(Rac)-Reparixin
Based on 1 Customer Validation
(Rac)-Reparixin is the isomer of Reparixin (HY-15251), and can be used as an experimental control. Reparixin is a non-competitive allosteric inhibitor of the chemokine receptors CXCR1 and CXCR2 activation with IC50s of 1 and 100 nM, respectively.
For research use only. We do not sell to patients.
- Purity: 99.75%
- CAS No.: 957407-64-6
- Formula: C14H21NO3S
- Molecular Weight:283.39
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chemical Information
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CAS No. 957407-64-6
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Appearance Solid
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Molecular Weight 283.39
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Formula C14H21NO3S
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Color White to off-white
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SMILES
CS(=O)(NC(C(C)C1=CC=C(CC(C)C)C=C1)=O)=O
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Synonyms
(Rac)-Repertaxin; (Rac)-DF 1681Y
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (352.87 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Sousa LF, et al. Blockade of CXCR1/2 chemokine receptors protects against brain damage in ischemic stroke in mice. Clinics (Sao Paulo). 2013;68(3):391-4. [Content Brief]
[2]. Bertini R, et al. Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11791-6. [Content Brief]
[3]. Krishnamurthy A, et al. Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss. Ann Rheum Dis. 2016 Apr;75(4):721-9. [Content Brief]
[4]. Crespo J, et al. Human Naive T Cells Express Functional CXCL8 and Promote Tumorigenesis. J Immunol. 2018 Jul 15;201(2):814-820. [Content Brief]
[5]. Moriconi A, et al. Design of noncompetitive interleukin-8 inhibitors acting on CXCR1 and CXCR2. J Med Chem. 2007 Aug 23;50(17):3984-4002. [Content Brief]
[6]. Bertini R, et al. Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2non-competitive allosteric inhibitor. Br J Pharmacol. 2012 Jan;165(2):436-54. [Content Brief]
[7]. Kim HY, et al. Reparixin, an inhibitor of CXCR1 and CXCR2 receptor activation, attenuates blood pressure and hypertension-related mediators expression in spontaneously hypertensive rats. Biol Pharm Bull. 2011;34(1):120-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5287 mL | 17.6433 mL | 35.2867 mL | 88.2167 mL |
| 5 mM | 0.7057 mL | 3.5287 mL | 7.0573 mL | 17.6433 mL | |
| 10 mM | 0.3529 mL | 1.7643 mL | 3.5287 mL | 8.8217 mL | |
| 15 mM | 0.2352 mL | 1.1762 mL | 2.3524 mL | 5.8811 mL | |
| 20 mM | 0.1764 mL | 0.8822 mL | 1.7643 mL | 4.4108 mL | |
| 25 mM | 0.1411 mL | 0.7057 mL | 1.4115 mL | 3.5287 mL | |
| 30 mM | 0.1176 mL | 0.5881 mL | 1.1762 mL | 2.9406 mL | |
| 40 mM | 0.0882 mL | 0.4411 mL | 0.8822 mL | 2.2054 mL | |
| 50 mM | 0.0706 mL | 0.3529 mL | 0.7057 mL | 1.7643 mL | |
| 60 mM | 0.0588 mL | 0.2941 mL | 0.5881 mL | 1.4703 mL | |
| 80 mM | 0.0441 mL | 0.2205 mL | 0.4411 mL | 1.1027 mL | |
| 100 mM | 0.0353 mL | 0.1764 mL | 0.3529 mL | 0.8822 mL |
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