KX1-141
KX1-141 is a non-ATP-competitive Src inhibitor. KX1-141 is largely ineffective in preventing noise-induced hearing loss.
For research use only. We do not sell to patients.
- CAS No.: 1000706-00-2
- Formula: C24H20F2N2O2
- Molecular Weight:406.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vivo
KX1-141 (delivered to the cochlea; administered before exposure) is essentially ineffective in preventing NIHL in chinchillas after impulse noise exposure[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Chinchillas[1]
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Dosage:50 µM (10 µL) in ≤0.5% DMSO/PBS
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Administration:topical (round window membrane/niche); single application; 30 minutes before impulse noise
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Result:Showed no significant reduction in impulse-noise-induced threshold shift relative to vehicle controls; there was a trend toward lower threshold shift, and showed the lowest mean permanent threshold shift at 0.5-2 kHz.
OHC loss was not significantly different from controls, and mean OHC loss was greater than in controls in sections of the middle cochlear turn.
Chemical Information
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CAS No. 1000706-00-2
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Molecular Weight 406.43
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Formula C24H20F2N2O2
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SMILES
O=C(NCC=1C=CC=C(F)C1)C2=CC=3C=C(F)C=C(C=4C=CC=C(OCC)C4)C3N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KX1-141 Related Classifications
HY-109792 Related Classifications
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