Search Result

Results for "

IGF

" in MedChemExpress (MCE) Product Catalog:

By Targets:	IGF-1R (95) ADC Antibody (1) Adenylate Cyclase (2) Akt (15) AMPK (5) Anaplastic lymphoma kinase (ALK) (14) Androgen Receptor (1) Antibiotic (2) Apoptosis (41) Aurora Kinase (3) Autophagy (4) Bacterial (2) Bcr-Abl (1) BRK (1) Btk (1) c-Kit (1) c-Myc (1) Calcium Channel (2) Carboxypeptidase (1) Caspase (2) Cholinesterase (ChE) (1) COX (2) DNA/RNA Synthesis (1) Drug Derivative (2) Drug Metabolite (6) EGFR (10) Endogenous Metabolite (8) Environmental Pollutants (1) ERK (1) FAK (3) Ferroptosis (5) FLT3 (1) Fungal (1) G Protein-coupled Receptor Kinase (GRK) (1) G-quadruplex (1) GHR (4) GHSR (3) Glycosidase (3) Influenza Virus (1) Insulin Receptor (35) Integrin (1) Interleukin Related (6) Isotope-Labeled Compounds (5) JAK (5) JNK (7) Keap1-Nrf2 (1) Mitochondrial Metabolism (1) MMP (2) mRNA (9) mTOR (2) NF-κB (8) NO Synthase (2) NOD-like Receptor (NLR) (1) p38 MAPK (6) Parasite (1) PARP (2) PDGFR (3) PDK-1 (1) PI3K (6) PKC (1) PPAR (1) PROTACs (2) Pyk2 (2) Pyroptosis (1) Reactive Oxygen Species (ROS) (2) Reference Standards (17) RET (1) ROCK (1) ROS Kinase (2) RSV (1) SARS-CoV (1) Ser/Thr Protease (1) Sirtuin (6) Small Interfering RNA (siRNA) (24) Somatostatin Receptor (5) Src (2) STAT (8) Telomerase (1) TGF-beta/Smad (2) TNF Receptor (5) Toll-like Receptor (TLR) (1) Trk Receptor (1) TSH Receptor (1) VEGFR (4)
By Research Areas:	Cancer (93) Cardiovascular Disease (12) Endocrinology (35) Infection (6) Inflammation/Immunology (33) Metabolic Disease (34) Neurological Disease (20)
Oligonucleotides:	Rat Pre-designed siRNA Sets (7) mRNA (9) Mouse Pre-designed siRNA Sets (7) Human Pre-designed siRNA Sets (8) Antisense Oligonucleotides (4) siRNAs (22)

179

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: IGF-1R

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10191

Linsitinib Maximum Cited Publications 51 Publications Verification OSI-906	IGF-1R Insulin Receptor	Endocrinology Cancer
Linsitinib (OSI-906) is a potent, selective and orally bioavailable dual inhibitor of the IGF-1 receptor and insulin receptor (IR) with IC₅₀s of 35 and 75 nM, respectively .

HY-15494

Picropodophyllin Maximum Cited Publications 30 Publications Verification AXL1717; Picropodophyllotoxin; PPP	IGF-1R Apoptosis	Endocrinology Cancer
Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC₅₀ of 1 nM.

HY-15656

Ceritinib 35+ Cited Publications LDK378	Anaplastic lymphoma kinase (ALK) Insulin Receptor IGF-1R	Metabolic Disease Inflammation/Immunology Cancer
Ceritinib (LDK378) is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC₅₀ of 200 pM. Ceritinib also inhibits *IGF-1R, InsR, and STK22D* with IC₅₀ values of 8, 7, and 23 nM, respectively. Ceritinib shows great antitumor potency .

HY-153274

CWI1-2 4 Publications Verification	Apoptosis	Cancer
CWI1-2 is an *IGF2BP2* inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects .

HY-N0908

Ginsenoside Rg5 3 Publications Verification	IGF-1R NF-κB COX	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Ginsenoside Rg5 is the main component of Red ginseng and *IGF-1R* agonist. Ginsenoside Rg5 compets for the binding site of IGF-1R and blocks the binding of *IGF-1* to IGF-1R (IC₅₀ about 90 nM). Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65.

HY-P99165

Teprotumumab 1 Publications Verification	IGF-1R TSH Receptor	Endocrinology
Teprotumumab is an **IGF-1 receptor (IGF-1R)** blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research .

HY-P99294

Ganitumab 1 Publications Verification AMG 479; Human Anti-IGF1R Recombinant Antibody	IGF-1R	Cancer
Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (K_D=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer .

