Search Result

Results for "

CAR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Constitutive Androstane Receptor (11) ADC Payload (1) Amino Acid Derivatives (1) Amyloid-β (1) Apoptosis (12) Bacterial (3) Bcl-2 Family (2) Biochemical Assay Reagents (5) Caspase (2) CaSR (13) CD19 (3) CD276/B7-H3 (1) CD3 (1) CD38 (1) Cholinesterase (ChE) (1) Cytochrome P450 (3) DGK (1) DNA/RNA Synthesis (1) Drug Isomer (1) Drug Metabolite (1) Endogenous Metabolite (12) Environmental Pollutants (1) FAP (1) Ferroptosis (1) Fluorescent Dye (1) Fungal (2) GABA Receptor (1) Histamine Receptor (5) IFNAR (4) iGluR (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Integrin (2) Interleukin Related (3) Isotope-Labeled Compounds (4) JAK (1) LAG-3 (1) MAP4K (1) MHC (1) Microtubule/Tubulin (1) Mitosis (1) mRNA (2) NF-κB (3) P-glycoprotein (1) Parasite (3) PD-1/PD-L1 (1) PERK (1) Phosphatase (1) Photosensitizer (1) PPAR (3) Pregnane X Receptor (PXR) (3) PROTACs (3) Reactive Oxygen Species (ROS) (4) Reference Standards (8) Small Interfering RNA (siRNA) (26) Src (1) Succinate Dehydrogenase (2) Tim3 (2) TNF Receptor (1) Topoisomerase (2) Transmembrane Glycoprotein (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (36) Cardiovascular Disease (8) Endocrinology (5) Infection (4) Inflammation/Immunology (15) Metabolic Disease (7) Neurological Disease (12)
Click Chemistry:	PROTAC Synthesis (1)
Oligonucleotides:	CAR-T (2) Rat Pre-designed siRNA Sets (7) mRNA (2) Mouse Pre-designed siRNA Sets (11) Human Pre-designed siRNA Sets (8) siRNAs (26)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Constitutive Androstane Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0488A

Vincristine Maximum Cited Publications 74 Publications Verification Leurocristine; NSC-67574; 22-Oxovincaleukoblastine	Apoptosis Microtubule/Tubulin Mitosis	Infection Cancer
Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .

HY-70037

Cinacalcet 15+ Cited Publications AMG 073	CaSR Endogenous Metabolite	Cardiovascular Disease Cancer
Cinacalcet (AMG 073) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease research.

HY-103244

CITCO 3 Publications Verification	Apoptosis	Cancer
CITCO, an imidazothiazole derivative, is a selective Constitutive androstane receptor (CAR) agonist. CITCO inhibits growth and expansion of brain tumour stem cells (BTSCs) and has an EC₅₀ of 49 nM over pregnane X receptor (PXR), and no activity on other nuclear receptors .

HY-153084A

*CD19 CAR* mRNA (Human)** 1 Publications Verification	mRNA CD19	Cancer
CD19 CAR mRNA (Human) expresses CAR protein that specifically targets human CD19. CD19 CAR mRNA can trigger transitory expression of CAR, allowing T cells to be targeted without permanent genetic modification. CD19 CAR mRNA targets CD19 which is a transmembrane glycoprotein primarily expressed on B lymphocytes and is important in B cell activation. CD19 CAR mRNA can be studied in cancer research such as lymphoma and leukemia .

HY-B0349

Meclizine dihydrochloride 4 Publications Verification Meclozine dihydrochloride	Histamine Receptor Apoptosis	Neurological Disease Endocrinology Cancer
Meclizine (Meclozine) dihydrochloride, an antihistamine, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine dihydrochloride is a member of the piperazine class of H1 antagonists. Meclizine dihydrochloride is an effective anti-motion sickness agent. Meclizine dihydrochloride crosses the blood-brain barrier. Meclizine dihydrochloride can be used for the research of polyQ toxicity disorders, such as Huntington's disease. Meclizine dihydrochloride is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR .

HY-103243

TCPOBOP 4 Publications Verification	Bcl-2 Family	Cancer
TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss . TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins .

