Phanginin J
Phanginin J is a Cassane-type furanoditerpene found in the seeds of Caesalpinia sappan L. Phanginin J docks with the TRPV1 molecule and may inhibit nociceptive sensory signal transduction by antagonizing TRPV1. Phanginin J can be used in research related to chemotherapy-induced peripheral neuropathy (CIPN).
For research use only. We do not sell to patients.
- CAS No.: 1011528-67-8
- Formula: C21H26O5
- Molecular Weight:358.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
TRPV1 |
In Vitro
Phanginin J (compound 10) shows no cytotoxic activity in the SRB cytotoxicity assay against MCF-7, HeLa, HT-29, and KB cells[1].
Phanginin J exhibits a predicted binding energy of -7.2 kcal/mol toward TRPV1 (PDB ID: 5IS0) in AutoDock Vina molecular docking, whereas capsazepine exhibits -7.1 kcal/mol[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 1011528-67-8
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Molecular Weight 358.43
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Formula C21H26O5
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SMILES
O=C[C@@]12[C@](CC[C@]3([H])[C@]2([H])CC4=C(C=CO4)[C@@H]3C)([H])[C@@](C=O)(CCC1)C(OC)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Phanginin J Related Classifications
HY-N21629 Related Classifications
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