Polyvinyl alcohol (Mw 146000-186000, 99+% hydrolyzed)

Name: Polyvinyl alcohol (Mw 146000-186000, 99+% hydrolyzed)
Brand: MedChemExpress
SKU: HY-Y0850
Rating: 5.0 (3 reviews)

Cat. No.: HY-Y0850 Assay: 99.60%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Polyvinyl alcohol (Mw 146000-186000, 99+% hydrolyzed) is a non-biodegradable, hydrophilic, odorless biomedical polymer with cell adhesion/proliferation inhibition, peripheral nerve regeneration induction, dissolution enhancement, and non-toxic, biocompatible properties.

For research use only. We do not sell to patients.

Polyvinyl alcohol (Mw 146000-186000, 99+% hydrolyzed) Chemical Structure

CAS No. : 9002-89-5

Size	Stock	Quantity
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	In-stock	Estimated Time of Arrival: December 31
100 g	In-stock	Estimated Time of Arrival: December 31
> 100 g	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Polyvinyl alcohol (Mw 146000-186000, 99+% hydrolyzed):

Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) In-stock
Polyvinyl alcohol (Mw 89000-98000, 99+% hydrolyzed) In-stock
Polyvinyl alcohol (Mw 9000-10000, 80% hydrolyzed) In-stock
Polyvinyl alcohol (Mw 13000-23000, 87-89% hydrolyzed) In-stock
Polyvinyl alcohol (Mw 31000-50000, 98-99% hydrolyzed) In-stock
Polyvinyl alcohol (Mw 85000-124000, 99+% hydrolyzed) In-stock
Polyvinyl alcohol (Mw 85000-124000, 87-89% hydrolyzed) In-stock
Polyvinyl alcohol (Mw 13000-23000, 98% hydrolyzed) In-stock
Polyvinyl alcohol (Mw 31000-50000, 87-89% hydrolyzed) In-stock
Polyvinyl alcohol (Mw 146000-186000, 87-89% hydrolyzed) In-stock

3 Publications Citing Use of MCE Polyvinyl alcohol (Mw 146000-186000, 99+% hydrolyzed)

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

PVA disk-shaped scaffolds (3-7 days) do not support SH-SY5Y cell adhesion or proliferation in vitro over 7 days^[1].
Polyvinyl alcohol (Mw 146000-186000, 98.0-98.8% hydrolyzed) can be fabricated into dimmed disk-shaped scaffolds and highly transparent tubular scaffolds with visible lumens^[1].
Polyvinyl alcohol (Mw 146000-186000, 99+% hydrolyzed) hydrogels (with/without sodium sulfate, 1-5 freeze-thaw cycles) exhibit no cytotoxicity to L929 fibroblasts and no haemolytic activity against sheep erythrocytes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[2]

Cell Line:	L929 fibroblasts; sheep erythrocytes
Concentration:	100 μg/mL (Neutral Red stain); 0.5 mg/mL (MTT stain); 10% (v/v) (Alamar Blue reagent)
Incubation Time:	24 h
Result:	Detected no significant difference in L929 viability compared to controls, with some samples showing minor growth stimulation. Matched control cell viability values with small SEM. Observed grade 0 reactivity (no toxicity) with no zones of inhibition for all hydrogel samples. Detected no significant cytotoxic effect, with no statistical difference between absorbance and fluorescence methods. Detected no significant LDH release. Measured haemolysis < 2% for all hydrogels, with no significant difference between samples .

In Vivo

Polyvinyl alcohol (Mw 146000-186000, 99+% hydrolyzed) (10 mm-long conduit; surgical implantation; single administration) supports peripheral nerve regeneration across a 5 mm gap in Rattus norvegicus over 12 weeks but has inferior axon density and total axon count outcomes in the central portion compared to the OxPVA conduit and reversed-autograft, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague-Dawley (weighing 200-250 g)^[1]
Dosage:	10 mm-long conduit
Administration:	surgical implantation; single administration
Result:	Supported regeneration of the injured nerve across the 5 mm gap over 12 weeks. Showed well-integrated explantation with no dislocation, inflammatory reaction, or neuroma formation. Achieved a mean regenerated nerve area of 191,485 μm² in the central portion of the conduit. Demonstrated a lower axon density (0.0282 axons/μm²) in the central portion compared to the OxPVA conduit (0.0496 axons/μm²). Showed a lower total axons/nerve count (5,455) in the central portion compared to the reversed-autograft (16,863).

Molecular Weight

146000-186000 (Approximately)

Formula

(C₂H₄O)n

CAS No.

9002-89-5

Appearance

Solid

Color

White to off-white

SMILES

CCC(O)C.[n]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.43 mg/mL; Clear solution

This protocol yields a clear solution of ≥ 1.43 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (14.3 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.43 mg/mL; Clear solution

This protocol yields a clear solution of ≥ 1.43 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (14.3 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.60%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (245 KB)

Handling Instructions (2659 KB)

References

[1]. Stocco E, et al. Partially oxidized polyvinyl alcohol conduitfor peripheral nerve regeneration. Sci Rep. 2018;8(1):604. Published 2018 Jan 12. [Content Brief]

[2]. Hayes JC, et al. An evaluation of the biocompatibility properties of a salt-modified polyvinyl alcohol hydrogel for a knee meniscus application. Mater Sci Eng C Mater Biol Appl. 2016;59:894-900. [Content Brief]