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Coupling agent

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41

Inhibitors & Agonists

1

Fluorescent Dye

17

Biochemical Assay Reagents

3

Peptides

1

Inhibitory Antibodies

3

Isotope-Labeled Compounds

3

Click Chemistry

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-Y1168
    DMTMM
    2 Publications Verification

    4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

    		 Biochemical Assay Reagents Neurological Disease Cancer
    DMTMM (4-(4,6-dimethoxy-1,3,5-triazine-2-yl)-4-methylmorpholinium chloride) is a coupling agent. DMTMM can activate carboxyl groups and promote the formation of amide bonds. DMTMM plays an important role in promoting the chemical modification of biomacromolecules such as polysaccharides and proteins. DMTMM can be used for research of tissue engineering, breast cancer, corneal regeneration, and biomaterials .
    DMTMM
  • HY-P99205
    Glembatumumab

    		ADC Antibody Cancer
    Glembatumumab is a fully human IgG2 monoclonal antibody directed against the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. Glembatumumab can be coupled to the microtubule inhibitor monomethyl auristatin E to form glembatumumab vedotin. Glembatumumab vedotin is an antibody-agent coupling (ADC) with antitumor activity .
    Glembatumumab
  • HY-W013151
    1-Pyrenebutyric acid N-hydroxysuccinimide ester

    		Biochemical Assay Reagents SARS-CoV Others
    1-Pyrenebutyric acid N-hydroxysuccinimide ester (PANHS) is a linker and interface coupling agent that can be used to prepare electrochemical biosensors. 1-Pyrenebutyric acid N-hydroxysuccinimide ester immobilizes SARS-CoV-2 spike antibodies on graphene sheets. 1-Pyrenebutyric acid N-hydroxysuccinimide ester is often used as an activation reagent for carboxylic acids in organic chemistry or biochemistry .
    1-Pyrenebutyric acid N-hydroxysuccinimide ester
  • HY-79880
    N,N'-Carbonyldiimidazole

    1,1'-Carbonyldiimidazole

    		 MOFs Others
    N,N'-Carbonyldiimidazole (1,1'-Carbonyldiimidazole) is a highly reactive carboxylating reagent that can activate hydroxyl groups to form reactive carbonyl groups. N,N'-Carbonyldiimidazole can be used as a coupling agent and a peptide synthesis reagent .
    N,N'-Carbonyldiimidazole
  • HY-W127711
    Fast Blue B Salt, Dye content ~95%

    		Phosphatase Lipase Metabolic Disease Inflammation/Immunology
    Fast Blue B Salt, Dye content ~95% is a diazo dye, primarily used as a chromogenic substrate in biochemical analysis. Fast Blue B Salt, Dye content ~95% is the coupling agent for the histochemical demonstration of proteases. Fast Blue B Salt, Dye content ~95% can be used for the detection of acid phosphatase in Clostridium perfringens, and also for the determination of lipase activity. Fast Blue B Salt, Dye content ~95% reacts directly with the active hydroxyl groups in phenolic compounds to determine the content of phenolic substances .
    Fast Blue B Salt, Dye content ~95%
  • HY-P5623A
    RVG-Cys

    RVG29-Cys; RDP-Cys; Rabies Virus Glycoprotein-29-Cys

    		 RABV Others
    RVG-Cys (RVG29-Cys) is a peptide derived from rabies virus glycoprotein (RVG29) with Cys attached to facilitate subsequent conjugation. RVG-Cys enhances the specific targeted delivery of proteins in brain tissue and neurons .
    RVG-Cys
  • HY-W105426
    3-(Trimethoxysilyl)propyl methacrylate

    [3-(Methacryloyloxy)propyl]trimethoxysilane

    		 Biochemical Assay Reagents Others
    3-(Trimethoxysilyl)propyl methacrylate is a reactive monomer and silane coupling agent with C=C and O-C=O functional groups, acting as a surface modifier and anti-agglomeration agent. 3-(Trimethoxysilyl)propyl methacrylate can be used to prepare nanoparticles .
    3-(Trimethoxysilyl)propyl methacrylate
  • HY-133513
    (±)-H3RESCA-TFP

