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Results for "

G0

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) 5 alpha Reductase (2) 5-HT Receptor (2) Adenosine Receptor (3) Akt (22) Aminoacyl-tRNA Synthetase (1) AMPK (1) Amylases (2) Anaplastic lymphoma kinase (ALK) (3) Androgen Receptor (2) Antibiotic (4) Apolipoprotein (1) Apoptosis (200) Aryl Hydrocarbon Receptor (2) Atg8/LC3 (3) ATP-binding cassette (ABC) transporters (1) Autophagy (23) Bacterial (9) Bcl-2 Family (16) Bcr-Abl (3) Biochemical Assay Reagents (14) Btk (1) c-Kit (1) c-Met/HGFR (6) c-Myc (7) Carbonic Anhydrase (2) Casein Kinase (2) Caspase (29) CCR (1) CDK (29) Ceramidase (1) COX (3) Cytochrome P450 (4) Deubiquitinase (4) Dihydrofolate reductase (DHFR) (2) Dihydroorotate Dehydrogenase (1) DNA Alkylator/Crosslinker (1) DNA Methyltransferase (2) DNA-PK (2) DNA/RNA Synthesis (14) Dopamine Receptor (2) Drug Derivative (1) Drug Intermediate (1) Drug Metabolite (2) EGFR (18) Endogenous Metabolite (5) Environmental Pollutants (2) Epigenetic Reader Domain (11) ERK (9) Estrogen Receptor/ERR (4) FAK (4) Farnesyl Transferase (1) Ferroptosis (3) FGFR (4) FLT3 (11) Fungal (5) GLP Receptor (1) GLUT (2) Glutathione Peroxidase (1) Glycosidase (2) HDAC (17) Heme Oxygenase (HO) (1) Histamine Receptor (1) Histone Acetyltransferase (1) Histone Demethylase (1) Histone Methyltransferase (9) HMG-CoA Reductase (HMGCR) (2) HSP (6) Hsp-targeting Chimeras (1) HyT (1) IKK (2) Influenza Virus (2) Integrin (3) Interleukin Related (9) Isotope-Labeled Compounds (1) JAK (1) JNK (5) Keap1-Nrf2 (3) Lactate Dehydrogenase (3) LIM Kinase (LIMK) (1) Liposome (2) Lipoxygenase (1) LXR (1) MALT1 (1) MAPKAPK2 (MK2) (1) MDM-2/p53 (12) MEK (2) Methylenetetrahydrofolate Dehydrogenase (MTHFD) (1) Microtubule/Tubulin (4) Mitochondrial Metabolism (5) Mitosis (1) MMP (4) MNK (1) Molecular Glues (3) mTOR (17) Necroptosis (3) NF-κB (9) NO Synthase (1) NOD-like Receptor (NLR) (2) Notch (2) OLIG2 (1) Opioid Receptor (1) Orphan Nuclear Receptor (2) p38 MAPK (7) p62 (3) PAK (4) Parasite (4) PARP (9) PD-1/PD-L1 (4) PDGFR (4) PERK (2) PGE synthase (1) Phosphatase (1) Phosphodiesterase (PDE) (1) Phytohormone (1) PI3K (14) PKA (1) PKC (1) Prostaglandin Receptor (1) PROTACs (9) Pyroptosis (3) Raf (3) Ras (6) Reactive Oxygen Species (ROS) (38) Reference Standards (12) RET (1) Ribosomal S6 Kinase (RSK) (2) SHP2 (3) Sigma Receptor (1) Sirtuin (1) Small Interfering RNA (siRNA) (3) SOD (2) Src (2) STAT (6) Steroid Sulfatase (1) Survivin (1) Telomerase (1) TGF-beta/Smad (1) TNF Receptor (2) Topoisomerase (6) Trk Receptor (4) VEGFR (5) Wnt (3) Xanthine Oxidase (3) Zinc Finger Protein (1) β-catenin (4)
By Research Areas:	Cancer (269) Cardiovascular Disease (10) Endocrinology (7) Infection (18) Inflammation/Immunology (32) Metabolic Disease (10) Neurological Disease (23)
Click Chemistry:	PROTAC Synthesis (1) Azide (1) Alkynes (1)
Oligonucleotides:	Nucleoside Analogs (1) Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Cationic Lipids (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

296

Inhibitors & Agonists

Biochemical Assay Reagents

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Natural
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Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17408

Mevastatin 5+ Cited Publications Compactin; ML236B	HMG-CoA Reductase (HMGCR) Bacterial Autophagy Apoptosis Antibiotic	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Mevastatin (Compactin) is a first HMG-CoA reductase inhibitor that belongs to the statins class. Mevastatin is a lipid-lowering agent, and induces apoptosis, arrests cancer cells in G₀/G₁ phase. Mevastatin also increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels. Mevastatin has antitumor activity and has the potential for cardiovascular diseases treatment .

HY-152229

G0-C14 2 Publications Verification	Liposome	Cancer
G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for agent and vaccine delivery .

HY-164607

YL-5092	DNA/RNA Synthesis Apoptosis	Cancer
YL-5092 is a selective YT521-B homology (YTH) domain-containing protein 1 (YTHDC1) inhibitor with an IC₅₀ of 7.4 nM and a K_D of 29.6 nM. YL-5092 can suppress cancer cell proliferation and induce cell G0/G1 phase arrest and apoptosis. YL-5092 can be used for the research of cancer, such as acute myeloid leukemia (AML) .

HY-13768

Topotecan 35+ Cited Publications SKF 104864A; NSC 609669	Topoisomerase Autophagy Apoptosis	Cancer
Topotecan (SKF 104864A; NSC 609669) is an orally active and potent Topoisomerase I inhibitor. Topotecan induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan shows anticancer activity .

HY-13680

Meisoindigo 2 Publications Verification Dian III; N-Methylisoindigotin; Natura-α	Apoptosis	Cancer
Meisoindigo (Dian III), a derivative of Indirubin (HY-N0117), halts the cell cycle at the G0/G1 phase and induces apoptosis in primary acute myeloid leukemia (AML) cells. Meisoindigo exhibits high antitumor activity .

HY-15221

Methylstat 3 Publications Verification	Apoptosis Histone Demethylase MDM-2/p53	Cardiovascular Disease Cancer
Methylstat is a potent histone demethylases inhibitor. Methylstat shows anti-proliferative activity with low cytotoxicity. Methylstat induces apoptosis and cell cycle arrest at G0/G1 phase. Methylstat increases the expression of p53 and p21 protein levels. Methylstat inhibits angiogenesis induced by various cytokines. Methylstat can be used as a chemical probe for addressing its role in angiogenesis .

HY-N7844

N6-Benzyladenosine Benzyladenosine	Apoptosis Adenosine Receptor	Inflammation/Immunology Cancer
N6-Benzyladenosine is an adenosine receptor agonist, has a cytoactive activity. N6-Benzyladenosine arrests cell cycle at G0/G1 phase and induces cell apoptosis. N6-Benzyladenosine also exerts inhibitory effect on T. gondii adenosine kinase and glioma ^- .

HY-120897

NS-3-008 hydrochloride	Bcl-2 Family Apoptosis	Inflammation/Immunology
NS-3-008 hydrochloride is an orally active transcriptional inhibitor of **G0/G1 switch 2 (G0s2) with an IC₅₀** of 2.25 μM. NS-3-008 hydrochloride can be used for chronic kidney disease .

HY-146980

GLUT4-IN-2	Apoptosis GLUT	Cancer
GLUT4-IN-2 is a potent and selective GLUT4 inhibitor with IC₅₀s of 11.4 µM and 6.8 µM for GLUT1 and GLUT4, respectively. GLUT4-IN-2 induces cell apoptosis and cell cycle arrest at G0/G1phase. GLUT4-IN-2 shows potent antitumor activity .

HY-148393

G0 N-glycan-Asn	Biochemical Assay Reagents	Others
G0 N-glycan-Asn is a glycopeptide. G0 N-glycan-Asn can be used for various biochemical studies .

HY-143490

PAK4-IN-2	PAK Apoptosis	Cancer
PAK4-IN-2 is a highly potent PAK4 inhibitor with IC₅₀ value of 2.7 nM. PAK4-IN-2 can arrest MV4-11 cells at G0/G1 phase and induce cell apoptosis. PAK4-IN-2 can be used for researching cancer .

HY-10815

σ1 Receptor antagonist-1 1 Publications Verification	Sigma Receptor Apoptosis	Neurological Disease Cancer
σ1 Receptor antagonist-1 is a highly potent and selective sigma 1 receptor antagonist (pK_i=10.28). σ1 Receptor antagonist-1 inhibits cell growth, arrests cell cycle at G0/G1 phase and induces apoptosis of MCF-7/ADR cells .