HY-15609

AZD-3463 1 Publications Verification ALK/IGF1R inhibitor	IGF-1R Anaplastic lymphoma kinase (ALK) Autophagy Apoptosis	Endocrinology Cancer
AZD-3463 (ALK/IGF1R inhibitor) is an orally active *ALK/IGF1R* inhibitor, with a K_i of 0.75 nM for ALK. AZD3463 induces apoptosis and autophagy in neuroblastoma cells .

HY-10262

BMS-536924 5+ Cited Publications	IGF-1R Insulin Receptor Apoptosis	Endocrinology Cancer
BMS-536924 is an orally active, competitive and selective insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IR) inhibitor with IC₅₀s of 100 nM and 73 nM, respectively. BMS-536924 has anti-cancer activity .

HY-10253

AG1024 5+ Cited Publications Tyrphostin AG 1024	IGF-1R Insulin Receptor Apoptosis	Endocrinology Cancer
AG1024 (Tyrphostin AG 1024) is a reversible, competitive and selective *IGF-1R* inhibitor with an IC₅₀ of 7 μM. AG1024 inhibits phosphorylation of IR (IC₅₀=57 μM). AG1024 induces apoptosis and has anti-cancer activity .

HY-15656A

Ceritinib dihydrochloride 35+ Cited Publications LDK378 dihydrochloride	Anaplastic lymphoma kinase (ALK) Insulin Receptor IGF-1R	Metabolic Disease Inflammation/Immunology Cancer
Ceritinib (LDK378) dihydrochloride is a selective, orally bioavailable and ATP-competitive ALK tyrosine kinase inhibitor with an IC₅₀ of 200 pM. Ceritinib dihydrochloride also inhibits *IGF-1R, InsR, and STK22D* with IC₅₀ values of 8, 7, and 23 nM, respectively. Ceritinib dihydrochloride shows great antitumor potency .

HY-144873

AVJ16	Insulin Receptor Apoptosis	Cancer
AVJ16 is a cancer cell migration inhibitor that targets the insulin-like growth factor 2 mRNA binding protein *IGF2BP1* with a good affinity of K_d of 1.4μM. AVJ16 interferes with IGF2BP1 binding target mRNA to regulate gene expression and translation .

HY-50866

NVP-AEW541 10+ Cited Publications AEW541	IGF-1R Insulin Receptor Autophagy	Endocrinology Cancer
NVP-AEW541 (AEW541 ) is an orally active inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with an IC₅₀ value of 0.15 μM. NVP-AEW541 also inhibits InsR, IC₅₀ with a value of 0.14 μM. NVP-AEW541 has antitumor activity .

HY-P99197

Figitumumab CP-751871	IGF-1R	Cancer
Figitumumab (CP-751871) is a potent and fully human monoclonal anti–insulin-like growth factor 1 receptor (IGF1R) antibody. Figitumumab prevents IGF1 from binding to IGF1R with an IC₅₀ of 1.8 nM .

HY-B0025

Voglibose 1 Publications Verification	Glycosidase	Metabolic Disease
Voglibose is an orally active alpha-glucosidase inhibitor that prevents the development of colorectal precancerous lesions induced by obesity and diabetes. Voglibose reduces oxidative stress in an inflammatory environment and inhibits the insulin-like growth factor/insulin-like growth factor-1 receptor (IGF/IGF-1R) functional axis .

HY-13203

NVP-TAE 226 5+ Cited Publications TAE226	FAK Pyk2 IGF-1R Insulin Receptor Apoptosis	Endocrinology Cancer
NVP-TAE 226 (TAE226) is a potent and ATP-competitive dual FAK and *IGF-1R* inhibitor with IC₅₀s of 5.5 nM and 140 nM, respectively. NVP-TAE 226 (TAE226) also effectively inhibits Pyk2 and insulin receptor (InsR) with IC₅₀s of 3.5 nM and 44 nM, respectively .

HY-P99274

Xentuzumab 1 Publications Verification BI 836845; Anti-Human IGF1 and IGF2 Recombinant Antibody	IGF-1R	Cancer
Xentuzumab (Anti-Human IGF1 and IGF2 Recombinant Antibody; BI836845) is a recombinant a human monoclonal antibody that targets IGF ligands *IGF1* and *IGF2. Xentuzumab inhibits both of IGF1* and *IGF2* growth-promoting signalling and suppresses AKT activation .

HY-108905

Mecasermin Human IGF-I; FK 780	IGF-1R	Metabolic Disease
Mecasermin (Human IGF-I; FK 780) is a recombinant human insulin-like growth factor I (IGF-I). Mecasermin has the potential for the study of the growth failure of growth hormone (GH) insensitivity caused by GH receptor defects or GH-inhibiting antibodies .

