Cat. No.: HY-153915

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PI3Kα-IN-11

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PI3Kα-IN-11 is a potent PI3Kα inhibitor with anticancer activity.

For research use only. We do not sell to patients.

Purity: 95.35%
CAS No.: 300803-79-6
Formula: C₁₇H₁₄N₂O₃
Molecular Weight:294.30

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

PI3Kα-IN-11 Chemical Structure

CAS No.: 300803-79-6

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Quantity

Sample (0.1mg)

In-stock

(In Japan)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

PI3Kα-IN-11 is a potent PI3Kα inhibitor with anticancer activity^[1].

IC₅₀ & Target^[1]

PI3Kα

All PI3K Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.73 μM Compound: 13, NSC 675972	Growth inhibition of human HCT116 cells overexpressing PI3Kalpha H1047R mutant after 48 hrs by MTT assay Growth inhibition of human HCT116 cells overexpressing PI3Kalpha H1047R mutant after 48 hrs by MTT assay	[PMID: 22212721]
HCT-116	IC₅₀	1.1 μM Compound: 13, NSC 675972	Growth inhibition of human HCT116 cells overexpressing PI3Kalpha after 48 hrs by MTT assay Growth inhibition of human HCT116 cells overexpressing PI3Kalpha after 48 hrs by MTT assay	[PMID: 22212721]
HCT-116	IC₅₀	1.8 μM Compound: 13, NSC 675972	Growth inhibition of human HCT116 cells after 48 hrs by MTT assay Growth inhibition of human HCT116 cells after 48 hrs by MTT assay	[PMID: 22212721]

In Vitro

The IC₅₀ of HCT116-WT and HCT116-MUT (H1047R) cell lines were 1.1 and 0.73 μM, respectively.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 300803-79-6
Appearance Solid
Molecular Weight 294.30
Formula C₁₇H₁₄N₂O₃
Color White to light yellow
SMILES

O=C1NC2=C(C(O)=C1C(NCC3=CC=CC=C3)=O)C=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (33.98 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.3979 mL

16.9895 mL

33.9789 mL

5 mM

0.6796 mL

3.3979 mL

6.7958 mL

10 mM

0.3398 mL

1.6989 mL

3.3979 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sabbah DA, et al.N-Phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Kα). Bioorg Med Chem. 2012 Dec 15;20(24):7175-83. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.3979 mL	16.9895 mL	33.9789 mL	84.9473 mL
	5 mM	0.6796 mL	3.3979 mL	6.7958 mL	16.9895 mL
	10 mM	0.3398 mL	1.6989 mL	3.3979 mL	8.4947 mL
	15 mM	0.2265 mL	1.1326 mL	2.2653 mL	5.6632 mL
	20 mM	0.1699 mL	0.8495 mL	1.6989 mL	4.2474 mL
	25 mM	0.1359 mL	0.6796 mL	1.3592 mL	3.3979 mL
	30 mM	0.1133 mL	0.5663 mL	1.1326 mL	2.8316 mL

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PI3Kα-IN-11

Kinase Inhibitor Library

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Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Anti-Rheumatic Arthritis Compound Library

Posttranslational Modification Library

Lactylation Compound Library

All PI3K Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

PI3Kα-IN-11 Related Classifications

Cat. No.: HY-153915