HY-W157376

PAMAM Dendrimer G0.0 amine (20% in methanol)	Bacterial Antibiotic Drug Intermediate	Infection Cancer
PAMAM Dendrimer G0.0 amine is a pore-forming channel antagonist, including anthrax toxin protective antigen 63 (PA63, IC₅₀ = 231 nM) and C. botulinum C2 toxin subunit (C2IIa, IC₅₀ = 940 nM). At concentrations of 10 and 20 µM, PAMAM Dendrimer G0.0 amine reduces C2 toxin-induced death in HeLa cells. Additionally, PAMAM Dendrimer G0.0 amine is a chelator of nickel. In complexes with polysulfone membrane-bound chitosan, PAMAM Dendrimer G0.0 amine selectively captures and stores carbon dioxide (CO2) in a gas-feed system. PAMAM Dendrimer G0.0 amine has been used in the synthesis of PAMAM Dendrimer G0.5 Carboxylate (CAS 339334-01-9) and PAMAM Dendrimer G1.0 Amine (CAS 142986-44-5). PAMAM Dendrimer G0.0 amine can be used in research related to infections, cancer, and drug delivery systems .

HY-120458

LCAHA 1 Publications Verification LCA hydroxyamide	Deubiquitinase	Cancer
LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC₅₀s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a .

HY-N1930

(-)-Hinesol Hinesol	Apoptosis	Cancer
(-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer .

HY-149891

HSP90-IN-23	HSP	Cancer
HSP90-IN-23 (Comp 12-1) is an inhibitor of heat shock protein 90(HSP90) with an IC₅₀ of 9 nM. HSP90-IN-23 induces apoptosis of tumor cells and arrests the tumor cell cycle in G0/G1 phase. HSP90-IN-23 can be used for cancer research .

HY-W747572

(+)-Perillyl alcohol (R)-(+)-Perillyl alcohol	Ras	Cancer
(+)-Perillyl alcohol is the enantiomer of S-(-)-Perillyl alcohol (HY-116514). (+)-Perillyl alcohol can inhibit the growth of polypeptides and block the cell cycle in the G0/G1 phase. (+)-Perillyl alcohol induces cell signaling that is associated with changes in cytoskeletal actin organization and reduced protein expression of growth regulatory proteins such as Ras and CDC2 kinase .

HY-159869

G0-C14 analog	Liposome	Others
G0-C14 analog is a G0-C14 derivative. G0-C14 is an ionizable cationic lipid that can be used to synthesize lipid nanoparticles (LNP) .

HY-N4171

Dihydrocucurbitacin B	Apoptosis	Inflammation/Immunology
Dihydrocucurbitacin B, a triterpene isolated from Cayaponia tayuya roots, inhibits nuclear factor of activated T cells (NFAT), induces cell cycle arrested in the G0 phase, and inhibits delayed type hypersensitivity .

HY-N16418

Epanorin	Bacterial Reactive Oxygen Species (ROS)	Infection Cancer
Epanorin is a secondary metabolite of the Acarospora lichenic species Epanorin can inhibit cancer cells proliferation, ROS production and induce G0/G1 phase arrest. Epanorin shows antibacterial activity. Epanorin can be used for the researches of cancer and infection, such as breast cancer and S. pneumonia infection .

HY-155285

YS-363	EGFR Apoptosis	Cancer
YS-363 is a potent, selective, and orally active EGFR inhibitor, with IC₅₀s of 0.96 nM and 0.67 nM for wild-type and L858R mutant forms of EGFR, respectively. YS-363 can induce G0/G1 cell cycle arrest and apoptosis .

HY-171047

Autophagy inducer 7	Apoptosis Autophagy DNA/RNA Synthesis Akt mTOR	Cancer
Autophagy inducer 7 (Compound SSA) is an Autophagy and Apoptosis inducer. Autophagy inducer 7 activates autophagy by inhibiting Akt/mTOR signaling and the expression of downstream proteins. Autophagy inducer 7 suppresses DNA synthesis and causes a G0-G1 cell-cycle arrest. Autophagy inducer 7 inhibits tumor cell growth .

HY-179143

EGFR-IN-185	EGFR Akt Apoptosis	Cancer
EGFR-IN-185 is a EGFR inhibitor. EGFR-IN-185 exhibits potent activity against non-small cell lung cancer (NSCLC) cells harboring EGFR mutations. EGFR-IN-185 inhibits colony formation and migration, induces G0/G1 arrest, and promots apoptosis, which are associated with the suppression of EGFR and AKT phosphorylation. EGFR-IN-185 can be used for the research of NSCLC .

HY-174129

TM471-1	Btk Apoptosis	Cancer
TM471-1 is an orally active and covalent Bruton's tyrosine kinase (BTK) inhibitor with IC₅₀ values of 1.3 nM (BTK ^WT), >40,000 nM (BTK ^C481S), 7.9 nM (TEC) and 12.4 nM (TXK). TM471-1 inhibits cell growth in vivo and in vitro, arrests cell cycle at G0/G1 phase and induces cell apoptosis .

HY-158496

A2 glycan (G0), 2-AB labelled A2 N-linked oligosaccharide, 2-AB labelled	Biochemical Assay Reagents	Others
A2 glycan (G0), 2-AB labelled (A2 N-linked oligosaccharide, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-124261

Sampangine	Apoptosis	Cancer
Sampangine is an alkaloid that induces apoptosis by inducing cell cycle arrest in the G0/G1 phase. Sampangine can inhibit the biosynthesis of heme .

HY-177766

GSPT1 degrader-17	Molecular Glues Apoptosis	Cancer
GSPT1 degrader-17 (Compound 9q) is a potent and selective cereblon-based molecular glue degrader that targets G1 to S phase transition 1 (GSPT1). GSPT1 degrader-17 degrades GSPT1 in U937 cells with a DC₅₀ of 35 nM and Dmax of 81.65%. GSPT1 degrader-17 has a strong inhibitory effect on U937, MOLT-4 and MV4-11 cells with IC₅₀ values of 0.019, 0.006 and 0.027 μM. GSPT1 degrader-17 can induce cells apoptosis and G0/G1 phase arrest. GSPT1 degrader-17 can be used for the research of cancer, such as acute myeloid leukemia .

HY-135217

Apiole	Apoptosis	Cancer
Apiole is an anti-tumor agent that induces apoptosis and inhibits human colon cancer cells by inducing G0/G1 cell cycle arrest. Apiole also significantly inhibited colon tumor development in an in vivo mouse xenograft model .

HY-144733

ERα antagonist 1	Estrogen Receptor/ERR Apoptosis	Cancer
ERα antagonist 1 (Compound 19d) is a potent, selective, covalent estrogen receptor α (ERα) antagonist. ERα antagonist 1 induces apoptosis and cell cycle G0/G1 phase arrest in MCF-7 cells .

HY-N16567

Acrofolione A	Apoptosis Caspase PARP Survivin	Cancer
Acrofolione A is an acetophenone dimer isolated from Acronychia pendunculata with anticancer effects. Acrofolione A induces G0/G1 phase cell cycle arrest and apoptosis in human NALM-6 pre-B cell leukaemia cells. Acrofolione A can be used for leukaemia research .

HY-N2298

Camellianin A	Apoptosis	Cancer
Camellianin A, the main flavonoid in A. nitida leaves, displays anticancer activity and angiotensin converting enzyme (ACE)-inhibitory activity. Camellianin A inhibits the proliferation of the human Hep G2 and MCF-7 cell lines and induces the significant increase of the G0/G1 cell population .

HY-144394

Antitumor agent-45	Apoptosis c-Met/HGFR	Cancer
Antitumor agent-45 (Compound 21) could induce and stimulate A549 cells apoptosis in G0/G1 and G2/M phase. Antitumor agent-45 (Compound 21) inhibits c-Met expression to regulate the growth of tumor cells .

HY-10638

AP23464	c-Kit Apoptosis	Cancer
AP23464 is an ATP-based inhibitor for Kit, that inhibits the phosphorylation of Kit wildtype and mutants, with IC₅₀ of 5-85 nM. AP23464 inhibits the proliferation of Kit mutated cells (IC₅₀ is 3-20 nM), arrests the cell cycle at G0/G1 phase, and induces apoptosis in Kit mutated cells .

HY-146445

P300 bromodomain-IN-1	Epigenetic Reader Domain Histone Acetyltransferase	Cancer
P300 bromodomain-IN-1 (Compoun 1u) is a potent p300 (EP300) bromodomain inhibitor with an IC₅₀ of 49 nM. P300 bromodomain-IN-1 suppresses the expression of c-Myc and induces G1/G0 phase arrest and apoptosis in OPM-2 cells .

HY-129592

p-Tolylmaleimide	Apoptosis	Cancer
p-Tolylmaleimide (compound 9) is a naphthalimide derivative that has cytotoxic effects on cancer cells. p-Tolylmaleimide can arrest the cell cycle of human acute myeloid leukemia cells K562 in the sub-G0/G1 phase and induce apoptosis .

HY-130616

EGFR-IN-11	EGFR Apoptosis	Cancer
EGFR-IN-11 is a fourth-generation EGFR-tyrosine kinase inhibitor (EGFR-TKI) with an IC₅₀ of 18 nM for triple mutant EGFR ^{L858R/T790M/C797S}. EGFR-IN-11 significantly suppresses the EGFR phosphorylation, induce the apoptosis, and arrest cell cycle at G0/G1 .

