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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
344 Results for "
GLUT2-null hepatocytes
" in MedChemExpress (MCE) Product Catalog:
Products (344)
344 Results for "GLUT2-null hepatocytes" in MCE Product Catalog:
Cat. No.: HY-151574
CAS No.: 2797225-49-9
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PfGSK3/PfPK6-IN-1 is a dual Plasmodium serine/threonine kinase inhibitor, with an IC50 of 97 nM against PfGSK3 and 8 nM against PfPK6 of Plasmodium falciparum. PfGSK3/PfPK6-IN-1 inhibits the proliferation of blood-stage parasites of Plasmodium falciparum 3D7. PfGSK3/PfPK6-IN-1 shows low cytotoxicity to hepatocytes at a concentration of 200 nM, and reduces cell viability at a concentration of 2 μM. PfGSK3/PfPK6-IN-1 is applicable to malaria-related research .
Cat. No.: HY-181152
FGFR3-IN-11(compound B11) is a Fibroblast growth factor receptor 3 (FGFR3) inhibitor with a Ka value of 4.8 μM. FGFR3-IN-11 induces apoptosis, suppresses colony formation, and causes dose-dependent G0/G1 cell cycle arrest in cancer cells. FGFR3-IN-11 exerts anticancer activity against cancer cells with minimal toxicity toward normal hepatocytes and demonstrates tumor growth suppression in xenograft mouse models. FGFR3-IN-11 can be used for the research of hepatocellular carcinoma .
Cat. No.: HY-18314B
CAS No.: 504433-24-3
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(Z)-GW 441756 is a hepatocyte nuclear factor 4α (HNF4α) activator, with an EC50 of 9.2 μM and a Ka of 4.6 μM in human systems. (Z)-GW 441756 directly interacts with the ligand-binding domain of HNF4α via persistent hydrogen bonds and hydrophobic interactions within the binding pocket. (Z)-GW 441756 reduces the accumulation of triglycerides and total cholesterol. (Z)-GW 441756 inhibits ferroptosis through a non-antioxidant mechanism. (Z)-GW 441756 decreases plasma triglyceride and total cholesterol levels in animal models of hyperlipidemia. (Z)-GW 441756 can be used in studies related to hyperlipidemia .
Cat. No.: HY-50662R
CAS No.: 844499-71-4
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A-769662 (Standard) is the analytical standard of A-769662 (HY-50662). This product is intended for research and analytical applications. A-769662 is a AMP-activated protein Kinase (AMPK) activator. A-769662 inhibits the function of the 26S proteasome by an AMPK-independent mechanism and leads to cell cycle arrest. A-769662 directly stimulates partially purified rat liver AMPK (EC50 = 0.8 μM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC50 = 3.2 μM). A-769662 can alleviate the symptoms of metabolic diseases such as type 2 diabetes [2] .
Cat. No.: HY-W587772
CAS No.: 1684398-38-6
Synonyms: MEHHTP
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Mono (2-ethyl-5-hydroxyhexyl) terephthalate (MEHHTP), a hydroxyl metabolite of the phthalate alternative Di-2-ethylhexyl terephthalate (DEHTP), is a liver X receptor α (LXRα) agonist with a binding energy of -7.41 kcal/mol. Mono (2-ethyl-5-hydroxyhexyl) terephthalate upregulates LXRα downstream targets such as SREBP-1c and FASN and increases lipogenic enzyme activity in hepatocytes, and elevating triglyceride (TG) levels. Mono (2-ethyl-5-hydroxyhexyl) terephthalate is promising for research of nonalcoholic fatty liver disease (NAFLD) .
