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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

HL60 human leukemia cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (4) Autophagy (1) C-type Lectin-like Receptors (CTLRs) (1) CDK (1) DNA/RNA Synthesis (5) Drug Derivative (3) EBV (2) Endogenous Metabolite (2) Farnesyl Transferase (1) Interleukin Related (1) Lipoxygenase (2) NO Synthase (1) Parasite (1) PKA (1) Potassium Channel (1) RANKL/RANK (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) SphK (1)
By Research Areas:	Cancer (23) Cardiovascular Disease (2) Infection (4) Inflammation/Immunology (2) Metabolic Disease (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor BMI1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2513

β-Boswellic acid 2 Publications Verification	Lipoxygenase DNA/RNA Synthesis	Cancer
β-Boswellic acid is isolated from the gum resin of Boswellia serrata with anticancer, antioxidant activity, anti-inflammatory activity and anti-arthritic pain.β-Boswellic acid is an orally active nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells with IC₅₀ values ranging from 0.6 to 7.1 μM. β-Boswellic acid is promising for research of diabetes, inflammatory and arthritic diseases .

HY-33350

Clofilium tosylate 1 Publications Verification	Potassium Channel Apoptosis	Cardiovascular Disease Cancer
Clofilium tosylate, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Antiarrhythmic agent .

HY-12892

SKI-178 1 Publications Verification	SphK Apoptosis	Cancer
SKI-178 is a potent sphingosine kinase-1 (SphK1) and SphK2 inhibitor. SKI-178 is cytotoxic at IC₅₀ concentrations ranging from 1.8 to 0.1 μM in both agent sensitive and multi-agent resistant cancer cell lines (i.e., MTR3, NCI-ADR and HL60/VCR cells). SKI-178 induces apoptosis in a CDK1-dependent manner in human acute myeloid leukemia cell lines .

HY-112328

Fascaplysin	Apoptosis Autophagy Reactive Oxygen Species (ROS) CDK	Infection Cancer
Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity .

HY-N1746

(2S)-2'-Methoxykurarinone 2'-O-Methylkurarinone	RANKL/RANK	Metabolic Disease Inflammation/Immunology Cancer
(2S)-2'-Methoxykurarinone, a compound isolated from the roots of Sophora flavescens, has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone (MK) inhibits osteoclastogenesis and bone resorption through down-regulation of RANKL signaling. (2S)-2'-Methoxykurarinone (MK) displays cytotoxic activity against human myeloid leukemia HL-60 cells .

HY-N15387

Hericenone J	Drug Derivative	Cancer
Hericenone J (Compound 6) is an aromatic compound with anticancer activity, which is found in Hericium erinaceum. Hericenone J is cytotoxic and can significantly reduce the viability of HL-60 human acute promyelocytic leukemia cells with an IC₅₀ value of 4.13 μM. Hericenone J is promising for research of leukemia .

HY-N7634

Tectol	Farnesyl Transferase Parasite	Infection Cancer
Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM . Tectol is a farnesyltransferase (FTase) inhibitor with IC₅₀s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC₅₀ of 3.44 μM .

HY-111008A

Trimidox hydrochloride VF-233 hydrocHLoride	DNA/RNA Synthesis	Cancer
Trimidox hydrochloride (VF-233) is a ribonucleotide reductase inhibitor with antileukemic activities. Trimidox hydrochloride inhibits the growth of human promyelocytic leukemia HL-60 cells with an IC₅₀ of 35 μM .

HY-N2513R

β-Boswellic acid (Standard)	Reference Standards Lipoxygenase DNA/RNA Synthesis	Cancer
β-Boswellic acid (Standard) is the analytical standard of β-Boswellic acid. This product is intended for research and analytical applications. β-Boswellic acid is isolated from the gum resin of Boswellia serrata. β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation . β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells .

HY-P3736

Myelopeptide-2 MP-2	Interleukin Related	Cancer
Myelopeptide-2 is a peptide originally isolated from the supernatant of porcine bone marrow cell cultures, can restore mitogenic reactivity of human T lymphocytes inhibited by HL-60 leukemia cells or measles virus conditions. Myelopeptide-2 also recover depressed interleukin-2 (IL-2) synthesis and interleukin-2 receptor (IL-2R) expression. Myelopeptide-2 involves in immunity homeostasis, is perspective to be applied in antitumor and antivirus research .

