10 Results for "

ras-in-2

" in MedChemExpress (MCE) Product Catalog:
Products (10)

10 Results for "ras-in-2" in MCE Product Catalog:

17
Daraxonrasib
Daraxonrasib
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17 Cited Publications
Cat. No.: HY-148439
CAS No.: 2765081-21-6
Purity:  99.68%
Synonyms: RMC-6236; ras-in-2
Target:  

Ras PERK

Research Areas:  

Cancer

Daraxonrasib (RMC-6236) is an orally active, non-covalent RAS (ON) inhibitor. Daraxonrasib disrupts the interaction of wild-type or mutant RAS proteins with the RAS binding domain of BRAF, with EC50 values ranging from 28-220 nM for wild-type KRAS, NRAS, HRAS, and multiple oncogenic RAS variants. Daraxonrasib inhibits pERK. Daraxonrasib has anti-tumor activity against KRAS mutant tumors [2] .
Pan-RAS-IN-2
Pan-RAS-IN-2
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Cat. No.: HY-158409
CAS No.: 3034673-92-9
Purity:  98.00%
Target:  

Molecular Glues Ras Cyclophilin PERK

Research Areas:  

Cancer

Pan-rasin-2 (compound 6A) is an orally active molecular glues that targets RAS. Pan-RAS-IN-2 inhibits pERK (IC50 in AsPC-1 cells: 0.3 nM). Pan-rasin-2 has significant inhibitory activity on cell proliferation of RAS mutant cell lines. Pan-rasin-2 can form ternary complexes with cyclophilin A (CYPA) and RAS (ON) proteins and the formation of ternary complexes can block the binding of RAF downstream of RAS, which has anti-tumor (such as colorectal cancer, pancreatic cancer) effects .
Broussoflavonol F
Broussoflavonol F
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Cat. No.: HY-N9330
CAS No.: 162558-94-3
Category:  

Flavonols other families Flavonoids Other Diseases Phenols Polyphenols Plants Disease Research Fields

Target:  

Xanthine Oxidase Ras EGFR MEK PERK Apoptosis

Broussoflavonol F is a potent dual inhibitor of the HER2-RAS-MEK-ERK signaling pathway and mushroom tyrosinase with an IC50 value of 82.3 μM. Broussoflavonol F downregulates the expression of RAS, HER2, phosphorylated BRAF, phosphorylated MEK and phosphorylated Erk proteins. Broussoflavonol F induces cell cycle arrest and apoptosis, and exhibits cytotoxicity in colon cancer cells. Broussoflavonol F inhibits endothelial proliferation, migration and tube formation, suppresses subintestinal vascular development, and reduces the mRNA levels of angiogenesis-associated genes.Broussoflavonol F can be used for colon cancer research [2].
BMS-214662 hydrochloride
BMS-214662 hydrochloride
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Cat. No.: HY-16111A
CAS No.: 195981-08-9
Target:  

Farnesyl Transferase Ras

Research Areas:  

Cancer

BMS-214662 hydrochloride is an inhibitor of farnesyltransferase (Farnesyl Transferase). BMS-214662 hydrochloride can effectively block the localization and function of Ras proteins on the cell membrane by inhibiting the prenylation modification of Ras proteins, thereby exerting anti-tumor activity. The IC50 value of BMS-214662 hydrochloride for H-Ras is 1.3 nM, and for K-Ras it is 8.4 nM. BMS-214662 hydrochloride can be used in the research of tumor diseases related to Ras .
PROTAC K-Ras Degrader-2
PROTAC K-Ras Degrader-2
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Cat. No.: HY-164365
CAS No.: 3043670-74-9
Target:  

PROTACs Ras

Research Areas:  

Cancer

PROTAC K-Ras degrader-2 (compound 48) is a KRAS G12V PROTAC degrader with an IC50 of 20-200 nM for KRAS G12V/RAF1. PROTAC K-Ras degrader-2 degrades SW620 KRAS G12V with a DC50 of 1-10 nM. PROTAC K-Ras degrader-2 inhibits cell growth of SW620 3D cell with an IC50 of ≤10 nM. PROTAC K-Ras degrader-2 can be used for the study of colorectal cancer (CRC) .
GGTI-297
GGTI-297
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Cat. No.: HY-120271
CAS No.: 181045-83-0
Target:  

Ras

Research Areas:  

Cancer

GGTI-297 is a geranylgeranyl transferase I (GGTase-1) inhibitor with IC50 values of 56 nM and 203 nM for GGTase-1 and fanesyl transferase (FTase), respectively. GGTI-297 inhibits the processing of the geranylgeranylated protein Rap1A without affecting the farnesylated protein H-Ras .
K-Ras-IN-2
K-Ras-IN-2
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Cat. No.: HY-156363
CAS No.: 905794-70-9
Target:  

Ras

Research Areas:  

Cancer

K-Ras-IN-2 (Compound CHI-000-667) is a K-Ras antagonist, and can be used for tumor research .
Anti-Mouse/Rat/Human v-H-Ras Antibody (Y13-238)
Anti-Mouse/Rat/Human v-H-Ras Antibody (Y13-238)
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Cat. No.: HY-P990146

Target:  

Ras

Research Areas:  

Inflammation/Immunology

Anti-Mouse/Rat/Human v-H-Ras Antibody (Y13-238) is an anti-mouse/rat/human v-H-Ras IgG2a monoclonal antibody. Anti-Mouse/Rat/Human v-H-Ras Antibody (Y13-238) can be used as a control antibody. Anti-Mouse/Rat/Human v-H-Ras Antibody (Y13-238) is often used for immunofluorescence and immunoprecipitation [2] .
RAS GTPase-IN-2
RAS GTPase-IN-2
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Cat. No.: HY-184359
CAS No.: 2252242-31-0
Target:  

Ras

Research Areas:  

Metabolic Disease Inflammation/Immunology Cancer

RAS GTPase-IN-2 is a RAS GTPase inhibitor. RAS GTPase-IN-2 can be used in the research of cancer, ras-related autoimmune leukocytosis and certain types of mitochondrial dysfunction .
Aspartyl-alanyl-diketopiperazine (Standard)
Aspartyl-alanyl-diketopiperazine (Standard)
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Cat. No.: HY-107091R
CAS No.: 110954-19-3
Synonyms: DA-DKP (Standard)
Target:  

Reference Standards MEK p38 MAPK IFNAR TNF Receptor Ras JNK

Research Areas:  

Inflammation/Immunology

Aspartyl-alanyl-diketopiperazine (DA-DKP) (Standard) is the analytical standard of Aspartyl-alanyl-diketopiperazine (HY-107091). This product is intended for research and analytical applications. Aspartyl-alanyl-diketopiperazine is an immunomodulatory molecule and anti-inflammatory agent. Aspartyl-alanyl-diketopiperazine increases the level of active Rap1 in activated human T lymphocytes and reduces the phosphorylation levels of Ras, ATF-2, c-jun, MEK1, MEKK1, ERK1, JNK1,2,3, p38MAPK and MEF-2. Aspartyl-alanyl-diketopiperazine inhibits the production of pro-inflammatory cytokines, including the levels of IFN-γ and TNF-α. Aspartyl-alanyl-diketopiperazine can be used in studies of inflammatory immune responses [2].
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