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2115

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Leukotriene D4 3 Publications Verification	Drug Metabolite Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Leukotriene D4 is a potent bronchoconstrictor. Leukotriene D4 has the potential for the research of asthma. Leukotriene D4 induces edema and increases capillary permeability .

Stavudine 4 Publications Verification D4T	Reverse Transcriptase HIV Nucleoside Antimetabolite/Analog NOD-like Receptor (NLR) Autophagy Apoptosis	Infection
Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis ^[4].

Vitamin D4 3 Publications Verification 22-Dihydroergocalciferol	VD/VDR	Metabolic Disease
Vitamin D4 (22-Dihydroergocalciferol) is a Vitamin D derived from fungi. The precursor of Vitamin D4 is 22,23-dihydroergosterol .

Eravacycline-d4 dihydrochloride TP-434-D4 dihydrochloride	Isotope-Labeled Compounds Beta-lactamase Antibiotic Bacterial	Infection
Eravacycline-d₄ (TP-434-d₄) dihydrochloride is deuterium labeled Eravacycline. Eravacycline is a potent and broad-spectrum antibacterial agent ^[4] .

Dopamine D4 receptor antagonist-1	Dopamine Receptor	Neurological Disease
Dopamine D4 receptor antagonist-1 is a selective *DRD4* antagonists, with a K_i of 9.0 nM for *Hd4.2*. Dopamine D4 receptor antagonist-1 can be used in study of schizophrenia .

D4-abiraterone Δ4-Abiraterone; CB-7627; Abiraterone D4A metabolite	Androgen Receptor Cytochrome P450	Cancer
D4-abiraterone is a major metabolite of abiraterone. D4-abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid-5a-reductase (SRD5A) and also an antagonist of androgen receptor.

Resolvin D4 RvD4	Bacterial	Inflammation/Immunology
Resolvin D4 (RvD4), a specialized proresolving mediator, can be produced in bioactive levels during S. aureus infection .

Canagliflozin-d4 JNJ 28431754-d₄	SGLT	Metabolic Disease Cancer
Canagliflozin-d₄ (JNJ 28431754-d₄) is a deuterium labeled Canagliflozin. Canagliflozin is a selective SGLT2 inhibitor .

APP-018 D-4F	Apolipoprotein	Cardiovascular Disease
APP-018 (D-4F) is 18 D-amino acids peptide that mimics apolipoprotein A-I (apoA-I). APP-018 improves the anti-inflammatory activity of high-density lipoprotein (HDL). APP-018 can be used in researches of cardiovascular diseases .

Dexmedetomidine-d4 L-tartrate (-d4-major)	Isotope-Labeled Compounds	Others
Dexmedetomidine-d₄ L-tartrate (-d₄-major) is deuterium labeled Dexmedetomidine L-tartrate (-d4-major) .

Pitavastatin-d4 sodium	Autophagy Apoptosis Mitophagy HMG-CoA Reductase (HMGCR) Isotope-Labeled Compounds	Others
Pitavastatin-d₄ (sodium) is deuterium labeled Pitavastatin (sodium).

Enclomiphene-d4 hydrochloride (E)-Clomiphene D4 hydrochloride; trans-Clomiphene D4 hydrochloride; Enclomifene D4 hydrochloride	Isotope-Labeled Compounds Estrogen Receptor/ERR	Inflammation/Immunology
Enclomiphene-d₄ ((E)-Clomiphene-d₄) hydrochloride?is a deuterium labeled Enclomiphene hydrochloride (HY-118861B). Enclomiphen hydrochloride?is a potent and orally active?estrogen receptor?antagonist with antioestrogenic property .

D-4-Hydroxyphenylglycine D-(-)-4-Hydroxyphenylglycine; 4-Hydroxy-D-phenylglycine	Antibiotic	Others
D-4-Hydroxyphenylglycine (D-(-)-4-Hydroxyphenylglycine) is one of the most important raw materials used in the production of semisynthetic β-lactam antibiotics, such as Amoxicillin (HY-B0467A) and Cefadroxil (HY-B1190) .