HY-N14556

L-2,5-Dihydrophenylalanine	Apoptosis	Cancer
L-2,5-Dihydrophenylalanine can cause apoptosis of HL-60 in human myeloblastoid leukemia cells .

HY-124273

C2 L-threo Ceramide (d18:1/2:0) L-threo Cer(d18:1/2:0); L-threo Ceramide (d18:1/2:0); N-acetyl-L-threo-Sphingosine	Endogenous Metabolite	Cardiovascular Disease
C2 L-threo Ceramide (d18:1/2:0) (L-threo Cer(d18:1/2:0); L-threo Ceramide (d18:1/2:0)) is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is 50% less than that stimulated by C2 ceramide. C2 L-threo Ceramide inhibits IL-4 production by 17% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. It also induces cell cycle arrest in the G0/G1 phase and a 7-fold increase in sphingosine accumulation as well as inhibits growth of HL-60 leukemia cells.

HY-111008

Trimidox VF-233	DNA/RNA Synthesis	Cancer
Trimidox (VF-233) is a ribonucleotide reductase inhibitor with antileukemic activities. Trimidox inhibits the growth of human promyelocytic leukemia HL-60 cells with an IC₅₀ of 35 μM .

HY-N9159

Piptocarphin F	Others	Cancer
Piptocarphin F (Compound 5) is a sesquiterpene lactone. Piptocarphin F shows cytotoxic activity on human leukemia cell line HL-60 (IC₅₀=5.69 μmol*L ^-1) .

HY-N10206

11-epi-Chaetomugilin I	Endogenous Metabolite	Cancer
11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line .

HY-N3210

Nb-Demethylechitamine	Others	Cancer
Nb-Demethylechitamine is an alkaloid isolated from the methanol extract of Alstonia rostrata twigs. Nb-Demethylechitamine has in vitro cytotoxic activity against several human cancer cell lines, including human myeloid leukemia HL-60, liver cancer SMMC-7721, lung cancer A-549, breast cancer MCF-7, and colon cancer SW480 cells .

HY-137632

Sp-8-Cl-cAMPS	PKA	Cancer
Sp-8-Cl-cAMPS is an analog of cAMP (HY-B1511) and a derivative of Sp-8-Cl-cAMP. Sp-8-Cl-cAMPS inhibits the growth of human leukemia cell HL-60 and colon cancer cell LS-174T, with IC₅₀ of 8-100 μM. Sp-8-Cl-cAMPS activates the protein kinases cAKI and cAKII, with K_a of 0.25 and 3.2 μM .

HY-W551344

dCTPase-IN-1	DNA/RNA Synthesis	Cancer
dCTPase-IN-1 is a highly selective deoxycytidine triphosphate pyrophosphatase 1 (dCTPase) inhibitor with an IC₅₀ of 20 nM. dCTPase-IN-1 functionally inhibits dCTPase, exhibits a synergistic effect in enhancing cytotoxicity, and has no inherent cytotoxicity. dCTPase-IN-1 can be used for the research of leukemia .

HY-N13130

(+)-Mollisacacidin	Others	Cancer
(+)-Mollisacacidin is a flavan compound found in the root bark of Albizia glaberrima. (+)-Mollisacacidin exhibits no significant antiproliferative effect on cancer cells .

HY-N18115

3-O-Deacetyl-3-O-tigloylsalannin	Drug Derivative	Cancer
3-O-Deacetyl-3-O-tigloylsalannin is a salannin-type limonoid and cytotoxic agent found in the fruits of Melia azedarach. 3-O-Deacetyl-3-O-tigloylsalannin can be used for the research of leukemia, stomach cancer, breast cancer .

HY-N19936

Qinyangshengenin-3-O-β-D-digitoxopyranoside	Drug Derivative	Cancer
Qinyangshengenin-3-O-β-D-digitoxopyranoside is a C₂₁ steroidal glycoside that can be found in the whole herb of Prunella vulgaris Linn. Qinyangshengenin-3-O-β-D-digitoxopyranoside can be used for research of leukemia and lung cancer .

HY-N18117A

23-Hydroxyohchininolide	NO Synthase EBV	Infection Inflammation/Immunology Cancer
23-Hydroxyohchininolide is a limonoid found in the leaves of Melia azedarach L.. 23-Hydroxyohchininolide inhibits LPS (HY-D1056)-induced NO production and exerts cytotoxic activity against human leukemia and stomach cancer cells. 23-Hydroxyohchininolide inhibits TPA (HY-18739)-induced Epstein-Barr virus early antigen activation. 23-Hydroxyohchininolide can be used for the research of cancer, infection and inflammatory disease .

