PF-07329640
Based on 1 Customer Validation
PF-07329640 is a humanized monoclonal antibody agonist that specifically targets NFRSF3/LTβR. PF-07329640 exhibits significant receptor activation and tumor immune microenvironment remodeling activity. PF-07329640 binds to and activates the TNFRSF3 receptor, inducing the formation of tertiary lymphoid structures within tumors, thereby recruiting and activating large numbers of immune cells to break immune tolerance. PF-07329640 can be used for research on advanced malignant solid tumors.
For research use only. We do not sell to patients.
- Purity : 95.25%
- Molecular Weight:146.05 kDa
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Storage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
[1]|
TNFRSF3 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized Human LTBR / TNFRSF3 Protein, His, Avi tag can bind PF-07329640. The EC50 for this effect is 46.8 ng/mL.
Chemical Information
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Appearance Liquid
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Molecular Weight 146.05 kDa
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Color Colorless to light yellow
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SMILES
N/A
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. PF-07329640.
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)