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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
189 Results for "
human fibroblasts
" in MedChemExpress (MCE) Product Catalog:
Products (189)
189 Results for "human fibroblasts" in MCE Product Catalog:
Cat. No.: HY-P991795
Cat. No.: HY-15768R
CAS No.: 142880-36-2
Synonyms: GM6001 (Standard); Galardin (Standard)
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Ilomastat (Standard) is the analytical standard of Ilomastat. This product is intended for research and analytical applications. Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC50s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a Ki of 0.4 nM for human skin fibroblast collagenase (MMP-1).
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Cat. No.: HY-N15343
CAS No.: 2222286-14-6
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Cat. No.: HY-N16437A
CAS No.: 1375224-56-8
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Cat. No.: HY-P991488
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Cat. No.: HY-119358R
CAS No.: 6402-36-4
Cat. No.: HY-144664
CAS No.: 2799607-71-7
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MtTMPK-IN-2 (compound 15) is a potent Mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 value of 1.1 μM. MtTMPK-IN-2 has inhibitory activity against Mtb H37Rv (MIC = 12.5 μM). MtTMPK-IN-2 exhibits certain cytotoxicity in human fibroblast cells MRC-5 (EC50 = 6.1 μM). MtTMPK-IN-2 can be used for researching tuberculosis .
Cat. No.: HY-144665
CAS No.: 2799607-80-8
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MtTMPK-IN-3 (compound 25) is a potent Mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 value of 0.12 μM. MtTMPK-IN-3 has inhibitory activity against Mtb H37Rv (MIC = 12.5 μM). MtTMPK-IN-3 exhibits certain cytotoxicity in human fibroblast cells MRC-5 (EC50 = 12.5 μM). MtTMPK-IN-3 can be used for researching tuberculosis .
Cat. No.: HY-178239
CAS No.: 276680-63-8
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DX-8951 Hydroxy-acid is a prodrug of phosphoramide. ProAX can effectively increase intracellular ATP levels. DX-8951 Hydroxy-acid activates the AMPK signaling pathway by increasing the AMP/ATP ratio. DX-8951 Hydroxy-acid can enhance mitochondrial function and antioxidant capacity while reducing reactive oxygen species (ROS) levels. DX-8951 Hydroxy-acid has shown significant anti-aging and longevity effects in both human fibroblast and nematode models .
Cat. No.: HY-182272
FAP-IN-9 (compound P12) is a fibroblast activation protein (FAP) inhibitor with an IC50 of 0.38 nM against human FAP. FAP-IN-9 functionally inhibits FAP activity, and its specific binding is verified by in vitro and in vivo blocking assays. FAP-IN-9 forms stable complexes and acts as a tumor-targeting agent. When labeled with 99mTc, FAP-IN-9 serves as a SPECT probe and is applicable to research related to glioblastoma .
Cat. No.: HY-188134
CAS No.: 1505452-80-1
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CWHM-117 is an orally active aspartic protease inhibitor with selective activity against Toxoplasma gondii. CWHM-117 inhibits the proliferation of Toxoplasma gondii tachyzoites in human fibroblasts, with an EC50 of 2.00 µM. CWHM-117 delays mortality in an acute mouse model of toxoplasmosis. In a chronic mouse model of toxoplasmosis, CWHM-117 reduces brain cyst burden and prolongs survival. CWHM-117 can be used for research on toxoplasmosis .
Cat. No.: HY-N11072
CAS No.: 29836-40-6
Cat. No.: HY-P5232
CAS No.: 960608-17-7
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Cat. No.: HY-155732
CAS No.: 3032452-65-3
NPD-2975 (compound 30) is an orally active antitrypanosomal agent, against Human African Trypanosomiasis (HAT). NPD-2975 has low toxicity potential against human MRC-5 lung fibroblasts, and acute mouse model of T. b. brucei infection. NPD-2975 shows acceptable metabolic stability, inhibits T. b. brucei with IC500 of 70 nM in vitro. NPD-2975 also inhibits CYP enzymes resulted in IC50 values of 0.16 and 0.42 μM against CYP1A2 and CYP2C19, respectively .
Cat. No.: HY-P2315
CAS No.: 452274-53-2
Synonyms: HβD-1
Human β-defensin-1 (HβD-1) is an antimicrobial peptide and immunomodulator that induces angiogenin secretion from fibroblasts through EGFR, JNK, NF-κB, Src, and p38 signaling pathways, and binds CCR6 to activate G protein signaling, while also inducing ER stress, apoptosis, cell cycle arrest, and autophagy. Human β-defensin-1 can be used in research on hepatocellular carcinoma, influenza A virus infection, male infertility, colon cancer, and bacterial infections caused by antibiotic-resistant strains .
Cat. No.: HY-106818
CAS No.: 103377-41-9
Synonyms: AJ-2615 free base
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Monatepil (AJ-2615 free base) is a calcium antagonist with potent α1-adrenoceptor blocking activity. Monatepil inhibits vasopressin- or methacholine-induced ischemic electrocardiographic changes in a rat model of vasospastic angina and reduces the mean arterial pressure in anesthetized rats. Monatepil also enhances low-density lipoprotein (LDL) receptor activity in human skin fibroblasts . Monatepil can be used in research related to hypertension, atherosclerosis, hyperlipidemia and vasospastic angina .
Cat. No.: HY-106818A
CAS No.: 103379-03-9
Synonyms: AJ-2615
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Monatepil (AJ-2615 free base) maleate is a calcium antagonist with potent α1-adrenoceptor blocking activity. Monatepil maleate inhibits vasopressin- or methacholine-induced ischemic electrocardiographic changes in a rat model of vasospastic angina and reduces the mean arterial pressure in anesthetized rats. Monatepil maleate also enhances low-density lipoprotein (LDL) receptor activity in human skin fibroblasts . Monatepil maleate can be used in research related to hypertension, atherosclerosis, hyperlipidemia and vasospastic angina .
Cat. No.: HY-106818B
CAS No.: 103379-02-8
Synonyms: AJ-2615 hydrochloride
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Monatepil (AJ-2615 free base) hydrochloride is a calcium antagonist with potent α1-adrenoceptor blocking activity. Monatepil hydrochloride inhibits vasopressin- or methacholine-induced ischemic electrocardiographic changes in a rat model of vasospastic angina and reduces the mean arterial pressure in anesthetized rats. Monatepil hydrochloride also enhances low-density lipoprotein (LDL) receptor activity in human skin fibroblasts . Monatepil hydrochloride can be used in research related to hypertension, atherosclerosis, hyperlipidemia and vasospastic angina .
Cat. No.: HY-125102
CAS No.: 851432-37-6
AZ12253801 is an ATP-competitive IGF-1R tyrosine kinase inhibitor that shows ∼10-fold selectivity over the insulin receptor. AZ12253801 inhibits IGF-1R–driven proliferation in 3T3 mouse fibroblasts (transfected with human IGF-1R) with an IC50 of 17 nmol/L. The IC50 for epidermal growth factor receptor (EGFR)–driven proliferation is 440 nmol/L. Anti-tumor activity.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