HY-N18117

21-Hydroxyisoohchininolide	EBV	Infection Cancer
21-Hydroxyisoohchininolide is a salannin-type limonoid. 21-Hydroxyisoohchininolide inhibits lipopolysaccharide (LPS, HY-D1056)-induced nitric oxide production in mouse macrophages. 21-Hydroxyisoohchininolide exhibits cytotoxic activity against leukemia cells and breast cancer cells. 21-Hydroxyisoohchininolide suppresses phorbol 12-myristate 13-acetate (PMA) (HY-18739)-induced activation of Epstein-Barr virus early antigen in lymphocytes. 21-Hydroxyisoohchininolide can be used for the research of leukemia, breast cancer and inflammatory diseases .

HY-P992333

CLT030 Antibody	C-type Lectin-like Receptors (CTLRs)	Cancer
CLT030 Antibody is a human monoclonal antibody targeting CLL1/CLEC12A/CD371, with a K_d value of 7.32 nM against human targets. CLT030 Antibody can be used to synthesize the ADC CLT030. It is applicable to research related to acute myeloid leukemia .

Cat. No.	Product Name	Target	Research Area

HY-P3736

Myelopeptide-2 MP-2	Interleukin Related	Cancer
Myelopeptide-2 is a peptide originally isolated from the supernatant of porcine bone marrow cell cultures, can restore mitogenic reactivity of human T lymphocytes inhibited by HL-60 leukemia cells or measles virus conditions. Myelopeptide-2 also recover depressed interleukin-2 (IL-2) synthesis and interleukin-2 receptor (IL-2R) expression. Myelopeptide-2 involves in immunity homeostasis, is perspective to be applied in antitumor and antivirus research .

Cat. No.	Product Name	Target	Research Area	Image

HY-P992333

CLT030 Antibody	C-type Lectin-like Receptors (CTLRs)	Cancer
CLT030 Antibody is a human monoclonal antibody targeting CLL1/CLEC12A/CD371, with a K_d value of 7.32 nM against human targets. CLT030 Antibody can be used to synthesize the ADC CLT030. It is applicable to research related to acute myeloid leukemia .

β-Boswellic acid 2 Publications Verification	Triterpenes other families Classification of Application Fields Terpenoids Boswellia serrata Plants Burseraceae Disease Research Fields Source Classification Cancer	Lipoxygenase DNA/RNA Synthesis
β-Boswellic acid is isolated from the gum resin of Boswellia serrata with anticancer, antioxidant activity, anti-inflammatory activity and anti-arthritic pain.β-Boswellic acid is an orally active nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells with IC₅₀ values ranging from 0.6 to 7.1 μM. β-Boswellic acid is promising for research of diabetes, inflammatory and arthritic diseases .

Fascaplysin	Infection Alkaloids Structural Classification Animals Classification of Application Fields Marine natural products Sponge Disease Research Fields Indole Alkaloids Cancer	Apoptosis Autophagy Reactive Oxygen Species (ROS) CDK
Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity .

(2S)-2'-Methoxykurarinone 2'-O-Methylkurarinone	Flavonoids Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Metabolic Disease Sophora flavescens Aiton Plants Inflammation/Immunology Disease Research Fields Source Classification	RANKL/RANK
(2S)-2'-Methoxykurarinone, a compound isolated from the roots of Sophora flavescens, has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone (MK) inhibits osteoclastogenesis and bone resorption through down-regulation of RANKL signaling. (2S)-2'-Methoxykurarinone (MK) displays cytotoxic activity against human myeloid leukemia HL-60 cells .

Hericenone J	Monophenols Microorganisms Phenols Source Classification	Drug Derivative
Hericenone J (Compound 6) is an aromatic compound with anticancer activity, which is found in Hericium erinaceum. Hericenone J is cytotoxic and can significantly reduce the viability of HL-60 human acute promyelocytic leukemia cells with an IC₅₀ value of 4.13 μM. Hericenone J is promising for research of leukemia .

Tectol	Infection other families Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification	Farnesyl Transferase Parasite
Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM . Tectol is a farnesyltransferase (FTase) inhibitor with IC₅₀s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC₅₀ of 3.44 μM .

