24 Results for "

AQP4

" in MedChemExpress (MCE) Product Catalog:
Products (24)

24 Results for "AQP4" in MCE Product Catalog:

25
25 Publications Verification
Cat. No.: HY-W008574
CAS No.: 51987-99-6
Target:  

PROTAC Linkers

Research Areas:  

Inflammation/Immunology Cancer

TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM . TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats [4].
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25
25 Publications Verification
Cat. No.: HY-W008574A
CAS No.: 1313731-99-5
Target:  

PROTAC Linkers

Research Areas:  

Inflammation/Immunology Cancer

TGN-020 sodium is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM . TGN-020 sodium is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . TGN-020 sodium alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats [4].
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3
3 Cited Publications
Cat. No.: HY-N10756
CAS No.: 3118-34-1
Target:  

TRP Channel

Research Areas:  

Neurological Disease

Hyp9 is a transient receptor potential canonical 6 (TRPC6)-specific agonist. Hyp9 can be used for the research of spinal cord injury (SCI) .
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1
1 Cited Publications
Cat. No.: HY-115460
CAS No.: 634913-39-6
Purity:  98.00%
Target:  

Aquaporin

AER-271, a phosphonate proagent derivative of AER-270, is an aquaporin-4 (AQP4) inhibitor for the research of acute ischemic stroke .
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Cat. No.: HY-P10936A
Target:  

Aquaporin

AQP4 (201-220) TFA is an encephalitogenic epitope of AQP-4. AQP4 (201-220) TFA can induce experimental autoimmune encephalomyelitis (EAE) (characterized by midline lesions in the brain, retinal pathology, and lesions at the grey matter/white matter border zone in the spinal cord). AQP-4 is a target antigen in neuromyelitis optica .
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Cat. No.: HY-W176557
CAS No.: 877459-36-4
Target:  

Aquaporin Amyloid-β

Research Areas:  

Neurological Disease

TGN-073 is an orally active, blood-brain barrier-permeable aquaporin 4 (AQP4) modulator. TGN-073 increases the uptake and distribution of brain MRI tracers in the brain parenchyma and reduces the levels of insoluble amyloid β-40 and β-42. TGN-073 can be used in research related to Alzheimer's disease, dementia, traumatic brain injury and pain .
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Cat. No.: HY-P10936
CAS No.: 2104700-59-4
Target:  

Aquaporin

AQP4 (201-220) is an encephalitogenic epitope of AQP-4. AQP4 (201-220) can induce experimental autoimmune encephalomyelitis (EAE) (characterized by midline lesions in the brain, retinal pathology, and lesions at the grey matter/white matter border zone in the spinal cord). AQP-4 is a target antigen in neuromyelitis optica .
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Cat. No.: HY-N4246
CAS No.: 382148-47-2
Bacopaside I is an orally active aquaporin AQP1 inhibitor and PKC modulator with neuroprotective and anticancer activities. Bacopaside I specifically blocks the water channel and cGMP-gated ion channel activities of AQP1 without affecting AQP4, thereby inhibiting the migration of colon cancer cells expressing AQP1. Bacopaside I activates the Akt pathway by interacting with PI3K, specifically inhibits MAO-A, effectively alleviates neuron necrosis and apoptosis induced by oxygen-glucose deprivation, reduces oxidative stress, and regulates the surface expression of neuroreceptors. When combined with Bacopaside II (HY-N6016), Bacopaside I significantly reduces the viability, proliferation and invasion ability of breast cancer cells, and binds to the pregnane X receptor (PXR). Bacopaside I is applicable to the research of colon cancer, breast cancer, vascular dementia, cerebral ischemia and other related diseases [4].
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Cat. No.: HY-P10937
CAS No.: 2891466-35-4
Target:  

Aquaporin

Research Areas:  