HY-156110

IGF2BP1-IN-1	Insulin Receptor	Cancer
IGF2BP1-IN-1 (Compound A11) is a *IGF2BP1* inhibitor and inhibits downstream signaling. IGF2BP1-IN-1 binds to IGF2BP1 protein with a K_D value of 2.88 nM. IGF2BP1-IN-1 inhibits cancer cells proliferation (IC₅₀: 9 nM for A549 cell, 34 nM for HCT116). IGF2BP1-IN-1 induces cancer cell apoptosis. GF2BP1-IN-1 inhibits tumor growth in A549 xenograft mouse model .

HY-176471

IGF2BP3-IN-1	Insulin Receptor	Cancer
IGF2BP3-IN-1 (Compound I3IN-122) is an *IGF2BP3* (a RNA binding protein) inhibitor (IC₅₀: > 50 μM), and can be used for cancer research .

HY-P99284

Dalotuzumab 1 Publications Verification MK-0646; h7C10	IGF-1R Apoptosis	Cancer
Dalotuzumab (MK-0646) is a recombinant humanized monoclonal antibody (IgG1 type) targeting *IGF-1R. Dalotuzumab acts by inhibiting IGF-1- and IGF-2*-mediated tumor cell proliferation, *IGF-1R* autophosphorylation, and Akt phosphorylation. Dalotuzumab also induces apoptosis and cycle arrest. Dalotuzumab in combination with other anticancer agents such as statins can enhance the antitumor activity of Dalotuzumab in vitro and in vivo .

HY-P99672

Istiratumab MM 141; MM-005	IGF-1R EGFR	Cancer
Istiratumab (M-6495) is bispecific monoclonal antibody targeting *IGF-1R* and ErbB3. Istiratumab induces IGF-1R and ErbB3 receptor degradation through the proteasome pathway Istiratumab can be used for research of cancers .

HY-13686

PQ401 2 Publications Verification	IGF-1R Apoptosis	Cancer
PQ401 is a potent inhibitor of *IGF-IR* signaling. PQ401 inhibits IGF-I-stimulated IGF-IR autophosphorylation with an IC₅₀ of 12.0 μM in a series of studies in MCF-7 cells. PQ401 is effective at inhibiting IGF-I-stimulated growth of MCF-7 cells (IC₅₀, 6 μM). PQ401 is a potential agent for breast and other IGF-I-sensitive cancers. PQ401 induces caspase-mediated apoptosis .

HY-15749

XL228 4 Publications Verification	Aurora Kinase Bcr-Abl IGF-1R Src	Endocrinology Cancer
XL228 is a multi-targeted tyrosine kinase inhibitor with IC₅₀s of 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, *IGF-1R, Src* and Lyn, respectively.

HY-153274A

CWI1-2 hydrochloride 4 Publications Verification	Apoptosis	Cancer
CWI1-2 hydrochloride is an *IGF2BP2* inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects .

HY-P1777

IGF-I (24-41) Insulin-like Growth Factor I (24-41)	IGF-1R	Metabolic Disease Inflammation/Immunology
IGF-I (24-41) (Insulin-like Growth Factor I (24-41)) is amino acids 24 to 41 fragment of IGF-I. IGF-I, a 70 aa polypeptide hormone, is a trophic factor for both neurons and glial cells. IGF-I is partly responsible for systemic growth hormone (GH) activities. IGF-I has anabolic, antioxidant, anti-inflammatory and cytoprotective actions. IGF-I (24-41) regulates somatic growth and behavioral development .

HY-P3226

JB-1	IGF-1R VEGFR Drug Derivative	Cardiovascular Disease Neurological Disease
JB-1, an IGF-I analog, is a selective *IGF-I* receptor inhibitor that does not interact with IGF-II. JB-1 competes with IGF-I for binding to *IGF-1R* and blocks receptor autophosphorylation. JB-1 increases the level of sVEGFR-1. JB-1 normalizes retinal abnormalities, including reducing retinal neovascularization. JB-1 is applicable to studies related to oxygen-induced retinopathy .

HY-18785

Indirubin Derivative E804	IGF-1R	Endocrinology Cancer
Indirubin Derivative E804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor *(IGF1R), with an IC₅₀* of 0.65 μM for IGF1R.

HY-115449

Chromeceptin 2 Publications Verification 94G6	IGF-1R Akt mTOR	Cancer
Chromeceptin (94G6) is an IGF signaling pathway inhibitor. Chromeceptin suppresses IGF2 expression at mRNA and protein levels in hepatocyte and HCC cells. Chromeceptin inhibits the phosphorylation levels of AKT and mTOR .