HY-N12044

Asparanin A	Apoptosis	Cancer
Asparanin A is an apoptosis inducer with anticancer activity. Asparanin A induces cell cycle arrest in the G0/G1 phase through mitochondria and PI3K/AKT signaling pathways, inhibiting cancer cell growth. Asparanin A also demonstrated in vivo efficacy in a mouse xenograft model of Ishikawa endometrial carcinoma, significantly inhibiting tumor growth .

HY-122359A

rel-Levormeloxifene rel-L-Centchroman; Ormeloxifene	Estrogen Receptor/ERR Apoptosis Reactive Oxygen Species (ROS)	Cancer
rel-Levormeloxifene (rel-L-Centchroman) is the relative configuration of Levormeloxifene (HY-122359). rel-Levormeloxifene is a selective estrogen receptor modulator (SERM). rel-Levormeloxifene inhibits proliferation of leukemia cells with IC₅₀ about 7 μM, arrests cell cycle at G0/G1 phase, and induces apoptosis. rel-Levormeloxifene induces differentation of myelogenesis leukemia, and enhances ROS production in K562 cells .

HY-E70678

CDK3/CycE1 Recombinant Human Active Protein Kinase	CDK	Cancer
CDK3 is a major player driving retinoblastoma (Rb) phosphorylation during the G0/G1 transition and in the early G1 phase of the cell cycle. CDK3 interacts with various transcription factors involved in cell proliferation, differentiation, and transformation driven by the EGFR/Ras signaling pathway. CDK3/CycE1 Recombinant Human Active Protein Kinase is an ortholog of CDK3 .

HY-163535

J208	HDAC DNA Methyltransferase Apoptosis	Inflammation/Immunology Cancer
J208 is a dual inhibitor for histone deacetylase (HDAC) and DNA methyltransferase (DNMT). J208 inhibits proliferation of cancer cells, as well as the migration/invasion of triple-negative breast cancer (TNBC) cells. J208 induces apoptosis, arrests the cell cycle at G0/G1 phase. J2008 activates the innate immune signalling pathway in TNBC, by inducing the expression of endogenous retroviruses (ERVs) .

HY-169477

PAMAM dendrimer G0.5 carboxylate sodium (8.78% w/w in water)	Biochemical Assay Reagents	Cancer
PAMAM Dendrimer G0.5 Carboxylate sodium is a polyamidoamine (PAMAM) dendrimer with carboxylate termini. PAMAM Dendrimer G0.5 Carboxylate sodium conjugated with DACHPt is cytotoxic to A2780 ovarian cancer cells, MCF-7 breast cancer cells, Caco-2 colon cancer cells and BJ fibroblasts with IC₅₀ values of 0.03, 1.6, 0.18 and 3 µM, respectively .

HY-158493

A2 glycan (G0), procainamide labelled A2 N-linked oligosaccharide, procainamide labelled	Biochemical Assay Reagents	Others
A2 glycan (G0), procainamide labelled (A2 N-linked oligosaccharide, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158497

A2 glycan (G0), APTS labelled A2 N-linked oligosaccharide, APTS labelled	Biochemical Assay Reagents	Others
A2 glycan (G0), APTS labelled (A2 N-linked oligosaccharide, APTS labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-N12603

Typhatifolin B	Apoptosis	Cancer
Typhatifolin B (Compd 2), an anti-cancer agent, could remarkably induce cell apoptosis and G0/G1 cycle arrest, as well as block cell migration and invasion .

HY-13768C

Topotecan hydrochloride hydrate SKF 104864A hydrochloride hydrate; NSC 609669 hydrochloride hydrate	Topoisomerase Apoptosis Autophagy	Cancer
Topotecan hydrochloride hydrate is an orally active and potent Topoisomerase I inhibitor. Topotecan hydrochloride hydrate induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan hydrochloride hydrate shows anticancer activity .

HY-162416

CDK7-IN-27	CDK	Cancer
CDK7-IN-27 (Compound 37) is a selective inhibitor for cyclin-dependent kinase 7 (CDK7), with K_i of 3 nM. CDK7-IN-27 arrests the cell cycle at G0/G1 phase .

HY-155544

Antitumor agent-111	c-Met/HGFR	Cancer
Antitumor agent-111 (compound 46) is an c-Met kinase inhibitor (IC₅₀=46 nM) with antitumor and antiproliferative activity. Antitumor agent-111 arrests cell cycle at G0/G1 phase, and induces apoptosis .

HY-147801

Topoisomerase IIα-IN-3	Topoisomerase Apoptosis	Cancer
Topoisomerase IIα-IN-3 (Compound 12c) is a DNA intercalative topoisomerase-IIα inhibitor. Topoisomerase IIα-IN-3 arrests cell cycle at the G0/G1 phase and induces apoptosis .

HY-145762

YM281	Apoptosis Histone Methyltransferase	Cancer
YM281 is a potent EZH2 inhibitor. YM281 induces cell apoptosis and cell cycle arrest at the G0/G1 phase. YM281 shows antitumor effects in vivo. YM281 has the potential for the research of lymphoma .

HY-155503

Antitumor agent-103	Apoptosis	Cancer
Antitumor agent-103 (compound 24l) is an apoptosis inducer with antiproliferative and anti-clony formation activities. Antitumor agent-103 arrests cell cycle at G0/G1 phase, enhances NO production, and exhibits anti-tumor activity .

Cat. No.	Product Name	Type

HY-152229

G0-C14 2 Publications Verification	Biochemical Assay Reagents
G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for agent and vaccine delivery .

HY-158498

FA2 glycan (G0F)

FA2 N-linked oligosaccharide; F(6)A2 glycan

Biochemical Assay Reagents

FA2 glycan (G0F) (FA2 N-linked oligosaccharide; F(6)A2 glycan) is a core-fucosylated biantennary N-linked oligosaccharide that serves as a prostate cancer biomarker. The level of FA2 glycan (G0F) is higher in prostate cancer than in benign prostatic hyperplasia, and it is further elevated in advanced prostate cancer with a Gleason score ≥8 compared with both benign prostatic hyperplasia and low-/intermediate-risk prostate cancer. FA2 glycan (G0F) can be used in prostate cancer research .

HY-157353

MacConkey Agar MAC	Biochemical Assay Reagents
MacConkey Agar (MAC) can be used for selective isolation and culture of intestinal pathogens. The composition of 1 liter of MacConkey Agar (MAC) is: 20.0g peptone, 10.0 g lactose, 1.5 g Bile salt number three, 5.0 g sodium chloride, 0.03g Neutral red, 0.001 g Crystal viol and 15.0 g agar .

HY-158496

A2 glycan (G0), 2-AB labelled A2 N-linked oligosaccharide, 2-AB labelled	Biochemical Assay Reagents
A2 glycan (G0), 2-AB labelled (A2 N-linked oligosaccharide, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158493

A2 glycan (G0), procainamide labelled A2 N-linked oligosaccharide, procainamide labelled	Biochemical Assay Reagents
A2 glycan (G0), procainamide labelled (A2 N-linked oligosaccharide, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158497

A2 glycan (G0), APTS labelled A2 N-linked oligosaccharide, APTS labelled	Biochemical Assay Reagents
A2 glycan (G0), APTS labelled (A2 N-linked oligosaccharide, APTS labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158454

FA2B glycan (G0B), 2-AB labelled FA2B N-linked oligosaccharide, 2-AB labelled; G0F with bisecting GlcNAc, 2-AB labelled	Biochemical Assay Reagents
FA2B glycan (G0B), 2-AB labelled (FA2B N-linked oligosaccharide, 2-AB labelled; G0F with bisecting GlcNAc, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158499

FA2 glycan (G0F), 2-AA labelled FA2 N-linked oligosaccharide, 2-AA labelled; F(6)A2 glycan, 2-AA labelled	Biochemical Assay Reagents
FA2 glycan (G0F), 2-AA labelled (FA2 N-linked oligosaccharide, 2-AA labelled; F(6)A2 glycan, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158500

FA2 glycan (G0F), 2-AB labelled FA2 N-linked oligosaccharide, 2-AB labelled; F(6)A2 glycan, 2-AB labelled	Biochemical Assay Reagents
FA2 glycan (G0F), 2-AB labelled (FA2 N-linked oligosaccharide, 2-AB labelled; F(6)A2 glycan, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158495

A2 glycan (G0), 2-AA labelled A2 N-linked oligosaccharide, 2-AA labelled	Biochemical Assay Reagents
A2[3]G1 & A2[6]G1 glycan (G1), 2-AB labeled Lewis sugar. SLeX is a ligand for the cell adhesion molecule E-selectin (E-selectin), which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions .

HY-158453

FA2B glycan (G0B), 2-AA labelled FA2B N-linked oligosaccharide, 2-AA labelled; G0F with bisecting GlcNAc, 2-AA labelled	Biochemical Assay Reagents
FA2B glycan (G0B), 2-AA labelled (FA2B N-linked oligosaccharide, 2-AA labelled; G0F with bisecting GlcNAc, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158527

FA2 glycan (G0F), APTS labelled FA2 N-linked oligosaccharide, APTS labelled; F(6)A2 glycan, APTS labelled	Biochemical Assay Reagents
FA2 glycan (G0F), APTS labelled (FA2 N-linked oligosaccharide, APTS labelled; F(6)A2 glycan, APTS labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

Cat. No.	Product Name	Target	Research Area

HY-P10323

T7 Peptide Tumstatin (74-98), human	Integrin FAK mTOR Apoptosis	Cancer
T7 Peptide is a protein synthesis inhibitor and anti-angiogenic agent, with a K_d of 10 nM for human transferrin receptor. T7 Peptide inhibits the phosphorylation of focal adhesion kinase, the activation of phosphatidylinositol 3-kinase and Akt, the kinase activity of mTOR, as well as the phosphorylation of 4E-BP1 in endothelial cells. T7 Peptide induces G0/G1 cell cycle arrest, apoptosis and protective autophagy in hepatocellular carcinoma cells, and suppresses tumor growth in mouse models. T7 Peptide is applicable to research related to cancer, glioblastoma, hepatocellular carcinoma and glioma .

HY-P10323A

T7 Peptide TFA Tumstatin (74-98), human TFA	Integrin FAK mTOR Apoptosis	Cancer
T7 Peptide TFA is a protein synthesis inhibitor and anti-angiogenic agent, with a K_d of 10 nM for human transferrin receptor. T7 Peptide TFA inhibits the phosphorylation of focal adhesion kinase, the activation of phosphatidylinositol 3-kinase and Akt, the kinase activity of mTOR, as well as the phosphorylation of 4E-BP1 in endothelial cells. T7 Peptide TFA induces G0/G1 cell cycle arrest, apoptosis and protective autophagy in hepatocellular carcinoma cells, and suppresses tumor growth in mouse models. T7 Peptide TFA is applicable to research related to cancer, glioblastoma, hepatocellular carcinoma and glioma .

HY-P11173

Cr-ACP1	DNA Alkylator/Crosslinker Apoptosis	Cancer
Cr-ACP1 is an anti-cancerous peptide. Cr-ACP1 binds to DNA, inducing cell cycle arrest in the G0-G1 phase, leading to the initiation of Apoptosis mechanisms. Cr-ACP1 exhibits anticancer effects against colon cancer and epidermoid carcinoma .

HY-P11490

DPMI-ω	MDM-2/p53	Inflammation/Immunology Cancer
DPMI-ω is a dual-specificity d-peptide antagonist of oncogenic proteins MDM2 and MDMX. DPMI-ω, upon fabrication on gold nanoparticles, efficiently traverses tumor cells and kills them by reactivating the p53 signaling pathway. DPMI-ω can disrupte the p53-MDM2/MDMX complex. DPMI-ω can inhibit B16 melanoma growth and induce cells G0/G1 phase arrest. DPMI-ω can augment the efficacy of immunotherapy by expanding CD3 ⁺/CD8 ⁺ cytotoxic T cells and suppressing CD4 ⁺/CD25 ⁺ regulatory T cells companied with anti-PD1 antibody. DPMI-ω can be used for research of melanoma .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0711

Carvacrol Maximum Cited Publications 10 Publications Verification Cymophenol	Structural Classification Monophenols Preservatives Classification of Application Fields Labiatae Phenols Derris elliptica (Roxb.) Benth. Plants Inflammation/Immunology Disease Research Fields Food Research	Environmental Pollutants Apoptosis Endogenous Metabolite Notch Fungal Bacterial
Carvacrol is an orally active and blood-brain barrier-permeable monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations .

HY-17408

Mevastatin 5+ Cited Publications Compactin; ML236B	Infection Cardiovascular Disease Natural Products Microorganisms Neurological Disease Classification of Application Fields Metabolic Disease Disease Research Fields Source Classification	HMG-CoA Reductase (HMGCR) Bacterial Autophagy Apoptosis Antibiotic
Mevastatin (Compactin) is a first HMG-CoA reductase inhibitor that belongs to the statins class. Mevastatin is a lipid-lowering agent, and induces apoptosis, arrests cancer cells in G₀/G₁ phase. Mevastatin also increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels. Mevastatin has antitumor activity and has the potential for cardiovascular diseases treatment .

HY-N0837

Veratramine 1 Publications Verification NSC17821; NSC23880	Alkaloids Piperidine Alkaloids Structural Classification other families Classification of Application Fields Plants Disease Research Fields Source Classification Cancer	PI3K Akt mTOR Autophagy Apoptosis
Veratramine (NSC17821; NSC23880) is an orally active inhibitor of the PI3K/Akt/mTOR signaling pathway and a SIGMAR1 modulator. Veratramine induces autophagic apoptosis of tumor cells, arrests the cell cycle at the G0/G1 phase, and inhibits epithelial-mesenchymal transition (EMT)-related proteins to reduce tumor migration. Veratramine reduces spinal cord and sciatic nerve pathological damage in a neuropathy model by inhibiting SIGMAR1 binding to NMDAR and phosphorylation of NMDAR Ser896. Veratramine has anti-tumor proliferation, apoptosis induction, anti-inflammatory and neuroprotective activities, and can be used in the study of cancers such as liver cancer and osteosarcoma, as well as diabetic peripheral neuropathy .

HY-13680

Meisoindigo 2 Publications Verification Dian III; N-Methylisoindigotin; Natura-α	Alkaloids other families Classification of Application Fields Plants Disease Research Fields Indole Alkaloids Source Classification Cancer	Apoptosis
Meisoindigo (Dian III), a derivative of Indirubin (HY-N0117), halts the cell cycle at the G0/G1 phase and induces apoptosis in primary acute myeloid leukemia (AML) cells. Meisoindigo exhibits high antitumor activity .

HY-N2414

Periplogenin 1 Publications Verification	Structural Classification other families Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	Reactive Oxygen Species (ROS) Necroptosis Pyroptosis Interleukin Related Caspase NOD-like Receptor (NLR)
Periplogenin is an orally active cardiac glycoside found in Cortex periplocae. Periplogenin can induce ROS production and necroptosis and cause G0/G1 phase arrest. Periplogenin can inhibit pyroptosis by regulating the NLRP3/Caspase-1/GSDMD signaling. Periplogenin suppresses growth of prostate carcinoma cells by docking to an ATP1A1 protein pocket and forming a hydrogen bond with T804. Periplogenin can be used for the researches of cancer, inflammation and immunology, such as prostate carcinoma, rheumatoid arthritis and psoriasis .

HY-17026E

Gemcitabine triphosphate trisodium dFdCTP trisodium	Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Drug Metabolite DNA/RNA Synthesis Apoptosis
Gemcitabine triphosphate (dFdCTP) trisodium is the active metabolite of Gemcitabine (HY-17026). The mechanism of Gemcitabine triphosphate trisodium cell-killing is its competition with cytidine triphosphate during DNA replication, which results in the inhibition of chain elongation. Gemcitabine triphosphate trisodium shows a K_i of 11.2 μM against DNA polymerase α and 14.4 μM against DNA polymerase ε. Gemcitabine triphosphate trisodium partially inhibits dCMP deaminase and acts as a substrate for DNA synthesis to incorporate into cellular DNA and RNA. Gemcitabine triphosphate trisodium disrupts DNA and RNA synthesis, arrests cell cycle in G0/G1 and S phases, triggers apoptosis, reduces tumor cell proliferation. Gemcitabine triphosphate trisodium can be used for the research of pancreatic cancer and non-small cell lung cancer .

HY-N2392

Kukoamine A 1 Publications Verification	Cardiovascular Disease Alkaloids Structural Classification other families Classification of Application Fields Other Alkaloids Phenols Polyphenols Plants Disease Research Fields Source Classification	Parasite Lipoxygenase Opioid Receptor Apoptosis Autophagy Reactive Oxygen Species (ROS) Interleukin Related TNF Receptor PGE synthase COX
Kukoamine A, a spermine alkaloid, is an orally active and brain-penetrant component found in the root barks of Lycium chinense (L. chinense) Miller. Kukoamine A inhibits purified Crithidia fasciculata trypanothione reductase and soybean lipoxygenase, activates μ-opioid receptor. Kukoamine A can inhibt cancer cell proliferation, migration and invasion, cause G0/G1 phase cell cycle arrest and induce apoptosis. Kukoamine A exerts neuroprotective effect and can induce autophagy . Kukoamine A inhibits LPS (HY-D1056)-induced NO, ROS, PGE₂, TNF-α, IL-1β, IL-6 production and COX-2 activity. Kukoamine A reverses palmitic acid-induced insulin resistance, lipid accumulation, and oxidative stress via downregulation of Srebp-1c. Kukoamine A can be used for the research of cancer, infection, inflammation, metabolic and neurological disease, such as glioblastoma and Parkinson's disease .

