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Cat. No.: HY-124514

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UC-857993

UC-857993 is a selective SOS1-Ras inhibitor (K_d=14.7 μM, His₆-SOS1_cat), suppressing catalytic activity. UC-857993 also inhibits ERK and Ras activation, suppresses the growth of mouse embryonic fibroblasts (MEFs).

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CAS No.: 487001-04-7
화학식: C₂₅H₂₂ClNO₂
분자량:403.90

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

UC-857993 Chemical Structure

CAS No.: 487001-04-7

사이즈

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수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Ras Isoforms :

All ERK Isoforms :

In Vitro

UC-857993 (0-80 μM; 3 d) specifically inhibits the growth of wild-type MEFs, but did not inhibit the growth of carcinogenic H-Ras(G12V) expressing MEF^[1].
UC-857993 (60 μM, 80 μM; 2 h) dose-dependently inhibits Ras activation and downstream ERK activation mediated through EGFR-SOS1-Ras-Raf1-MEK-ERK signaling^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

Mouse embryonic fibroblasts
Concentration:

0, 40, 60, and 80 μ M
Incubation Time:

3 days
Result:

Selectively inhibited the growth of mouse fibroblasts, as exerting inhibition against wild-type mouse embryonic fibroblasts but not mouse embryonic fibroblasts expressing carcinogenic H-Ras(G12V).

Western Blot Analysis^[1]

Cell Line:

NIH/3T3 cells
Concentration:

60 μM, 80 μM
Incubation Time:

2 hours; stimulated with 50 ng/ml EGF for 5 min
Result:

Inhibited EGF-induced the increase of the level of p-ERK and Ras-GTP.

Chemical Information

CAS No. 487001-04-7
분자량 403.90
화학식 C₂₅H₂₂ClNO₂
SMILES

O=C(C1=CC2=C3N(C(C4=CC=CC=C4Cl)C5C2C=CC5)CC(CC=C6)C6C3=C1)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Evelyn CR, et al. Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme. J Biol Chem. 2015 May 15;290(20):12879-98. [Content Brief]

Calculators

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Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

UC-857993

All Ras Isoforms

All ERK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

UC-857993 Related Classifications

HY-124514 Related Classifications