1119 Results for "

toad bladder preparations

" in MedChemExpress (MCE) Product Catalog:
Products (1119)

1119 Results for "toad bladder preparations" in MCE Product Catalog:

8
8 Cited Publications
Cat. No.: HY-101878
CAS No.: 60311-02-6
Purity:  99.72%
Synonyms: Sulforhodamine 101; SR101
Texas Red (Sulforhodamine 101) is an amphoteric rhodamine red fluorescent dye (excitation/emission: 586/605 nm). Texas Red is used extensively for investigating neuronal morphology and acts as acell type-selective fluorescent marker of astrocytes bothin vivoand in slice preparations .
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7
7 Cited Publications
Cat. No.: HY-N0815
CAS No.: 465-39-4
Synonyms: Bufogenin; Recibufogenin
Resibufogenin is an orally active anticancer agent. Resibufogenin can be extracted from toad venom. Resibufogenin blocks signaling pathways such as PI3K/Akt, NF-κB, AP-1, activates GSK-3β, and regulates cyclin D1. Resibufogenin can activate central neurons. Resibufogenin has anti-inflammatory activity. Resibufogenin has anti-tumor effects on a variety of tumors such as multiple myeloma, renal cancer, colorectal cancer, pancreatic cancer, and glioma .
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6
6 Cited Publications
Cat. No.: HY-N0880
CAS No.: 1108-68-5
Cinobufotalin is a cardiotonic steroids or bufadienolides, is extracted from the skin secretions of the giant toads. Cinobufotalin has been used as a cardiotonic, diuretic and a hemostatic agent, Cinobufotalin is also a potential anti-lung cancer agent .
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6
6 Cited Publications
Cat. No.: HY-12454
CAS No.: 796073-69-3
Purity:  99.64%
Synonyms: Ravtansine
Research Areas:  

Cancer

DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody agent conjugate.
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6
6 Cited Publications
Cat. No.: HY-129046
CAS No.: 9001-99-4
Synonyms: Ribonuclease A; EC 4.6.1.18; RNase A
Research Areas:  

Others

RNase A (Bovine pancreatic RNase) is a widely used Endonuclease in DNA purification by specifically hydrolyzing cytosine or uracil residues of RNA. RNase A degrades the RNA in the RNA/DNA duplex. RNase A catalyses the breakdown of 3',5'-phosphodiester linkages of single stranded RNA. RNase A family members in organisms are tightly involved in various physiological and pathological processes including cell growth and development, proliferation, differentiation and migration. Dysregulation of RNase A activity or expression level is closely related to pancreatic, ovarian, bladder and thyroid cancer. RNase A has tumor cell-killing ability .
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5
5 Cited Publications
Cat. No.: HY-125853
CAS No.: 97281-47-5
Purity:  99.08%
Synonyms: Soybean phosphatidylcholine
Target:  

Liposome

Phosphatidylcholines,soya is a phosphatidylcholine from soybean used in the preparation of liposomes. Phosphatidylcholines,soya can be used as a vehicle in animal agent administration .
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5
5 Cited Publications
Cat. No.: HY-Y0873I
CAS No.: 25322-68-3
Synonyms: Polyethylene glycol 6000
PEG6000 can be used as an excipient, such as Ointment base, lubricant, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
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5
5 Cited Publications
Cat. No.: HY-P7170
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FGF10; Produced By Fibroblasts Of Urinary bladder Lamina Propria; Fibroblast Growth Factor 10; Fibroblast Growth Factor; Keratinocyte Growth Factor 2; LADD3; FGF-10; FGF
Species:  
Mouse
Source:  
E. coli
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4
4 Cited Publications
Cat. No.: HY-115718A
Purity:  98.62%
Target:  

PROTACs Bcl-2 Family

Research Areas:  

Cancer

PZ703b TFA is a Bcl-xl PROTAC degradation agent that induces apoptosis and inhibits cancer cell proliferation for bladder cancer research .
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4
4 Cited Publications
Cat. No.: HY-115718
CAS No.: 2471970-56-4
Purity:  98.00%
Target:  

PROTACs Bcl-2 Family

Research Areas:  

Cancer

PZ703b is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b can be used for the research of bladder cancer research .
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4
4 Cited Publications
Cat. No.: HY-115718B
Purity:  99.18%
Research Areas:  

Cancer

PZ703b hydrochloride is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b hydrochloride can be used for the research of bladder cancer research .
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4
4 Cited Publications
Cat. No.: HY-15574
CAS No.: 152811-62-6
Purity:  99.09%
Synonyms: SB-207266
Target:  

5-HT Receptor

Research Areas:  