HY-145110

IGF-1R inhibitor-2	IGF-1R	Cancer
IGF-1R inhibitor-2 (example 121) is an insulin-like growth factor-1 receptor (IGF-1R) inhibitor. Downregulation of IGF-1R can reverse the transformed phenotype of tumor cells and potentially render them susceptible to apoptosis .

HY-110135A

NBI-31772 hydrate 3 Publications Verification	IGF-1R	Neurological Disease
NBI-31772 hydrate is a potent inhibitor of interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs). NBI-31772 hydrate is also a nonpeptide ligand that releases bioactive IGF-I from the IGF-I/IGFBP-3 complex (K_is=1-24 nM for all six human subtypes). Anxiolytic and antidepressant-like effects .

HY-P990084

Veligrotug AVE1642; VRDN-001	IGF-1R Akt	Neurological Disease Endocrinology
Veligrotug (AVE1642) is a selective, fully human *IGF-1R* antagonist antibody with a K_d value of 0.55 nM for hIGF-1R. Veligrotug blocks the phosphorylation of downstream AKT. Veligrotug is applicable to research related to thyroid eye disease .

HY-P10044

IGF1Rtide	RET	Others
IGF1Rtide can be used as a RET kinase substrate for RET kinase assays .

HY-RS06620

IGF2BP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IGF2BP2 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2BP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IGF2BP2 Human Pre-designed siRNA Set A IGF2BP2 Human Pre-designed siRNA Set A

HY-P99712

Lonigutamab hz208F2-4	IGF-1R Apoptosis ADC Antibody	Cancer
Lonigutamab (hz208F2-4) is a humanized anti-IGF-1R monoclonal antibody, serveing as a targeting vector for antibody-drug conjugates (ADCs). Lonigutamab causes G2-M phase cell cycle arrest and increases apoptosis in IGF-1R-overexpressing tumor cells. Lonigutamab demonstrates potent antitumor efficacy in *IGF-1R*-overexpressing xenograft models. Lonigutamab can be used for the study of Solid tumors with overexpression of *IGF-1R* and thyroid eye diseases .

HY-135436

AG 538	IGF-1R	Cancer
AG 538 is a potent, competitive inhibitor of IGF-1 receptor kinase, with an IC₅₀ of 400 nM .

HY-135680

I-OMe-Tyrphostin AG 538 1 Publications Verification I-OMe-AG 538	IGF-1R	Metabolic Disease Cancer
I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of *IGF-1R* (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells.?I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC₅₀?of 1 μM .

HY-15494R

Picropodophyllin (Standard) AXL1717 (Standard); Picropodophyllotoxin (Standard); PPP (Standard)	IGF-1R Apoptosis Reference Standards	Endocrinology Cancer
Picropodophyllin (Standard) is the analytical standard of Picropodophyllin. This product is intended for research and analytical applications. Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM.

HY-P99218

Robatumumab Sch 717454; 19D12	IGF-1R	Cancer
Robatumumab (Sch 717454) is an anti-human *IGF-1R* (insulin-like growth factor receptor-1) antibody. Robatumumab shows anti-tumor activity and anti-proliferative activity to cancer cells. Robatumumab can be used in osteosarcoma and Ewing sarcoma research .

HY-N6611

Chimaphilin	IGF-1R	Infection Inflammation/Immunology Cancer
Chimaphilin is an *IGF-1R* inhibitor (IC₅₀: 0.086 μM). Chimaphilin has antifungal, antioxidant and anticancer activities. Chimaphilin inhibits the growth of both drug-sensitive and drug-resistant osteosarcoma cell lines. Chimaphilin can induce cancer cell apoptosis. Chimaphilin is a main component of pyrola .

HY-156914

IGF-1R/SRC-IN-1	IGF-1R Src	Cancer
IGF-1R/SRC-IN-1 (Compound 3b) is an inhibitor for *IGF-1R* (IC₅₀ is 63 μM) and SRC .

HY-174655

*Human IGF1 mRNA*	mRNA	Metabolic Disease
Human IGF1 mRNA encodes the human insulin like growth factor 1 (IGF1) protein which is involved in mediating growth and development.

HY-RS06618

IGF2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IGF2 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IGF2 Human Pre-designed siRNA Set A IGF2 Human Pre-designed siRNA Set A

HY-RS06619

IGF2BP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IGF2BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IGF2BP1 Human Pre-designed siRNA Set A IGF2BP1 Human Pre-designed siRNA Set A

HY-RS06621

IGF2BP3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IGF2BP3 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2BP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IGF2BP3 Human Pre-designed siRNA Set A IGF2BP3 Human Pre-designed siRNA Set A

HY-153485

Cimdelirsen ISIS 766720; IONIS-GHR-LRx	GHR Small Interfering RNA (siRNA)	Others
Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor-1 (IGF-1) levels in acromegaly patients.

