Search Result

Results for "

GIRK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Adrenergic Receptor (2) AMPK (1) Calcium Channel (2) Cannabinoid Receptor (1) Dopamine Receptor (5) Drug Intermediate (1) iGluR (3) Influenza Virus (2) mGluR (1) Potassium Channel (15) Reference Standards (1)
By Research Areas:	Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (16)

Inhibitors & Agonists

Peptides

Natural
Products

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19545A

SCH-23390 hydrochloride Maximum Cited Publications 31 Publications Verification R-(+)-SCH-23390 hydrochloride	Dopamine Receptor 5-HT Receptor Potassium Channel	Neurological Disease
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D₁-like receptor antagonist with K_is of 0.2 nM and 0.3 nM for the D₁ and D₅ receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT_2C receptor agonist with a K_i of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT₂ and 5-HT_1C receptors. SCH-23390 hydrochloride inhibits *G protein-coupled inwardly rectifying potassium (GIRK) channels* with an IC₅₀ of 268 nM .

HY-12882A

Ifenprodil tartrate 5+ Cited Publications NP-120 tartrate; RC-61-91 tartrate	iGluR Adrenergic Receptor Potassium Channel Calcium Channel Influenza Virus	Infection Neurological Disease
Ifenprodil (NP-120) tartrate, a cerebral vasodilator, is a noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC₅₀=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC₅₀=146 μM) . Ifenprodil tartrate is an α1 adrenergic receptor antagonist. Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has reliable inhibitory effects against A/H1N1 strains (EC₅₀ of 6.6 µM). Ifenprodil tartrate has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil tartrate can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease .

HY-P1275

Tertiapin-Q 3 Publications Verification	Potassium Channel	Cardiovascular Disease
Tertiapin-Q is a highly selective blocker of *GIRK1/4* heterodimer and ROMK1 (Kir_1.1).

HY-127106

VU0810464 1 Publications Verification	Potassium Channel	Neurological Disease
VU0810464 is a potent and selective non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator. VU0810464 displays nanomolar potency for neuronal (EC₅₀=165 nM) and GIRK1/4 (EC₅₀=720 nM) channels with improved brain penetration .

HY-110192

ML 297 1 Publications Verification VU 0456810; CID 56642816	Potassium Channel	Neurological Disease
ML 297 (VU 0456810) is a potent and selective *GIRK_1/2* activator, with an EC₅₀ of 0.16 μM. ML 297 can cross the blood-brain barrier with brain-to-plasma ratio of 0.2 in mice model (i.p.). ML 297 is potential for the treatment of epilepsy .

HY-12882

Ifenprodil 5+ Cited Publications NP-120; RC-61-91	iGluR Adrenergic Receptor Potassium Channel Calcium Channel Influenza Virus	Infection Neurological Disease
Ifenprodil (NP-120), a cerebral vasodilator, is a noncompetitive NMDA receptor antagonist. Ifenprodil exerts high affinity at NR1A/NR2B receptors (IC₅₀=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC₅₀=146 μM) . Ifenprodil is an α1 adrenergic receptor antagonist. Ifenprodil inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil has reliable inhibitory effects against A/H1N1 strains (EC₅₀ of 6.6 µM). Ifenprodil has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease .

HY-112705

VU0529331	Potassium Channel	Neurological Disease Metabolic Disease
VU0529331 is a homomeric *GIRK* channel activator, with an EC₅₀ value of 5.1 μM for human *GIRK2* and an EC₅₀ value of 22.3 μM for *GIRK4. VU0529331 serves as a starting point for the development of non-GIRK1/X* channel probes and also acts as a tool for studying homomeric *GIRK* channels. VU0529331 is applicable to research related to addiction, primary aldosteronism and delayed-onset obesity .