Cardiovascular Disease

Piboserod is an orally available selective antagonist of the 5-HT4 receptor, with a Ki value of approximately 0.1 nM for human 5-HT4 receptors. Piboserod can competitively bind to the 5-HT4 receptor and block the activation of the 5-HT4 receptor. Piboserod can inhibit the enhancing effect of 5-HT on the nerve-mediated contraction response of the human bladder detrusor muscle. Piboserod is mainly used in the research of urinary system diseases (such as overactive bladder) and cardiovascular diseases (such as chronic heart failure) .
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4
4 Cited Publications
Cat. No.: HY-N0876
CAS No.: 464-74-4
Arenobufagin is a natural bufadienolide that can be extracted from toad venom. Arenobufagin can induce apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Arenobufagin has potent antineoplastic activity against HCC HepG2 cells as well as corresponding multidrug-resistant HepG2/ADM cells. Arenobufagin can inhibit VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway .
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4
4 Cited Publications
Cat. No.: HY-16346
CAS No.: 290297-26-6
Synonyms: CID 6451149
Target:  

Neurokinin Receptor

Netupitant (CID 6451149) is a blood-brain barrier penetrable, orally active NK1 receptor inhibitor with a Ki of 0.95 nM (CHO cells) against the human receptor. Netupitant antagonizes the effects induced by Substance P, inhibits the maximal response of Substance P with a long-lasting action, and suppresses NK1 agonist-induced behaviors in mice and gerbils. Netupitant reduces the frequency of bladder contractions, prolongs contraction intervals, decreases basal pressure at high doses, and acts on the afferent branch of the micturition reflex. Netupitant can be used in research related to overactive bladder, chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, anxiety disorders, and depression .
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4
4 Cited Publications
Cat. No.: HY-145411
CAS No.: 1443687-74-8
Purity:  ≥98.0%
Target:  

Liposome

Research Areas:  

Endocrinology

PEG2000-C-DMG, a pegylated lipid, can be used for the preparation of Onpattro. Onpattro, a hepatically directed investigational RNAi therapeutic agent, harnesses this process to reduce the production of mutant and wild-type transthyretin by targeting the 3′ untranslated region of transthyretin mRNA .
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4
4 Cited Publications
Cat. No.: HY-K1022

MCE PBS-T Powder (1 L of 1×) consists of NaCl, KCl, Phosphate and Tween 20, and is widely used in ELISA and Western Blot, and can also be used for antibody dilution and preparation of blocking solution. The 20 pouches are defined as the base specification. All larger sizes correspond to incremental volumes of this base.

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4
4 Cited Publications
Cat. No.: HY-W007376
CAS No.: 487-89-8
Synonyms: 3-Formylindole
Indole-3-carboxaldehyde (3-Formylindole), a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. Indole-3-carboxaldehyde is a biochemical used to prepare analogs of the indole phytoalexin cyclobrassinin. Indole-3-carboxaldehyde also enhances the epithelial barrier and anti-inflammatory activity in the intestinal tract .
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4
4 Cited Publications
Cat. No.: HY-N2593
CAS No.: 32507-66-7
Isorhapontigenin is an orally active dietary polyphenol. Isorhapontigenin acts as a potent antioxidant that reduces the production of reactive oxygen species (ROS). Isorhapontigenin promotes the binding of JUN to the AP-1 site on the SESN2 promoter, induces SESN2 transcription, triggers MAPK8-dependent JUN activation, and upregulates the expression of PPAR-α, PGC-1α and CPT-1A to facilitate fatty acid oxidation. Isorhapontigenin induces autophagy, apoptosis and preadipocyte differentiation; it inhibits tumor growth, cell invasion, NF-κB transcriptional activity, the PI3K/Akt signaling pathway, STAT1 phosphorylation and MMP-2 expression. Isorhapontigenin alleviates oxidative stress, inflammatory cytokine release and triglyceride accumulation; it increases intracellular ATP levels and promotes Nrf2 nuclear translocation. Isorhapontigenin improves insulin sensitivity in adipose tissue and glucose tolerance, and reduces postprandial blood glucose, insulin and free fatty acid levels. Isorhapontigenin is applicable to research on bladder cancer, liver injury, chronic obstructive pulmonary disease, acute lung injury and type 2 diabetes .
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3
3 Cited Publications
Cat. No.: HY-B1659
CAS No.: 56-81-5
Synonyms: Trihydroxypropane
Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis.
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3
3 Cited Publications
Cat. No.: HY-N5106
CAS No.: 37951-13-6
(E)-Flavokawain A, a chalcone extracted from Kava, has anticarcinogenic effect. (E)-Flavokawain A induces apoptosis in bladder cancer cells by involvement of bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice .
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