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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
84 Results for "
HIV-1 Integrase
" in MedChemExpress (MCE) Product Catalog:
Products (84)
84 Results for "HIV-1 Integrase" in MCE Product Catalog:
Cat. No.: HY-122229
CAS No.: 2219362-41-9
GS-9822 is a potent antivira agent with nanomolar activity against wild-type HIV-1 viruses. GS-9822 potently inhibits the LEDGF/p75-integrase interaction with an IC50 of 0.07 μM. GS-9822 has high in vitro metabolic stability and favorable oral pharmacokinetic profiles with low systemic clearance in rats, dogs, and monkeys .
Cat. No.: HY-161945
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IN-RNA-IN-2 (compound 1a) is an inhibitor (IC50=70 nM) of the interaction between HIV-1 integrase and the viral RNA genome. IN-RNA-IN-2 exerts its anti-HIV activity by inhibiting the viral replication process .
Cat. No.: HY-13269R
CAS No.: 729607-74-3
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BMS-707035 (Standard) is the analytical standard of BMS-707035. This product is intended for research and analytical applications. BMS-707035 is a potent orally active HIV-1 integrase strand transfer inhibitor (INSTI). BMS-707035 has enzyme inhibitory with an IC50 value of 3 nM. BMS-707035 also has weak CYP inhibiton and antiviral activity. BMS-707035 can be used for the research of human immunodeficiency virus-1 (HIV-1) .
Cat. No.: HY-153247
CAS No.: 2081127-77-5
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GSK3839919A is a potent and allosteric HIV-1integrase inhibitor .
Cat. No.: HY-14740S2
Synonyms: GS-9137-13C6 ; JTK-303-13C6 ; D06677-13C6
Cat. No.: HY-14740S1
Synonyms: GS-9137-d6; JTK-303-d6; D06677-d6
Cat. No.: HY-N18192
CAS No.: 88524-65-6
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Cat. No.: HY-N20732
CAS No.: 871949-32-5
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Cat. No.: HY-182277
CAS No.: 1392118-63-6
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GSK-1264 is an HIV-1 integrase inhibitor. GSK-1264 binds to a site spanning the HIV-1 integrase catalytic core domain and C-terminal domain, mediates formation of an open polymer of HIV-1 integrase dimers via inhibitor-bridged contacts between adjacent dimers. GSK-1264 disrupts late-stage HIV replication by interfering with viral particle assembly. GSK-1264 stimulates inappropriate polymerization of HIV-1 integrase. GSK-1264 can be used for the research of HIV infection .
Cat. No.: HY-183926
CAS No.: 384361-09-5
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D719 is an HIV-1 integrase inhibitor. D719 binds to the hydrophobic pocket of HIV-1 integrase CCD dimer, disrupts interaction with LEDGF/P75, and prevents integrase nuclear translocation. D719 reduces HIV-1 p24 antigen production in acute infection of human T cells. D719 can be used for the research of HIV infection .
Cat. No.: HY-182678
CAS No.: 251922-77-7
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L-731988 is an inhibitor targeting HIV-1 integrase. L-731988 inhibits HIV-1 replication by blocking integrase function. L-731988 exhibits ED50 values ranging from 0.5 μM to 3.14 μM against various HIV-1 isolates. L-731988 can be used for the research of human immunodeficiency virus type 1 (HIV-1) infection .
Cat. No.: HY-184318
CAS No.: 915407-80-6
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GS-9160 is a HIV-1 integrase strand transfer inhibitor with an IC50 of 28 nM. GS-9160 elevates the level of HIV-1 double long terminal repeat circles and reduces integration junctions. GS-9160 exhibits selective antiviral activity against HIV-1 in cells. GS-9160 can select for integrase mutants E92V and L74M, and shows synergistic activity with other HIV-1 inhibitors. GS-9160 can be used in studies related to HIV-1 infection .
Cat. No.: HY-184700
CAS No.: 3124729-94-5
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HIV-1-IN-94 is a dual inhibitor of HIV-1 integrase (INST) and reverse transcriptase RNase H, with IC50 values of 12 μM and 0.11 μM, respectively. HIV-1-IN-94 inhibits HIV-1 replication with low cytotoxicity. HIV-1-IN-94 can be used in studies related to HIV-1 infection .
Cat. No.: HY-N16888
CAS No.: 450407-31-5
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Cat. No.: HY-178833
CAS No.: 180740-99-2
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CNI-H0294 hydrochloride is a selective HIV-1 integrase inhibitor. CNI-H0294 hydrochloride is promising for research of HIV-associated central nervous system diseases .
Cat. No.: HY-185448
CAS No.: 1246741-36-5
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HIV RT-IN-1 is an inhibitor of HIV integrase and HIV reverse transcriptase-associated ribonuclease H. HIV RT-IN-1 is applicable to research related to HIV-1 infection .
Cat. No.: HY-N17982
CAS No.: 879627-80-2
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Simple Phenylpropanols Phenylpropanoids Plants Gardenia jasminoides Ellis Rubiaceae Extract
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Cat. No.: HY-135210
CAS No.: 223393-69-9
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V-165 is an inhibitor of HIV Integrase and HIV Reverse transcriptase, with an IC50 value of 3.8 μM against HIV integrase and an IC50 value of 4.8 μM against HIV reverse transcriptase. V-165 inhibits HIV-1 replication. V-165 can be used in studies related to immunodeficiency virus infections .
Cat. No.: HY-123066A
CAS No.: 1263143-51-6
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(E)-DIDS monohydrate sodium is the E-isomer of DIDS monohydrate sodium (HY-123066). DIDS is a hRAD51 inhibitor with an IC50 value of 90 μM. DIDS exhibits significant inhibitory activity against HIV-1 integrase with an IC50 value of 5 μM .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