    (±)-H3L28

    		 Drug Derivative Cancer
    (±)-H3RESCA-TFP ((±)-H3L28) is a tetrafluorophenyl ester derivative of restrained complexing agent (RESCA). (±)-H3RESCA-TFP can be used to conjugate the chelator with a biomolecule via amine coupling (e.g., N terminus and/or the ε-amino groups of lysine) .
    (±)-H3RESCA-TFP
  • HY-147363
    DIBAC-GGFG-NH2CH2-Dxd

    		Drug-Linker Conjugates for ADC Others
    DIBAC-GGFG-NH2CH2-Dxd (compound LP4), a Camptothecin (HY-16560) derivative, is a linker-payload of protein-agent conjugates . Dxd (HY-13631D) can be used as a payload for the antibody-coupling drug ADC (DS-8201a).DIBAC-GGFG-NH2CH2-Dxd is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups .
    DIBAC-GGFG-NH2CH2-Dxd
  • HY-B0558
    Carbimazole
    2 Publications Verification

    		 p38 MAPK Neurological Disease Endocrinology
    Carbimazole is an orally active antithyroid agent which rapidly converts to Methimazole after absorption and prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of thyroxine. Carbimazole also displays anti-inflammatory and neuronal-protective activities, suggesting its application for hyperthyroidism and neurological research .
    Carbimazole
  • HY-147168
    Biocytin hydrazide

    		Biochemical Assay Reagents Others
    Biocytin hydrazide is a long-chain biotin-containing hydrazide, serving as a biotin-derived active coupling reagent, selective labeling agent and biotinylating reagent. Biocytin hydrazide targets aldehyde, carboxyl, amino and guanidino groups to biotinylate glycoconjugates, K99 lectin, peptides and proteins through its hydrazide moiety, and achieves nonradioactive detection of sialic acid- and galactose-containing glycoconjugates via the avidin–biotin system .
    Biocytin hydrazide
  • HY-15929
    TBHBA
    1 Publications Verification

    2,4,6-Tribromo-3-hydroxybenzoic acid

    		 Biochemical Assay Reagents Others
    TBHBA (2,4,6-Tribromo-3-hydroxybenzoic acid) is a chemical colorimetric agent and nanomaterial surface modifier. TBHBA can react with some oxidants (such as H2O2) to generate high-absorbance quinoneimine dyes, which enhance the sensitivity of HDL cholesterol enzymatic determination. TBHBA can be used as a bromine-containing coupling agent to modify the surface of silica nanoparticles through esterification reaction. Thereby, organic flame retardant groups are introduced to improve the thermal stability and flame retardant properties of nanocomposites. TBHBA can be used in clinical biochemical testing (such as serum lipoprotein analysis) and the preparation of flame-retardant polymer nanocomposites .
    TBHBA
  • HY-101532
    6A-Azido-6A-deoxy-β-cyclodextrin

    β-CDN3; 6A-deoxy-6A-azido-β-cyclodextrin

    		 Biochemical Assay Reagents Others
    6A-Azido-6A-deoxy-β-cyclodextrin (β-CDN3) is a site-specifically modified β-cyclodextrin with a single azido group replacing the hydroxyl group at the C6 position. 6A-Azido-6A-deoxy-β-cyclodextrin forms a host-guest inclusion complex with Dexamethasone (HY-14648), localizing the drug within its hydrophobic cavity, which restricts the rotational mobility of the drug and places Dexamethasone in a less polar environment. 6A-Azido-6A-deoxy-β-cyclodextrin acts as a coupling agent to graft β-cyclodextrin onto thermosensitive nanogels via strain-promoted alkyne-azide cycloaddition (SPAAC). 6A-Azido-6A-deoxy-β-cyclodextrin also serves as a click chemistry reagent. It contains an azide group and undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules bearing an alkyne group. It also undergoes strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .
    6A-Azido-6A-deoxy-β-cyclodextrin
  • HY-158067
    Deferoxamine-DBCO

