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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
58 Results for "
PDE-4D
" in MedChemExpress (MCE) Product Catalog:
Products (58)
58 Results for "PDE-4D" in MCE Product Catalog:
Target:
Research Areas:
LEO 39652 is a dual-soft PDE4 inhibitor with IC50s of 1.2 nM, 1.2 nM, 3.0 nM and 3.8 nM for PDE4A, PDE4B, PDE4C and PDE4D, respectively. LEO 39652 also inhibits TNF-α with an IC50 value of 6.0 nM. LEO 39652 is used for topical research of Atopic dermatitis (AD) .
Cat. No.: HY-RS24072
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Pde4d Rat Pre-designed siRNA Set A contains three designed siRNAs for Pde4d gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-121037
CAS No.: 505068-32-6
Synonyms: EGM1
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Eggmanone (EGM1) is a potent and selective phosphodiesterase 4 (PDE4) antagonist with an IC50 of 72 nM for PDE4D3. Eggmanone shows approximately 40- to 50-fold selective for PDE4D3 over other PDEs. Eggmanone exerts its Hh-inhibitory effects through selective antagonism of PDE4, leading to protein kinase A activation and subsequent Hh blockade .
Cat. No.: HY-14918
CAS No.: 183659-72-5
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Catramilast is a PDE4D inhibitor. Catramilast can be used in pain research .
Cat. No.: HY-121041
CAS No.: 1776944-03-6
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GEBR-7b is a selective PDE4D inhibitor with an IC50 of 0.67 μM. GEBR-7b increases hippocampal cAMP and does not influence Aβ levels in rodents. GEBR-7b also improves spatial and can be used for the study of cognitive deficits .
Cat. No.: HY-176234
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PDE4-IN-28 (Compound G1) is a PDE4D inhibitor (IC50: 29 nM). PDE4-IN-28 inhibits the production of TNF-α and NO (IC50: 13.32 and 2.32 μM, respectively). PDE4-IN-28 exhibits anti-inflammatory, antibacterial and analgesic effects in a rat pressure ulcer (PU) model and promotes HUVEC cell migration, thereby accelerating wound healing .
Cat. No.: HY-RS17612
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Pde4d Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pde4d gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-173290
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PDE4-IN-1 is a PDE4 inhibitor with high potency (IC50 : 8.6 nM) and selectivity over other PDE subtypes. PDE4-IN-1 inhibits the release of inflammatory cytokines and chemokines. PDE4-IN-1 greatly restores impaired cAMP-CREB signaling pathway. PDE4-IN-1 inhibits proliferation and promotes differentiation to reverse the formation of psoriasis .
Cat. No.: HY-112704
CAS No.: 2244517-61-9
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PDE5-IN-2 is a potent, highly selective, and orally active PDE5 inhibitor, with an IC50 of 0.31 nM, less potently inhibits PDE2A, PDE10A, PDE4D2, and PDE6C, with IC50s of 106, 46, 43, 1.2 nM, respectively. Anti-pulmonary arterial hypertension activity .
Cat. No.: HY-179407
CAS No.: 2574572-03-3
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LT-104A is a potent PDE4 inhibitor that elevates intracellular cAMP levels (EC50 = 1.9 μM) and inhibits PDE4D3 activity (IC50 = 9.3 μM). LT-104A activates the cAMP-PKA-CREB anti-inflammatory signaling pathway and suppresses NF-κB-related gene expression (Il1b and Nos2). LT-104A can be used for inflammation-related disease research .
Cat. No.: HY-168558
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PDE4B/D-IN-4 (compound 4p) is a potent inhibitor of PDE-4B and PDE-4D, with IC50s of 5.50 nM and 6.81 nM, respectively. PDE4B/D-IN-4 shows an increase in the level of intracellular cAMP .
Cat. No.: HY-130262
CAS No.: 2370966-46-2
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PDE1-IN-3, compound 4 (WO2019156861), is a selective human phosphodiesterase 1 (PDE1) inhibitor. PDE1-IN-3 inhibits PDE4D and PDE6AB with IC50 values of 23.99 μM and 10 μM, respectively .
Cat. No.: HY-131340
CAS No.: 3029936-02-2
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LASSBio-1632 is a new anti-asthmatic lead candidate associated with selective inhibition of PDE4A and PDE4D isoenzymes and blockade of airway hyper-reactivity (AHR) and TNF-α production in the lung tissue. LASSBio-1632 (7j) displays high experimental BBB permeability across BBB through passive diffusion .
Cat. No.: HY-154957
CAS No.: 3033409-32-1
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mTOR inhibitor-11 (Compound 9) is a brain-penetrant mTOR inhibitor (IC50: 21 nM for pS6). mTOR inhibitor-11 also inhibits pCHK1 and PDE4D with IC50s of 17.2 and 17.0 μM. mTOR inhibitor-11 can be used for research of CNS disease .
Cat. No.: HY-147846
CAS No.: 3033234-46-4
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AChE/PDE4-IN-1 (compound 12c) is a potent and selective dual PDE4/AChE inhibitor, with IC50s of 0.28 μM and 1.88 μM for AChE and PDE4D, respectively. AChE/PDE4-IN-1 exhibits anti-neuroinflammatory effect for the research of Alzheimer's disease .
Cat. No.: HY-162583
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PDE4-IN-17 (compound 4e) is a potent PDE4 inhibitor. PDE4-IN-17 inhibits PDE4B and PDE4D with IC50s of 10.0 and 15.2 nM, respectively. PDE4-IN-17 has good oral bioavailability (F=66%) and longer half-life (t1/2=2.0 h) in SD rats .
Cat. No.: HY-115913
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PDE4-IN-6 is a potent, safe and moderately selective PDE4 inhibitor with IC50s of 0.125 and 0.43 µM for PDE4B and PDE4D, respectively. PDE4-IN-6 can downregulate the expression level of TNF-α and IL-6. PDE4-IN-6 has potent immunomodulatory activity thereby its potential against rheumatoid arthritis. Anti-inflammatory and anti-arthritic effects .
Cat. No.: HY-P701960
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PDE4D; CAMP-Specific Phosphodiesterase PDE4D6; Prev. DPDE3; CAMP-Specific Phosphodiesterase 4D; CAMP-Specific 3',5'-Cyclic Phosphodiesterase 4D; Testicular Tissue Protein Li 136; 3',5'-Cyclic-AMP Phosphodiesterase 4D; Phosphodiesterase; PDE43; ACRDYS2; Ph
Species:
Human
Source:
E. coli
Cat. No.: HY-114052
CAS No.: 426268-06-6
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Research Areas:
NVP-ABE171 is an efficient, long-lasting and orally active PDE4 inhibitor with IC50 values for PDE4D, PDE4B, PDE4A and PDE4C of 1.5, 34, 602 and 1230 nM respectively. NVP-ABE171 enhances the cAMP accumulation induced by isoproterenol, inhibits the oxidative burst of eosinophils and the release of inflammatory cytokines from T cells and monocytes. NVP-ABE171 exhibits potent anti-inflammatory activity in animal models of asthma and pulmonary inflammation. NVP-ABE171 can be used for research on asthma and chronic obstructive pulmonary disease .
Cat. No.: HY-P701961
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PDE4D; CAMP-Specific Phosphodiesterase PDE4D6; Prev. DPDE3; CAMP-Specific Phosphodiesterase 4D; CAMP-Specific 3',5'-Cyclic Phosphodiesterase 4D; Testicular Tissue Protein Li 136; 3',5'-Cyclic-AMP Phosphodiesterase 4D; Phosphodiesterase; PDE43; ACRDYS2; Ph
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
