AGC

AGC is one of the major branches of the human kinome, named after its founding members protein kinase A (PKA), protein kinase G (PKG) and protein kinase C (PKC). Members share a conserved catalytic domain whose hydrophobic motif is phosphorylated by PDK1 or related upstream regulators. Through cAMP, cGMP, diacylglycerol and PI3K/AKT signaling, AGC kinases control metabolism, secretion, cell survival, contractility and cytoskeletal dynamics. The group includes AKT isoforms, SGK, S6K, RSK, MSK, GRKs and the PRK/PKN subfamily. Because AKT, PKC isoforms and S6K sit at hubs of oncogenic and metabolic pathways, several AGC members are prominent oncology drug targets.