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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
113 Results for "
FABP
" in MedChemExpress (MCE) Product Catalog:
Products (113)
113 Results for "FABP" in MCE Product Catalog:
31
31 Publications Verification
Target:
Forschungsgebiete:
BMS-309403 is a potent, orally active and selective adipocyte fatty acid binding protein (also known as FABP4, aP2) inhibitor with Kis of <2, 250, and 350 nM for FABP4, FABP3, and FABP5, respectively. BMS-309403 interacts with the fatty-acid-binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids. BMS-309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells .
31
31 Publications Verification
Target:
Forschungsgebiete:
BMS-309403 sodium is a potent, orally active, and selective adipocyte fatty acid binding protein (also known as FABP4, aP2) inhibitor, with Kis of <2, 250, and 350 nM for FABP4, FABP3, and FABP5, respectively. BMS-309403 sodium interacts with the fatty-acid-binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids. BMS-309403 sodium improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells .
4
4 Cited Publications
Art. -Nr.: HY-N2445
CAS. Nr.: 37308-75-1
3
3 Cited Publications
Art. -Nr.: HY-P75215
Reinheit: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FABP4; Adipocyte Fatty Acid Binding Protein; Fatty Acid Binding Protein 4; Epididymis Secretory Protein Li 104; A-FABP; Adipocyte Lipid-Binding Protein; AP2; HEL-S-104; Adipocyte-Type Fatty Acid-Binding Protein; AFABP; Fatty Acid Binding Protein 4, Adipoc
Species:
Mouse
Source:
E. coli
3
3 Cited Publications
Art. -Nr.: HY-N2303
CAS. Nr.: 84745-95-9
2
Target:
Forschungsgebiete:
FABPs ligand 6 (MF6) is an FABP5 and FABP7 inhibitor with KD values of 874 nM and 20 nM, respectively. FABPs ligand 6 can be used for multiple sclerosis research .
2
1
1 Cited Publications
Target:
Forschungsgebiete:
FABP1-IN-1 (44) is a selective FABP1 inhibitor, with an IC50 of 4.46 μM. FABP1-IN-1 (44) can be used for the research of NASH .
1
1 Cited Publications
Target:
Forschungsgebiete:
HTS01037 is an inhibitor of fatty acid binding; and a competitive antagonist of protein-protein interactions mediated by AFABP/aP2 with a Ki of 0.67 μM.
1
1 Cited Publications
Art. -Nr.: HY-P75214
Reinheit: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FABP5; Psoriasis-Associated Fatty Acid-Binding Protein Homolog; Fatty Acid Binding Protein 5; Epidermal-Type Fatty Acid-Binding Protein; PA-FABP; Fatty Acid-Binding Protein 5; E-FABP; Fatty Acid-Binding Protein, Epidermal; Fatty Acid Binding Protein 5 (Ps
Species:
Human
Source:
E. coli
1
1 Cited Publications
Art. -Nr.: HY-Q66655
CAS. Nr.: 3120494-74-5
Forschungsgebiete:
YRDC-IN-1 is a blood-brain barrier-permeable YRDC inhibitor. YRDC is a key enzyme that catalyzes the formation of N 6-threonylcarbamoyladenosine at position 37 of tRNA (t 6A37). YRDC-IN-1 selectively inhibits the translation of ANN codon-enriched FABP7, thereby reducing lipid droplet formation, increasing ROS, and reversing the acquired resistance of GBM to Temozolomide (TMZ) (HY-17364). YRDC-IN-1 can be used for the research of glioblastoma .
Art. -Nr.: HY-D1736
CAS. Nr.: 158757-82-5
Art. -Nr.: HY-161702
CAS. Nr.: 1433901-75-7
Target:
Forschungsgebiete:
RO6806051 is a selectivity FABP4 and FABP5 inhibitor with human FABP4 Ki values of 0.011 μM and 0.23 μM, and human FABP5 Ki values of 0.086 μM and 1.17 μM. RO6806051 can be used for the research of inflammation-related diseases .
Art. -Nr.: HY-W040255
CAS. Nr.: 89947-79-5
Synonyms: PGPC
Forschungsgebiete:
1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine is an oxidized phospholipid. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine reduces the viability of HUVECs, increases the levels of ferrous ions and lipid peroxidation, promotes the production of superoxide anions, and decreases the levels of glutathione and GPX4 in cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine upregulates the mRNA and protein levels of FABP3 in HUVECs, impairs mitochondrial membrane potential, and induces ferroptosis-related changes as well as mitochondrial dysfunction and damage. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine activates caspase-11 and promotes the continuous release of IL-1β from macrophages and dendritic cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine inhibits the proliferation of aortic smooth muscle cells and induces apoptosis in these cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine is applicable to relevant research on atherosclerosis .
Art. -Nr.: HY-163032
CAS. Nr.: 3053862-47-5
Target:
Forschungsgebiete:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
FABP4-IN-3 (compound C3) is a highly selective FABP4 inhibitor (FABP4 Ki = 25 ± 3 a nM, FABP3 Ki = 15.03 μM) which exhibits a 601-fold selectivity over FABP3. FABP4-IN-3 also shows metabolic stability and potent cellular anti-inflammatory activity, making it promising to get involved in the research of metabolic disease, cardiac dysfunction and inflammation-related disease .
Art. -Nr.: HY-W012865
CAS. Nr.: 80-69-3
Forschungsgebiete:
Tartronic acid, a dicarboxylic acid derive, is an inhibitor of the transformation of carbohydrates into fat under fat-deficient diet conditions. Tartronic acid promotes 3T3-L1 adipocyte differentiation by increasing the protein expression of FABP-4, PPARγ and SREBP-1. Tartronic acid promotes de novo lipogenesis and inhibits CPT-1β by upregulating acetyl-CoA and malonyl-CoA. Tartronic acid promotes weight gain and induces adipocyte hypertrophy in epididymal white adipose tissue and lipid accumulation in the livers of high-fat diet induced obese mice. Tartronic acid can be used for lipid metabolic disease research .
Art. -Nr.: HY-N14035
CAS. Nr.: 90045-23-1
Art. -Nr.: HY-160457
CAS. Nr.: 2862791-11-3
Target:
Forschungsgebiete:
FABP4/5-IN-5 (compound D9) is a potent inhibitor of FABP4 and FABP5,? with the IC50s of 4.68 μM and 10.72 μM, respectively.FABP4/5-IN-5 plays an important role in metabolism disorder like diabetes mellitus .
Art. -Nr.: HY-161904
CAS. Nr.: 2378625-66-0
Forschungsgebiete:
CDYL-IN-1 is a selective small-molecule inhibitor of CDYL with a KD value of 0.5 μM. CDYL-IN-1 improves renal dysfunction, pathological damage and renal tubular pyroptosis, inhibits FABP4-mediated ROS production, and alleviates renal tubular epithelial cell injury. CDYL-IN-1 is applicable to the research of acute kidney injury .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
