1082 Results for "

Steroidal

" in MedChemExpress (MCE) Product Catalog:
Products (1082)

1082 Results for "Steroidal" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-N2322
CAS No.: 32449-98-2
Khasianine is a steroidal glycoalkaloid . Khasianine alleviates psoriasis-like skin inflammation by inhibiting the TNF-α/NF-κB axis. Khasianine can downregulate the RhoA pathway and exhibits potential antimetastatic activity. Khasianine upregulates the expression of TNFR I and TNFR II without inducing apoptotic effects . Khasianine can be used in studies related to psoriasis, pancreatic ductal adenocarcinoma, and liver cancer .
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3
3 Cited Publications
Cat. No.: HY-B1402
CAS No.: 2203-97-6
Synonyms: Hydrocortisone 21-hemisuccinate
Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID) with anti-inflammatory and immunomodulatory activities. Hydrocortisone hemisuccinate inhibits the bioactivity of IL-6 and IL-3 with IC50 values of 6.7 and 21.4 μM, respectively. Hydrocortisone hemisuccinate can be used in the study of ulcerative colitis (UC) and recurrent oral ulcers .
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3
3 Cited Publications
Cat. No.: HY-B1402A
CAS No.: 83784-20-7
Synonyms: Hydrocortisone 21-hemisuccinate hydrate
Hydrocortisone hemisuccinate hydrate (Hydrocortisone 21-hemisuccinate hydrate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID) with anti-inflammatory and immunomodulatory activities. Hydrocortisone hemisuccinate hydrate inhibits the bioactivity of IL-6 and IL-3 with IC50 values of 6.7 and 21.4 μM, respectively. Hydrocortisone hemisuccinate hydrate can be used in the study of ulcerative colitis (UC) and recurrent oral ulcers .
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3
3 Cited Publications
Cat. No.: HY-B0580
CAS No.: 74103-06-3
Synonyms: RS37619
Target:  

COX Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Ketorolac (RS37619) is a non-steroidal anti-inflammatory drug (NSAID), acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. Ketorolac tromethamine is used as 0.5% ophthalmic solution for the research of allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and postoperative ocular inflammation and pain. Ketorolac tromethamine is also a DDX3 inhibitor that can be used for cancer research .
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3 Cited Publications
Cat. No.: HY-N0836
CAS No.: 469-59-0
Synonyms: 11-Ketocyclopamine
Jervine (11-Ketocyclopamine) is an orally active steroidal alkaloid and Hedgehog signaling pathway inhibitor. Jervine can be isolated from Veratrum californicum. Jervine regulates Wnt, inhibits the AKT/mTOR signaling pathway, and activates the AMPK signaling pathway. Jervine induces DNA damage, Apoptosis, Autophagy, ROS production and Mitochondrial damage. Jervine exhibits anti-cancer and anti-inflammatory activities. Jervine reduces tumor growth rate and weight in xenograft models. Jervine can be used in studies related to triple-negative breast cancer, nasopharyngeal carcinoma and non-small cell lung cancer .
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3
3 Cited Publications
Cat. No.: HY-N1993
CAS No.: 82517-12-2
5-Methyl-7-methoxyisoflavone is an orally active anti-oxidant with remyelinating activity. 5-Methyl-7-methoxyisoflavone inhibits the enzyme aromatase, interfering with the normal metabolic pathways of testosterone. 5-Methyl-7-methoxyisoflavone is a non-steroidal anabolic isoflavone, used as a anabolic agent. 5-Methyl-7-methoxyisoflavone shows better potency increasing muscle mass and endurance than Ipriflavone (HY-N0094). 5-Methyl-7-methoxyisoflavone can be used for fat loss besides the maintenance of low cholesterol level and strengthen bones. 5-Methyl-7-methoxyisoflavone is the inhibitor for NF-κB .
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2
2 Cited Publications
Cat. No.: HY-100471
CAS No.: 1632006-28-0
Purity:  99.93%
Synonyms: CS-3150; XL-550
Research Areas:  

