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Results for "

ATIC

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Androgen Receptor (1) Autophagy (1) DNA/RNA Synthesis (2) Drug Derivative (1) Endogenous Metabolite (1) Estrogen Receptor/ERR (1) Fungal (2) Histone Methyltransferase (1) Interleukin Related (1) Mitophagy (1) mTOR (1) Opioid Receptor (1) PARP (3) PI3K (1) Prostaglandin Receptor (2) PROTAC Linkers (1) Reference Standards (1) Small Interfering RNA (siRNA) (4) Thyroid Hormone Receptor (1) TNF Receptor (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (2) Infection (3) Inflammation/Immunology (5) Metabolic Disease (1) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (4)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0499

Cyanidin Chloride 4 Publications Verification IdB 1027	Prostaglandin Receptor	Inflammation/Immunology
Cyanidin Chloride (IdB 1027) is an orally active antioxidant and enzyme inhibitor. Cyanidin Chloride has IC₅₀ values of 90 μM and 60 μM against PGHS-1 and PGHS-2, respectively. Cyanidin Chloride exhibits excellent antioxidant and anti-inflammatory activities, scavenges free radicals, inhibits lipid peroxidation, and protects DNA from cleavage. Cyanidin Chloride can be used in the research of inflammatory diseases .

HY-W011927

4,4'-Sulfonyldiphenol Bisphenol S; Bis(4-hydroxyphenyl) sulfone	Estrogen Receptor/ERR Histone Methyltransferase Thyroid Hormone Receptor PI3K Akt mTOR Androgen Receptor Drug Derivative	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an oally ative estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC₅₀ values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae .

HY-N0485

Liensinine Diperchlorate 15+ Cited Publications	Autophagy Mitophagy	Cardiovascular Disease
Liensinine Diperchlorate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlorate inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. Liensinine Diperchlorate has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc .

HY-150252A

ATIC-IN-1 acetate 1 Publications Verification	Endogenous Metabolite	Cancer
ATIC-IN-1 (compound 14) acetate is an inhibitor targeting to *Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization* with a K_i value of 685 nM, whcich catalyzes de novo purine biosynthesis. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 acetate exhibits anti-tumor activity via reduction in cell numbers and cell division rates .

HY-133157

FAICAR 5-Formamidoimidazole-4-carboxamide ribotide	DNA/RNA Synthesis	Infection
FAICAR (5-Formamidoimidazole-4-carboxamide ribotide) is a purine nucleotide and the IMP cyclohydrolase substrate of Cryptococcus neoformans ATIC. It is a key intermediate in the de novo purine synthesis pathway. FAICAR can be used in studies related to Cryptococcus neoformans infection .

HY-N1448

Vincetoxicoside B	Fungal	Infection
Vincetoxicoside B shows antifungal activity .

HY-N0499A

Cyanidin	Prostaglandin Receptor	Inflammation/Immunology
Cyanidin is an orally active antioxidant and enzyme inhibitor. Cyanidin has IC₅₀ values of 90 μM and 60 μM against PGHS-1 and PGHS-2, respectively. Cyanidin exhibits excellent antioxidant and anti-inflammatory activities, scavenges free radicals, inhibits lipid peroxidation, and protects DNA from cleavage. Cyanidin can be used in the research of inflammatory diseases .

HY-P990067

Evunzekibart ATOR-1017	TNF Receptor	Cancer
Evunzekibart (ATOR-1017) is an Fc-γ receptor conditional 4-1BB agonist and IgG4-type antibody. Evunzekibart can be used as monotherapy or in combination with anti-PD1 to exert anticancer activity.

HY-29244

ATIC-IN-2	DNA/RNA Synthesis	Cancer
ATIC-IN-2 (Compound 1) is a competitive inhibitor for the bifunctional enzyme AICAR Tfase/IMPCH (ATIC), that binds to inosine monophosphate cyclohydrolase (IMPCH) with a K_i of 0.13 μM .

HY-150252

ATIC-IN-1	Others	Cancer
ATIC-IN-1(compound 14) is an inhibitor targeting to *Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization* with a K_i value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates .

HY-RS01156

ATIC Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ATIC Human Pre-designed siRNA Set A contains three designed siRNAs for ATIC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ATIC Human Pre-designed siRNA Set A ATIC Human Pre-designed siRNA Set A

HY-178468

PARP1-IN-47	PARP	Cancer
PARP1-IN-47 (Compound 35) is a highly selective PARP1 inhibitor (IC₅₀ <100 nM). PARP1-IN-47 blocks poly(ADP-ribosyl)ation and disrupts DNA damage repair pathways to induce tumor cell apoptosis. PARP1-IN-47 is promising for research of solid tumors and hematological malignancies .