    DFO-DBCO

    		 Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) Cancer
    Deferoxamine-DBCO is a bifunctional chelating agent. Deferoxamine-DBCO efficiently chelates with radioactive metals (such as 89Zr) through the DFO structure to achieve radiolabeling. Deferoxamine-DBCO undergoes a metal-free Huisgen cycloaddition reaction with azide-containing biomolecules (such as siRNA, monoclonal antibodies) under bioorthogonal conditions through the DBCO structure to achieve targeted coupling. Deferoxamine-DBCO has efficient metal chelating ability and specific bioorthogonal reaction activity. Deferoxamine-DBCO can be used for targeted radioactive imaging studies of tumors .
    Deferoxamine-DBCO
  • HY-46225
    DEX-maleimide

    		Drug Intermediate Inflammation/Immunology
    DEX-maleimide is a coupling agent that can be used to synthesize conjugates containing single-domain antibodies (VHH) conjugated with antigens and anti-inflammatory agents. DEX-maleimide can be used for research on autoimmune diseases .
    DEX-maleimide
  • HY-W036410
    Aminopropyltrimethoxysilane
    1 Publications Verification

    3-Aminopropyltrimethoxysilane

    		 Environmental Pollutants Biochemical Assay Reagents Others
    Aminopropyltrimethoxysilane (APTMS) is a silane coupling agent. Aminopropyltrimethoxysilane couples with Tosylcellulose. Aminopropyltrimethoxysilane improves the thermal stability of the material. Aminopropyltrimethoxysilane can be used in the preparation of GNBP substrates .
    Aminopropyltrimethoxysilane
  • HY-91018
    Trimethyl[3-(trimethoxysilyl)propyl]ammonium chloride (50% in methanol)

    N-[3-(Trimethoxysilyl)propyl]-N,N,N-trimethylammonium chloride, 50% in methanol

    		 Biochemical Assay Reagents Others
    Trimethyl[3-(trimethoxysilyl)propyl]ammonium (N-[3-(Trimethoxysilyl)propyl]-N,N,N-trimethylammonium) chloride (50% in methanol) is a functional organic silane coupling agent and quaternary ammonium salt cationic functional monomer, which can be used for functionalizing mesoporous silica with electrochemical modified electrodes or surface chemical modification .
    Trimethyl[3-(trimethoxysilyl)propyl]ammonium chloride (50% in methanol)
  • HY-Y0198
    2,6-Diaminopyridine

    		Biochemical Assay Reagents Drug Intermediate Neurological Disease
    2,6-Diaminopyridine is an intermediate and coupling agent for hair dyes. 2,6-Diaminopyridine participates in organic synthesis reactions such as N-methylation and can bind metal ions by forming macrocyclic ligands through condensation with aldehydes. 2,6-Diaminopyridine can be used to synthesize the analgesic phenazopyridine hydrochloride (HY-B0985) .
    2,6-Diaminopyridine
  • HY-W101718
    Fmoc-N-(2-Boc-aminoethyl)-Gly-OH

    		ADC Linker Cancer
    Fmoc-N-(2-Boc-aminoethyl)-Gly-OH is a Fmoc-protected glycine derivative that can be used in antibody agent coupling (ADC) synthesis. ADC consists of antibodies that are linked to ADC cytotoxins via ADC junctions .
    Fmoc-N-(2-Boc-aminoethyl)-Gly-OH
  • HY-W004650A
    TETA tetraTFA

    		Biochemical Assay Reagents Others
    TETA (tetraTFA) is an effective selective chelating agent for copper (II). TETA (tetraTFA) can be used for drug coupling .
    TETA tetraTFA
  • HY-W688571
    T-02

    		Biochemical Assay Reagents Others
    T-02 is an isocyanate silane coupling agent .
    T-02
  • HY-174358D
    HOOC-PEG10000-COOH

    		Biochemical Assay Reagents Others
    HOOC-PEG10000-COOH has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG10000-COOH is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
    HOOC-PEG10000-COOH
  • HY-D0181
    1-Acetylimidazole