HY-112171

γ-L-Glutamyl-L-alanine 1 Publications Verification γ-Glu-Ala	Endogenous Metabolite CaSR	Others
γ-L-Glutamyl-L-alanine (γ-Glu-Ala), composed of gamma-glutamate and alanine, is a proteolytic breakdown product of larger proteins. γ-L-Glutamyl-L-alanine is a natural substrate of the γ-Glutamylcyclotransferase. γ-L-Glutamyl-L-alanine is a positive modulator of calcium-sensing receptor (CaR) function .

HY-70037A

Cinacalcet hydrochloride 15+ Cited Publications AMG-073 hydrochloride	CaSR Endogenous Metabolite	Cardiovascular Disease Cancer
Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.

HY-119459

Fluopyram 1 Publications Verification	Environmental Pollutants Constitutive Androstane Receptor Parasite Caspase Fungal NF-κB Succinate Dehydrogenase Pregnane X Receptor (PXR)	Infection Cancer
Fluopyram is an orally active succinate dehydrogenase inhibitor, antifungal and nematicide. Fluopyram inhibits succinate dehydrogenase activity, activates *CAR/PXR* nuclear receptors, and increases caspase-3, TNF-α and NF-κB. Fluopyram inhibits the growth of F. virguliforme, Botrytis cinerea and Alternaria solani with EC₅₀ values of 3.35, 5.389 and 0.244 µg/mL, respectively. Fluopyram induces liver and thyroid tumor formation. Fluopyram is nephrotoxic and embryotoxic .

HY-159649

BMS-986408	DGK PERK Interleukin Related	Inflammation/Immunology Cancer
BMS-986408 is an orally active inhibitor of DGKα and DGKζ, with IC₅₀ values of 0.0003 μM and 0.002 μM, respectively. BMS-986408 activates intratumoral T cell responses, enhances the priming and expansion of tumor-reactive T cells in tumor-draining lymph nodes, and functions as an immunostimulant. BMS-986408 can be used in the research of tumors .

HY-163028

ML-T7	Tim3	Cancer
ML-T7 is a potent Tim-3 inhibitor. ML-T7 blocks Tim-3 interactions with PtdSer and CEACAM1. ML-T7 not only enhances the antitumor activity of adoptive transfer therapy with cytotoxic T lymphocytes (CTLs) and CAR T cells but also increases the effector function of T cell. ML-T7 promotes NK cells’ killing activity against tumor cells and DC antigen-presenting capacity. ML-T7 directly exerts antitumor efficacy in preclinical tumor models either alone or in combination with Nivolumab (HY-P9903A). ML-T7 can be used for tumor immunotherapy research .

HY-164899

2A3 2-aminopyridine-3-CARboxylic acid imidazolide	Transmembrane Glycoprotein	Cancer
2A3 (2-aminopyridine-3-carboxylic acid imidazolide) is a T cell activator that specifically binds to CEACAM6 and CEACAM5. 2A3 exhibits enzymatic activity that catalyzes the glucuronidation of specific substrates (e.g., 1-naphthol), and possesses significant cytotoxic activity. When integrated into CAR T cells or used alone, 2A3 acts by inducing cytokine release, degranulation, and direct cytotoxicity. 2A3 kills pancreatic and breast cancer cells with high target antigen expression in vitro, and significantly inhibits the growth of pancreatic cancer xenografts in vivo. 2A3 broadly targets malignant tumors with overexpressed CEACAM5, CEACAM6, or co-expressed both, and shows high expression mainly in tissues such as the liver and colon. 2A3 serves as an important research tool for the immunotherapy of pancreatic and breast cancer . 2A3 is a novel SHAPE reagent, which can be used for the analysis of RNA structure both in vitro and in vivo . 2A3 is an electrophilic chemical probe that acylates the 2'-OH in the RNA backbone. 2A3 can be used for RNA SHAPE-MaP experiments and is capable of analyzing the RNA secondary structures at single nucleotide resolution.

HY-131911

PROTAC IDO1 Degrader-1	PROTACs Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology
PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to Cereblon E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC₅₀=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells .

HY-P990245

Anti-Mouse FAP Antibody (73.3)	FAP	Cancer
Anti-Mouse FAP Antibody (73.3) is an anti-mouse FAP IgG1 monoclonal antibody. Anti-Mouse FAP Antibody (73.3) can be used to accurately detect the expression and localization of FAP protein in mice. Anti-Mouse FAP Antibody (73.3) can be used for research on cancer .

HY-144987

RBN013209 1 Publications Verification	CD38 LAG-3 Tim3 PD-1/PD-L1	Inflammation/Immunology Cancer
RBN013209 is an orally active small molecule inhibitor of CD38 with an IC₅₀ of 0.01 to 0.1 μM for human CD38. RBN013209 prevents the conversion of extracellular NAD ⁺ to ADPR or cADPR in tumor cells and PBMCs. RBN013209 can be used in the study of tumor. In addition, RBN013209 enables CAR-T cells to maintain the naive state and central memory state, and decreases the expression of cell activation markers and exhaustion-related inhibitory receptors .

HY-N1457

Chrysosplenetin 3 Publications Verification	P-glycoprotein Topoisomerase Apoptosis DNA/RNA Synthesis Wnt β-catenin Parasite	Infection Metabolic Disease Cancer
Chrysosplenetin is an orally active polymethoxyflavone. Chrysosplenetin exerts anticancer effects by inhibiting topoisomerase, protecting DNA and inducing apoptosis. Chrysosplenetin acts as an antimalarial sensitizer, reverses Artemisinin (HY-B0094) resistance by inhibiting and downregulating P-glycoprotein, and enhances the efficacy of Artemisinin. Chrysosplenetin promotes bone formation by activating the Wnt/β-catenin pathway and exerts anti-osteoporotic effects .

HY-P99157

Omburtamab	CD276/B7-H3	Cancer
Omburtamab is a humanized monoclonal antibody targeting B7-H3 (CD276). Omburtamab selectively binds to B7-H3 highly expressed on the surface of tumor cells and activates anti-tumor immune responses mediated by T cells and natural killer (NK) cells. Omburtamab can promote the specific infiltration of *CAR-T* cells into tumors, enhance the killing function of NK cells through the CD16 signaling pathway, and regulate tumor cell glucose metabolism (such as inhibiting the Warburg effect). Omburtamab has the potential to inhibit solid tumors such as non-small cell lung cancer (NSCLC) .

HY-157959

Orphenadrine (±)-Orphenadrine	iGluR Cytochrome P450 Cholinesterase (ChE)	Neurological Disease Cancer
Orphenadrine ((±)-Orphenadrine) is a skeletal muscle relaxant and NMDA antagonist that also has antiparkinsonian, antihistamine, antitremor, antispasmodic, and analgesic effects. Orphenadrine inhibits the binding of ^[3H]MK-801 to the phencyclidine (PCP) binding site of the NMDA receptor. Orphenadrine is also an anticholinergic and CYP2B inducer. Orphenadrine may exert pro-tumor effects, causing CAR nuclear translocation, resulting in microsomal reactive oxygen species (ROS) production and oxidative stress. Orphenadrine also exerts neuronal protection, protecting rat cerebellar granule cells (CGC) from 3-NPA-induced death and has inhibitory potential against neurodegenerative diseases mediated by NMDA receptor overactivation .

HY-W013854

5α-Androstan-3β-ol 3β-Hydroxy-5α-androstane	Endogenous Metabolite	Others
5α-Androstan-3β-ol (Androstan), a saturated sterol, is a CAR (constitutive androstane receptor) inverse agonist ligand. 5α-Androstan-3β-ol (Androstan) increases the AmB-channel conductance in a concentration dependent manner .

HY-110249

CINPA1 1 Publications Verification	Constitutive Androstane Receptor	Metabolic Disease
CINPA1 is a potent and specific inhibitor of constitutive androstane receptor (CAR) that does not activate pregnane X receptor (PXR). CINPA1 reduces CAR-mediated transcription with an IC₅₀ of ~70 nM. CINPA1 can be used as a molecular tool for understanding CAR function .

HY-W015026

Isobutylparaben Isobutyl-P-Hydroxybenzoate	Bacterial Apoptosis Reactive Oxygen Species (ROS) Constitutive Androstane Receptor PPAR	Neurological Disease Endocrinology
Isobutylparaben (Isobutyl 4-hydroxybenzoate) is the agonist for PXR, *CAR* and PPAR. Isobutylparaben has a broad-spectrum antimicrobial activity and widely used in personal care products and cosmetics .

