1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. SB-221284

SB-221284 

Cat. No.: HY-103155
Handling Instructions

SB 221284 is a selective 5-HT2C/2B receptor antagonist with pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. SB 221284 can be used for the research of neurological disease.

For research use only. We do not sell to patients.

SB-221284 Chemical Structure

SB-221284 Chemical Structure

CAS No. : 196965-14-7

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Description

SB 221284 is a selective 5-HT2C/2B receptor antagonist with pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. SB 221284 can be used for the research of neurological disease[1].

IC50 & Target[1]

5-HT2A Receptor

6.4 (pKi)

5-HT2B Receptor

7.9 (pKi)

5-HT2C Receptor

8.6 (pKi)

In Vivo

SB 221284 (0.1~1 mg/kg, i.p.) pre-treatment doses shows to block mCPP induced hypolocomotion, significantly enhances the hyperactivity induced by phencyclidine or MK-801[1].
SB 221284 (1 mg/kg, i.p.) significantly enhances the magnitude and duration of the increase induced by phencyclidine[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats (250–360 g)[1]
Dosage: 0.1~1 mg/kg
Administration: I.p.
Result: Pre-treatment doses showed to block mCPP induced hypolocomotion, significantly enhanced the hyperactivity induced by phencyclidine or MK-801.
Animal Model: Male Sprague Dawley rats (250–360 g)[1]
Dosage: 1 mg/kg
Administration: I.p.
Result: Significantly enhanced the magnitude and duration of the increase induced by phencyclidine.
Molecular Weight

353.36

Formula

C₁₆H₁₄F₃N₃OS

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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SB-221284
Cat. No.:
HY-103155
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