HY-112720

AGL-2263 1 Publications Verification	Insulin Receptor	Metabolic Disease Endocrinology
AGL-2263 is an insulin receptor and *insulin-like growth factor (IGF) receptor* inhibitor .

HY-13312A

GTx-134	IGF-1R Insulin Receptor Akt Apoptosis	Cancer
GTx-134 is a dual insulin-like growth factor 1 receptor/insulin receptor (IGF-1R/IR) inhibitor with an IC₅₀ values for IGF-1R and IR of 97 and 187 nM respectively. GTx-134 inhibits the autophosphorylation of IGF-1R and its downstream signaling pathway (Akt), thereby blocking the proliferation and survival signals of tumor cells. GTx-134 has broad-spectrum inhibitory activity against multiple myeloma cell lines and can induce apoptosis in sensitive cells. GTx-134 significantly inhibits tumor growth in mice with MM1.S cell transplantation. GTx-134 works in synergy with existing therapies (such as protease preparations, immunomodulators). GTx-134 can be used in high-risk myeloma research .

HY-153485A

Cimdelirsen sodium ISIS 766720 sodium; IONIS-GHR-LRx sodium	GHR Small Interfering RNA (siRNA)	Others
Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor-1 (IGF-1) levels in acromegaly patients.

HY-162506

IGF-1R inhibitor-3	IGF-1R	Cancer
IGF-1R inhibitor-3 (Compound C11) is an allosteric inhibitor for insulin-like growth factor receptor 1 kinase (IGF-1R), with an IC₅₀ of 0.2 μM .

Cat. No.	Product Name

HY-L034

Anti-Aging Compound Library

7,297 compounds

Aging is a complex biological process characterized by functional decline of tissues and organs, structural degeneration, and reduced adaptability and resistance, all of which contribute to an increase in morbidity and mortality caused by multiple chronic diseases, such as Alzheimer's disease, cancer, and diabetes. Many theories, which fall into two main categories: programmed and error theories, have been proposed to explain the process of aging, but neither of them appears to be fully satisfactory. The programmed theories imply that aging relies on specific gene regulation, and the error theories emphasize the internal and environmental damages accumulated to living organisms. The damage theories proposed the nine hallmarks that were generally considered to contribute to the aging process: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication.

MCE Anti-Aging Compound Library contains 7,297 compounds, mainly targeting Sirtuin, mTOR, IGF-1R, AMPK, p53, Telomerase, Mitophagy, Mitochondrial Metabolism, COX, Cytochrome P450, Oxidase, etc. This library is a useful tool for anti-aging research.

HY-L124

Anti-Prostate Cancer Compound Library

3,419 compounds

Cancer is one of the leading causes of mortality amongst world’s population, in which prostate cancer (PCa) is one of the most encountered malignancies among men. Several molecular mechanisms are involved in prostate cancer development and progression. These include common survival factors in prostate cancer (IGF-1), growth factors (TGF-α, EGF), Wnt, Hedgehog, NF-κB, and mTOR and other signaling pathways. These provide potential therapeutic target in prostate cancer treatment.

MCE offers a unique collection of 3,419 compounds with identified and potential anti-prostate cancer activity. MCE Anti-Prostate Cancer Compound Library is a useful tool for anti-prostate cancer drugs screening and other related research.

HY-L034M

Anti-Aging Compound Library Mini

381 compounds

Research has shown that drugs targeting aging pathways demonstrate promising potential in models of age-related diseases such as Alzheimer's disease, cardiovascular diseases, metabolic syndrome, osteoarthritis, and various malignancies. This suggests that intervening in the biological processes of aging may enable synergistic prevention and treatment of multiple chronic diseases. Against the backdrop of the gradual elucidation of core aging mechanisms-including cellular senescence, telomere attrition, epigenetic dysregulation, and chronic inflammation anti-aging research has shifted from traditional phenotypic interventions toward targeting key pathways that regulate biological age.

The MCE Anti-Aging Compound Library Mini is precisely built upon this cutting-edge concept. It focuses on aging-related targets validated through genetic or functional studies, comprising 381 compounds designed to provide systematic research tools for aging biology and intervention strategy development. The library covers core mechanisms such as mTOR, SIRT, energy metabolism, clearance of senescent cells, optimization of mitochondrial function, and telomere maintenance. For each target, 1-5 compounds with clear activity and strong representativeness have been carefully selected, spanning the entire translational spectrum from preclinical tool molecules to clinically investigational drugs.

