291 Results for "

DFG aspartate

" in MedChemExpress (MCE) Product Catalog:
Products (291)

291 Results for "DFG aspartate" in MCE Product Catalog:

25
25 Cited Publications
Cat. No.: HY-107994
CAS No.: 2921-14-4
Purity:  ≥98.0%
Synonyms: Carboxymethoxylamine hemihydrochloride; Aminooxyacetate hemihydrochloride
Target:  

GABA Receptor

Research Areas:  

Cancer

Aminooxyacetic acid (Carboxymethoxylamine) hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T.
loading...
    loading...
25
25 Cited Publications
Cat. No.: HY-107994A
CAS No.: 645-88-5
Synonyms: Carboxymethoxylamine; Aminooxyacetate
Target:  

GABA Receptor

Research Areas:  

Cancer

Aminooxyacetic acid (Carboxymethoxylamine) is a malate-aspartate shuttle (MAS) inhibitor. Aminooxyacetic acid also inhibits the GABA degradating enzyme GABA-T.
loading...
    loading...
9
9 Cited Publications
Cat. No.: HY-N0215
CAS No.: 63-91-2
Synonyms: (S)-2-Amino-3-phenylpropionic acid
L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca + channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
loading...
    loading...
7
7 Cited Publications
Cat. No.: HY-N2311
CAS No.: 2552-55-8
Synonyms: (RS)-Ibotenic acid; DL-Ibotenic acid
Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites.
loading...
    loading...
7
7 Cited Publications
Cat. No.: HY-100807
CAS No.: 89-00-9
Purity:  99.85%
Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis .
loading...
    loading...
6
6 Cited Publications
Cat. No.: HY-112732B
CAS No.: 70962-66-2
Purity:  ≥98.0%
Target:  

Apoptosis

Research Areas:  

Metabolic Disease Cancer

Sparfosic acid trisodium is a DNA antimetabolite agent and a potent inhibitor of aspartate transcarbamoyl transferase. Aspartate transcarbamoyl transferase catalyzes the second step of de novo pyrimidine biosynthesis. Sparfosic acid trisodium synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines .
loading...
    loading...
6
6 Cited Publications
Cat. No.: HY-79136
CAS No.: 396091-77-3
Synonyms: SOM230 L-aspartate
Target:  

Somatostatin Receptor

Research Areas:  

Endocrinology Cancer

Pasireotide (SOM230) L-aspartate salt, a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide L-aspartate salt exhibits antisecretory, antiproliferative, and proapoptotic activity .
loading...
    loading...
6
6 Cited Publications
Cat. No.: HY-112732
CAS No.: 51321-79-0
Target:  

Apoptosis

Research Areas:  

Metabolic Disease Cancer

Sparfosic acid, a DNA antimetabolite agent, is a potent inhibitor of aspartate transcarbamoyl transferase, the enzyme catalyzing the second step of de novo pyrimidine biosynthesis. Sparfosic acid synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines .
loading...
    loading...
6
6 Cited Publications
Cat. No.: HY-17387
CAS No.: 102518-79-6
Synonyms: Huperzine A
(-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease .
loading...
    loading...
5
5 Cited Publications
Cat. No.: HY-N0666B
CAS No.: 10389-09-0
Synonyms: Calcium L-aspartate
Aspartic acid calcium (calcium L-aspartate) is a NMDA receptor agonist and acidic amino acid. Aspartic acid calcium has no independent analgesic activity. Aspartic acid calcium can antagonize the analgesic effects of D-Aspartic acid and Morphine. Aspartic acid calcium regulates polymorph transformation, crystal growth/aggregation and nucleation processes of calcium carbonate, and can serve as a biomineralization template. Aspartic acid calcium promotes burst firing of central neurons. Aspartic acid calcium can be used in studies related to cerebral ischemia and epilepsy .
loading...
    loading...
5
5 Cited Publications
Cat. No.: HY-N0666C
CAS No.: 3792-50-5
Synonyms: Sodium L-aspartate
L-Aspartic acid sodium (Sodium L-aspartate) is a NMDA receptor agonist and acidic amino acid. L-Aspartic acid sodium has no independent analgesic activity. L-Aspartic acid sodium can antagonize the analgesic effects of D-Aspartic acid and Morphine. L-Aspartic acid sodium regulates polymorph transformation, crystal growth/aggregation and nucleation processes of calcium carbonate, and can serve as a biomineralization template. L-Aspartic acid sodium promotes burst firing of central neurons. L-Aspartic acid sodium can be used in studies related to cerebral ischemia and epilepsy .
loading...
    loading...
5
5 Cited Publications
Cat. No.: HY-N0666D
CAS No.: 5598-53-8
Synonyms: Disodium L-aspartate
L-Aspartic acid disodium (disodium L-aspartate) is a NMDA receptor agonist and acidic amino acid. L-Aspartic acid disodium has no independent analgesic activity. L-Aspartic acid disodium can antagonize the analgesic effects of D-Aspartic acid and Morphine. L-Aspartic acid disodium regulates polymorph transformation, crystal growth/aggregation and nucleation processes of calcium carbonate, and can serve as a biomineralization template. L-Aspartic acid disodium promotes burst firing of central neurons. L-Aspartic acid disodium can be used in studies related to cerebral ischemia and epilepsy .
loading...
    loading...
5
5 Cited Publications
Cat. No.: HY-N0666A
CAS No.: 1115-63-5
L-Aspartic acid potassium (potassium L-aspartate) is a NMDA receptor agonist and acidic amino acid. L-Aspartic acid potassium has no independent analgesic activity. L-Aspartic acid potassium can antagonize the analgesic effects of D-Aspartic acid and Morphine. L-Aspartic acid potassium regulates polymorph transformation, crystal growth/aggregation and nucleation processes of calcium carbonate, and can serve as a biomineralization template. L-Aspartic acid potassium promotes burst firing of central neurons. L-Aspartic acid potassium can be used in studies related to cerebral ischemia and epilepsy .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-100807S
CAS No.: 138946-42-6
Purity:  99.90%
Quinolinic acid-d3 is the deuterium labeled Quinolinic acid. Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis.
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-100811
CAS No.: 18000-24-3
Purity:  99.86%
Synonyms: 7-CKA
Target:  

iGluR

Research Areas:  

Neurological Disease

7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent antinociceptive actions after neuraxial delivery .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-100811A
CAS No.: 1263094-00-3
Purity:  99.79%
Synonyms: 7-CKA sodium salt
Target:  

iGluR

Research Areas:  

Neurological Disease

7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid sodium salt is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid sodium salt has potent antinociceptive actions after neuraxial delivery .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-N2370
CAS No.: 30271-38-6
Category:  

Animals Steroids

Target:  

iGluR LXR

24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-100714
CAS No.: 76326-31-3
Purity:  ≥98.0%
Synonyms: 2-APV; DL-2-Amino-5-phosphonovaleric acid
Target:  

iGluR

DL-AP5 (2-APV) is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 shows significantly antinociceptive activity. DL-AP5 specifically blocks on channels in the rabbit retina .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-100714C
CAS No.: 1303993-72-7
Purity:  99.20%
Synonyms: 2-APV sodium; DL-2-Amino-5-phosphonovaleric acid sodium
Target:  

iGluR

DL-AP5 (2-APV) sodium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 sodium shows significantly antinociceptive activity. DL-AP5 sodium specifically blocks on channels in the rabbit retina .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-101037
CAS No.: 107-97-1
Purity:  ≥98.0%
Synonyms: N-Methylglycine; Sarcosin
Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia .
loading...
    loading...