PRMT5-MTA-IN-2
PRMT5-MTA-IN-2 (compund 1) is a MTA co-inhibitor of PRMT5 with IC50 less than 1.5 nM.
For research use only. We do not sell to patients.
- Formula: C30H25F2N7O2
- Molecular Weight:553.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Histone Methyltransferase Isoforms
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Biological Activity
Description
IC50 & Target
PRMT5[1]
Chemical Information
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Molecular Weight 553.56
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Formula C30H25F2N7O2
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SMILES
NC1=NC2=C(C3=C1COC3)NC(C(N([C@@H]4CCCC5=CC=CN=C54)CC6=NC=C(C=C6)C7=C(C=NC=C7F)F)=O)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. WO2024199255A1
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)