Cat. No.	Product Name	Target	Research Area

HY-16381

Pasireotide Maximum Cited Publications 6 Publications Verification SOM230	Somatostatin Receptor	Endocrinology Cancer
Pasireotide (SOM230), a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pK_i=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide can suppress GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. Pasireotide also exhibits antisecretory, antiproliferative, and proapoptotic activity .

HY-108905

Mecasermin Human IGF-I; FK 780	IGF-1R	Metabolic Disease
Mecasermin (Human IGF-I; FK 780) is a recombinant human insulin-like growth factor I (IGF-I). Mecasermin has the potential for the study of the growth failure of growth hormone (GH) insensitivity caused by GH receptor defects or GH-inhibiting antibodies .

HY-P5133

Synstatin (92-119) 1 Publications Verification SSTN92-119	Integrin	Cancer
Synstatin (92-119) is an inhibitor of αvβ3/αvβ5 integrins and *IGF1R* with anti-angiogenic, anti-proliferative, antioxidant and anti-tumor activities. Synstatin (92-119) competitively blocks the capture of αvβ3/αvβ5 integrins and *IGF1R* by syndecan-1, disrupts the formation of the syndecan-1 : integrin : *IGF1R* ternary complex, inhibits integrin activation and talin-mediated signaling pathways, and blocks VEGF-induced angiogenesis. Synstatin (92-119) is applicable to research related to cancer and hepatocellular carcinoma .

HY-16381A

Pasireotide acetate 2 Publications Verification SOM230 acetate	Somatostatin Receptor	Endocrinology Cancer
Pasireotide (SOM230) acetate, a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pK_i=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide acetate can suppress GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. Pasireotide acetate also exhibits antisecretory, antiproliferative, and proapoptotic activity .

HY-P1777

IGF-I (24-41) Insulin-like Growth Factor I (24-41)	IGF-1R	Metabolic Disease Inflammation/Immunology
IGF-I (24-41) (Insulin-like Growth Factor I (24-41)) is amino acids 24 to 41 fragment of IGF-I. IGF-I, a 70 aa polypeptide hormone, is a trophic factor for both neurons and glial cells. IGF-I is partly responsible for systemic growth hormone (GH) activities. IGF-I has anabolic, antioxidant, anti-inflammatory and cytoprotective actions. IGF-I (24-41) regulates somatic growth and behavioral development .

HY-P3226

JB-1	IGF-1R VEGFR Drug Derivative	Cardiovascular Disease Neurological Disease
JB-1, an IGF-I analog, is a selective *IGF-I* receptor inhibitor that does not interact with IGF-II. JB-1 competes with IGF-I for binding to *IGF-1R* and blocks receptor autophosphorylation. JB-1 increases the level of sVEGFR-1. JB-1 normalizes retinal abnormalities, including reducing retinal neovascularization. JB-1 is applicable to studies related to oxygen-induced retinopathy .

HY-P5438

Srctide	Btk c-Kit FAK FLT3 Insulin Receptor	Others
Srctide is a biological active peptide. (This is a peptide substrate for many protein kinases, such as Blk, BTK, cKit, EPHA1, EPHB2, EPHB3, ERBB4, FAK, Flt3, IGF-1R, ITK, Lck, MET, MUSK, Ret, Src, TIE2, TrkB, VEGF-R1 (Flt-1) and VEGF-R2 (KDR).)

HY-P10044

IGF1Rtide	RET	Others
IGF1Rtide can be used as a RET kinase substrate for RET kinase assays .

HY-P4813

Preptin (rat)	DNA/RNA Synthesis	Metabolic Disease
Preptin, an osteogenic peptide product of the pancreatic beta-cell, corresponds to Asp ⁶⁹-Leu ¹⁰² of pro-IGF-II .

HY-P2090A

Angiopeptin TFA	Somatostatin Receptor Adenylate Cyclase	Cardiovascular Disease
Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, is a weak sst₂/sst₅ receptor partial agonist with IC₅₀ values of 0.26 nM and 6.92 nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin TFA has the potential for coronary atherosclerosis research .

HY-P11431

Cyclo(Gly-Pro)	IGF-1R	Neurological Disease Inflammation/Immunology
Cyclo(Gly-Pro) is a cyclic dipeptide. Cyclo(Gly-Pro) can be derived from the Nterminus of the *IGF-1*. Cyclo(Gly-Pro) attenuates nociceptive behaviour and inflammatory response in mice .

HY-P1777A

IGF-I (24-41) TFA Insulin-like Growth Factor I (24-41) TFA	IGF-1R	Metabolic Disease Inflammation/Immunology
IGF-I (24-41) (Insulin-like Growth Factor I (24-41)) TFA is amino acids 24 to 41 fragment of IGF-I. IGF-I TFA, a 70 aa polypeptide hormone, is a trophic factor for both neurons and glial cells. IGF-I TFA is partly responsible for systemic growth hormone (GH) activities. IGF-I TFA has anabolic, antioxidant, anti-inflammatory and cytoprotective actions. IGF-I (24-41) TFA regulates somatic growth and behavioral development .