HY-P990870

Anti-CD19 Antibody (4G7)	CD19 IFNAR Interleukin Related	Inflammation/Immunology
Anti-CD19 Antibody (4G7) is an anti-human CD19 IgG1 monoclonal antibody. Anti-CD19 Antibody (4G7) reduces the killing effect of CAR T cells on Raji cells. Anti-CD19 Antibody (4G7) can be used for research on immunology. Anti-CD19 Antibody (4G7) is often used in flow cytometry. The recommend isotype control of Anti-CD19 Antibody (4G7): Mouse IgG1 kappa, Isotype Control (HY-P99977) .

HY-119459R

Fluopyram (Standard)	Reference Standards Succinate Dehydrogenase Fungal Parasite Constitutive Androstane Receptor Caspase NF-κB	Infection Cancer
Fluopyram (Standard) is the analytical standard of Fluopyram (HY-119459). This product is intended for research and analytical applications. Fluopyram is an orally active succinate dehydrogenase inhibitor, antifungal and nematicide. Fluopyram inhibits succinate dehydrogenase activity, activates *CAR/PXR* nuclear receptors, and increases caspase-3, TNF-α and NF-κB. Fluopyram inhibits the growth of F. virguliforme, Botrytis cinerea and Alternaria solani with EC₅₀ values of 3.35, 5.389 and 0.244 µg/mL, respectively. Fluopyram induces liver and thyroid tumor formation. Fluopyram is nephrotoxic and embryotoxic .

HY-RS01933

CARS1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CARS1 Human Pre-designed siRNA Set A contains three designed siRNAs for CARS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CARS1 Human Pre-designed siRNA Set A CARS1 Human Pre-designed siRNA Set A

HY-W653718

o-Cresol-d7	Isotope-Labeled Compounds	Others
o-Cresol-d₇ is the deuterium labeled o-Cresol (HY-156199). o-Cresol sulfate is a biomarker related to CAR T cell-independent and dependent metabolic and inflammatory .

HY-146231A

SS47 TFA	MAP4K PROTACs	Inflammation/Immunology Cancer
SS47 TFA, a PROTAC-based HPK1 degrader, exerts proteasome-mediated HPK1 degradation. The degradation of HPK1 via SS47 also significantly enhances the in vivo antitumor efficacy of BCMA CAR-T cell research. HPK1, an immunosuppressive regulatory kinase, is a promising target for cancer immunotherapies . SS47 (TFA) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-153085

*CD19 CAR* circRNA**	CD19	Inflammation/Immunology Cancer
CD19 CAR circRNA will express CD19 car protein, and can be used in chimeric antigen receptor T cell immunotherapy (CAR-CD19). The CD19 car is a chimeric antigen receptor. Among them, CD19 is a CD molecule expressed by B cells (i.e. leukocyte differentiation antigen), an important membrane antigen involved in B cell proliferation, differentiation, activation and antibody production, and can also promote BCR signal transduction.

HY-RS03382

CXADR Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CXADR Human Pre-designed siRNA Set A contains three designed siRNAs for CXADR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CXADR Human Pre-designed siRNA Set A CXADR Human Pre-designed siRNA Set A

HY-B0349A

Meclizine Meclozine	Histamine Receptor Apoptosis	Neurological Disease Inflammation/Immunology
Meclizine (Meclozine), an antihistamine, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine is a member of the piperazine class of H1 antagonists. Meclizine is an effective anti-motion sickness agent. Meclizine crosses the blood–brain barrier. Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR. Meclizine can be used for the research of polyQ toxicity disorders, such as Huntington's disease .

HY-135601

Cinacalcet metabolite M4	Drug Metabolite	Cardiovascular Disease
Cinacalcet metabolite M4 is a metabolite of Cinacalcet. Cinacalcet is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease .

HY-W101305

Fmoc-Pen(Acm)-OH	Amino Acid Derivatives	Others
Fmoc-Pen(Acm)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize chemically modified cyclic peptides containing cell adhesion recognition (CAR) sequences .

