MANS peptide
Based on 1 publication(s) in Google Scholar
MANS peptide is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis.
For research use only. We do not sell to patients.
- Purity: 99.66%
- CAS No.: 479482-23-0
- Formula: C111H184N30O35
- Molecular Weight:2498.83
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MANS peptide
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Biological Activity
MANS peptide (0-100 μM, 12-24 h) inhibits migration and invasion of lung cancer cells CL1-0/F3, CL1-5, PC9 and A549 without causing toxicity to normal cells[1].
MANS peptide (0-100 μM, 16 h) inihibits MARCKS phosphorylation and PI3K and AKT phosphorylation, leads to downstream changes in Slug and E-cadherin expression levels, prevents the loss of cell-cell adhesion, alters epithelial-mesenchymal transition (EMT) characteristics of cancer cells, and thus decreases tumor metastasis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CL1-0/F3, CL1-5 and PC9
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Concentration:0-100 μM
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Incubation Time:12-24 h
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Result:Inhibited migration.
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Cell Line:CL1-0/F3, CL1-5, PC9 and NHBE
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Concentration:0-100 μM
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Incubation Time:16 h
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Result:Upregulated levels of E-cadherin, downregulated levels of Slug.
Suppressed MARCKS phosphorylation and AKT/Slug pathway.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NOD/SCID mice model[1]
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Dosage:50 nmol/injection
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Administration:Ip, every 3 days for 6 times
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Result:Suppressed micrometastatic lesions.
Chemical Information
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CAS No. 479482-23-0
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Appearance Solid
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Molecular Weight 2498.83
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Formula C111H184N30O35
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Color White to off-white
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Sequence
{Myristic acid-Gly}-Ala-Gln-Phe-Ser-Lys-Thr-Ala-Ala-Lys-Gly-Glu-Ala-Ala-Ala-Glu-Arg-Pro-Gly-Glu-Ala-Ala-Val-Ala
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Sequence Shortening
{Myristic acid-Gly}-AQFSKTAAKGEAAAERPGEAAVA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Mol Biol Rep
MARCKS N-terminal sequence-derived inhibitor peptides impair monocytic ROS production and migration via MARCKS-independent effects. [Abstract]2025 Sep 17;52(1):911. PMID: 40960646
Solvent & Solubility
DMSO : 25 mg/mL (10.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.4002 mL | 2.0009 mL | 4.0019 mL | 10.0047 mL |
| 5 mM | 0.0800 mL | 0.4002 mL | 0.8004 mL | 2.0009 mL |
MANS peptide Related Classifications
HY-P10218 Related Classifications
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