HY-N7844

N6-Benzyladenosine Benzyladenosine	Natural Products Classification of Application Fields Umbelliferae Plants Phytohormone Eupatorium buniifolium Hook. & Arn. Inflammation/Immunology Disease Research Fields Cytokinin Source Classification Cancer Agricultural Research	Apoptosis Adenosine Receptor
N6-Benzyladenosine is an adenosine receptor agonist, has a cytoactive activity. N6-Benzyladenosine arrests cell cycle at G0/G1 phase and induces cell apoptosis. N6-Benzyladenosine also exerts inhibitory effect on T. gondii adenosine kinase and glioma ^- .

HY-N9330

Broussoflavonol F	Flavonols Structural Classification Flavonoids other families Classification of Application Fields Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Xanthine Oxidase
Broussoflavonol F is a HER2-RAS-MEK-ERK signaling pathway modulator and mushroom tyrosinase inhibitor, with an IC₅₀ of 82.3 μM against mushroom tyrosinase. Broussoflavonol F reduces the protein expression levels of RAS, HER2, phosphorylated BRAF, phosphorylated MEK and phosphorylated Erk. It induces cell apoptosis, triggers G₀/G₁ phase cell cycle arrest, and exhibits cytotoxicity against colon cancer cells. Broussoflavonol F is applicable to related research on colon cancer .

HY-N6588

3,4,5-Tricaffeoylquinic acid 3,4,5-triCQA	Classification of Application Fields Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants Convolvulaceae Inflammation/Immunology Disease Research Fields Ipomoea batatas (Linn.) Lamarck Source Classification	Akt NF-κB
3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. 3,4,5-Tricaffeoylquinic acid induces cell cycle arrest at G0/G1, actin cytoskeleton organization, chromatin remodeling, neuronal differentiation, and bone morphogenetic protein signaling in human neural stem cells. 3,4,5-Tricaffeoylquinic acid has the potential for the research of aging-associated diseases .

HY-N0429

Diosbulbin B 1 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Ranunculaceae Clematis terniflora DC. Diterpenoids Plants Disease Research Fields Source Classification Cancer	Apoptosis MDM-2/p53 Bcl-2 Family CDK
Diosbulbin B, a diterpene lactone, is an anticancer agent. Diosbulbin B is an orally active component of Dioscorea. bulbifera L. Diosbulbin B can inhibit cell proliferation, induce G0/G1 phase arrest and apoptosis. Diosbulbin B can induce autophagy and mitochondrial dysfunction. Diosbulbin B can induce liver injury. Diosbulbin B can be used for the research of cancer, such as non-small cell lung cancer (NSCLC) .

HY-N0440

Germacrone 2 Publications Verification	Infection Classification of Application Fields Terpenoids Sesquiterpenes Plants Curcuma longa Disease Research Fields Source Classification Zingiberaceae	Influenza Virus NF-κB 5 alpha Reductase Keap1-Nrf2 Lactate Dehydrogenase Apoptosis
Germacrone is a sesquiterpene compound with multiple biological activities. Germacrone inhibits the H1N1 and H3N2 inﬂuenza A virus and the inﬂuenza B virus. Germacrone blocks the progressionof arthritis by regulating Th1/Th2 balance and inhibiting NF-κB signaling. Germacrone can arrest the cell cycle at G0/G1 and G2/M phases and induce apoptosis in breast cancer cells. Germacrone inhibits 5α-reductase and has anti-androgenic effect. Germacrone has neuroprotective functions and can be used for the study of traumatic brain injury (TBI). Germacrone also has antioxidant activity .

HY-17026A

Gemcitabine triphosphate dFdCTP	Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Drug Metabolite DNA/RNA Synthesis Apoptosis
Gemcitabine triphosphate (dFdCTP) is the active metabolite of Gemcitabine (HY-17026). The mechanism of Gemcitabine triphosphate cell-killing is its competition with cytidine triphosphate during DNA replication, which results in the inhibition of chain elongation. Gemcitabine triphosphate shows a K_i of 11.2 μM against DNA polymerase α and 14.4 μM against DNA polymerase ε. Gemcitabine triphosphate partially inhibits dCMP deaminase and acts as a substrate for DNA synthesis to incorporate into cellular DNA and RNA. Gemcitabine triphosphate disrupts DNA and RNA synthesis, arrests cell cycle in G0/G1 and S phases, triggers apoptosis, reduces tumor cell proliferation. Gemcitabine triphosphate can be used for the research of pancreatic cancer and non-small cell lung cancer .

HY-16942

Damulin B 1 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino Disease Research Fields Source Classification Cancer	Apoptosis Reactive Oxygen Species (ROS) Bcl-2 Family CDK MMP Interleukin Related MDM-2/p53
Damulin B is a dammarane-type saponin found in Gynostemma pentaphyllum. Damulin B can inhibit cancer cell apoptosis, decrease mitochondrial membrane potential, inhibit ROS production and cause G0/G1 phase arrest. Damulin B can prevent Cisplatin (HY-17394)-induced acute kidney injury and induce hair growth. Damulin B shows anti-inflammation anti-diabetic and anti-obesity effect. Damulin B can be used for the researches of cancer, inflammation, metabolic disease, such as lung cancer, osteoarthritis and diabetes .

HY-W100287

Murrayafoline A	Alkaloids Murraya tetramera C. C. Huang Rutaceae Carbazole Alkaloids Plants Source Classification	NF-κB p38 MAPK Interleukin Related IKK JNK β-catenin Wnt
Murrayafoline A is a carbazole alkaloid that can be extracted from Murraya tetramera. Murrayafoline A directly targets Specificity protein 1 (Sp1), thereby inhibiting NF-κB and MAPK signaling pathways. Murrayafoline a induces a G0/G1-phase arrest in platelet-derived growth factor (PDGF)-stimulated vascular smooth muscle cells. Murrayafoline A attenuates the Wnt/β-catenin pathway by promoting the degradation of intracellular β-catenin proteins. Murrayafoline A enhances the contraction of rat ventricular myocytes and L-type calcium current by activating protein kinase C. Murrayafoline A inhibits LPS (HY-D1056)-induced neuroinflammation in vivo. Murrayafoline A can be used for the study of inflammation, vascular complications and colon cancer .

HY-N1930

(-)-Hinesol Hinesol	Structural Classification Terpenoids Sesquiterpenes Plants Compositae Erythrina sigmoidea Hua	Apoptosis
(-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer .

HY-149132

Dendrogenin A DDA	Triterpenes Terpenoids Endogenous metabolite Source Classification	LXR
Dendrogenin A (DDA) is a ligand for liver X receptor (LXR), that induces the expression of sodium/iodine symporter, and increases iodine uptake. Dendrogenin A induces cell differentiation of MCF-7, and reactivates the function of lactating cells. Dendrogenin A induces the expressions of the TSH receptor, thyroid peroxidase, and thyroglobulin, and affects thyroid hormone generation. Dendrogenin A exhibits cytotoxicity in cancer cell B-CPAP and 8505c with IC₅₀ of 4.1 and 6.2 µM. Dendrogenin A arrests the cell cycle at G0/G1 phase .

HY-N4309

Lotusine	Cardiovascular Disease Alkaloids Structural Classification other families Classification of Application Fields Phenols Polyphenols Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Amylases Glycosidase
Lotusine is an orally active signaling pathway modulator and enzyme inhibitor, with an IC₅₀ of 30.60 μg/mL against α-amylase and an IC₅₀ of 36.15 μg/mL against α-glucosidase. Lotusine inhibits the EGFR-Akt-ERK signaling pathway by reducing the levels of phosphorylated EGFR, Akt and ERK. Lotusine induces apoptosis, triggers G₀/G₁ cell cycle arrest and inhibits cancer cell proliferation. Lotusine reduces lipid peroxidation and increases the activities of SOD, CAT and GPx. Lotusine is applicable to researches related to non-small cell lung cancer, type 2 diabetes and autism spectrum disorder .

HY-N8389

Globulol	Structural Classification Terpenoids Sesquiterpenes Myrtaceae Plants Eucalyptus globulus Labill. Source Classification	Bacterial Fungal PAK Akt STAT PD-1/PD-L1 Apoptosis CCR
Globulol is a terpenoid metabolite and Antimicrobial agent. Globulol can be isolated from Alpinia oxyphylla Miq. Globulol binds to PAK4, reduces the expression level of PAK4 in cancer cells, decreases the phosphorylation of AKT, and downregulates the expressions of STAT3, phosphorylated STAT3, and PD-L1. Globulol promotes the secretion of CCL4 by cancer cells. Globulol reduces the viability and proliferation ability of cancer cells, induces G0/G1 cell cycle arrest and Apoptosis in cancer cells, and inhibits cancer cell migration and the integrity of 3D tumor spheres. Globulol enhances the relevant effects of anti-PD-1 agents in the cancer cell microenvironment. Globulol exhibits anticancer activity against liver cancer. Globulol inhibits the mycelial growth of phytopathogenic fungi and the growth of phytopathogenic bacteria. Globulol can be used in studies related to hepatocellular carcinoma .

