U-62162
U-62162 is an Antibiotic. U-62162 is found in Streptomyces verdensis. U-62162 inhibits the growth of Gram-positive bacteria. U-62162 exhibits no in vivo protective effect in animals with experimental S. aureus infection.
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- CAS No.: 82516-67-4
- 화학식: C23H33NO6
- 분자량:419.51
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
Microbial Metabolite |
In Vitro
U-62162 exhibits the most potent in vitro growth inhibitory activity against three strains of Staphylococcus aureus, with an MIC of 1.0 μg/mL, and shows selective activity against Gram-positive bacteria with no meaningful activity against the tested Gram-negative strains[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:strain not specified[1]
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Dosage:12.5 mg/kg/day (healthy animals); 8 mg/kg/day (S. aureus-infected animals)
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Administration:i.p.
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Result:Detected no animal protection at the 8 mg/kg/day dose in S. aureus-infected mice.
Chemical Information
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CAS No. 82516-67-4
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분자량 419.51
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화학식 C23H33NO6
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SMILES
O=C(NC1=CC(CCCCC(O)=O)(C2OC2C1=O)O)/C=C/C(CC(C)/C=C(C)\C)C
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Structure Classification
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Initial Source
Streptomyces verdensis
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Gram Staining of Tissue Sections
Gram staining of tissue sections is a histochemical technique used to differentiate Gram-positive and Gram-negative bacteria within histological specimens based on differences in bacterial cell wall structure and dye retention, adapted from classical bacteriological Gram staining into tissue-compatible “histological Gram stain” variants. In tissue applications, modifications of the Brown-Hopps and Brown-Brenn methods are commonly used to improve differentiation of microorganisms embedded within host connective tissue and to reduce overstaining or loss of Gram-negative signal, which are known limitations of earlier approaches. The principle relies on crystal violet-iodine complex retention in Gram-positive organisms and subsequent decolorization and counterstaining steps that allow contrast visualization of Gram-negative organisms against tissue background.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
U-62162 Related Classifications
HY-N21846 Related Classifications
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