2. Cell Cycle/DNA Damage Epigenetics NF-κB
  3. PARP NF-κB
  4. L-2286

L-2286 is an orally active PARP-1 inhibitor. L-2286 alleviates carotid artery remodeling, oxidative stress and inflammation in spontaneously hypertensive rats, protects neurons in the dorsal hippocampus, and reduces pyramidal cell loss and gliosis without affecting blood pressure. L-2286 can be used in research related to hypertension.

For research use only. We do not sell to patients.

L-2286

L-2286 Chemical Structure

CAS No. : 684276-17-3

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

L-2286 Related Antibodies

Top Publications Citing Use of Products

View All PARP Isoform Specific Products:

View All Isoforms
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

View All NF-κB Isoform Specific Products:

View All Isoforms
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

L-2286 is an orally active PARP-1 inhibitor. L-2286 alleviates carotid artery remodeling, oxidative stress and inflammation in spontaneously hypertensive rats, protects neurons in the dorsal hippocampus, and reduces pyramidal cell loss and gliosis without affecting blood pressure. L-2286 can be used in research related to hypertension[1].

IC50 & Target[1]

PARP-1

 

In Vivo

L-2286 (5 mg/kg, administered via drinking water for 32 weeks) alleviates carotid vascular remodeling and oxidative damage in the dorsal hippocampus of spontaneously hypertensive rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Spontaneously Hypertensive Rats (SHR) (10-week-old male, hypertension model)[1]
Dosage: 5 mg/kg/day
Administration: administered via drinking water for 32 weeks
Result: Significantly reduced carotid intima‑media thickening, interstitial fibrosis, oxidative/nitrosative stress, nuclear factor‑κB (NF‑κB) nuclear translocation, and apoptosis‑inducing factor (AIF)‑dependent cell death in carotid arteries, while improving endothelium‑dependent vasodilation in spontaneously hypertensive rats.
Mitigated oxidative damage, pyramidal neuron loss, DNA oxidation, poly(ADP‑ribose) polymerase (PAR) formation, reactive astrogliosis, and perivascular white matter lesions in the dorsal hippocampus, all without altering systolic blood pressure.
Molecular Weight

289.40

Formula

C15H19N3OS
CAS No.
SMILES

O=C1NC(SCCN2CCCCC2)=NC3=C1C=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

L-2286 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-2286684276-17-3L2286L 2286PARPNF-κBpoly ADP ribose polymerase Nuclear factor-κBNuclear factor-kappaBcarotid arteriesspontaneously hypertensive ratsPARP-1dorsal hippocampusreactive astrogliosisInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
L-2286
Cat. No.:
HY-129599
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.