HY-N0440R

Germacrone (Standard)	Structural Classification Terpenoids Sesquiterpenes Plants Curcuma longa Source Classification Zingiberaceae	Reference Standards Influenza Virus NF-κB 5 alpha Reductase Keap1-Nrf2 Lactate Dehydrogenase Apoptosis
Germacrone (Standard) is an analytical standard of Gemmacrone (HY-N0440). This product is intended for research and analytical applications. Germacrone (Standard) is a sesquiterpene compound with multiple biological activities. Germacrone (Standard) inhibits the H1N1 and H3N2 inﬂuenza A viruses and the inﬂuenza B virus. Germacrone (Standard) blocks the progressionof arthritis by regulating Th1/Th2 balance and inhibiting NF-κB signaling. Germacrone (Standard) can arrest the cell cycle at G0/G1 and G2/M phases and induce apoptosis in breast cancer cells. Germacrone (Standard) inhibits 5α-reductase and has anti-androgenic effect. Germacrone (Standard) has neuroprotective functions and can be used for the study of traumatic brain injury (TBI). Germacrone (Standard) also has antioxidant activity .

HY-Y0106

2,6-Dihydroxyacetophenone	Classification of Application Fields Ketones, Aldehydes, Acids Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	mTOR Xanthine Oxidase Apoptosis
2,6-Dihydroxyacetophenone, a polyphenolic derivative of Acetophenone (HY-Y0989), is an orally active mTOR inhibitor. 2,6-Dihydroxyacetophenone shows antioxidant activity. 2,6-Dihydroxyacetophenone inhibits cell growth and proliferation in CRC cells. 2,6-Dihydroxyacetophenone arrests at G0/G1 phase of cell cycle, induces apoptosis and suppresses cell migration in CRC cells. 2,6-Dihydroxyacetophenone inhibits xanthine oxidase (XOD) with an IC₅₀ of 1.24 mM. 2,6-dihydroxyacetophenone improves uric acid metabolism in hyperuricemia mice, reduces plasma cholesterol in hypercholesterolemic rats, and inhibits lipid accumulation in HFD-induced obese mice. 2,6-Dihydroxyacetophenone can be used for the study of colorectal cancer (CRC), hyperuricemia and hypercholesterolemia .

HY-N0837R

Veratramine (Standard) NSC17821 (Standard); NSC23880 (Standard)	Alkaloids Piperidine Alkaloids Structural Classification other families Plants Source Classification	Reference Standards PI3K Akt mTOR Autophagy Apoptosis
Veratramine (NSC17821; NSC23880) (Standard) is the analytical standard of Veratramine (HY-N0837). This product is intended for research and analytical applications. Veratramine (NSC17821; NSC23880) is an orally active inhibitor of the PI3K/Akt/mTOR signaling pathway and a SIGMAR1 modulator. Veratramine induces autophagic apoptosis of tumor cells, arrests the cell cycle at the G0/G1 phase, and inhibits epithelial-mesenchymal transition (EMT)-related proteins to reduce tumor migration. Veratramine reduces spinal cord and sciatic nerve pathological damage in a neuropathy model by inhibiting SIGMAR1 binding to NMDAR and phosphorylation of NMDAR Ser896. Veratramine has anti-tumor proliferation, apoptosis induction, anti-inflammatory and neuroprotective activities, and can be used in the study of cancers such as liver cancer and osteosarcoma, as well as diabetic peripheral neuropathy .

HY-N4171

Dihydrocucurbitacin B	Triterpenes other families Classification of Application Fields Terpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis
Dihydrocucurbitacin B, a triterpene isolated from Cayaponia tayuya roots, inhibits nuclear factor of activated T cells (NFAT), induces cell cycle arrested in the G0 phase, and inhibits delayed type hypersensitivity .

HY-N16418

Epanorin	Natural Products Microorganisms Source Classification	Bacterial Reactive Oxygen Species (ROS)
Epanorin is a secondary metabolite of the Acarospora lichenic species Epanorin can inhibit cancer cells proliferation, ROS production and induce G0/G1 phase arrest. Epanorin shows antibacterial activity. Epanorin can be used for the researches of cancer and infection, such as breast cancer and S. pneumonia infection .

HY-124261

Sampangine	Alkaloids Other Alkaloids Cananga odorata Plants Annonaceae Source Classification	Apoptosis
Sampangine is an alkaloid that induces apoptosis by inducing cell cycle arrest in the G0/G1 phase. Sampangine can inhibit the biosynthesis of heme .

HY-135217

Apiole	Natural Products Umbelliferae Plants Petroselinum crispum (Mill.) Fuss Source Classification	Apoptosis
Apiole is an anti-tumor agent that induces apoptosis and inhibits human colon cancer cells by inducing G0/G1 cell cycle arrest. Apiole also significantly inhibited colon tumor development in an in vivo mouse xenograft model .

HY-N16567

Acrofolione A	Structural Classification Acronychia haplophylla Ketones, Aldehydes, Acids Rutaceae Plants Source Classification	Apoptosis Caspase PARP Survivin
Acrofolione A is an acetophenone dimer isolated from Acronychia pendunculata with anticancer effects. Acrofolione A induces G0/G1 phase cell cycle arrest and apoptosis in human NALM-6 pre-B cell leukaemia cells. Acrofolione A can be used for leukaemia research .

HY-N2298

Camellianin A	Adinandra nitida Merr. ex Li Flavonoids Classification of Application Fields Flavones Phenols Polyphenols Plants Disease Research Fields Source Classification Theaceae Cancer	Apoptosis
Camellianin A, the main flavonoid in A. nitida leaves, displays anticancer activity and angiotensin converting enzyme (ACE)-inhibitory activity. Camellianin A inhibits the proliferation of the human Hep G2 and MCF-7 cell lines and induces the significant increase of the G0/G1 cell population .

HY-N12044

Asparanin A	Structural Classification Liliaceae Plants Steroids Source Classification Asparagus officinalis L.	Apoptosis
Asparanin A is an apoptosis inducer with anticancer activity. Asparanin A induces cell cycle arrest in the G0/G1 phase through mitochondria and PI3K/AKT signaling pathways, inhibiting cancer cell growth. Asparanin A also demonstrated in vivo efficacy in a mouse xenograft model of Ishikawa endometrial carcinoma, significantly inhibiting tumor growth .

HY-N0711R

Carvacrol (Standard) Cymophenol (Standard)	Structural Classification Monophenols Labiatae Phenols Derris elliptica (Roxb.) Benth. Plants	Reference Standards Notch Apoptosis Fungal Endogenous Metabolite Bacterial
Carvacrol (Standard) is the analytical standard of Carvacrol. This product is intended for research and analytical applications. Carvacrol is an orally active and blood-brain barrier-permeable monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations .

HY-N2199

Sotetsuflavone	Structural Classification Flavonoids Classification of Application Fields Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Source Classification Cancer	Apoptosis Autophagy PI3K JNK mTOR p38 MAPK CDK MMP TGF-beta/Smad STAT β-catenin Reactive Oxygen Species (ROS) Bcl-2 Family Caspase
Sotetsuflavone is a flavonoid that can be isolated from Cycas revolute. Sotetsuflavone inhibits phosphorylation of PI3K, Akt, mTOR, JNK, and p38 MAPK; modulates expression of Cyclin D1, CDK4, Bcl-2, Bax, cleaved caspases 3/9, MMP-9, TGF-β, STAT3, and β-catenin. Sotetsuflavone induces G₀/G₁ cell cycle arrest, apoptosis, autophagy, and intracellular ROS elevation, inhibits cancer cell proliferation. Sotetsuflavone inhibits tumor growth in mouse tumor xenograft models. Sotetsuflavone can be used for the research of non-small cell lung cancer and Crohn’s disease .

HY-N12603

Typhatifolin B	Flavonoids Typhaceae Flavonones Typha angustifolia L. Plants Source Classification	Apoptosis
Typhatifolin B (Compd 2), an anti-cancer agent, could remarkably induce cell apoptosis and G0/G1 cycle arrest, as well as block cell migration and invasion .

HY-135217R

Apiole (Standard)	Structural Classification Natural Products Umbelliferae Plants Petroselinum crispum (Mill.) Fuss Source Classification	Apoptosis Reference Standards
Apiole (Standard) is the analytical standard of Apiole. This product is intended for research and analytical applications. Apiole is an anti-tumor agent that induces apoptosis and inhibits human colon cancer cells by inducing G0/G1 cell cycle arrest. Apiole also significantly inhibited colon tumor development in an in vivo mouse xenograft model .

