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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
246 Results for "
retinal
" in MedChemExpress (MCE) Product Catalog:
Products (246)
246 Results for "retinal" in MCE Product Catalog:
1
1 Cited Publications
Target:
Research Areas:
AZ 12216052 is a mGluR8 positive allosteric modulator, and helps mGluR8 modulate signaling inputing to retinal ganglion cells. AZ 12216052 exhibits antianxiety effect .
1
1 Cited Publications
1
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Cosdosiran is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.
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Cosdosiran sodium is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.
1
1 Cited Publications
Cat. No.: HY-P76196
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PROM1; AC133 Antigen; Prev. PROML1; Prominin-1; Prev. STGD4; Stargardt Disease 4 (Autosomal Dominant); Prev. MCDR2; Hematopoietic Stem Cell Antigen; CORD12; Macular Dystrophy, retinal 2; CD133; Prominin (Mouse)-Like 1; AC133; CD133 Isoform H; RP41; CD133
Species:
Rat
Source:
HEK293
1
1 Cited Publications
Synonyms: Glucogallin; 1-O-Galloyl-β-D-glucose
1
1 Cited Publications
Cat. No.: HY-P71358A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TFPI2; Placental Protein 5; Tissue Factor Pathway Inhibitor 2; retinal Pigment Epithelium Cell Factor 1; TFPI-2; Tissue Factor Pathway Inhibitor; PP5; TFPI2 Variant; REF1
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-140739A
CAS No.: 185844-12-6
Target:
Research Areas:
DSPE-PEG2000-Maleimide free acid is a phospholipid-PEG conjugate. DSPE-PEG2000-Maleimide free acid utilizes the amphiphilicity of DSPE to insert into the lipid bilayer of liposomes or nanoparticles. DSPE-PEG2000-Maleimide free acid covalently couples to the sulfhydryl (-SH) of ligands (such as antibodies, peptides, or proteins) via thiol-maleimide click chemistry, giving the particles targeting capabilities. DSPE-PEG2000-Maleimide free acid can be used in the researches of breast cancer, lymphoma, and inherited retinal degeneration .
1
1 Cited Publications
Cat. No.: HY-P74527A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TFPI2; Placental Protein 5; Tissue Factor Pathway Inhibitor 2; retinal Pigment Epithelium Cell Factor 1; TFPI-2; Tissue Factor Pathway Inhibitor; PP5; TFPI2 Variant; REF1
Species:
Mouse
Source:
HEK293
1
1 Cited Publications
Synonyms: 8-CPT-2'-O-Me-cAMP sodium
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Research Areas:
8-pCPT-2′-O-Me-cAMP (8-CPT-2'-O-Me-cAMP) sodium, an analog of cAMP, is an activator of exchange proteins activated by cAMP (Epac). 8-pCPT-2′-O-Me-cAMP sodium activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 >10 μM). 8-pCPT-2′-O-Me-cAMP sodium stimulates Epac-mediated Ca 2+ release in pancreatic β-cells in vitro. 8-pCPT-2′-O-Me-cAMP sodium is a Rap1 activator. 8-pCPT-2′-O-Me-cAMP sodium enhances the retinal pigment epithelium barrier against the pathological choroidal endothelial cell invasion that occurs in macular degeneration .
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L-Glutamic acid (2, 5, 10, 20 mM, 24-48 h) can induce neuroexcitotoxicity in neuroblastoma .
In Vivo: L-Glutamic acid (3 g/kg, subcutaneous injection) can promote excitotoxic degeneration of retinal ganglion cells in mice .
L-Glutamic acid (750 mg/kg, intraperitoneal injection) can reduce and inhibit oxidative stress induced by chlorpyrifos (CPF) in rats .
1
1 Cited Publications
Cat. No.: HY-112624I
CAS No.: 9004-54-0
Synonyms: Dextran 3; Dextran D3; Dextran T3(MW 2400-3600)
1
1 Cited Publications
Cat. No.: HY-N0819
CAS No.: 89412-79-3
Cat. No.: HY-W009310
CAS No.: 514-85-2
Target:
Cat. No.: HY-P99116
CAS No.: 1607793-29-2
Synonyms: RG7716; RO-6867461
Target:
Cat. No.: HY-136234
CAS No.: 13312-52-2
Synonyms: 9Z β-Carotene
Target:
Research Areas:
9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal. 9-cis-β-Carotene inhibits photoreceptor degeneration and restores retinal function in vivo. 9-cis-β-Carotene has the potential for the study of congenital stationary night blindness and fundus albipunctatus .
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Synonyms: AR-13324 M1 metabolite
Research Areas:
AR-13503 (AR-13324 M1 metabolite) is the hydrolytic metabolite of AR-13324 mesylate. AR-13324 is a ROCK kinase and PKC inhibitor with anti-angiogenic and retinal health-improving effects, showing potential for use in retinal disease research .
Cat. No.: HY-134928
CAS No.: 173449-96-2
Synonyms: A2E
Research Areas:
Pyridinium bisretinoid A2E (A2E) is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E can be used in the study of retinal degenerative diseases .
Cat. No.: HY-W009123
CAS No.: 112-84-5
Synonyms: cis-13-Docosenamide
Target:
Research Areas:
Erucamide is an orally active, blood-brain barrier-permeable TMEM19 ligand and T3SS inhibitor. Erucamide exerts retinal neuroprotective effects in mouse models of retinal degeneration. Erucamide attenuates depression- and anxiety-like behaviors in mice.\n\nErucamide binds to the conserved hydrophobic pocket in HrcC, disrupts its outer membrane localization, and blocks T3SS-mediated effector protein secretion in Gram-negative pathogenic bacteria. Erucamide enhances the antimicrobial immunity of plants against pathogenic bacteria. Erucamide can be used in research related to retinitis pigmentosa, anxiety and depression, bacterial wilt, and bacterial blight .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
