IFN-γ
Interferon-gamma (IFN-γ), the sole type II interferon, is a 143-amino-acid homodimeric cytokine produced almost exclusively by NK cells, NKT cells, cytotoxic CD8+ T cells and Th1 cells upon antigen or IL-12/IL-18 stimulation. Unlike type I interferons, IFN-γ signals through a unique heterodimeric receptor-IFNGR1 and IFNGR2-activating JAK1/JAK2 and STAT1 homodimers (GAF), which bind GAS elements to induce T-bet, MHC class I/II, antigen-processing components (TAP1/2, immunoproteasome subunits), chemokines (CXCL9/10/11) and nitric oxide synthase. These effects endow IFN-γ as the signature macrophage-activating factor, augmenting microbial killing, antigen presentation and Th1 polarization. IFN-γ additionally drives immune checkpoint PD-L1 induction, class switching to IgG subclasses, and tissue remodeling. Its dysregulation causes susceptibility to intracellular pathogens (mycobacteria, Salmonella) in deficiency, and autoimmune pathology in excess; IFN-γ assays underlie immunodiagnosis of tuberculosis and anti-IFN-γ autoantibody disease is a recognized adult immunodeficiency.
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IFN-γ Recombinant Proteins (24)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
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- 2
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