Inflammation/Immunology

AQP4 (205-215) is a fragment of Aquaporin-4 (AQP4). AQP4 is a neuromyelitis optica autoantigen that is upregulated and presented in B cells after engagement of CD40. AQP4 is associated with autoimmune inflammatory diseases of the central nervous system (CNS), neuromyelitis optica (NMO) .
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Cat. No.: HY-P10937A
Target:  

Aquaporin

Research Areas:  

Inflammation/Immunology

AQP4 (205-215) TFA is a fragment of Aquaporin-4 (AQP4). AQP4 is a neuromyelitis optica autoantigen that is upregulated and presented in B cells after engagement of CD40. AQP4 is associated with autoimmune inflammatory diseases of the central nervous system (CNS), neuromyelitis optica (NMO) .
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Cat. No.: HY-RS00876
Research Areas:  

Others

AQP4 Human Pre-designed siRNA Set A contains three designed siRNAs for AQP4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS23136
Research Areas:  

Others

Aqp4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Aqp4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-157226
Target:  

Aquaporin

Research Areas:  

Others

ORI-TRN-002 is an AQP4 inhibitor with an IC50 value of 3μM. ORI-TRN-002 can be used in the research area of cerebral edema .
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Cat. No.: HY-RS16702
Research Areas:  

Others

Aqp4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aqp4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P991869
Synonyms: AQmabAM; rAb-53

Target:  

Aquaporin

Research Areas:  

Neurological Disease

Aquaporumab (AQmabAM) is an engineered human monoclonal IgG antibody. Aquaporumab is a selective inhibitor of aquaporin 4 (AQP4), binding tightly to AQP4 and competitively displacing AQP4-IgG from serum [1][2]. Aquaporumab significantly reduces neuromyelitis optica lesions in spinal cord slice cultures and in mice receiving intracerebral injection of AQP4-IgG and complement [1][2]. Aquaporumab can be used for research on neuromyelitis optica spectrum disorders [1][2]."}
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Cat. No.: HY-P72087A
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AQP 4; AQP-4; AQP4; AQP4_HUMAN; Aquaporin type 4; Aquaporin-4; Aquaporin4; HMIWC 2; HMIWC2; Mercurial insensitive water channel; Mercurial-insensitive water channel; MGC22454; MIWC; WCH 4; WCH4
Species:  
Source:  
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Cat. No.: HY-P72087
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AQP 4; AQP-4; AQP4; AQP4_HUMAN; Aquaporin type 4; Aquaporin-4; Aquaporin4; HMIWC 2; HMIWC2; Mercurial insensitive water channel; Mercurial-insensitive water channel; MGC22454; MIWC; WCH 4; WCH4
Species:  
Source:  
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Cat. No.: HY-W017091
CAS No.: 538-43-2
Category:  

Natural Products Plants

Target:  

Aquaporin

3-Phenoxy-1,2-propanediol (compound 15) is a weak aquaporin 4 (AQP4) inhibitor . 3-Phenoxy-1,2-propanediol is an important intermediate for pharmaceuticals .
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Cat. No.: HY-18805
CAS No.: 1752-96-1
Synonyms: N-Phenylnicotinamide
Target:  

Aquaporin

Research Areas:  

Neurological Disease

Nicotinanilide (N-Phenylnicotinamide) (Compound 12) is an aquaporin 4 (AQP4) inhibitor. Nicotinanilide can be used for research on diseases associated with AQP4 dysfunction, such as epilepsy and migraine .
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Cat. No.: HY-P83459A
Synonyms: aquaporin 4; WCH4; Mercurial-insensitive water channel; MIWC; AQP 4; AQP4; Aquaporin4; HMIWC 2; HMIWC2; Mercurial insensitive water channel; MGC22454; MIWC; AQP4_HUMAN; Aquaporin-4; AQP-4.

Host:  

Rabbit

Application:  

WB, IHC-P, IHC-F, FC, ICC/IF

Reactivity:  

Human, Mouse, Rat

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