HY-70037AR

Cinacalcet hydrochloride (Standard) AMG-073 hydrochloride (Standard)	Reference Standards CaSR Endogenous Metabolite	Cardiovascular Disease Cancer
Cinacalcet (hydrochloride) (Standard) is the analytical standard of Cinacalcet (hydrochloride). This product is intended for research and analytical applications. Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.

HY-145525

Linoleoyl-L-carnitine chloride CAR 18:2; C18:2 CARnitine; L-CARnitine linoleoyl ester	Endogenous Metabolite	Others
Linoleoyl-L-carnitine is a naturally occurring long-chain acylcarnitine. Hepatic levels of linoleoyl-L-carnitine are increased following high-dose (200 mg/kg) administration of Isoniazid (Item No. 20378) in mice.

HY-W015026S

Isobutylparaben-d4 Isobutyl 4-hydroxybenzoate-d₄	Bacterial Apoptosis Reactive Oxygen Species (ROS) Constitutive Androstane Receptor PPAR	Neurological Disease Endocrinology
Isobutylparaben-d₄ is the deuterium labeled Isobutylparaben. Isobutylparaben (Isobutyl 4-hydroxybenzoate) is the agonist for PXR, *CAR* and PPAR. Isobutylparaben has a broad-spectrum antimicrobial activity and widely used in personal care products and cosmetics .

HY-160151

TP1L	PROTACs Phosphatase JAK IFNAR MHC	Cancer
TP1L is a potent and selective T-cell protein tyrosine phosphatase (TC-PTP) PROTAC degrader, with a DC₅₀ value of 35.8 nM. TP1L elevates the phosphorylation level of TC-PTP substrates including pSTAT1 and pJAK1. TP1L selectively enhances IFN-γ signaling and increases MHC-I expression. TP1L activates TCR signaling through increases phosphorylation of LCK. TP1L enhances CAR-T cell mediated tumor killing efficacy through activation of the CAR-T cells. TP1L can be used for the study of cancer. (Pink: TC-PTP ligand: (HY-138964), Blue: E3 ligase CRBN Ligand (HY-A0003), Black: Linker: (HY-140002)) .

HY-148495

Carnosine conjugated hyalyronate	Amyloid-β	Neurological Disease
Carnosine conjugated hyalyronate is a hyaluronic acid derivative functionalized with the dipeptide carnosine (Carnosine, Car) and has the ability to resist Aβ amyloid aggregation. Carnosine conjugated hyalyronate dissolves amyloid fibrils and reduces Aβ-induced toxicity in vitro. The effectiveness of Carnosine conjugated hyalyronate against amyloid aggregation is directly proportional to the Carnosine loading .

HY-W709413

Panaxytriol	NF-κB TNF Receptor Interleukin Related Pregnane X Receptor (PXR) Constitutive Androstane Receptor Cytochrome P450	Neurological Disease
Panaxytriol is an active component of ginseng. Panaxytriol inhibits the nuclear translocation of NF-κB, thereby reducing the production of pro-inflammatory factors (such as TNF-α, IL-1β, IL-6) and nitric oxide (NO) induced by LPS (HY-D1056). Panaxytriol upregulates CYP3A4 by activating the nuclear receptor *PXR/CAR*. Panaxytriol improves motor dysfunction in a mouse model of brain inflammation. Panaxytriol can be used in the research of neurodegenerative diseases (such as Alzheimer's disease) .

HY-W722556

5α-Androstan-3α-ol 3α,5α-Androstanol	GABA Receptor Constitutive Androstane Receptor	Metabolic Disease
5α-Androstan-3α-ol is a γ-aminobutyric acid (GABA) receptor agonist. 5α-Androstan-3α-ol can inhibit the transcriptional activity of the orphan nuclear receptor CAR (constitutive androstane receptor). 5α-Androstan-3α-ol negatively regulates the activity of CAR by binding to CAR and promoting its dissociation from coactivator proteins. 5α-Androstan-3α-ol can be used to study nuclear receptor-mediated hormone metabolism and drug detoxification mechanisms .