Ethane-1,2-diamine-d4 dihydrochloride Ethylenediamine-D4 dihydrochloride	Isotope-Labeled Compounds	Others
Ethane-1,2-diamine-d₄ (Ethylenediamine-d₄) dihydrochloride is a deuterium labeled Ethane-1,2-diamine.

2-Benzothiazolethiol-d4	Isotope-Labeled Compounds	Others
2-Benzothiazolethiol-d4 is the deuterium labeled 2-Benzothiazolethiol-d4 (HY-W653751) .

Etravirine D4 TMC-125 d₄; R-165335 d₄	Reverse Transcriptase HIV	Infection
Etravirine-d₄ is the deuterium labeled Etravirine. Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

Higenamine-d4 hydrochloride Norcoclaurine-D4 hydrochloride; Demethyl-Coclaurine-D4 hydrochloride	ROS Kinase MDM-2/p53 Apoptosis Isotope-Labeled Compounds	Cancer
Higenamine-d₄ (Norcoclaurine-d₄; Demethyl-Coclaurine-d₄) hydrochloride is deuterium-labeled Higenamine (hydrochloride) (HY-N2037A) .

Stavudine sodium D4T sodium	Reverse Transcriptase HIV Nucleoside Antimetabolite/Analog NOD-like Receptor (NLR) Autophagy Apoptosis	Infection
Stavudine (d4T) sodium is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine sodium has activity against HIV-1 and HIV-2. Stavudine sodium also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine sodium reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine sodium induces apoptosis ^[4].

Stavudine (Standard) D4T (Standard)	Reference Standards Reverse Transcriptase HIV Nucleoside Antimetabolite/Analog NOD-like Receptor (NLR) Autophagy Apoptosis	Infection
Stavudine (Standard) is the analytical standard of Stavudine. This product is intended for research and analytical applications. Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis ^[4].

Leukotriene D4-d5	Drug Metabolite Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Leukotriene D4-d₅ is the deuterium labeled Leukotriene D4. Leukotriene D4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. Leukotriene D4 is the first cysteinyl-leukotriene metabolite of LTC4. Leukotriene D4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.

Phthalic Acid Anhydride-d4	Isotope-Labeled Compounds	Others
Phthalic Acid Anhydride-d₄ is the deuterium labeled Phthalic Acid Anhydride-d₄ .

Velnacrine-d4 hydrochloride HP 029-D4 hydrochloride; Hydroxytacrine-D4 hydrochloride	Isotope-Labeled Compounds	Others
Velnacrine-d₄ (hydrochloride) is deuterium labeled Velnacrine.

D4-Ribavirin	Dengue Virus Flavivirus	Infection
D4-Ribavirin (Compound 4) is a deoxygenated ribavirin analogue. D4-Ribavirin has antiviral property in vitro against the RNA-containing bunyaviruses–Rift Valley Fever () with an IC₅₀ of 61 μg/mL .

Leflunomide-d4	Dihydroorotate Dehydrogenase	Cancer
Leflunomide-d₄ (HWA486-d₄) is the deuterium labeled Leflunomide. Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase (DHODH), and acts as a disease-modifying antirheumatic agent .

Ethanolamine-d4 hydrochloride 2-Aminoethanol-D4 hydrochloride	Isotope-Labeled Compounds	Others
Ethanolamine-d₄ hydrochloride is the deuterium labeled Ethanolaminel hydrochloride .

Biliverdine-d4	Isotope-Labeled Compounds	Others
Biliverdine-d₄ is the deuterium labeled Biliverdine.

Cerexin D4	Bacterial	Infection
Cerexin D4 has anti-Gram-positive bacterial activity .

Dopamine D4 receptor ligand 2	Dopamine Receptor	Neurological Disease
Dopamine D4 receptor ligand 2 (compound 17) is a potent and selective dopamine D4 ligand with IC₅₀ values of 0.057, >1000, 220, 270 nM for D4, D2, 5-HT1A, α1, respectively .

