTT assay
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 6 days by MTT assay
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[PMID: 27310249] |
| THP-1 | IC50 |
13.53 μM
Compound: 4
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Anti-cancer activity against human THP-1 cells
Anti-cancer activity against human THP-1 cells
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[PMID: 32711292] |
Tristin exhibits broad-spectrum antifungal activity with MIC values ranging from 96.2 to 384.6 μM[2].
Tristin is inactive against HeLa, MCF-7, and A549 cancer cell lines with an IC50 value greater than 10 μM[2].
Tristin inhibits the proliferation of human HL-60 leukemia cells with an IC50 of 29 μM and human THP-1 leukemia cells with an IC50 of 13 μM[3].
Tristin (25 μM) inhibits NO production in LPS-stimulated RAW264.7 macrophages by 27.23%[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Alternaria brassicicola, Phytophthora parasitica var. nicotianae, Colletotrichum capsici, Bipolaris oryzae, Diaporthe medusaea nitschke, Ceratocystis paradoxa moreau, Exserohilum turcicum, Pestallozzia theae, and Alternaria citri
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Concentration:96.2-384.6 μM
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Incubation Time:/
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Result:Exhibited broad-spectrum antifungal activity with MIC values ranging from 96.2 to 384.6 μM.
Chemical Information
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CAS No. 139101-67-0
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Appearance Solid
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분자량 260.29
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화학식 C15H16O4
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Color White to off-white
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SMILES
OC1=CC(CCC2=CC=C(O)C(OC)=C2)=CC(O)=C1
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
순도&문서
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[2]. Zhou XM, et al. Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile. J Nat Prod. 2016;79(7):1791-1797. [Content Brief]
[3]. He L, et al. Recent research progress on natural small molecule bibenzyls and its derivatives in Dendrobium species. Eur J Med Chem. 2020;204:112530. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tristin Related Classifications
HY-N1117 Related Classifications
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