Cat. No.: HY-123581R
CAS No.: 81810-66-4
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Reference Standards Antibiotic Bacterial ATF6 DAPK Autophagy NF-κB NO Synthase Apoptosis Reactive Oxygen Species (ROS)
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Quinocetone (Standard) is the analytical standard of Quinocetone (HY-123581). This product is used for research and analytical purposes. Quinocetone is an orally active animal feed additive used to increase the meat production of livestock and poultry. Quinocetone exhibits antibacterial activity against a variety of pathogenic microorganisms. Quinocetone exhibits tissue-specific (liver, lymphocyte) toxicity. Quinocetone induces autophagy in cells through the ATF6/DAPK1 pathway. Quinocetone activates the NF-κB and iNOS pathways, leading to cell apoptosis, hepatocyte vacuolar degeneration and fibrosis. Quinocetone can inhibit Nrf2/HO-1 and induce the generation of reactive oxygen species (ROS), leading to oxidative stress and DNA damage.
Cat. No.: HY-177839
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
Liposomal Coenzyme Q10 is an orally effective delivery system that encapsulates fat-soluble Coenzyme Q10 (CoQ10) (HY-N0111) via liposomal nanocarriers. Liposomal Coenzyme Q10 alleviates hepatic oxidative stress, attenuates hepatic inflammatory responses, reduces hepatocyte apoptosis, and ameliorates liver fibrosis. Liposomal Coenzyme Q10 activates the ferroptosis suppressor protein 1 (FSP1)/Coenzyme Q10 system, reduces the accumulation of malondialdehyde and ROS, and inhibits neuronal ferroptosis. Liposomal Coenzyme Q10 can be used in studies related to Propanoic acid (HY-W020017)-induced liver injury and subarachnoid hemorrhage [2].
Cat. No.: HY-182302
CAS No.: 1695550-43-6
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SMTIN-P01 is a TRAP1 inhibitor that is selective for cytosolic Hsp90 and accumulates in mitochondria. SMTIN-P01 binds to the ATP-binding site of TRAP1 as an ATP mimic, thereby inhibiting ATPase and foldase activities. SMTIN-P01 induces mitochondrial membrane depolarization and proteolytic degradation in cancer cells. SMTIN-P01 exhibits significant cytotoxicity, but shows extremely low toxicity to primary mouse hepatocytes, and does not interfere with SIRT3-related functions or the levels of cytosolic Hsp90 substrates. SMTIN-P01 has important application value in cancer-related research [2] .
Cat. No.: HY-N13285
CAS No.: 17291-05-3
Synonyms: (-)-EGC-4'-O-ME
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Cat. No.: HY-NP134
Cat. No.: HY-W013150
CAS No.: 82626-01-5
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Alpidem, an anxiolytic agent, is an orally active and brain-penetrant GABAA receptor ligand, binds to α1β2γ2 subunit-containing GABAA receptors (IC50 of 17 nM) over α5β2γ2 subunit-containing GABAA receptors (IC50 of >10 μM). Alpidem modulates calcium-induced mitochondrial permeability transition, induces glutathione depletion and hepatocyte necrosis, potentiates TNF-α toxicity, inhibits marble-burying and locomotor activity, enhances stressed rodent feeding behavior, and exerts anticonvulsant effects. Alpidem can be used for the research of anxiety, anxiety disorders, and convulsions [2] .
Cat. No.: HY-175033
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BRD4-IN-11 is an orally active and selective BRD4 inhibitor (IC50 = 26.35 nM (BD1), IC50 = 72.81 nM (BD2)). BRD4-IN-11 is approximately 3- to 18-fold more potent against BRD4 than againstBRD2, BRD3, and BRDT. BRD4-IN-11 enhances H2S release and inhibits the upregulation of fibrotic markers (α-SMA and fibronectin), c-Myc, and CDC25B. BRD4-IN-11 reduces apoptosis in LO2 hepatocytes. BRD4-IN-11 significantly improves liver and lung function in a hepatopulmonary fibrosis model and can be used to study hepatopulmonary fibrosis .
