720 Results for "

Enzyme Substrate

" in MedChemExpress (MCE) Product Catalog:
Products (720)

720 Results for "Enzyme Substrate" in MCE Product Catalog:

5
5 Cited Publications
Cat. No.: HY-W017443
CAS No.: 5794-13-8
L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .
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4
4 Cited Publications
Cat. No.: HY-W015495
CAS No.: 5988-19-2
L-Dihydroorotic acid is an important intermediate in the metabolism of orotic acid and a substrate of dihydroorotate dehydrogenase (DHODH). L-Dihydroorotic acid can reversibly hydrolyze to yield the acyclic L-ureidosuccinic acid by dihydrowhey enzyme .
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3
3 Cited Publications
Cat. No.: HY-116285
CAS No.: 29836-26-8
Purity:  99.92%
n-Octyl-β-d-glucopyranoside is a non-ionic detergent, it can be widely used in the research of biotechnical, biochemical applications, solubilization and crystallization of membrane proteins. n-Octyl-β-d-glucopyranoside can completely inhibit cavitation-induced cell lysis in vitro .
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3
3 Cited Publications
Cat. No.: HY-D0183
CAS No.: 1800401-93-7
ATP-polyamine-biotin, the first cell-permeable ATP analogue, is an efficient kinase cosubstrate. ATP-polyamine-biotin promotes biotin labeling of kinase substrates in live cells .
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3
3 Cited Publications
Cat. No.: HY-W017386
CAS No.: 3715-31-9
3-Methyl-2-oxovaleric acid sodium is a degradation product from Isoleucine. 3-Methyl-2-oxovaleric acid sodium is a biomarker of mustard airway diseases (MADs) and uric acid stone .
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3
3 Cited Publications
Cat. No.: HY-N2464
CAS No.: 34612-38-9
Synonyms: Amylotetraose; Fujioligo 450; α-1,4-Tetraglucose
Maltotetraose can serve as a substrate for enzyme-linked assays to measure amylase activity in biological fluids. Maltotetraose has oral active, and reduces TNF-α-induced inflammatory responses by inhibiting NF-κB activity and decreasing ICAM-1 expression. Maltotetraose also inhibits PDGF-induced vascular smooth muscle cell migration and neovascularization. Additionally, Maltotetraose derivatives can function as probes for detecting bacterial infections by targeting the maltodextrin transporter. With good long-term safety, Maltotetraose holds promise for research in atherosclerosis-related diseases .
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3
3 Cited Publications
Cat. No.: HY-W010991
CAS No.: 64967-39-1
Synonyms: FAPGG
Research Areas:  

Others

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly (FAPGG) is a specific substrate of angiotensin converting enzyme (ACE) with a Ki of 2.546×10 -4 M. It is used as a chromogenic probe for quantitative detection of ACE activity. N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly can be hydrolyzed by ACE to generate N-[3-(2-furyl)acryloyl]-Phe (FAP) and Gly-Gly, and the ACE inhibitory effect is monitored by photometry. FAPGG competitively binds to the active center of ACE and is a key tool for screening ACE inhibitors such as Captopril (HY-B0368) and Dioscorin. Its reversible mechanism of action supports hypertension research and drug development targeting the renin-angiotensin system .
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2
2 Cited Publications
Cat. No.: HY-134434
CAS No.: 136132-67-7
Purity:  99.79%
Research Areas:  

Others

Z-Arg-Arg-AMC hydrochloride is a highly selective fluorescent Cathepsin B substrate. Z-Arg-Arg-AMC hydrochloride can be hydrolyzed by Cathepsin B to produce a fluorescent product for enzyme activity detection .
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2
2 Cited Publications
Cat. No.: HY-113263
CAS No.: 387-79-1
Purity:  99.61%
Synonyms: 17-OHP5
17a-Hydroxypregnenolone (17-OHP5) is a metabolite of Pregnenolone (HY-B0151) and a precursor in the biosynthesis of Dehydroepiandrosterone (HY-14650). 17a-Hydroxypregnenolone is a substrate for the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD) .
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2
2 Cited Publications
Cat. No.: HY-116022A
CAS No.: 333338-18-4
Purity:  99.80%
Synonyms: p-Nitrophenyl phosphate disodium hexahydrate
4-Nitrophenyl phosphate (p-nitrophenyl phosphate) disodium hexahydrate is widely used as a small molecule phosphotyrosine-like substrate in activity assays for protein tyrosine phosphatases. 4-Nitrophenyl phosphate disodium hexahydrate is a colorless substrate that upon hydrolysis is converted to a yellow 4-nitrophenolate ion that can be monitored by absorbance at 405 nm .
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2
2 Cited Publications
Cat. No.: HY-126388
CAS No.: 9035-81-8
Trypsin Inhibitor, soybean is a potent and reversible inhibitor of trypsin .
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2
2 Cited Publications
Cat. No.: HY-W011704
CAS No.: 10526-80-4
Synonyms: Phosphoenolpyruvate cyclohexylammoniu​m salt
Phosphoenolpyruvic acid (Phosphoenolpyruvate) cyclohexylammonium salt is a glycolysis metabolite with a high-energy phosphate group. Phosphoenolpyruvic acid cyclohexylammonium salt is involved in glycolysis and gluconeogenesis, and used as energy source to produce ATP, under the energy-limited conditions. Phosphoenolpyruvic acid cyclohexylammonium salt also exhibits cytoprotective and anti-oxidative properties .
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2
2 Cited Publications
Cat. No.: HY-W016412
CAS No.: 605-94-7
Synonyms: CoQ0
Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling .
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2
2 Cited Publications
Cat. No.: HY-N2574
CAS No.: 511-96-6
Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC50 values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms .
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2
2 Cited Publications
Cat. No.: HY-110197
CAS No.: 1774353-12-6
Purity:  99.35%
Target:  

