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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10839 Results for "
microsphere embolization rat model
" in MedChemExpress (MCE) Product Catalog:
Products (10839)
10839 Results for "microsphere embolization rat model" in MCE Product Catalog:
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18 Cited Publications
RMC-7977 is an orally active triple-complex RAS inhibitor that can simultaneously bind to cyclophilin A (CYPA) (Kd = 195 nM) and KRAS (G12V) (Kd = 292 μM). It exhibits broad-spectrum inhibitory activity against KRAS, NRAS, and HRAS proteins and their various wild-type and mutant variants. RMC-7977 induces apoptosis by inhibiting the phosphorylation of ERK, CRAF, and RSK, as well as increasing PARP cleavage. This leads to tumor regression, reduces resistance in KRAS G12C cancer models, and demonstrates good tolerability across various RAS cancer models .
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17 Cited Publications
Cat. No.: HY-50697
CAS No.: 861393-28-4
Target:
Research Areas:
A-740003 is a potent, selective and competitive P2X7 receptor antagonist with IC50 values are 18 and 40 nM for rat and human P2X7 receptors, respectively.
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Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with Ki of 2.2 nM in experimental models of Parkinson's disease.
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16 Cited Publications
Synonyms: Tangeritin; NSC53909; NSC618905
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15
15 Cited Publications
Cat. No.: HY-P1010
CAS No.: 210345-04-3
Research Areas:
15
15 Cited Publications
Target:
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AU-15330 is a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4. AU-15330 induces potent inhibition of tumour growth in xenograft models of prostate cancer and synergizes with the AR antagonist enzalutamide. AU-15330 induces disease remission in castration-resistant prostate cancer (CRPC) models without toxicity .
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15 Cited Publications
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TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis .
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15 Cited Publications
Synonyms: NSC 231634; Casein Kinase II Inhibitor I
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TBB is a cell-permeable and ATP-competitive CK2 inhibitor with an IC50 of 0.15 μM for rat liver CK2.
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15 Cited Publications
Cat. No.: HY-P7116A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BDNF; Abrineurin; Brain Derived Neurotrophic Factor; Brain-Derived Neurotrophic Factor Preproprotein Isoform 2; ProBDNF; Brain-Derived Neurotrophic Factor Isoform 1; Neurotrophic Factor BDNF Precursor Form; ANON2; Brain-Derived Neurotrophic Factor; BULN2
Species:
Mouse
Rat
Human
Source:
E. coli
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14 Cited Publications
Cat. No.: HY-B0199A
CAS No.: 116680-01-4
Synonyms: RS 61443 hydrochloride; TM-MMF hydrochloride
Target:
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14 Cited Publications
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AZD5904 is a selective and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat.
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14 Cited Publications
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Research Areas:
NF-56-EJ40 is a potent, high-affinity, and highly selective human SUCNR1 (GPR91) antagonist with an IC50 of 25 nM and a Ki of 33 nM, and shows almost no activity towards rat SUCNR1. NF-56-EJ40 has high affinity for humanized rat SUCNR1 with a Ki value of 17.4 nM .
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14 Cited Publications
Cat. No.: HY-130246A
CAS No.: 2728500-80-7
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Research Areas:
NF-56-EJ40 hydrochloride is a potent, high-affinity, and highly selective human SUCNR1 (GPR91) antagonist with an IC50 of 25 nM and a Ki of 33 nM, and shows almost no activity towards rat SUCNR1. NF-56-EJ40 hydrochloride has high affinity for humanized rat SUCNR1 with a Ki value of 17.4 nM .
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13 Cited Publications
Synonyms: Hypocretin-1 (human, rat, mouse)
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Research Areas:
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13 Cited Publications
Cat. No.: HY-106224A
Purity: 97.13%
Synonyms: Hypocretin-1 (human, rat, mouse) TFA
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13
13 Cited Publications
Cat. No.: HY-106224B
Purity: 99.93%
Synonyms: Hypocretin-1 (human, rat, mouse) acetate
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13
13 Cited Publications
Cat. No.: HY-P70664
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FNDC5; Fibronectin Type III Domain-Containing Protein 5; Fibronectin Type III Domain Containing 5; Fibronectin Type III Repeat-Containing Protein 2; FRCP2; Irisin
Species:
Human
Rat
Mouse
Source:
HEK293
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13 Cited Publications
Cat. No.: HY-P7278
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDGFB; Platelet-Derived Growth Factor 2; Prev. SIS; PDGF Subunit B; Platelet-Derived Growth Factor Beta Polypeptide; PDGF2; Platelet-Derived Growth Factor Subunit B; Platelet-Derived Growth Factor, Beta Polypeptide (Oncogene SIS); Platelet-Derived Growth
Species:
Rat
Source:
E. coli
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12 Cited Publications
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TAK-715 is an orally active and potent p38 MAPK inhibitor with IC50s of 7.1 nM, 200 nM for p38α and p38β, respectively. TAK-715 inhibits casein kinase I (CK1δ/ε) to regulate activation of Wnt/β-catenin signaling. TAK-715 shows good significant efficacy in a rat arthritis model .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