HY-N16400

Aspergillumarin A	Natural Products Microorganisms Source Classification	Bacterial
Aspergillumarin A is a dihydroisocoumarin derivative with various biological activity. Aspergillumarin A inhibits cell proliferation by inducing G0/G1 phase arrest in HepG2 hepatocellular carcinoma cells.. Aspergillumarin A exhibits weak antibacterial activity against Staphylococcus aureus and Bacillus subtilis. Aspergillumarin A can be used for the study of hepatocellular carcinoma (HCC)

HY-13680R

Meisoindigo (Standard) Dian III (Standard); N-Methylisoindigotin (Standard); Natura-α (Standard)	Alkaloids Structural Classification other families Plants Indole Alkaloids Source Classification	Apoptosis Reference Standards
Meisoindigo (Standard) is the analytical standard of Meisoindigo. This product is intended for research and analytical applications. Meisoindigo (Dian III), a derivative of Indirubin (HY-N0117), halts the cell cycle at the G0/G1 phase and induces apoptosis in primary acute myeloid leukemia (AML) cells. Meisoindigo exhibits high antitumor activity .

HY-N3764

Diosbulbin C	Terpenoids Diterpenoids Plants Dioscorea bulbifera Linn. Dioscoreaceae Source Classification	Akt Dihydrofolate reductase (DHFR) Endogenous Metabolite
Diosbulbin C is a diterpene lactone component, which can be extracted from traditional Chinese medicine Dioscorea bulbifera L.. Diosbulbin C possesses high anticancer activity in non-small cell lung cancer (NSCLC). Diosbulbin C could induce cell cycle arrest at G0/G1 phase in NSCLC. Diosbulbin C also inhibits the proliferation of NSCLC cells, possibly by downregulating the expression/activation of AKT, DHFR, and TYMS .

HY-N2414R

Periplogenin (Standard)	Structural Classification other families Plants Steroids Source Classification	Reference Standards Reactive Oxygen Species (ROS) Necroptosis Pyroptosis Interleukin Related Caspase NOD-like Receptor (NLR)
Periplogenin (Standard) is the analytical standard of Periplogenin (HY-N2414). Periplogenin is an orally active cardiac glycoside found in Cortex periplocae. Periplogenin can induce ROS production and necroptosis and cause G0/G1 phase arrest. Periplogenin can inhibit pyroptosis by regulating the NLRP3/Caspase-1/GSDMD signaling. Periplogenin suppresses growth of prostate carcinoma cells by docking to an ATP1A1 protein pocket and forming a hydrogen bond with T804. Periplogenin can be used for the researches of cancer, inflammation and immunology, such as prostate carcinoma, rheumatoid arthritis and psoriasis .

HY-N4309A

Lotusine hydroxide	Cardiovascular Disease Alkaloids Classification of Application Fields Phenols Polyphenols Nelumbo nucifera Gaertn. Plants Isoquinoline Alkaloids Nymphaeaceae Disease Research Fields Source Classification	Amylases Glycosidase
Lotusine hydroxide is an orally active signaling pathway modulator and enzyme inhibitor, with an IC₅₀ of 30.60 μg/mL against α-amylase and an IC₅₀ of 36.15 μg/mL against α-glucosidase. Lotusine hydroxide inhibits the EGFR-Akt-ERK signaling pathway by reducing the levels of phosphorylated EGFR, Akt and ERK. Lotusine hydroxide induces apoptosis, triggers G₀/G₁ cell cycle arrest and inhibits cancer cell proliferation. Lotusine hydroxide reduces lipid peroxidation and increases the activities of SOD, CAT and GPx. Lotusine hydroxide is applicable to researches related to non-small cell lung cancer, type 2 diabetes and autism spectrum disorder .

HY-W014701R

1,4-Dihydroxy-2-naphthoic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Reference Standards Aryl Hydrocarbon Receptor Cytochrome P450 Apoptosis Interleukin Related
1,4-Dihydroxy-2-naphthoic acid (Standard) is the analytical standard for 1,4-Dihydroxy-2-naphthoic acid (HY-W014701). 1,4-Dihydroxy-2-naphthoic acid is an orally active aryl hydrocarbon receptor (AhR) agonist and a bifidogenic growth stimulator. 1,4-Dihydroxy-2-naphthoic acid can improve the motor dysfunction in parkinson's disease (PD) model through AhR-dependent and -independent pathways. 1,4-Dihydroxy-2-naphthoic acid exerts anti-inflammatory effects by regulating the gut microbiota (such as promoting the proliferation of Bifidobacterium) and directly regulating the host immune system. 1,4-Dihydroxy-2-naphthoic acid induces apoptosis through G0/G1 cell cycle arrest in human keratinocyte to inhibit psoriasis .

HY-Y0106R

2,6-Dihydroxyacetophenone (Standard)	Structural Classification Ketones, Aldehydes, Acids Phenols Polyphenols Endogenous metabolite Source Classification	Reference Standards mTOR Xanthine Oxidase Apoptosis
2,6-Dihydroxyacetophenone (Standard) is the analytical standard of 2,6-Dihydroxyacetophenone (HY-Y0106). This product is intended for research and analytical applications. 2,6-Dihydroxyacetophenone, a polyphenolic derivative of Acetophenone (HY-Y0989), is an orally active mTOR inhibitor. 2,6-Dihydroxyacetophenone shows antioxidant activity. 2,6-Dihydroxyacetophenone inhibits cell growth and proliferation in CRC cells. 2,6-Dihydroxyacetophenone arrests at G0/G1 phase of cell cycle, induces apoptosis and suppresses cell migration in CRC cells. 2,6-Dihydroxyacetophenone inhibits xanthine oxidase (XOD) with an IC₅₀ of 1.24 mM. 2,6-dihydroxyacetophenone improves uric acid metabolism in hyperuricemia mice, reduces plasma cholesterol in hypercholesterolemic rats, and inhibits lipid accumulation in HFD-induced obese mice. 2,6-Dihydroxyacetophenone can be used for the study of colorectal cancer (CRC), hyperuricemia and hypercholesterolemia .

HY-N15348

Aphidicolins B32	Microorganisms Terpenoids Diterpenoids Source Classification	Others
Aphidicolins B32 is a diterpenoid compound discovered in the marine fungus Botryotinia fuckeliana, exhibiting cytotoxic activity against human bladder cancer cells. It inhibits the proliferation of T24 cells in the G0/G1 phase, with an IC₅₀ of 27.6 μM. Aphidicolins B32 holds potential for research in the field of cancer therapy .

HY-N18190

N-Desmethyldauricine	Structural Classification Alkaloids Plants Isoquinoline Alkaloids Menispermaceae Menispermum dauricum Source Classification	NF-κB Apoptosis
N-Desmethyldauricine is a NF-κB p65 inhibitor and apoptosis inducer. N-Desmethyldauricine reduces the protein expression level of p65, induces apoptosis, arrests the cell cycle at the G0/G1 phase, attenuates intercellular adhesion, and inhibits the growth of 3D spheroids of triple-negative breast cancer. N-Desmethyldauricine can be used in studies related to triple-negative breast cancer .

HY-N7844R

N6-Benzyladenosine (Standard) Benzyladenosine (Standard)	Natural Products Umbelliferae Plants Eupatorium buniifolium Hook. & Arn. Source Classification	Apoptosis Adenosine Receptor Phytohormone Reference Standards
N6-Benzyladenosine (Standard) (Benzyladenosine (Standard)) is the analytical standard of N6-Benzyladenosine (HY-N7844). This product is intended for research and analytical applications. N6-Benzyladenosine is an adenosine receptor agonist, has a cytoactive activity. N6-Benzyladenosine arrests cell cycle at G0/G1 phase and induces cell apoptosis. N6-Benzyladenosine also exerts inhibitory effect on T. gondii adenosine kinase and glioma - .

HY-N17736

Chikusetsusaponin IVa methyl ester CME	Structural Classification Terpenoids Achyranthes bidentata var. japonica Miq. Amaranthaceae Plants Pentacyclic Triterpenoids Source Classification	NF-κB COX Interleukin Related TNF Receptor NO Synthase Prostaglandin Receptor CDK β-catenin Wnt Apoptosis
Chikusetsusaponin IVa methyl ester (CME) is a natural triterpenoid saponin compound. Chikusetsusaponin IVa methyl ester induces G0/G1 cell cycle arrest and apoptosis in colon cancer cells by inhibiting the Wnt/β-catenin signaling pathway. By inhibiting the NF-κB and AP-1 signaling pathways, Chikusetsusaponin IVa methyl ester significantly reduces the production of NO, PGE₂ and pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), and downregulates the levels of iNOS and COX-2. Chikusetsusaponin IVa methyl ester can be used in researches on colorectal cancer and inflammation .