Dopamine D4 receptor ligand 3	Dopamine Receptor Reactive Oxygen Species (ROS)	Cancer
Dopamine D4 receptor ligand 3 (Compound 16) is a dopamine D4 receptor (D4R) antagonist (pK_i: 8.86). Dopamine D4 receptor ligand 3 has pIC₅₀ values of 5.78, 5.55, and 6.17 for Go, Gi, and βArr2 sensors in HEK-293T cells, respectively. Dopamine D4 receptor ligand 3 inhibits the viability of three human glioma cell lines, U87 MG, T98G, and U251 MG. Dopamine D4 receptor ligand 3 induces ROS production and mitochondrial dysfunction in glioma cells .

17(R)-Resolvin D4 17(R)-RvD4	Bacterial	Inflammation/Immunology
17(R)-Resolvin D4 (17(R)-RvD4) is the R-enantiomer of Resolvin D4. Resolvin D4 (RvD4), a specialized proresolving mediator, can be produced in bioactive levels during S. aureus infection .

14,15-Leukotriene D4 14,15-LTD4; Eoxin D4	Endogenous Metabolite	Inflammation/Immunology
14,15-Leukotriene D4 (14,15-LTD4) is a leukotriene that producted by eosinophils with Arachidonic acid (HY-109590), and through the 15-lipoxygenase-1 pathway .

Bendamustine-d4 SDX-105 D4 free base	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Bendamustine-d₄ is the deuterium labeled Bendamustine. Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties.

Rupatadine-d4 fumarate UR-12592 D4 fumarate	Isotope-Labeled Compounds Histamine Receptor Autophagy	Inflammation/Immunology
Rupatadine-d₄ fumarate is a deuterium labeled Rupatadine fumarate. Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with K_i values of 0.55/0.1 μM (rabbit platelet membranes/guinea pig cerebellum membranes) .

1alpha-Hydroxy VD4 1 Publications Verification 1α-Hydroxy vitamin D4	VD/VDR	Cancer
1alpha-Hydroxy VD4, a 1alpha(OH)D derivative, can effectively induce the differentiation of monoblastic leukaemia U937, P39/TSU and P31/FUJ cells.

Fananserin RP 62203	5-HT Receptor Dopamine Receptor	Neurological Disease
Fananserin (RP 62203) is an orally bioavailable, potent and selective 5-hydroxytryptamine2 (5-HT₂) receptor antagonist, with a K_i of 0.37 nM for the rat 5-HT_2A receptor. Fananserin also is a selective dopamine D4 receptor antagonist, with a K_i of 2.93 nM for the human dopamine D4 receptor .

Vitamin D4-d5 22-Dihydroergocalciferol-d₅	Isotope-Labeled Compounds VD/VDR	Metabolic Disease
Vitamin D4-d₅ is the deuterium labeled Vitamin D4. Vitamin D4 (22-Dihydroergocalciferol) is a Vitamin D derived from fungi. The precursor of Vitamin D4 is 22,23-dihydroergosterol .

Iloprost-d4	Isotope-Labeled Compounds Prostaglandin Receptor	Endocrinology
Iloprost-d₄ (Ciloprost-d₄) is the deuterium labeled Iloprost. Iloprost (ZK 36374) is a synthetic analogue of prostacyclin PGI2 .

Linifanib-d4 ABT-869-d₄; AL-39324-d₄	Autophagy FLT3 Apoptosis c-Kit VEGFR PDGFR c-Fms Isotope-Labeled Compounds	Cancer
Linifanib-d₄ (ABT-869-d₄; AL-39324-d₄) is deuterium-labeled Linifanib (HY-50751) .

Baloxavir-d4 Baloxavir acid-d₄; S-033447-d₄	Isotope-Labeled Compounds	Others Cancer
Baloxavir-d₄ (Baloxavir acid-d₄; S-033447-d₄) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d₄ (Baloxavir-d₄ acid), derived from the proagent Baloxavir-d₄ marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d₄ inhibits viral RNA transcription and replication and has potently antiviral activity .

3-Chlorobenzoic acid-d4 LULAYUGMBFYYEX-RHQRLBAQSA-N	Isotope-Labeled Compounds	Others
3-Chlorobenzoic acid-d₄ is the deuterium labeled 3-Chlorobenzoic acid-d₄ .

