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Cat. No.: HY-119765

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VU0366248

VU0366248 is a mGlu5 negative allosteric modulator.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1243310-20-4
화학식: C₁₄H₇ClF₂N₂O
분자량:292.67

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

VU0366248 Chemical Structure

CAS No.: 1243310-20-4

사이즈

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재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

VU0366248 is a mGlu5 negative allosteric modulator^[1].

IC₅₀ & Target

mGluR5

All mGluR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293-A	IC₅₀	347 nM Compound: 41	Antagonist activity at rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium mobilization Antagonist activity at rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium mobilization	[PMID: 20598884]

Chemical Information

CAS No. 1243310-20-4
분자량 292.67
화학식 C₁₄H₇ClF₂N₂O
SMILES

O=C(C1=CC(F)=CC(C#N)=C1)NC2=CC=CC(Cl)=C2F
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Karen J Gregory, et al. Investigating Metabotropic Glutamate Receptor 5 Allosteric Modulator Cooperativity, Affinity, and Agonism: Enriching Structure-Function Studies and Structure-Activity Relationships. Mol Pharmacol. 2012 Nov;82(5):860-75. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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VU0366248

All mGluR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

VU0366248 Related Classifications

HY-119765 Related Classifications