SB-221284
SB 221284 is a selective 5-HT2C/2B receptor antagonist with pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. SB 221284 can be used for the research of neurological disease.
For research use only. We do not sell to patients.
- CAS No.: 196965-14-7
- Formula: C16H14F3N3OS
- Molecular Weight:353.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All 5-HT Receptor Isoforms
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Biological Activity
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5-HT2A Receptor |
5-HT2B Receptor |
5-HT2C Receptor |
5-HT2A Receptor 6.4 (pKi) |
5-HT2B Receptor 7.9 (pKi) |
5-HT2C Receptor 8.6 (pKi) |
SB 221284 (1 mg/kg, i.p.) significantly enhances the magnitude and duration of the increase induced by phencyclidine[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague Dawley rats (250–360 g)[1]
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Dosage:0.1~1 mg/kg
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Administration:I.p.
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Result:Pre-treatment doses showed to block mCPP induced hypolocomotion, significantly enhanced the hyperactivity induced by phencyclidine or MK-801.
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Animal Model:Male Sprague Dawley rats (250–360 g)[1]
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Dosage:1 mg/kg
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Administration:I.p.
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Result:Significantly enhanced the magnitude and duration of the increase induced by phencyclidine.
Chemical Information
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CAS No. 196965-14-7
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Molecular Weight 353.36
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Formula C16H14F3N3OS
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SMILES
O=C(N1CCC2=C1C=C(C(F)(F)F)C(SC)=C2)NC3=CC=CN=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hutson PH, et al. Activation of mesolimbic dopamine function by phencyclidine is enhanced by 5-HT(2C/2B) receptor antagonists: neurochemical and behavioural studies. Neuropharmacology. 2000;39(12):2318-2328. [Content Brief]
[2]. Bromidge SM, et al. Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines. J Med Chem. 1998;41(10):1598-1612. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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