SB-221284

Cat. No.: HY-103155: FAQs
Data Sheet Handling Instructions

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SB 221284 is a selective 5-HT_2C/2B receptor antagonist with pK_i values are 6.4, 7.9 and 8.6 for 5-HT_2A, 5-HT_2B and 5-HT_2C receptors, respectively. SB 221284 can be used for the research of neurological disease.

For research use only. We do not sell to patients.

SB-221284 Chemical Structure

CAS No. : 196965-14-7

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5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

5-HT_2A Receptor

6.4 (pKi)

5-HT_2B Receptor

7.9 (pKi)

5-HT_2C Receptor

8.6 (pKi)

In Vivo

SB 221284 (0.1~1 mg/kg, i.p.) pre-treatment doses shows to block mCPP induced hypolocomotion, significantly enhances the hyperactivity induced by phencyclidine or MK-801^[1].
SB 221284 (1 mg/kg, i.p.) significantly enhances the magnitude and duration of the increase induced by phencyclidine^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague Dawley rats (250–360 g)^[1]
Dosage:	0.1~1 mg/kg
Administration:	I.p.
Result:	Pre-treatment doses showed to block mCPP induced hypolocomotion, significantly enhanced the hyperactivity induced by phencyclidine or MK-801.

Animal Model:	Male Sprague Dawley rats (250–360 g)^[1]
Dosage:	1 mg/kg
Administration:	I.p.
Result:	Significantly enhanced the magnitude and duration of the increase induced by phencyclidine.

Molecular Weight

353.36

Formula

C₁₆H₁₄F₃N₃OS

CAS No.

196965-14-7

SMILES

O=C(N1CCC2=C1C=C(C(F)(F)F)C(SC)=C2)NC3=CC=CN=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hutson PH, et al. Activation of mesolimbic dopamine function by phencyclidine is enhanced by 5-HT(2C/2B) receptor antagonists: neurochemical and behavioural studies. Neuropharmacology. 2000;39(12):2318-2328. [Content Brief]

[2]. Bromidge SM, et al. Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines. J Med Chem. 1998;41(10) [Content Brief]

SB-221284 Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB-221284196965-14-7SB221284SB 2212845-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorselectiveneurologicalmCPPhypolocomotionhyperactivityInhibitorinhibitorinhibit

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