    		Biochemical Assay Reagents Drug Intermediate Others
    1-Acetylimidazole is an acetylation agent and an important intermediate for the synthesis of various bioactive molecules. 1-Acetylimidazole can be used to close the residual α-amino group remaining after coupling and to synthesize cyclic imidazole derivatives .
    1-Acetylimidazole
  • HY-79880R
    N,N'-Carbonyldiimidazole (Standard)

    1,1'-Carbonyldiimidazole (Standard)

    		 Biochemical Assay Reagents Reference Standards Others
    N,N'-Carbonyldiimidazole (Standard) (1,1'-Carbonyldiimidazole (Standard)) is the analytical standard of N,N'-Carbonyldiimidazole (HY-79880). This product is intended for research and analytical applications. N,N'-Carbonyldiimidazole (1,1'-Carbonyldiimidazole) is a highly reactive carboxylating reagent that can activate hydroxyl groups to form reactive carbonyl groups. N,N'-Carbonyldiimidazole can be used as a coupling agent and a peptide synthesis reagent .
    N,N'-Carbonyldiimidazole (Standard)
  • HY-P4565
    Phe-Arg-Arg-Gly

    		Cathepsin Others
    Phe-Arg-Arg-Gly is a polypeptide that can be used for agent coupling .
    Phe-Arg-Arg-Gly
  • HY-174358A
    HOOC-PEG2000-COOH

    		Biochemical Assay Reagents Others
    HOOC-PEG2000-COOH has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG2000-COOH is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
    HOOC-PEG2000-COOH
  • HY-174358E
    HOOC-PEG20000-COOH

    		Biochemical Assay Reagents Others
    HOOC-PEG20000-COOH has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG20000-COOH is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
    HOOC-PEG20000-COOH
  • HY-131838A
    N6-4-aminobutyl-ADP trisodium

    6-AB-ADP trisodium

    		 Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Others
    N6-4-aminobutyl-ADP (6-AB-ADP) trisodium is an ADP derivative that can be used as a nucleotide mimetic or coupling agent for labeling enzyme substrates (such as kinases), constructing biological probes, or functionalizing nucleotide chains .
    N6-4-aminobutyl-ADP trisodium
  • HY-W744953
    Carbimazole-d3

    		Isotope-Labeled Compounds p38 MAPK Neurological Disease Endocrinology
    Carbimazole-d3 is deuterium labeled Carbimazole. Carbimazole is an orally active antithyroid agent which rapidly converts to Methimazole after absorption and prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of thyroxine. Carbimazole also displays anti-inflammatory and neuronal-protective activities, suggesting its application for hyperthyroidism and neurological research .
    Carbimazole-d3
  • HY-B0558S
    Carbimazole-d5

    		Isotope-Labeled Compounds Neurological Disease Endocrinology
    Carbimazole-d5 is deuterium labeled Carbimazole. Carbimazole is an orally active antithyroid agent which rapidly converts to Methimazole after absorption and prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of thyroxine. Carbimazole also displays anti-inflammatory and neuronal-protective activities, suggesting its application for hyperthyroidism and neurological research .
    Carbimazole-d5
  • HY-B0558R
    Carbimazole (Standard)

    		Reference Standards p38 MAPK Neurological Disease Endocrinology
    Carbimazole (Standard) is the analytical standard of Carbimazole. This product is intended for research and analytical applications. Carbimazole is an orally active antithyroid agent which rapidly converts to Methimazole after absorption and prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of thyroxine. Carbimazole also displays anti-inflammatory and neuronal-protective activities, suggesting its application for hyperthyroidism and neurological research .
    Carbimazole (Standard)
  • HY-Y0198R
    2,6-Diaminopyridine (Standard)