ZCL367-d4	Isotope-Labeled Compounds	Others
ZCL367-d₄ is the deuterium labeled ZCL367.

11-trans Leukotriene D4 11-trans LTD4	Drug Isomer	Others
11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4. It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea.

D-4-77	SARS-CoV Virus Protease	Infection
D-4-77 is a potent inhibitor of SARS-CoV-2 Mpro with an IC₅₀ value of 0.95 μM. D-4-77 has antiviral active with an EC₅₀ value of 0.49 μM. D-4-77 suppresses SARS-CoV-2 Mpro -induced antagonism of the host NF-κB innate immune response .

4-Acetamidobenzene-1-sulfonyl chloride D4	Isotope-Labeled Compounds	Others
4-Acetamidobenzene-1-sulfonyl chloride d₄ is the deuterium labeled 4-Acetamidobenzene-1-sulfonyl chloride .

Gatifloxacin-d4 hydrochloride AM-1155-D4 hydrochloride; BMS-206584-D4 hydrochloride; PD135432-D4 hydrochloride	Antibiotic Bacterial Topoisomerase Isotope-Labeled Compounds	Infection
Gatifloxacin-d₄ (AM-1155-d₄; BMS-206584-d₄; PD135432-d₄) hydrochloride is deuterium-labeled Gatifloxacin (hydrochloride) (HY-10581A) .

Nordoxepin-d4 hydrochloride Desmethyldoxepin-D4 hydrochloride	Drug Metabolite Isotope-Labeled Compounds	Neurological Disease
Nordoxepin-d₄ (Desmethyldoxepin-d₄) hydrochloride is deuterium-labeled Nordoxepin (hydrochloride) (HY-100046) .

Cat. No.	Product Name

HY-L165

Dopamine Receptor Compound Library

267 compounds

Dopamine receptor (DAR), widely distributed in the brain, plays a key role in regulating motor function, motivation, driving force and cognition. The role of DA is mediated by D1-type (D1, D5) and D2-type receptors (D2S, D2L, D3, D4), which are distributed in presynaptic, postsynaptic and extrasynaptic, projection neurons and interneurons. Each receptor has a different function. D1 and D5 receptors couple with G stimulation sites and activate Adenylyl cyclase. The activation of Adenylyl cyclase leads to the production of the second messenger cAMP, which leads to the production of protein kinase A (PKA), which leads to further transcription in the nucleus. D2 to D4 receptors are coupled to G inhibitory sites to inhibit adenylyl cyclase and activate potassium Ion channel. These receptors utilize phosphorylation cascades or direct membrane interactions to affect the functions of voltage-gated and neurotransmitter-gated channels, cytoplasmic enzymes, and transcription factors. Dopamine receptor plays an important role in daily life.

MCE designs a unique collection of 267 small molecules related to dopamine receptor. It is a good tool for screening drugs from nervous system disease.

Cat. No.	Product Name	Type

HY-112624J

Dextran T4 (MW 4,000)

Dextran 4; Dextran D4; Dextran T4(MW 3200-4800)

Biochemical Assay Reagents

Dextran 4,000 is a mucus rheology modifier. The dextran molecules in Dextran 4,000 can reduce the cross-link density of mucus through osmotic effects and hydrogen bond substitution, and reduce viscoelasticity and improve the mucociliary/cough clearance index by destroying the DNA-mucin network structure in mucus. Dextran 4,000 has the ability to improve the rheological properties and clearance ability of cystic fibrosis (CF) sputum, and can be used in the study of inhalation therapy or aerosol delivery of mucostatic respiratory diseases. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .

HY-109541S1

Colfosceril miristate-d4 DMPC-d₄; 1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d₄	Biochemical Assay Reagents
Colfosceril miristate-d₄ (DMPC-d₄) is deuterium labeled Colfosceril miristate. Colfosceril miristate is a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery .

HY-W002114

4-Amino-3-hydroxybenzoic acid	Biochemical Assay Reagents
4-Amino-3-hydroxybenzoic acid is an aromatic substrate degradable by Bordetella sp. strain 10d. 4-Amino-3-hydroxybenzoic acid can serve as a carbon source, nitrogen source and energy source for the growth of Bordetella sp. strain 10d. 4-Amino-3-hydroxybenzoic acid acts as a substrate for 2-amino-5-carboxymuconate-6-semialdehyde deaminase and 4-amino-3-hydroxybenzoate 2,3-dioxygenase .

HY-W127840

Ethylene-d4-diamine 1,1,2,2-tetradeuterioethane-1,2-diamine-d₄	Biochemical Assay Reagents
Ethylene-d₄-diamine is the deuterium labeled Ethylene-diamine .

HY-18572C

2,4-D Sterile Solution (1 mg/ml)	Biochemical Assay Reagents
2,4-D Sterile Solution (1 mg/mL) is a ready-to-use, filtered and sterilized plant hormone storage solution commonly used in plant tissue culture research.

Cat. No.	Product Name	Target	Research Area

HY-P5126

DOTA-LM3 2 Publications Verification	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor	Cancer
DOTA-LM3 is a somatostatin receptor (SSTR) antagonist. LM3 refers to p-Cl-Phe- cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr- NH2, as well as a somatostatin antagonist. DOTA-LM3 is often isotopically labeled for tracing tumors in vivo, such as 177Lu-DOTA-LM3 and 68 Ga-DOTA-LM3. 68 Ga-DOTA-LM3 shows favorable biodistribution, high tumor uptake, good tumor retention, and few safety concerns. 177Lu-DOTA-LM3 can be used for research in DOTATOC-negative liver metastases, such as pancreatic NET and extensive tumor thrombosis . DOTA-LM3 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-P5126A

DOTA-LM3 TFA 2 Publications Verification	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor	Cancer
DOTA-LM3 TFA is a somatostatin receptor (SSTR) antagonist. LM3 refers to p-Cl-Phe- cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr- NH2, as well as a somatostatin antagonist. DOTA-LM3 TFA is often isotopically labeled for tracing tumors in vivo, such as 177Lu-DOTA-LM3 TFA and 68 Ga-DOTA-LM3 TFA. 68 Ga-DOTA-LM3 TFA shows favorable biodistribution, high tumor uptake, good tumor retention, and few safety concerns. 177Lu-DOTA-LM3 TFA can be used for research in DOTATOC-negative liver metastases, such as pancreatic NET and extensive tumor thrombosis . DOTA-LM3 (TFA) can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-P11078

LARLLT	EGFR	Cancer
LARLLT (D4) is an EGFR-binding peptide. LARLLT has the potential for research of EGFR overexpressing cancers, such as lung, ovarian and colorectal cancer .

HY-P6365B

APP-018 D-4F	Apolipoprotein	Cardiovascular Disease
APP-018 (D-4F) is 18 D-amino acids peptide that mimics apolipoprotein A-I (apoA-I). APP-018 improves the anti-inflammatory activity of high-density lipoprotein (HDL). APP-018 can be used in researches of cardiovascular diseases .

HY-W009023

*Fmoc-D-4-Pal-OH*	Amino Acid Derivatives	Others
Fmoc-D-4-Pal-OH is an alanine derivative .

HY-W009402

*Boc-D-4-Pal-OH*	Amino Acid Derivatives	Others
Boc-D-4-Pal-OH is an alanine derivative .

HY-W022404

*H-D-4-Pal-OH.2HCl*	Amino Acid Derivatives	Others
H-D-4-Pal-OH.2HCl is an alanine derivative .

HY-P11244

150D4	Ephrin Receptor	Neurological Disease
150D4 is an efficient, selective, and blood-brain barrier penetrable *EphA4* agonist. 150D4 has excitatory activity and neuroprotective effects. 150D4 can be used for research on neurological conditions .