HY-RS16275

Cxadr Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cxadr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cxadr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cxadr Mouse Pre-designed siRNA Set A Cxadr Mouse Pre-designed siRNA Set A

HY-15105

SB-423562	CaSR	Inflammation/Immunology
SB-423562 is a short-acting calcium-sensing receptor *(CaR)* antagonist. SB-423562 has the potential for osteoporosis research.

HY-111634

Epsilon-momfluorothrin	Constitutive Androstane Receptor	Cancer
Epsilon-momfluorothrin is a type I synthetic pyrethroid insecticide, activates constitutive androstane receptor (CAR), and induces hepatocellular tumors in rats .

HY-70037AS

Cinacalcet-d3 hydrochloride AMG 073-d₃ hydrochloride	Isotope-Labeled Compounds CaSR Endogenous Metabolite	Cardiovascular Disease
Cinacalcet-d₃ (hydrochloride) is the deuterium labeled Cinacalcet (hydrochloride). Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.

HY-173033

MI-883	Pregnane X Receptor (PXR) Constitutive Androstane Receptor Cytochrome P450	Metabolic Disease
MI-883 is the orally active agonist for Constitutive Androstane Receptor (CAR, EC₅₀=73 nM) and the antagonist for Pregnane X Receptor (PXR, IC₅₀=0.1 μM). MI-883 stimulates CAR LBD assembly (EC₅₀=0.38 µM) and CAR3 variant activation (EC₅₀=0.074 µM), induces CYP2B6 mRNA expression in HepaRG and primary human hepatocytes. MI-883 inhibits basal PXR activity IC₅₀=2.03 µM) in transiently transfected HepG2 cells, blocks CYP3A4 mRNA expression in HepG2. MI-883 regulates cholesterol metabolism and bile acid excretion, improves hypercholesterolemia in mouse models .

HY-P10417

RTDLDSLRTYTL	Integrin IFNAR	Cancer
RTDLDSLRTYTL is an Alpha (v) beta (6) integrin (avb6) inhibitor with high affinity and specificity. RTDLDSLRTYTL binds to avb6 integrin, a peptide sequence that activates cytotoxicity and cytokine production in T cells, such as interferon-gamma. RTDLDSLRTYTL is designed through a chimeric T cell antigen receptor (CAR) so that T cells can be redirected to specifically recognize and attack tumor cells. RTDLDSLRTYTL can be used in the research of cancer immunotherapy and targeted drug development .

HY-180888

Lck-IN-5	Src CD3	Inflammation/Immunology
Lck-IN-5 (example C10) is a potent and selective lymphocyte-specific protein tyrosine kinase (LCK) inhibitor. Lck-IN-5 selectively disrupts the interaction between the SH3 domain of LCK and the RK motif of CD3ε, thereby impairing LCK recruitment to the TCR. Lck-IN-5 modulates the activity of CD3ε-containing CAR and TRuC T cells, attenuating cytokine production and promoting a central-memory-like phenotype associated with enhanced persistence. Lck-IN-5 can be used for autoimmune diseases and graft-versus-host disease research .

HY-D2620

CAR-2	Photosensitizer Reactive Oxygen Species (ROS) Ferroptosis	Cancer
CAR-2 is a BODIPY-based photosensitizer that induces ferroptosis in photodynamic therapy (PDT) by targeting the endoplasmic reticulum (ER) and lipid droplets (LDs). CAR-2 exhibits phototoxicity in breast cancer cells with IC₅₀ of 0.01-0.02 μM. CAR-2 exhibits antitumor efficacy in 4T1 xenograft mouse models .

HY-RS01906

Car1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Car1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Car1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Car1 Rat Pre-designed siRNA Set A Car1 Rat Pre-designed siRNA Set A

HY-RS01914

Car9 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Car9 Rat Pre-designed siRNA Set A contains three designed siRNAs for Car9 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Car9 Rat Pre-designed siRNA Set A Car9 Rat Pre-designed siRNA Set A

HY-RS01910

Car2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Car2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Car2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Car2 Rat Pre-designed siRNA Set A Car2 Rat Pre-designed siRNA Set A

HY-RS01905

Car1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Car1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Car1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Car1 Mouse Pre-designed siRNA Set A Car1 Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Category	Target	Chemical Structure