VEGFR2-IN-86
VEGFR2-IN-86 is a dual VEGFR2/CDK2 inhibitor, with an IC50 of 0.06 μM against VEGFR2 and an IC50 of 0.78 μM against CDK2. VEGFR2-IN-86 induces G-phase cell cycle arrest, reduces colony-forming ability and tumor cell migration capacity, and exerts antiproliferative activity in cancer cells. VEGFR2-IN-86 can be used for the research of breast cancer and prostate cancer.
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- 화학식: C20H15N3O2
- 분자량:329.35
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All VEGFR Isoforms
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Biological Activity
제품 설명
IC50 & Target
[1]|
VEGFR2 0.06 μM (IC50) |
CDK2 0.78 μM (IC50) |
In Vitro
VEGFR2-IN-86 (Compound 10) (48 h) potently inhibits the viability of PC3 and MCF7 cells, with IC50 values of 5.39 and 4.71 μM[1].
VEGFR2-IN-86 (5.39 and 4.71 μM; 48 h) induces apoptosis in PC3 and MCF7 cells after treatment at its IC50 concentration for 48 hours[1].
VEGFR2-IN-86 (5.39 and 4.71 μM; 48 h) does not significantly alter the cell cycle phase distribution of PC3 and MCF7 cells[1].
VEGFR2-IN-86 (5.39 and 4.71 μM; 48 h) potently inhibits the long-term clonogenic survival of PC3 and MCF7 cells when acting at IC50 concentrations for 48 hours[1].
VEGFR2-IN-86 (5.39 and 4.71 μM; 48 h) inhibits the migration of PC3 and MCF7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC3 prostate cancer cell line
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Concentration:5.39 μM (IC50)
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Incubation Time:48 h
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Result:Resulted in a cell cycle phase distribution pattern comparable to untreated control cells, with no significant alteration in G1, S, or G2/M phase populations relative to control.
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Cell Line:MCF7 breast cancer cell line
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Concentration:4.71 μM (IC50)
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Incubation Time:48 h
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Result:Produced no significant alterations in G1, S, or G2/M phase populations relative to untreated control cells.
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Cell Line:PC3 prostate cancer cell line
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Concentration:5.39 μM (IC50)
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Incubation Time:48 h (treatment); 14 days (colony formation)
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Result:Markedly suppressed colony formation, resulting in a surviving fraction significantly lower than that of untreated control cells.
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Cell Line:MCF7 breast cancer cell line
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Concentration:4.71 μM (IC50)
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Incubation Time:48 h (treatment); 14 days (colony formation)
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Result:Markedly suppressed colony formation, resulting in a surviving fraction significantly lower than that of untreated control cells.
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Cell Line:PC3 prostate cancer cell line
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Concentration:5.39 μM (IC50)
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Incubation Time:48 h
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Result:Resulted in a scratch closure percentage of 73%, showing a slight reduction compared to the untreated control's 78% closure.
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Cell Line:MCF7 breast cancer cell line
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Concentration:4.71 μM (IC50)
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Incubation Time:48 h
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Result:Resulted in a scratch closure percentage of 26%, showing a marked reduction compared to the untreated control's 64% closure.
Chemical Information
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분자량 329.35
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화학식 C20H15N3O2
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SMILES
O=C1NC2=C(C=CC=C2)/C1=C\C(C3=C(C)N=C(C4=CC=CC=C4)N3)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VEGFR2-IN-86 Related Classifications
HY-182789 Related Classifications
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