Cardiovascular Disease

Esaxerenone (CS-3150) is a highly potent and selective non-steroidal mineralocorticoid receptor antagonist .
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2
2 Cited Publications
Cat. No.: HY-141672
CAS No.: 4999-79-5
Purity:  ≥99.0%
Synonyms: 17β-Estradiol 3-sulfate sodium
Target:  

GABA Receptor

Research Areas:  

Neurological Disease

17β-Estradiol sulfate (sodium), also known as β-Estradiol 3-sulfate sodium salt, is a neuroactive steroid .
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2
2 Cited Publications
Cat. No.: HY-N0437S2
CAS No.: 327048-87-3
Synonyms: Pregn-4-ene-3,20-dione-13C3
Progesterone- 13C3 is the 13C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
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2
2 Cited Publications
Cat. No.: HY-12524
CAS No.: 188011-69-0
Purity:  99.96%
Synonyms: Abrasin
Target:  

GSK-3

Research Areas:  

Others

Bikinin is a non-steroidal, ATP-competitive inhibitor of plant GSK-3/Shaggy-like kinases and activates BR (brassinosteroids) signaling.
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2 Cited Publications
Cat. No.: HY-N0706
CAS No.: 19083-00-2
Gracillin is a steroidal saponin that can be extracted from the roots of the plant and has anti-tumor properties. Gracillin can induce cancer cell apoptosis and autophagy .
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2 Cited Publications
Cat. No.: HY-N0812
CAS No.: 136656-07-0
Synonyms: Prototimosaponin A III
Timosaponin BII (Prototimosaponin A III) is a steroid saponin found in the rhizomes of Anemarrhena asphodeloides. Timosaponin BII has neuronal protective, anti-inflammatory and antioxidant activities .
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2
2 Cited Publications
Cat. No.: HY-B1025
CAS No.: 1672-46-4
Synonyms: Lanadigenin
Digoxigenin (DIG) is a steroid. DIG is used for situ hybridization as a labeling molecule probe due to long shelf life and fast detection and high sensitivity of DIG-labeled riboprobes .
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2
2 Cited Publications
Cat. No.: HY-108243
CAS No.: 1034148-04-3
Purity:  99.85%
AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM) . AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma .
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2
2 Cited Publications
Cat. No.: HY-B0293A
CAS No.: 64872-76-0
Target:  

Fungal

Research Areas:  

Infection

Butoconazole, an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candida albicans. Butoconazole is presumed to function as other imidazole derivatives via inhibition of steroid synthesis .
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2
2 Cited Publications
Cat. No.: HY-106628
CAS No.: 34042-85-8
Purity:  99.96%
Target:  

COX

Research Areas:  

Inflammation/Immunology

Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory drug (NSAID) from the enol-carboxamide class. Sudoxicam has potent anti-inflammatory, anti-edema and antipyretic activity .
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2 Cited Publications
Cat. No.: HY-109197
CAS No.: 1192171-69-9
Purity:  99.32%
Synonyms: EYP001
Target:  

FXR HBV

Research Areas:  

Infection

Vonafexor (EYP001) is an orally active, non-steroidal and selective FXR agonist. Vonafexor shows significant HBsAg reduction when combined with Peg-IFNα. Vonafexor can be used for anti-HBV research .
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2
2 Cited Publications
Cat. No.: HY-14281
CAS No.: 13647-35-3
Purity:  99.81%
Synonyms: Win 24540
Target:  

3β-HSD

Research Areas:  

Endocrinology Cancer

Trilostane (Win 24540) is a competitive and orally active 3-β-hydroxysteroiddehydrogenase (3β-HSD) inhibitor. Trilostane is a synthetic nonhormonal steroid. Trilostane can be used for the research of breast cancer and prostate cancer .
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2
2 Cited Publications
Cat. No.: HY-B0574
CAS No.: 61-68-7
Mefenamic acid is a BBB-permeable and non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.
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2 Cited Publications
Cat. No.: HY-B0293
CAS No.: 64872-77-1
Synonyms: RS 35887
Target:  

Fungal

Research Areas:  

Infection

Butoconazole nitrate (RS 35887), an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candida albicans. Butoconazole nitrate is presumed to function as other imidazole derivatives via inhibition of steroid synthesis .
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