    		Biochemical Assay Reagents Reference Standards Drug Intermediate Neurological Disease
    2,6-Diaminopyridine (Standard) is the analytical standard of 2,6-Diaminopyridine (HY-Y0198). This product is intended for research and analytical applications. 2,6-Diaminopyridine is an intermediate and coupling agent for hair dyes. 2,6-Diaminopyridine participates in organic synthesis reactions such as N-methylation and can bind metal ions by forming macrocyclic ligands through condensation with aldehydes. 2,6-Diaminopyridine can be used to synthesize the analgesic phenazopyridine hydrochloride (HY-B0985) .
    2,6-Diaminopyridine (Standard)
  • HY-145547
    1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine

    14:0 Lyso PE; 1-Myristoyl-2-hydroxy-sn-glycero-3-PE; 1-Tetradecanoyl-sn-glycero-3-phosphoethanolamine

    		 Liposome Metabolic Disease
    1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine (14:0 Lyso PE) is a lysophospholipid with a phosphoethanolamine head and a myristoyl tail. The free amine group can conjugate with NHS active ester or coupled with carboxylic acid in the presence of a coupling agent. It also induces transient increases in intracellular calcium in PC12 cells . Serum levels of 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine are elevated in patients with malignant breast cancer compared to healthy controls .
    1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine
  • HY-W654567
    N,N-Dimethyl-N-(3-(trimethoxysilyl)propyl)tetradecan-1-aminium chloride

    		Biochemical Assay Reagents Bacterial Infection
    N,N-Dimethyl-N-(3-(trimethoxysilyl)propyl)tetradecan-1-aminium chloride is a cationic surfactant of the silylated quaternary ammonium salt type, possessing dual functions of antibacterial activity and silane coupling. N,N-Dimethyl-N-(3-(trimethoxysilyl)propyl)tetradecan-1-aminium chloride can be used as a cationic silane coupling agent, antibacterial surface treatment agent, and disinfectant.
    N,N-Dimethyl-N-(3-(trimethoxysilyl)propyl)tetradecan-1-aminium chloride
  • HY-174358C
    HOOC-PEG5000-COOH

    		Biochemical Assay Reagents Others
    HOOC-PEG5000-COOH has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG5000-COOH is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
    HOOC-PEG5000-COOH
  • HY-174358
    HOOC-PEG1000-COOH

    		Biochemical Assay Reagents Others
    HOOC-PEG1000-COOH has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG1000-COOH is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
    HOOC-PEG1000-COOH
  • HY-174358H
    HOOC-PEG40000-COOH

    		Biochemical Assay Reagents Others
    HOOC-PEG40000-COOH has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG40000-COOH is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
    HOOC-PEG40000-COOH
  • HY-174358B
    HOOC-PEG3400-COOH

    		Biochemical Assay Reagents Others
    HOOC-PEG3400-COOH has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG3400-COOH is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
    HOOC-PEG3400-COOH
  • HY-180563
    ADC 38 drug linker

    		Drug-Linker Conjugates for ADC Infection
    ADC 38 drug linker is a drug linker coupling agent used for ADCs, consisting of a CD4 mimic and a linker. ADC 38 drug linker can be used to synthesize antibody-drug conjugates (ADCs), such as ADC 38 .
    ADC 38 drug linker
  • HY-155885
    mPEG40000-amine

    mPEG40000-NH2

    		 Biochemical Assay Reagents Others
    mPEG40000-amine (mPEG40000-NH2) is a monofunctional polyPEG with a terminal amine. The coupling between NHS ester and amine produces a stable amide bond. The amine moieties is also reactive with carboxyl in the presence of activating agent .
    mPEG40000-amine
  • HY-145547S
    1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine-d27

    14:0 Lyso PE-d27; 1-Myristoyl-2-hydroxy-sn-glycero-3-PE-d27; 1-Tetradecanoyl-sn-glycero-3-phosphoethanolamine-d27

    		 Isotope-Labeled Compounds Metabolic Disease
    1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine-d27 (14:0 Lyso PE-d27) is the deuterium labeled 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine. 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine (14:0 Lyso PE) is a lysophospholipid with a phosphoethanolamine head and a myristoyl tail. The free amine group can conjugate with NHS active ester or coupled with carboxylic acid in the presence of a coupling agent. It also induces transient increases in intracellular calcium in PC12 cells .
    1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine-d27

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