HY-121685A

Tipepidine hydrochloride 1 Publications Verification	Potassium Channel	Neurological Disease
Tipepidine hydrochloride reversibly inhibits dopamine (DA) D₂ receptor-mediated **GIRK currents (I_DA(GIRK)) with an IC₅₀** of 7.0 μM. Tipepidine hydrochloride subsequently activates VTA dopamine neuron . Tipepidine hydrochloride, a non-narcotic antitussive, exerts an antidepressant-like effect .

HY-117825

RU-TRAAK-2	Potassium Channel	Neurological Disease
RU-TRAAK-2 is a completely reversible TRAAK (TWIK-related arachidonic acid-stimulated K ⁺ channel) inhibitor. RU-TRAAK-2 exerts no activity for non-K2P channels (Kv1.2, Slo1 and GIRK2) . RU-TRAAK-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-121685

Tipepidine	Potassium Channel	Neurological Disease
Tipepidine reversibly inhibits dopamine (DA) D₂ receptor-mediated **GIRK currents (I_DA(GIRK)) with an IC₅₀** of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron . Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect .

HY-108400

SCH-23390 maleate R-(+)-SCH-23390 maleate	Dopamine Receptor 5-HT Receptor Potassium Channel	Neurological Disease
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective dopamine D₁-like receptor antagonist with K_is of 0.2 nM and 0.3 nM for the D₁ and D₅ receptor, respectively. SCH-23390 maleate is a potent and high efficacy human 5-HT_2C receptor agonist with a K_i of 9.3 nM. SCH-23390 maleate also binds with high affinity to the 5-HT₂ and 5-HT_1C receptors. SCH-23390 maleate inhibits *G protein-coupled inwardly rectifying potassium (GIRK) channels* with an IC₅₀ of 268 nM .

HY-122647

Valiglurax VU0652957; VU2957	mGluR	Neurological Disease
Valiglurax (VU0652957) is a potent, orally active and selective mGlu4 positive allosteric modulator with EC₅₀ values of 64.6 nM and 197 nM for hmGlu₄/Gqi5 and rmGlu₄ GIRK, respectively. Valiglurax is a central nervous system (CNS) penetrant. Valiglurax can be used in research of Parkinson's disease .

HY-12520B

(R)-SKF 38393 hydrochloride (±)-SKF-38393 hydrochloride; SKF-38393A hydrochloride	Dopamine Receptor Potassium Channel	Neurological Disease
(R)-SKF 38393 ((±)-SKF-38393) hydrochloride is a potent and selective D1 dopamine receptor antagonist. (R)-SKF 38393 hydrochloride inhibits *G protein-coupled inwardly rectifying potassium (GIRK) channel* .

HY-12882AR

Ifenprodil tartrate (Standard) NP-120 tartrate (Standard); RC-61-91 tartrate (Standard)	iGluR Potassium Channel Reference Standards	Neurological Disease
Ifenprodil (tartrate) (Standard) is the analytical standard of Ifenprodil (tartrate). This product is intended for research and analytical applications. Ifenprodil tartrate is a typical noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC50=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC50=146 μM) . Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has the potential to be a cerebral vasodilator .

HY-117403

AB-FUBICA	Cannabinoid Receptor Potassium Channel
AB-FUBICA (Compound 13) is a CB1 and CB2 receptor agonist that activates G-protein coupled inwardly rectifying potassium channels (GIRK) by binding to CB1 and CB2 receptors, displaying notable cannabinoid-like activity. AB-FUBICA has EC₅₀ values of 21 nM for CB1 and 15 nM for CB2. AB-FUBICA may be suitable for studying pain management, neurodegenerative diseases, and inflammation-related mechanisms .

HY-175556

CNV-dopamine	Dopamine Receptor	Neurological Disease
CNV-dopamine is a photoreleasable D2 receptor-selective agonist. CNV-dopamine activates D2 receptors and induces G protein-coupled inwardly rectifying potassium (GIRK) currents. CNV-dopamine is promising for research of disorders like Parkinson’s disease and addiction .