HY-W100287R

Murrayafoline A (Standard)	Structural Classification Alkaloids Murraya tetramera C. C. Huang Rutaceae Carbazole Alkaloids Plants Source Classification	NF-κB Reference Standards p38 MAPK Interleukin Related IKK JNK β-catenin Wnt
Murrayafoline A (Standard) is the analytical standard of Murrayafoline A (HY-W100287). This product is intended for research and analytical applications. Murrayafoline A is a carbazole alkaloid that can be extracted from Murraya tetramera. Murrayafoline A directly targets Specificity protein 1 (Sp1), thereby inhibiting NF-κB and MAPK signaling pathways. Murrayafoline a induces a G0/G1-phase arrest in platelet-derived growth factor (PDGF)-stimulated vascular smooth muscle cells. Murrayafoline A attenuates the Wnt/β-catenin pathway by promoting the degradation of intracellular β-catenin proteins. Murrayafoline A enhances the contraction of rat ventricular myocytes and L-type calcium current by activating protein kinase C. Murrayafoline A inhibits LPS (HY-D1056)-induced neuroinflammation in vivo. Murrayafoline A can be used for the study of inflammation, vascular complications and colon cancer .

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HY-P7769

	LD78-beta/CCL3L1 Protein, Human (HEK293 His) rHuCCL3L1, His; C-C Motif Chemokine 3-Like 1; Small-Inducible Cytokine A3-Like 1; Tonsillar Lymphocyte LD78 Beta Protein; CCL3L1; D17S1718; G0S19-2; SCYA3L1; CCL3L3	Human	HEK293
	LD78-beta/CCL3L1 Protein, Human (HEK293 His) is a multiallelic copy number variable, which plays a crucial role in immunoregulatory and hosts defense through the production of macrophage inflammatory protein (MIP)-1α.

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HY-N7844S

N6-Benzyladenosine-d5
N6-Benzyladenosine-d₅ (Benzyladenosine-d₅) is deuterium labeled N6-Benzyladenosine. N6-Benzyladenosine is an adenosine receptor agonist, has a cytoactive activity. N6-Benzyladenosine arrests cell cycle at G0/G1 phase and induces cell apoptosis. N6-Benzyladenosine also exerts inhibitory effect on T. gondii adenosine kinase and glioma .

Host:	Mouse (3) Rabbit (5)
Reactivity:	Human (8) Rat (4) Mouse (5)
Application:	IHC-P (5) ICC/IF (6) IF-Tissue (1) IP (2) WB (5) FC (3) ELISA (3)
Isotype:	IgG (4) IgG1 (2) IgG/Kappa (1)
Conjugation:	Non-conjugated (8)
Clonality:	Polyclonal (1) Monoclonal (6) Recombinant (2)
Modification:	Unmodified (7)

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HY-P86657

	c-Fos Antibody (YA6349) Cellular oncogene fos; FBJ murine osteosarcoma viral v fos oncogene homolog antibody FBJ Osteosarcoma Virus; FOS; FOS protein; G0 G1 switch regulatory protein 7; G0S7; Oncogene FOS; Proto oncogene protein c fos; v fos FBJ murine osteosarcoma viral oncogene homolog; AP-1; p55; FOS_HUMAN; Proto-oncogene c-Fos; G0/G1 switch regulatory protein 7.	FC	Human
	c-Fos Antibody (YA6349) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to c-Fos.

HY-P80616

	c-Fos Antibody 3 Publications Verification FOS; G0S7; Proto-oncogene c-Fos; Cellular oncogene fos; G0/G1 switch regulatory protein 7	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	c-Fos Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to c-Fos.

HY-P85738

	c-Fos Antibody (YA5430) FOS; G0S7; Proto-oncogene c-Fos; Cellular oncogene fos; G0/G1 switch regulatory protein 7	WB, ELISA, IF-Tissue	Human, Mouse, Rat
	c-Fos Antibody (YA5430) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to c-Fos.

HY-P86346

	c-Fos Antibody (YA6038) FOS; G0S7; Proto-oncogene c-Fos; Cellular oncogene fos; G0/G1 switch regulatory protein 7	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	c-Fos Antibody (YA6038) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to c-Fos.

HY-P81753

	Fos B Antibody (YA1498) G0/G1 switch regulatory protein 3; G0S3; Protein fosB; GOSB; Oncogene FOSB; Activator protein 1	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Fos B Antibody (YA1498) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Fos B.

HY-P88202

	ZFP36 Antibody (YA7886) G0S24; GOS24; NUP475; RNF162A; TIS11; TTP; zfp-36	IHC-P, ICC/IF, FC	Human
	ZFP36 Antibody (YA7886) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZFP36.

HY-P88202A

	ZFP36 Antibody (YA7886)(PBS only) G0S24; GOS24; NUP475; RNF162A; TIS11; TTP; zfp-36	IHC-P, ICC/IF, FC	Human
	ZFP36 Antibody (YA7886) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZFP36.

HY-P86801

	CCL3/MIP-1 alpha Antibody (YA6494) C C motif chemokine 3 antibody; CCL 3 antibody; CCL3 antibody; CCL3_HUMAN antibody; Chemokine (C C motif) ligand 3 antibody; Chemokine C C motif ligand 3 antibody; Chemokine ligand 3 antibody; G0/G1 switch regulatory protein 19 1 antibody; G0/G1 switch regulatory protein 19-1 antibody; G0S19 1 antibody; C C motif chemokine 3 antibody; CCL 3 antibody; CCL3 antibody; CCL3_HUMAN antibody; Chemokine (C C motif) ligand 3 antibody; Chemokine C C motif ligand 3 antibody; Chemokine ligand 3 antibody; G0/G1 switch regulatory protein 19 1 antibody; G0/G1 switch regulatory protein 19-1 antibody; G0S19 1 antibody; G0S19 1 protein antibody; Heparin binding chemotaxis protein antibody; L2G25B antibody; LD78 alpha antibody; LD78-alpha(4-69) antibody; LD78alpha antibody; Macrophage inflammatory protein 1 alpha antibody; Macrophage inflammatory protein 1-alpha antibody; macrophage inflammatory protein 1a antibody; M; IP : 1 alpha antibody; M; IP : 1A antibody; MIP-1-alpha antibody; MIP-1-alpha(4-69) antibody; MIP1 alpha antibody; MIP1A antibody; PAT 464.1 antibody; SCYA 3 antibody; SCYA3 antibody; SIS alpha antibody; SIS beta antibody; SIS-beta antibody; Small inducible cytokine A3 antibody; small inducible cytokine A3 (homologous to mouse Mip-1a) antibody; Small-inducible cytokine A3 antibody; Tonsillar lymphocyte LD78 alpha protein antibody;	WB, ICC/IF, IHC-P	Human, Mouse
	CCL3/MIP-1 alpha Antibody (YA6494) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CCL3/MIP-1 alpha.

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Cat. No.	Product Name		Classification

HY-152263

HEMTAC CDK4/6 degrader 1		PROTAC Synthesis
HEMTAC CDK4/6 degrader 1 is a PROTAC connected by ligands for HSP90 and CDK4/6 with a K_d value of 35.7 μM. HEMTAC CDK4/6 degrader 1 induces CDK4/6 degradation in B16F10 melanoma cells. HEMTAC CDK4/6 degrader 1 arrests cell cycle at G0/G1 phase and induces apoptosis. HEMTAC CDK4/6 degrader 1 can be used in research of cancer . HEMTAC CDK4/6 degrader 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159519

EGFR/HER2-IN-16		Azide
EGFR/HER2-IN-16 (compound 12K) is an effective dual-target inhibitor of EGFR (IC₅₀=6.15 nM) and HER-2 (IC₅₀=9.78 nM) with anti-tumor activity. EGFR/HER2-IN-16 can inhibit the migration of SK-BR-3 cells, arrest the cell cycle in the G0/G1 phase, and induce apoptosis. EGFR/HER2-IN-16 exhibits good anti-proliferative activity against tumor cell models and has little damage to healthy cells. EGFR/HER2-IN-16 can be used in breast cancer research .

HY-180200

RNK08954		Alkynes
RNK08954 is an orally active KRAS^G12D inhibitor with a K_d of 0.0395 nM. RNK08954 selectively binds the inactive GDP-bound KRAS^G12D form, suppresses downstream KRAS-mediated signaling pathways p-ERK1/2 experssion. RNK08954 inhibits KRAS^G12D-mutant cell proliferation, induces G0-G1 cell cycle arrest, and inhibits tumor growth in mouse xenograft models. RNK08954 can be used for the research of non-small cell lung cancer, pancreatic ductal adenocarcinoma .

Cat. No.	Product Name		Classification

HY-152229

G0-C14 2 Publications Verification		Cationic Lipids
G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for agent and vaccine delivery .

HY-115567

5-NIdR 1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole		Nucleoside Analogs
5-NIdR (1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole), an artificial nucleoside, exhibits the ability to inhibit the replication of DNA lesions generated by Temozolomide (HY-17364). 5-NIdR induces cancer cells apoptosis and arrests cell cycle at G0 phase. 5-NIdR enhances Temozolomide anti-tumor efficacy in murine glioblastoma model .

HY-RS18241

G0s2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
G0s2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for G0s2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS05187

G0S2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
G0S2 Human Pre-designed siRNA Set A contains three designed siRNAs for G0S2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24720

G0s2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
G0s2 Rat Pre-designed siRNA Set A contains three designed siRNAs for G0s2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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