HY-W044285

*Fmoc-D-4-Aph(cBm)-OH*	Amino Acid Derivatives	Others
Fmoc-D-4-Aph(cBm)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize biologically active peptide mimetics, such as Ac-D2Nal-D4Cpa-D3Pal-Ser-4Aph/4Amf(P)-D4Aph/D4Amf(Q)-Leu-ILys-Pro-DAla-NH2 with gonadotropin-releasing hormone (GnRH) antagonist activity .

HY-P1560

*Allergen Gal d 4* (46-61), chicken** Lysozyme C (46-61) (chicken)	Bacterial	Infection
Allergen Gal d 4 (46-61), chicken is a hen egg white lysozyme peptide.

HY-W006937

*Boc-D-(4-fmoc)-aminophenylalanine* Boc-p-amino-D-Phe(Fmoc)-OH; Boc-D-phe(4-NH-fmoc)-OH	Amino Acid Derivatives	Others
Boc-D-(4-fmoc)-aminophenylalanine (Boc-p-amino-D-Phe(Fmoc)-OH) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptides with gonadotropin-releasing hormone antagonist activity .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990144

Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2)	Integrin	Inflammation/Immunology Cancer
Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) is an anti-mouse/human *VLA-4/CD49d* IgG2b monoclonal antibody. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can reduce VLA-4 positive cells. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can inhibit the migration of Tc1 cells to tumors. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) inhibits the retention of leukemia cells in the spleen and bone marrow by blocking VLA-4. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can be used for research on inflammation conditions and cancer such as experimental autoimmune encephalomyelitis (EAE), melanoma and leukemia .

HY-P991110

Anti-Mouse CD25 Antibody (7D4)	Interleukin Related	Inflammation/Immunology
Anti-Mouse CD25 Antibody (7D4) is a mouse IgG2 monoclonal antibody targeting CD25. Anti-Mouse CD25 Antibody (7D4) enables the isolation of naive CD4 ⁺ T cells by depleting CD25-expressing cells .

HY-P991229

MK-4721 AGS-1C4D4; AGS-PSCA	Complement System	Cancer
AGS-1C4D4 is a fully human IgG1κ monoclonal antibody targeting PSCA, with a K_a value of 0.2 nM. AGS-1C4D4 mediates antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) against PSCA-expressing cells. AGS-1C4D4 can be used for the research of pancreatic cancer .

Species:	Human (3) Mouse (1) Cat (1)
Tag:	SUMO (1) His (4) GST (1)
Source:	HEK293 (3) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71400

	UBE2D4 Protein, Human (GST) Ubiquitin-Conjugating Enzyme E2 D4; HBUCE1; Ubiquitin Carrier Protein D4; Ubiquitin-Protein Ligase D4; UBE2D4; UBCH5D	Human	E. coli
	The UBE2D4 protein is an important ubiquitin-proteasome system component that acts as an E2 ubiquitin-conjugating enzyme, accepting ubiquitin from the E1 complex and catalyzing its covalent attachment to proteins. In vitro, UBE2D4 exhibits multifunctionality by promoting polyubiquitination of all seven ubiquitin Lys residues, possibly favoring polyubiquitination of “Lys-11” and “Lys-48” linkages. UBE2D4 Protein, Human (GST) is the recombinant human-derived UBE2D4 protein, expressed by E. coli , with N-GST labeled tag.

HY-P71573

	*Allergen Fel d 4* Protein, Cat (His-SUMO)** Allergen Fel d 4; allergen Fel d 4	Cat	E. coli
	Allergen Fel d 4 Protein, Cat (His-SUMO) is a recombinant protein with a His-SUMO tag. Fel d 4 is a lipocalin allergen produced by the cat, which binds IgE at relatively high frequency in cat-sensitive individuals.

HY-P77623

	CD99 Protein, Human (HEK293, His) 12E7; E2 antigen; MIC2; MIC2X; MIC2Y; CD99; HBA71; MSK5X; 12E7; 1110061M03Rik; 2410026K10Rik; D4; pilr-1; Pilr-l; CD99 molecule	Human	HEK293
	The CD99 protein is involved in the important T cell adhesion process and helps red blood cells spontaneously form rosettes. It also contributes to the later stages of leukocyte extravasation, helping leukocytes to overcome the endothelial basement membrane during the immune response. CD99 Protein, Human (HEK293, His) is the recombinant human-derived CD99 protein, expressed by HEK293 , with N-His labeled tag.