HY-RS23569

Atic Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Atic Rat Pre-designed siRNA Set A contains three designed siRNAs for Atic gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Atic Rat Pre-designed siRNA Set A Atic Rat Pre-designed siRNA Set A

HY-RS01126

ATE1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ATE1 Human Pre-designed siRNA Set A contains three designed siRNAs for ATE1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ATE1 Human Pre-designed siRNA Set A ATE1 Human Pre-designed siRNA Set A

HY-N1448R

Vincetoxicoside B (Standard)	Reference Standards Fungal	Infection
Vincetoxicoside B (Standard) is the analytical standard of Vincetoxicoside B. This product is intended for research and analytical applications. Vincetoxicoside B shows antifungal activity .

HY-141324

*Tetraethyl butane-1,4-diylbis(phosphoramidate)*	PROTAC Linkers	Cancer
Tetraethyl butane-1,4-diylbis(phosphoramidate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-135238

(rel)-RSD 921 PD-117302	Opioid Receptor	Others
(rel)-RSD 921 (PD-117302) is a κ-opioid receptor agonist. (rel)-RSD 921 did not have a greater food-inducing effect in obese than in lean Zucker rats; in both obese and lean Zucker rats, lean rats were more sensitive to its initial food-inducing effect but ultimately ate less.

HY-RS17124

Atic Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Atic Mouse Pre-designed siRNA Set A contains three designed siRNAs for Atic gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Atic Mouse Pre-designed siRNA Set A Atic Mouse Pre-designed siRNA Set A

HY-136263

Biotin-NAD+	PARP	Cancer
Biotin-NAD ⁺ is a PARylation donor and also a substrate of poly (ADP-ribose) polymerase-1 (PARP1). Under the mediation of PARP1, Biotin-NAD ⁺ undergoes poly (ADP-ribosyl) ation to generate biotinylated poly (ADP-ribose) polymers. Biotin-NAD ⁺ can be used for pull-down assays of PARylated proteins in renal epithelial cells. Biotin-NAD ⁺ is applicable to cancer-related research .

HY-N17727

Divaricatol	Interleukin Related TNF Receptor	Neurological Disease Inflammation/Immunology
Divaricatol is an orally ative chromone natural product and an active component in Saposhnikovia divaricata. Divaricatol reduces the release of pro-inflammatory cytokines and restores immune homeostasis by stably binding to 5KIR (a target of the TNF/IL-17 pathway). Divaricatol exerts analgesic effects in mouse models. Divaricatol can be used in the research of pain, diarrhea-predominant irritable bowel syndrome (IBS-D) and qi deficiency syndrome .

HY-182246

MC2050	PARP	Neurological Disease Inflammation/Immunology Cancer
MC2050 is a selective PARP-1 inhibitor with an IC₅₀ of 119 nM. MC2050 functionally inhibits PARP-1 activity, including hyperactivation induced by oxidative stress, and reduces the poly (ADP-ribosyl) ation level of histone H1. MC2050 protects neuroblastoma cells from oxidative stress-mediated cell death induced by hydrogen peroxide. MC2050 is applicable to research related to neuroblastoma and Burkitt lymphoma .

Cat. No.	Product Name	Type

HY-W011927

4,4'-Sulfonyldiphenol Bisphenol S; Bis(4-hydroxyphenyl) sulfone	Biochemical Assay Reagents
4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an oally ative estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC₅₀ values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae .

4,4'-Sulfonyldiphenol

Bisphenol S; Bis(4-hydroxyphenyl) sulfone

Biochemical Assay Reagents

4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an oally ative estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC₅₀ values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990067

Evunzekibart ATOR-1017	TNF Receptor	Cancer
Evunzekibart (ATOR-1017) is an Fc-γ receptor conditional 4-1BB agonist and IgG4-type antibody. Evunzekibart can be used as monotherapy or in combination with anti-PD1 to exert anticancer activity.

Cyanidin Chloride 4 Publications Verification IdB 1027	Structural Classification Anthocyans Flavonoids other families Classification of Application Fields Anti-aging Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	Prostaglandin Receptor
Cyanidin Chloride (IdB 1027) is an orally active antioxidant and enzyme inhibitor. Cyanidin Chloride has IC₅₀ values of 90 μM and 60 μM against PGHS-1 and PGHS-2, respectively. Cyanidin Chloride exhibits excellent antioxidant and anti-inflammatory activities, scavenges free radicals, inhibits lipid peroxidation, and protects DNA from cleavage. Cyanidin Chloride can be used in the research of inflammatory diseases .

Liensinine Diperchlorate 15+ Cited Publications	Cardiovascular Disease Alkaloids Piperidine Alkaloids Classification of Application Fields Phenols Polyphenols Nelumbo nucifera Gaertn. Plants Disease Research Fields Nymphaeaceae Source Classification	Autophagy Mitophagy
Liensinine Diperchlorate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlorate inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. Liensinine Diperchlorate has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc .

FAICAR 5-Formamidoimidazole-4-carboxamide ribotide	Source Classification	DNA/RNA Synthesis
FAICAR (5-Formamidoimidazole-4-carboxamide ribotide) is a purine nucleotide and the IMP cyclohydrolase substrate of Cryptococcus neoformans ATIC. It is a key intermediate in the de novo purine synthesis pathway. FAICAR can be used in studies related to Cryptococcus neoformans infection .

Vincetoxicoside B	Infection Flavonols Flavonoids Classification of Application Fields Phenols Polyphenols Erythrina stricta Roxb. Plants Compositae Disease Research Fields Source Classification	Fungal
Vincetoxicoside B shows antifungal activity .

Cyanidin	Structural Classification Caprifoliaceae Phenols Polyphenols Sambucus williamsii Hance Plants Source Classification	Prostaglandin Receptor
Cyanidin is an orally active antioxidant and enzyme inhibitor. Cyanidin has IC₅₀ values of 90 μM and 60 μM against PGHS-1 and PGHS-2, respectively. Cyanidin exhibits excellent antioxidant and anti-inflammatory activities, scavenges free radicals, inhibits lipid peroxidation, and protects DNA from cleavage. Cyanidin can be used in the research of inflammatory diseases .

Vincetoxicoside B (Standard)	Flavonols Structural Classification Flavonoids Phenols Polyphenols Erythrina stricta Roxb. Plants Compositae Source Classification	Reference Standards Fungal
Vincetoxicoside B (Standard) is the analytical standard of Vincetoxicoside B. This product is intended for research and analytical applications. Vincetoxicoside B shows antifungal activity .

Divaricatol	Structural Classification Monophenols Xeranthemum annuum L. Phenols Umbelliferae Plants Source Classification	Interleukin Related TNF Receptor
Divaricatol is an orally ative chromone natural product and an active component in Saposhnikovia divaricata. Divaricatol reduces the release of pro-inflammatory cytokines and restores immune homeostasis by stably binding to 5KIR (a target of the TNF/IL-17 pathway). Divaricatol exerts analgesic effects in mouse models. Divaricatol can be used in the research of pain, diarrhea-predominant irritable bowel syndrome (IBS-D) and qi deficiency syndrome .

Host:	Mouse (3)
Reactivity:	Human (3) mouse (1) rat (1) Rat (2) Mouse (2)
Application:	WB FC ICC/IF (1) WB (2)
Isotype:	IgG1 (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85553

	ATIC Antibody (YA5245) 5 aminoimidazole 4 carboxamide 1 beta D ribonucleotide transformylase/inosinicase; 5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase; 5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AICAR; AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme; AICAR transformylase; AICARFT; AICARFT/IMPCHASE; ATIC; Bifunctional purine biosynthesis protein PURH; FLJ93545; IMP cyclohydrolase; IMP synthase; IMP synthetase; IMPCHASE; Inosinicase; OK/SW-cl.86; Phosphoribosylaminoimidazolecarboxamide formyltransferase; Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PUR9_HUMAN; PURH.	WB	Human, Mouse, Rat
	ATIC Antibody (YA5245) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ATIC.

HY-P81327

	ATIC Antibody (YA1072) PURH; AICAR; AICARFT; IMPCHASE	WB	Human, Mouse, Rat
	ATIC Antibody (YA1072) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ATIC.

HY-P810469

	ATIC Antibody (YA9768) ATIC, 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase, PURH, IMPCHASE, AICARFT, Phosphoribosylaminoimidazolecarboxamide Formyltransferase/IMP Cyclohydrolase, AICAR Transformylase/Inosine Monophosphate Cyclohydrolase, Bifunctional Purine Biosynthesis Protein ATIC, 5-Aminoimidazole-4-Carboxamide-1-Beta-D-Ribonucleotide Transformylase/Inosinicase, AICAR Formyltransferase/IMP Cyclohydrolase Bifunctional Enzyme, Epididymis Secretory Sperm Binding Protein Li 70p, Bifunctional Purine Biosynthesis Protein PURH, AICARFT/IMPCHASE, HEL-S-70p, AICAR	WB FC ICC/IF	Human, mouse, rat
	ATIC Antibody (YA9768) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to ATIC.

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ATIC Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ATIC Human Pre-designed siRNA Set A contains three designed siRNAs for ATIC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Atic Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Atic Rat Pre-designed siRNA Set A contains three designed siRNAs for Atic gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

ATE1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ATE1 Human Pre-designed siRNA Set A contains three designed siRNAs for ATE1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Atic Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Atic Mouse Pre-designed siRNA Set A contains three designed siRNAs for Atic gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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ATIC

Inhibitors & Agonists

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Inhibitory Antibodies

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