β-Boswellic acid (Standard)	other families Classification of Application Fields Terpenoids Boswellia serrata Plants Burseraceae Disease Research Fields Source Classification Cancer	Reference Standards Lipoxygenase DNA/RNA Synthesis
β-Boswellic acid (Standard) is the analytical standard of β-Boswellic acid. This product is intended for research and analytical applications. β-Boswellic acid is isolated from the gum resin of Boswellia serrata. β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation . β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells .

L-2,5-Dihydrophenylalanine	Microorganisms Antibiotics Other Antibiotics Source Classification	Apoptosis
L-2,5-Dihydrophenylalanine can cause apoptosis of HL-60 in human myeloblastoid leukemia cells .

Piptocarphin F	Terpenoids Sesquiterpenes Plants Compositae Dalbergia frutescens (Vell.) Britton Source Classification	Others
Piptocarphin F (Compound 5) is a sesquiterpene lactone. Piptocarphin F shows cytotoxic activity on human leukemia cell line HL-60 (IC₅₀=5.69 μmol*L ^-1) .

11-epi-Chaetomugilin I	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Cancer Source Classification	Endogenous Metabolite
11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line .

Nb-Demethylechitamine	Apocynaceae Alkaloids Plants Indole Alkaloids Source Classification Alstonia rostrata C. E. C. Fischer	Others
Nb-Demethylechitamine is an alkaloid isolated from the methanol extract of Alstonia rostrata twigs. Nb-Demethylechitamine has in vitro cytotoxic activity against several human cancer cell lines, including human myeloid leukemia HL-60, liver cancer SMMC-7721, lung cancer A-549, breast cancer MCF-7, and colon cancer SW480 cells .

(+)-Mollisacacidin	Structural Classification Leguminosae Phenols Polyphenols Plants Albizia glaberrima (Schumach. & Thonn.) Benth. Source Classification	Others
(+)-Mollisacacidin is a flavan compound found in the root bark of Albizia glaberrima. (+)-Mollisacacidin exhibits no significant antiproliferative effect on cancer cells .

3-O-Deacetyl-3-O-tigloylsalannin	Structural Classification Terpenoids Melia azedarach L. Diterpenoids Plants Meliaceae Source Classification	Drug Derivative
3-O-Deacetyl-3-O-tigloylsalannin is a salannin-type limonoid and cytotoxic agent found in the fruits of Melia azedarach. 3-O-Deacetyl-3-O-tigloylsalannin can be used for the research of leukemia, stomach cancer, breast cancer .

Qinyangshengenin-3-O-β-D-digitoxopyranoside	Structural Classification Labiatae Plants Physostigma venenosum Balf. Steroids Source Classification	Drug Derivative
Qinyangshengenin-3-O-β-D-digitoxopyranoside is a C₂₁ steroidal glycoside that can be found in the whole herb of Prunella vulgaris Linn. Qinyangshengenin-3-O-β-D-digitoxopyranoside can be used for research of leukemia and lung cancer .

23-Hydroxyohchininolide	Structural Classification Terpenoids Melia azedarach L. Diterpenoids Plants Meliaceae Source Classification	NO Synthase EBV
23-Hydroxyohchininolide is a limonoid found in the leaves of Melia azedarach L.. 23-Hydroxyohchininolide inhibits LPS (HY-D1056)-induced NO production and exerts cytotoxic activity against human leukemia and stomach cancer cells. 23-Hydroxyohchininolide inhibits TPA (HY-18739)-induced Epstein-Barr virus early antigen activation. 23-Hydroxyohchininolide can be used for the research of cancer, infection and inflammatory disease .

21-Hydroxyisoohchininolide	Structural Classification Terpenoids Melia azedarach L. Diterpenoids Plants Meliaceae Source Classification	EBV
21-Hydroxyisoohchininolide is a salannin-type limonoid. 21-Hydroxyisoohchininolide inhibits lipopolysaccharide (LPS, HY-D1056)-induced nitric oxide production in mouse macrophages. 21-Hydroxyisoohchininolide exhibits cytotoxic activity against leukemia cells and breast cancer cells. 21-Hydroxyisoohchininolide suppresses phorbol 12-myristate 13-acetate (PMA) (HY-18739)-induced activation of Epstein-Barr virus early antigen in lymphocytes. 21-Hydroxyisoohchininolide can be used for the research of leukemia, breast cancer and inflammatory diseases .

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HL60 human leukemia cells

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