HY-P78019

	PLD4 Protein, Human (HEK293, His) 5'-3' exonuclease PLD4; Choline phosphatase 4; Phospholipase D4; PLD 4	Human	HEK293
	PLD4 Protein, a phospholipase, plays a crucial role in immune responses and inflammation. Dysregulation of PLD4 Protein has been associated with autoimmune disorders and inflammatory diseases. Targeting PLD4 Protein may provide potential therapeutic interventions in these conditions by modulating immune responses, suppressing inflammation, and managing related disorders. PLD4 Protein, Human (HEK293, His) is the recombinant human-derived PLD4 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77821

	PLD4 Protein, Mouse (HEK293, His) 5'-3' exonuclease PLD4; Choline phosphatase 4; Phospholipase D4; PLD 4	Mouse	HEK293
	PLD4 Protein, with 5'->3' DNA exonuclease activity, efficiently digests single-stranded DNA (ssDNA). It crucially regulates inflammatory cytokine responses by degrading nucleic acids, reducing ssDNA concentrations activating TLR9. Additionally, PLD4 actively participates in the phagocytosis process of activated microglia, emphasizing its role in immune responses. PLD4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived PLD4 protein, expressed by HEK293 , with C-His labeled tag.

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Source
Tag
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Gene ID
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Purity
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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Mouse (3) Rabbit (3)
Reactivity:	Human (5) Rat (3) Mouse (4) human (1)
Application:	IHC-P (6) ICC/IF (4) IF-Tissue (1) IP (2) IHC-F (1) WB (4) ELISA (2)
Isotype:	IgG (2) IgG1 (2) IgG/Kappa (1) IgG2a (1)
Conjugation:	Non-conjugated (6)
Clonality:	Monoclonal (4) Recombinant (2)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82893

	D4 GDI Antibody (YA2638) Rho GDP dissociation inhibitor (GDI) beta; D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1; RhoGDI2	WB, IHC-F, IHC-P, ICC/IF	Human
	D4 GDI Antibody (YA2638) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to D4 GDI.

HY-P86847

	DPF2 Antibody (YA6540) Apoptosis response zinc finger protein antibody; BAF45D antibody; BRG1-associated factor 45D antibody; D4 antibody; D4 zinc and double PHD fingers family 2 antibody; Double PHD fingers 2 antibody; double PHD fingers family 2 antibody; DPF 2 antibody; DPF2 antibody; MGC10180 antibody; Apoptosis response zinc finger protein antibody; BAF45D antibody; BRG1-associated factor 45D antibody; D4 antibody; D4 zinc and double PHD fingers family 2 antibody; Double PHD fingers 2 antibody; double PHD fingers family 2 antibody; DPF 2 antibody; DPF2 antibody; MGC10180 antibody; Protein requiem antibody; REQ antibody; REQU_HUMAN antibody; Requiem antibody; Requiem apoptosis response zinc finger antibody; UBI D4 antibody; ubi-D4 antibody; UBID 4 antibody; UBID4 antibody; zinc and double PHD fingers family 2 antibody; Zinc finger protein ubi D4 antibody; Zinc finger protein ubi-D4 antibody;	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	DPF2 Antibody (YA6540) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DPF2.

HY-P810095

	SH2D4A Antibody (YA9439)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human
	SH2D4A Antibody (YA9439) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to SH2D4A.

HY-P89118

	UBE2D4 Antibody (YA8802) HBUCE1	IHC-P	Human, Mouse, Rat
	UBE2D4 Antibody (YA8802) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to UBE2D4.

HY-P89118A

	UBE2D4 Antibody (YA8802)(PBS only) HBUCE1	IHC-P	Human, Mouse, Rat
	UBE2D4 Antibody (YA8802) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to UBE2D4.