HY-B2185

Tipepidine citrate	Dopamine Receptor Potassium Channel AMPK	Neurological Disease Metabolic Disease Inflammation/Immunology
Tipepidine citrate is a non-narcotic antitussive agent. Tipepidine citrate reversibly inhibits dopamine D₂ receptor-mediated *GIRK* current (I_DA(GIRK)), thereby activating VTA dopamine neurons, with an IC₅₀ of 7.0 μM for I_DA(GIRK). Tipepidine activates AMPK. Tipepidine citrate has antidepressant-like effects. Tipepidine citrate enhances the analgesic effect of Carbamazepine (HY-B0246). Tipepidine citrate improves adipose tissue fibrosis and glucose intolerance in high-fat diet-induced obese mice .

HY-175099

AB-ICA	Drug Intermediate	Neurological Disease
AB-ICA is a precursor of AB-FUBICA (HY-117403). AB-FUBICA (Compound 13) is a CB1 and CB2 receptor agonist that activates G-protein coupled inwardly rectifying potassium channels (GIRK) by binding to CB1 and CB2 receptors, displaying notable cannabinoid-like activity .

Tertiapin-Q 3 Publications Verification	Potassium Channel	Cardiovascular Disease
Tertiapin-Q is a highly selective blocker of *GIRK1/4* heterodimer and ROMK1 (Kir_1.1).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-12882A

Ifenprodil tartrate 5+ Cited Publications NP-120 tartrate; RC-61-91 tartrate	Alkaloids Piperidine Alkaloids Neurological Disease Classification of Application Fields Crassulaceae Sedum sarmentosum Bunge Plants Disease Research Fields Source Classification	iGluR Adrenergic Receptor Potassium Channel Calcium Channel Influenza Virus
Ifenprodil (NP-120) tartrate, a cerebral vasodilator, is a noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC₅₀=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC₅₀=146 μM) . Ifenprodil tartrate is an α1 adrenergic receptor antagonist. Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has reliable inhibitory effects against A/H1N1 strains (EC₅₀ of 6.6 µM). Ifenprodil tartrate has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil tartrate can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease .

HY-12882AR

Ifenprodil tartrate (Standard) NP-120 tartrate (Standard); RC-61-91 tartrate (Standard)	Alkaloids Piperidine Alkaloids Crassulaceae Sedum sarmentosum Bunge Plants Source Classification	iGluR Potassium Channel Reference Standards
Ifenprodil (tartrate) (Standard) is the analytical standard of Ifenprodil (tartrate). This product is intended for research and analytical applications. Ifenprodil tartrate is a typical noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC50=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC50=146 μM) . Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has the potential to be a cerebral vasodilator .

Host:	Mouse (2) Rabbit (1)
Reactivity:	Human (3) Rat (3) Mouse (3) Monkey (2)
Application:	IHC-P (3) ICC/IF (2) IP (1) IHC-F (1) WB (1) FC (2)
Isotype:	IgG (1) IgG2b (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P88600

	*KCNJ3 (GIRK1 ) Antibody (YA8284)* GIRK1; KGA; KIR3.1	IHC-P, ICC/IF, FC	Human, Monkey, Mouse, Rat
	KCNJ3 (GIRK1 ) Antibody (YA8284) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to KCNJ3 (GIRK1 ).

HY-P88600A

	*KCNJ3 (GIRK1 ) Antibody (YA8284)(PBS only)* GIRK1; KGA; KIR3.1	IHC-P, ICC/IF, FC	Human, Monkey, Mouse, Rat
	KCNJ3 (GIRK1 ) Antibody (YA8284) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to KCNJ3 (GIRK1 ).

HY-P87200

	GIRK2 Antibody (YA6888) inwardly rectifying subfamily J member 6 antibody	WB, IHC-P, IP, IHC-F	Human, Mouse, Rat
	GIRK2 Antibody (YA6888) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GIRK2.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.

GIRK

Inhibitors & Agonists

Peptides

NaturalProducts

Antibodies

Natural
Products