HY-P1773

IGF-I (30-41) Insulin-like Growth Factor I (30-41)	Insulin Receptor	Metabolic Disease Inflammation/Immunology
IGF-I (30-41) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I). IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions) .

HY-P1773A

IGF-I (30-41) TFA Insulin-like Growth Factor I (30-41) TFA	IGF-1R	Metabolic Disease Inflammation/Immunology
IGF-I (30-41) (TFA) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I). IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions) .

HY-P5527F

FAM-CSKtide	Peptides	Others
FAM-CSKtide is a biological active peptide. (This is a FAM labeled peptide substrate (Abs/Em = 494/521 nm) for C-terminal Src kinase (Csk) and many other kinases such as Axl, cKit, ERBB4, Fes, Flt3, IGF-1 R, MET, MUSK, PYK2, Ret, TIE2, TrkA, VEGF-R1 and VEGF-R2.)

HY-P2090

Angiopeptin	Somatostatin Receptor Adenylate Cyclase	Cardiovascular Disease
Angiopeptin, a cyclic octapeptide analogue of somatostatin, is a weak sst₂/sst₅ receptor partial agonist with IC₅₀ values of 0.26 nM and 6.92 nM, respectively. Angiopeptin is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin has the potential for coronary atherosclerosis research .

HY-175053

Pasireotide (aspartate) TFA SOM230 (aspartate) TFA	Somatostatin Receptor Apoptosis	Metabolic Disease
Pasireotide (aspartate) TFA, a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pK_i=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide (aspartate) TFA can suppress GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. Pasireotide (aspartate) TFA also exhibits antisecretory, antiproliferative, and proapoptotic activity .

HY-P11620

H-Asn-Pro-Glu-Tyr(PO3H2)-OH	Drug Derivative	Others
H-Asn-Pro-Glu-Tyr(PO3H2)-OH is a phosphorylated peptide derivative of the tetramine motif Asn-Pro-Glu-Tyr (NPEY), and is a substrate binding domain common to the insulin-like growth factor-I receptor (IGF-IR) and the insulin receptor (IR).

Cat. No.	Product Name	Target	Research Area	Image

HY-P99165

Teprotumumab 1 Publications Verification	IGF-1R TSH Receptor	Endocrinology
Teprotumumab is an **IGF-1 receptor (IGF-1R)** blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research .

HY-P99294

Ganitumab 1 Publications Verification AMG 479; Human Anti-IGF1R Recombinant Antibody	IGF-1R	Cancer
Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (K_D=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer .

HY-P99197

Figitumumab CP-751871	IGF-1R	Cancer
Figitumumab (CP-751871) is a potent and fully human monoclonal anti–insulin-like growth factor 1 receptor (IGF1R) antibody. Figitumumab prevents IGF1 from binding to IGF1R with an IC₅₀ of 1.8 nM .

HY-P99274

Xentuzumab 1 Publications Verification BI 836845; Anti-Human IGF1 and IGF2 Recombinant Antibody	IGF-1R	Cancer
Xentuzumab (Anti-Human IGF1 and IGF2 Recombinant Antibody; BI836845) is a recombinant a human monoclonal antibody that targets IGF ligands *IGF1* and *IGF2. Xentuzumab inhibits both of IGF1* and *IGF2* growth-promoting signalling and suppresses AKT activation .

HY-P99189

Cixutumumab IMC-A12; NSC742460	IGF-1R	Cancer
Cixutumumab (IMC-A12) is a human anti-IGF-1R monoclonal antibody with high affinity that inhibits ligand-dependent receptor activation and downstream signaling. Cixutumumab also mediates the internalization and degradation of *IGF-IR*. Cixutumumab shows broad-spectrum anti-tumour activity and can be used in studies of cancers such as lung cancer, malignancies, leukaemia, non-small cell lung cancer and prostate cancer .

HY-P99284

Dalotuzumab 1 Publications Verification MK-0646; h7C10	IGF-1R Apoptosis	Cancer
Dalotuzumab (MK-0646) is a recombinant humanized monoclonal antibody (IgG1 type) targeting *IGF-1R. Dalotuzumab acts by inhibiting IGF-1- and IGF-2*-mediated tumor cell proliferation, *IGF-1R* autophosphorylation, and Akt phosphorylation. Dalotuzumab also induces apoptosis and cycle arrest. Dalotuzumab in combination with other anticancer agents such as statins can enhance the antitumor activity of Dalotuzumab in vitro and in vivo .