Cat. No.: HY-175266
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MI1013 is a PROTAC PXR degrader (DC50 = 89 nM, Dmax = 82%). MI1013 degrades PXR in human hepatocellular carcinoma RG cells (HepaRG). MI1013 specifically and safely regulates CYP3A4 promoter activity through PXR degradation. MI1013 affects several key genes involved in sulfate conjugation (e.g., SULT1E1), bile acid synthesis (CYP7A1), gluconeogenesis (PCK1), ketone synthesis (HMGCS20), and hepatocyte proliferation (MKI67). (Pink: PXR ligand 3: HY-175267, Blue: Pomalidomide-propargyl ligand: HY-W410002, Pink + Black: PXR ligand-Linker Conjugate 1: HY-175268) .
Cat. No.: HY-189412
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Antibacterial agent 376 is an antibacterial agent. Antibacterial agent 376 exhibits antibacterial efficacy against S. aureus and E. coli. Antibacterial agent 376 induces mild hepatic alterations, including slight inflammatory cell infiltration, moderate vacuolar degeneration, and moderate hepatocyte enlargement, while the overall liver architecture remains largely preserved. Antibacterial agent 376 induces mild renal alterations, including vascular congestion, limited inflammatory cell infiltration, and mild tubular degeneration, while the overall kidney structure remains intact. Antibacterial agent 376 causes a significant decrease in serum antioxidant markers GSH, GPx, and CAT, indicating the induction of oxidative stress in rats. Antibacterial agent 376 can be used for research on bacterial infections (Staphylococcus aureus and Escherichia coli) .
Synonyms: 1-Perfluoroheptanesulfonic acid; Perfluoroheptanesulphonic acid; PFHpS
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Perfluoroheptanesulfonic acid (1-Perfluoroheptanesulfonic acid; Perfluoroheptanesulphonic acid; PFHpS) is a per- and polyfluoroalkyl substance (PFAS) that penetrates the skin and induces systemic toxicity and immunotoxicity. Perfluoroheptanesulfonic acid reduces the expression of PPARδ in liver tissue; it induces hepatocyte hypertrophy and necrosis in liver tissue and alters serum biochemical markers associated with liver injury. Perfluoroheptanesulfonic acid upregulates genes related to fatty acid metabolism, cell necrosis and inflammation, reduces the relative weights of the spleen and thymus, suppresses humoral immune responses, and alters the composition of immune cell subsets in the spleen and skin. The plasma concentration of Perfluoroheptanesulfonic acid correlates with food intake. Perfluoroheptanesulfonic acid and perfluorooctanesulfonic acid exhibit synchronous pulse events in influent samples from wastewater treatment plants. Perfluoroheptanesulfonic acid can be used in studies related to liver injury and immune system damage [2] .
Cat. No.: HY-N4177
CAS No.: 24577-90-0
Synonyms: Rubrofusarin-6-β-gentiobioside
Category:
Seeds of Cassia tora Linn. Monophenols Metabolic Disease Phenols Leguminosae Extract Plants Other Families Extract Disease Research Fields
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Cat. No.: HY-W013150R
CAS No.: 82626-01-5
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Alpidem (Standard) is the analytical standard of Alpidem (HY-W013150). This product is intended for research and analytical applications. Alpidem, an anxiolytic agent, is an orally active and brain-penetrant GABAA receptor ligand, binds to α1β2γ2 subunit-containing GABAA receptors (IC50 of 17 nM) over α5β2γ2 subunit-containing GABAA receptors (IC50 of >10 μM). Alpidem modulates calcium-induced mitochondrial permeability transition, induces glutathione depletion and hepatocyte necrosis, potentiates TNF-α toxicity, inhibits marble-burying and locomotor activity, enhances stressed rodent feeding behavior, and exerts anticonvulsant effects. Alpidem can be used for the research of anxiety, anxiety disorders, and convulsions.
Cat. No.: HY-W013150S
CAS No.: 1189962-23-9
Cat. No.: HY-W019704
CAS No.: 1115-47-5
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
