Phosphodiesterase I
Based on 1 publication(s) in Google Scholar
Phosphodiesterase I (PDE) is an enzyme that can catalyze the hydrolysis of the 3' ring phosphate bond of cyclic nucleotides, and is often used in biochemical research. Phosphodiesterase I acts as an important regulator of signal transduction mediated by the second messenger molecules cAMP and cGMP. According to their specificity to cyclic nucleotides, they can also be divided into different types, such as PDE1-PDE11, which also have certain potential in various diseases.
For research use only. We do not sell to patients.
- CAS No.: 9025-82-5
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Phosphodiesterase I
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Biological Activity
Product Information
Phosphodiesterase I is an enzyme preparation made by fermentation of bacterial strains, advanced extraction technology, ultrafiltration concentration, drying and purification.
Temperature range: Effective temperature range: 45°C-85°C, Optimum temperature range: 65°C-75°C
pH range: Effective pH range: 4.0-8.0, Optimum pH range: 4.5-5.5
Activator: Mg2+
Inhibitor: Reducing agents, such as glutathione, cysteine and ascorbic acid, 5 mM EDTA can completely inhibit the enzyme, while ATP, ADP and AMP can partially inhibit the enzyme
Instructions
Soluble in water (Mg2+ needs to be added to the reaction buffer), or dissolved according to the specific experimental reference (such as using 0.11 M Tris-HCl buffer, pH 8.9, with 0.11 M NaCl and 15 mM MgCl2 to dissolve).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 9025-82-5
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Appearance Solid
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Color White to light yellow
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SMILES
[Phosphodiesterase I]
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Synonyms
PDE
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Curr Protoc
Programmable Aptamer-Drug Conjugates: Expanding Automated and Modular Platforms for Targeted Therapeutics. [Abstract]2025 Nov;5(11):e70249. PMID: 41196659
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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