HY-P86232

	TBC1D4 Antibody (YA5924) TBC1D4; AS160; KIAA0603; TBC1 domain family member 4; Akt substrate of 160 kDa; AS160	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse
	TBC1D4 Antibody (YA5924) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TBC1D4.

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Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-B0216S

Ethynyl Estradiol-d4 17α-Ethynylestradiol-d₄; Ethynylestradiol-d₄		Alkynes
Ethynyl Estradiol-d₄ is the deuterium labeled Ethynyl Estradiol. Ethynyl Estradiol (17α-Ethynylestradiol;Ethynylestradiol) is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills. Ethynyl Estradiol-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-13256AS1

Desmethyl Erlotinib-d4-1 OSI-420-D4-1 free base; CP-373420-D4-1		Alkynes
Desmethyl Erlotinib-d₄-1 (OSI-420-d₄-1 (free base); CP-373420-d₄-1) is deuterium-labeled Desmethyl Erlotinib (HY-13256A) .

HY-151117S

Methylacetylene-d4		Alkynes
Methylacetylene-d₄ is the deuterium labeled Methylacetylene . Methylacetylene-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-143963S

Irbesartan impurity 20-d4		Azide
Irbesartan impurity 20-d₄ is the deuterium labeled Irbesartan impurity 20 . Irbesartan impurity 20-d₄ is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-143980S

Losartan impurity 21-d4		Azide
Losartan impurity 21-d₄ is the deuterium labeled Losartan impurity 21 . Losartan impurity 21-d4 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-143964S

Irbesartan impurity 14-d4		Azide
Irbesartan impurity 14-d₄ is the deuterium labeled Irbesartan impurity 14 . Irbesartan impurity 14-d₄ is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-13256AS

Desmethyl Erlotinib-d4		Alkynes
Desmethyl Erlotinib-d₄ is the deuterium labeled Desmethyl Erlotinib. Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor . Desmethyl Erlotinib-d₄ is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0390S1

Mestranol-d4		Alkynes
Mestranol-d₄ is the deuterium labeled Mestranol. Mestranol is an inactive proagent and becomes biologically active on conversion to ethinyl estradiol (EE). Mestranol acts as an estrogen receptor agonist. Mestranol combines with a progestin in vivo and can be used for the research of menopausal hormone or menstrual disorders . Mestranol-d₄ is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-132707S

2-[(2-Azidoethoxy-d4)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine		Azide
2-[(2-Azidoethoxy-d₄)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine is the deuterium labeled 2-[(2-Azidoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine .

Cat. No.	Product Name		Classification

HY-RS02576

CGAS Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CGAS Human Pre-designed siRNA Set A contains three designed siRNAs for CGAS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS21985

Arhgdib Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Arhgdib Mouse Pre-designed siRNA Set A contains three designed siRNAs for Arhgdib gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS15136

TSC22D4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TSC22D4 Human Pre-designed siRNA Set A contains three designed siRNAs for TSC22D4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14244

TBC1D4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TBC1D4 Human Pre-designed siRNA Set A contains three designed siRNAs for TBC1D4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS09821

OR7D4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
OR7D4 Human Pre-designed siRNA Set A contains three designed siRNAs for OR7D4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS03599

DCUN1D4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
DCUN1D4 Human Pre-designed siRNA Set A contains three designed siRNAs for DCUN1D4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01804

CACNA2D4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CACNA2D4 Human Pre-designed siRNA Set A contains three designed siRNAs for CACNA2D4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17583

Cd99 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Cd99 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cd99 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12825

SH2D4A Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SH2D4A Human Pre-designed siRNA Set A contains three designed siRNAs for SH2D4A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00944

ARHGDIB Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ARHGDIB Human Pre-designed siRNA Set A contains three designed siRNAs for ARHGDIB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-152556

3-Deaza-4’-C-methyluridine		Nucleoside Analogs Uridine
3-Deaza-4’-C-methyluridine, 4-Hydroxy-1-β-D-(4-C-methylribofuranosyl)-2(1H)-pyridinone is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-RS28579

Cacna2d4 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Cacna2d4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cacna2d4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS22061

Cacna2d4 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Cacna2d4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cacna2d4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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