U 93385
U93385 is a 5-HT₁A receptor agonist. U93385 exhibits no significant α₂ adrenergic, D₂ dopamine, or other receptor activities. U93385 has a heart rate regulating effect, stimulating the vagus nerve to induce bradycardia. U93385 can be used to study the 5-HT₁A receptor-mediated vagal nerve tolerance mechanism.
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- CAS No.: 147145-16-2
- 화학식: C16H22N2O
- 분자량:258.36
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Biological Activity
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5-HT1A Receptor |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Spinal cord transection model established in cats (2.5-4 kg)[1]
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Dosage:0.3, 1.0, 3.0 mg/kg (single dose); 0.01, 0.03, 0.1, 0.3, 1.0, 3.0 mg/kg (cumulative dose); 1 mg/kg (infusion)
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Administration:Intravenous injection (i.v.), single dose, cumulative administration or intravenous infusion
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Result:Dose-dependently reduced bradycardia and arterial blood pressure at single dose.
Failed to lower heart rate in animals pretreated in this cumulative manner.
Chemical Information
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CAS No. 147145-16-2
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분자량 258.36
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화학식 C16H22N2O
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SMILES
NC(C1=C2[C@@]3([H])[C@](CCC2=CC=C1)([H])N(CCC)CC3)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
U 93385 Related Classifications
HY-106928 Related Classifications
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