IDE

Research Areas:  

Metabolic Disease

6bK TFA is a selective insulin-degrading enzyme (IDE) inhibitor with an IC50 of 50 nM. 6bK TFA binds to the distal pocket of IDE, thereby blocking substrate binding, peptide unfolding and cleavage processes, and reducing the degradation of insulin, glucagon and amylin. 6bK TFA improves oral glucose tolerance but impairs intraperitoneal glucose tolerance. 6bK TFA can be used in research related to type 2 diabetes .
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2
2 Cited Publications
Cat. No.: HY-D0256
CAS No.: 1937-37-7
Synonyms: Chlorazol Black E; Ferristatin II disodium; C.I. 30235
Direct Black 38 (Chlorazol Black E) is a benzidine-based azo dye, a substrate of Enterococcus gallinarum, and is mainly used for textile dyeing. Direct Black 38 is biodegradable after being reduced by microbial enzymes (such as Enterococcus gallinarum azoreductase), breaking the azo bonds and releasing benzidine and 4-aminobiphenyl. Direct Black 38 can be used in environmental toxicology, wastewater treatment and carcinogenicity studies, but its metabolite benzidine is listed as a human carcinogen .
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2
2 Cited Publications
Cat. No.: HY-P2733
CAS No.: 9046-28-0
Synonyms: GPO
Glycerol-3-phosphate oxidase, E. coli (GPO) is a key intermediate in glycerol metabolism. Glycerol-3-phosphate oxidase, E. coli is the skeleton of phospholipids in membrane lipids, and also a substrate in the respiratory chain. Glycerol-3-phosphate oxidase, E. coli produces electrons through oxidation. Glycerol-3-phosphate oxidase, E. coli is an enzyme with important functions in the field of biochemistry, and is widely used in medical testing and scientific research .
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2
2 Cited Publications
Cat. No.: HY-N0419
CAS No.: 491-50-9
Synonyms: Quercetin-7-O-β-D-glucopyranoside
Quercimeritrin (Quercetin-7-O-β-D-glucopyranoside) is an orally active α-glucosidase inhibitor (with an IC50 of 79.88 μM against the Saccharomyces cerevisiae enzyme) and a P-gp substrate, with anti-angiogenic and antioxidant activities. Quercimeritrin does not cross the blood-brain barrier and does not inhibit cytochrome P450 enzymes. Quercimeritrin precisely binds to and inhibits the active sites of c-Kit, MMP-2, Aurora-A kinases and α-glucosidase, thereby disrupting target functions. Quercimeritrin effectively regulates postprandial blood glucose and also exhibits significant anti-angiogenic activity, which inhibits endothelial cell proliferation and microvascular growth. Quercimeritrin can be used in the research of diabetes and breast cancer .
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2
2 Cited Publications
Cat. No.: HY-100713
CAS No.: 111902-57-9
Purity:  98.14%
Temocapril is an orally active angiotensin-converting enzyme (ACE) inhibitor. Temocapril can be used for the research of hypertension, congestive heart failure, acute myocardial infarction, insulin resistance, and renal diseases .
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2
2 Cited Publications
Cat. No.: HY-B0384
CAS No.: 110221-44-8
Temocapril hydrochloride is an orally active angiotensin-converting enzyme (ACE) inhibitor. Temocapril hydrochloride can be used for the research of hypertension, congestive heart failure, acute myocardial infarction, insulin resistance, and renal diseases .
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