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Cat. No.: HY-176457

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ZS3-046

ZS3-046 is a TAF1 PROTAC degrader. ZS3-046 promotes the ubiquitination and degradation of TAF1. ZS3-046 activates p53 and induces apoptosis in acute myeloid leukemia (AML) cells. ZS3-046 has antitumor activity in an AML tumor xenograft mouse model.
(Pink: TAF1 ligand (HY-176467); Blue: Cereblon ligand (HY-41547); Black: linker (HY-176469)).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3087879-97-5
화학식: C₄₉H₅₇N₉O₇
분자량:884.03

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

ZS3-046 Chemical Structure

CAS No.: 3087879-97-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

ZS3-046 is a TAF1 PROTAC degrader. ZS3-046 promotes the ubiquitination and degradation of TAF1. ZS3-046 activates p53 and induces apoptosis in acute myeloid leukemia (AML) cells. ZS3-046 has antitumor activity in an AML tumor xenograft mouse model^[1]. (Pink: TAF1 ligand (HY-176467); Blue: Cereblon ligand (HY-41547); Black: linker (HY-176469)).

All PROTACs Isoforms :

Chemical Information

CAS No. 3087879-97-5
분자량 884.03
화학식 C₄₉H₅₇N₉O₇
SMILES

O=C(N1C2CCC(NC2=O)=O)C3=C(NCC4CCN(CCCCCCCN5C6=C(C(C(C7=C8NC=C7)=CN(CCC=C)C8=O)=CC(C(N9CCOCC9)=O)=C6)N=C5)CC4)C=CC=C3C1=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen L, et al. PROTAC-Mediated Degradation of TAF1 Induces Apoptosis in AML Cells and Inhibits Tumor Growth In Vivo. Mol Cancer Ther. 2025 May 16:OF1-OF10. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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수량:
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ZS3-046

All PROTACs Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

ZS3-046 Related Classifications

HY-176457 Related Classifications