CETP
Cholesteryl ester transfer protein
Cholesteryl ester transfer protein (CETP) is a plasma glycoprotein that facilitates the transfer of cholesteryl esters from the atheroprotective high density lipoprotein (HDL) to the proatherogenic low density lipoprotein cholesterol (LDL) and very low density lipoprotein cholesterol (VLDL) leading to lower levels of HDL but raising the levels of proatherogenic LDL and VLDL. CETP inhibitors are a class of drugs that targets the CETP enzyme to significantly increase serum HDL-C and decrease LDL-C levels. Inhibition of CETP is considered a potential approach to treat dyslipidemia.
Alterations of CETP activity levels can be caused by single-base polymorphisms as well as by alternative splicing. Several common variants in CETP have been reported to be associated with variation in plasma lipid levels, CAD risk and/or CETP mass/activity. The rare genetic variants in the CETP gene also contribute to the phenotypic variation of HDL-C in the general population.
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CETP Related Products (33)
Related Products (33)
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Antibodies (1)
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20-HC-Me-Pyrrolidine
0 ImagesCat. No.: HY-145001Purity: 99.69%20-HC-Me-Pyrrolidine (compound AI-3d) is a potent Aster protein inhibitor with IC50s of 0.11 μM, 0.06 μM, and 0.71 μM for Aster-A, Aster-B, and Aster-C, respectively. 20-HC-Me-Pyrrolidine blocks the ability of Asters to bind and transfer cholesterol. 20-HC-Me-Pyrrolidine also inhibits the movement of low-density lipoprotein (LDL) cholesterol to the endoplasmic reticulum (ER).
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Torcetrapib
0 ImagesSynonyms: CP-529414
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Obicetrapib
0 ImagesSynonyms: TA-8995; DEZ-001; AMG-899Obicetrapib (TA-8995; DEZ-001) is an orally active cholesteryl ester transfer protein (CETP) inhibitor. Obicetrapib potently reduces atherogenic lipoproteins (such as LDL-C, ApoB, Lp (a)) and increases HDL-C. Obicetrapib can be used for the research of dyslipidemia and atherosclerotic cardiovascular disease (ASCVD).
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UBA6-IN-1
0 ImagesCat. No.: HY-153774CAS No.: 1557137-61-7UBA6-IN-1 is a UBA6/UBE1L2 inhibitor (IC50 ≤50 nM) that acts by reducing the level of squalene epoxidase (SQLE). UBA6-IN-1 affects SREBP-dependent lipid metabolism processes and downstream cholesteryl ester transport, and can be used for cancer research.
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Obicetrapib potassium
0 ImagesCat. No.: HY-18778BCAS No.: 866399-90-8Synonyms: TA-8995 potassium; DEZ-001 potassium; AMG-899 potassiumObicetrapib (TA-8995; DEZ-001) potassium is an orally active cholesteryl ester transfer protein (CETP) inhibitor. Obicetrapib potassium potently reduces atherogenic lipoproteins (such as LDL-C, ApoB, Lp (a)) and increases HDL-C. Obicetrapib potassium can be used for the research of dyslipidemia and atherosclerotic cardiovascular disease (ASCVD).
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Obicetrapib sodium
0 ImagesCat. No.: HY-18778ACAS No.: 866399-88-4Synonyms: TA-8995 sodium; DEZ-001 sodium; AMG-899 sodiumObicetrapib (TA-8995; DEZ-001) sodium is an orally active cholesteryl ester transfer protein (CETP) inhibitor. Obicetrapib sodium potently reduces atherogenic lipoproteins (such as LDL-C, ApoB, Lp (a)) and increases HDL-C. Obicetrapib sodium can be used for the research of dyslipidemia and atherosclerotic cardiovascular disease (ASCVD).
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α-Amylcinnamaldehyde
0 ImagesSynonyms: 2-Benzylideneheptanal; α-Pentylcinnamaldehydeα-Amylcinnamaldehyde is a ligand for the Niemann-Pick type C2 (NPC2) protein of arthropod moths and may play a key role in the identification of moth volatiles. NPC2 is a key enzyme for cholesterol transport in the body.
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CP-532623
0 ImagesCat. No.: HY-123039CAS No.: 261947-38-0CP-532623 is a CETP inhibitor and elevates high-density lipoprotein cholesterolion. CP-532623 is a close structural analogue of Torcetrapib. CP-532623 has highly lipophilic properties.
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MK-8262
0 ImagesCat. No.: HY-132303CAS No.: 1432054-03-9MK-8262 is an orally active and potent cholesteryl ester transfer protein (CETP) inhibitor with an IC50 of 53 nM and a log D of 5.3. MK-8262, a bistrifluoromethyl analogue, has the potential for coronary heart disease (CHD) correlated high-density lipoprotein (HDL) and low-density lipoprotein (LDL) research.
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TAP311
0 ImagesCat. No.: HY-107997CAS No.: 1149362-88-8TAP311 is a cholesteryl ester transfer protein (CETP) inhibitor with an IC50 of 62 nM.
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CETP-IN-3
0 ImagesCat. No.: HY-128338CAS No.: 939391-31-8CETP-IN-3 (Compound 13) is an small molecule inhibitor of the plasma glycoprotein cholesterol ester transfer protein (CETP), elevating HDL-C through inhibition of CETP. CETP-IN-3 for the CETP inhibitory activity in the scintillation proximity (SPA) and whole plasma assay (WPA) with IC50s of 0.002 μM and 0.06 μM, respectively.
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Rosenonolactone
0 ImagesRosenonolactone shows inhibitory activity against prolyl endopeptidase and thrombin and cholesterol ester transfer protein.
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3-Pyridinemethanol-d6
0 ImagesCat. No.: HY-W740341CAS No.: 1189493-62-63-Pyridinemethanol-d6 is the deuterium labeled 3-Pyridinemethanol (HY-B0893). 3-Pyridinemethanol (Nicotinyl alcohol), a pyridine derivative, is a cholesterol-lowering agent.
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BMS-795311
0 ImagesCat. No.: HY-19614CAS No.: 939390-99-5BMS-795311 is a potent and orally bioavailable inhibitor of cholesteryl ester transfer protein (CETP), with IC50s of 4 nM in an enzyme-based scintillation proximity assay (SPA) and 0.22 μM in a human whole plasma assay (hWPA), respectively.
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Tiqueside
0 ImagesCat. No.: HY-106106CAS No.: 99759-19-0Synonyms: CP‐88,818; β‐Tigogenin cellobiosideTiqueside (CP‐88,818) is an orally active cholesterol absorption inhibitor. Tiqueside inhibits absorption of both dietary cholesterol and endogenous cholesterol excreted into the intestinal lumen via the bile. Tiqueside can be used in the research of hypercholesterolemia.
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BI-5756
0 ImagesCat. No.: HY-171883CAS No.: 1332485-18-3BI-5756 is a CETP inhibitor and cannabinoid receptor 1 (CB1) agonist. BI-5756 can significantly increase HDL-C levels and reduce LDL-C levels. BI-5756 can also enhance the function of regulatory T cells while maintaining T cell-mediated anti-tumor activity. BI-5756 can directly inhibit the growth of tumor cells and upregulate the expression of MHC I, MHC II, and CD80 on tumor cells. BI-5756 has a protective effect in graft-versus-host disease models. BI-5756 can be used in research on tumors, graft-versus-host disease, and metabolic diseases.
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