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Cat. No.: HY-123442

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L 775,606

L 775,606 is a potent and selective 5-HT1D receptor agonist. L 775,606 can be used to study migraine headache.

For research use only. We do not sell to patients.

CAS No.: 188400-51-3
Formula: C₂₅H₂₉FN₆
Molecular Weight:432.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

L 775,606 Chemical Structure

CAS No.: 188400-51-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

L 775,606 is a potent and selective 5-HT1D receptor agonist. L 775,606 can be used to study migraine headache^[1].

IC₅₀ & Target

5-HT_1D Receptor

All 5-HT Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	1 nM Compound: 3	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	[PMID: 10377215]
CHO	EC₅₀	1 nM Compound: 7f	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor. Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	[PMID: 10052976]
CHO	EC₅₀	1.2 nM Compound: 15	Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor. Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.	[PMID: 9357515]
CHO	EC₅₀	1.2 nM Compound: 4	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	[PMID: 9667955]
CHO	EC₅₀	430 nM Compound: 3	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor	[PMID: 10377215]
CHO	IC₅₀	0.5 nM Compound: 3	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	[PMID: 10377215]
CHO	IC₅₀	0.5 nM Compound: 7f	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	[PMID: 10052976]
CHO	IC₅₀	0.6 nM Compound: 15	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	[PMID: 9357515]
CHO	IC₅₀	0.6 nM Compound: 4	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	[PMID: 9667955]
CHO	IC₅₀	72 nM Compound: 3	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells	[PMID: 10377215]
CHO	IC₅₀	72 nM Compound: 7f	Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells. Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.	[PMID: 10052976]
CHO	IC₅₀	75 nM Compound: 15	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells	[PMID: 9357515]
CHO-K1	IC₅₀	0.6 nM Compound: L-775606	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	[PMID: 18507369]

Chemical Information

CAS No. 188400-51-3
Molecular Weight 432.54
Formula C₂₅H₂₉FN₆
SMILES

FC1=CC(CCN2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Prueksaritanont T, et al. Interspecies comparison and role of human cytochrome P450 and flavin-containing monooxygenase in hepatic metabolism of L-775,606, a potent 5-HT(1D) receptor agonist. Xenobiotica. 2000 Jan;30(1):47-59. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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L 775,606

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

L 775,606 Related Classifications

HY-123442 Related Classifications