HY-P99672

Istiratumab MM 141; MM-005	IGF-1R EGFR	Cancer
Istiratumab (M-6495) is bispecific monoclonal antibody targeting *IGF-1R* and ErbB3. Istiratumab induces IGF-1R and ErbB3 receptor degradation through the proteasome pathway Istiratumab can be used for research of cancers .

HY-P991487

LASN01	Interleukin Related	Inflammation/Immunology
LASN01 is a human IgG1 monoclonal antibody (mAb) targeting IL-11RA. LASN01 inhibits IGF-1 and IL-11-induced hyaluronic acid (HA) release and TGFβ-stimulated procollagen in orbital fibroblasts. LASN01 can be used in thyroid eye disease (TED) research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990084

Veligrotug AVE1642; VRDN-001	IGF-1R Akt	Neurological Disease Endocrinology
Veligrotug (AVE1642) is a selective, fully human *IGF-1R* antagonist antibody with a K_d value of 0.55 nM for hIGF-1R. Veligrotug blocks the phosphorylation of downstream AKT. Veligrotug is applicable to research related to thyroid eye disease .

HY-P99712

Lonigutamab hz208F2-4	IGF-1R Apoptosis ADC Antibody	Cancer
Lonigutamab (hz208F2-4) is a humanized anti-IGF-1R monoclonal antibody, serveing as a targeting vector for antibody-drug conjugates (ADCs). Lonigutamab causes G2-M phase cell cycle arrest and increases apoptosis in IGF-1R-overexpressing tumor cells. Lonigutamab demonstrates potent antitumor efficacy in *IGF-1R*-overexpressing xenograft models. Lonigutamab can be used for the study of Solid tumors with overexpression of *IGF-1R* and thyroid eye diseases .

HY-P99218

Robatumumab Sch 717454; 19D12	IGF-1R	Cancer
Robatumumab (Sch 717454) is an anti-human *IGF-1R* (insulin-like growth factor receptor-1) antibody. Robatumumab shows anti-tumor activity and anti-proliferative activity to cancer cells. Robatumumab can be used in osteosarcoma and Ewing sarcoma research .

HY-P991042

Anti-IGFBP2 Antibody (M14)	IGF-1R	Cancer
Anti-IGFBP2 Antibody (M14) is an human anti-IGFBP2 monoclonal inhibitory antibody, which binds IGFBP2 with high affinity and blocks its binding with IGF1. Anti-IGFBP2 Antibody (M14) inhibits human endothelial cell recruitment, thus blocks the tumor progression of human metastatic cancer .

HY-P990441

*Anti-IGF-2 Antibody (DX-2647)* DX-2647	Inhibitory Antibodies	Inflammation/Immunology
Anti-IGF-2 Antibody (DX-2647) is a CHO-expressed human antibody that targets *IGF-2. Anti-IGF-2 Antibody (DX-2647) has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.78 kDa. The isotype control for Anti-IGF*-2 Antibody (DX-2647) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P99867

Dusigitumab MEDI 573	Inhibitory Antibodies	Cancer
Dusigitumab is a fully human IgG2λ monoclonal antibody that targets *IGF-1* and *IGF-2* with picomolar binding affinity. Dusigitumab blocks *IGF-1* and *IGF-2*-induced phosphorylation of *IGF-1R* as well as activation of IR-A, thereby inhibiting the activation of downstream signaling pathways. Dusigitumab is applicable to research related to advanced solid tumors and hormone receptor-positive metastatic breast cancer .

HY-P991253

BIIB022	IGF-1R	Cancer
BIIB022 is a human IgG4 monoclonal antibody (mAb) targeting *IGF1R/CD221. BIIB022 blocks IGF-1 and IGF-2-induced phosphorylation of IGF*-1R and downstream substrates. BIIB022 can be used in lung, pancreatic, and colon cancer research. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003) .

HY-P991134

Elegrobart	IGF-1R	Inflammation/Immunology
Elegrobart is an immunoglobulin G1-κ monoclonal antibody targeting the human insulin-like growth factor 1 receptor (IGF1R). Elegrobart is promising for research of diseases associated with abnormal IGF1R signaling, especially thyroid eye disease .

HY-P991255

VRDN-002	IGF-1R	Inflammation/Immunology
VRDN-002 is a human monoclonal antibody (mAb) targeting *IGF1R/CD221*. VRDN-002 reduces inflammation and proptosis in thyroid eye disease (TED). VPI-2690B can be used in Graves ophthalmopathy research .

HY-P990966

Redalsomatropin alfa JR-142	GHR IGF-1R	Others
Redalsomatropin alfa (JR-142) is a recombinant long-acting growth hormone. Redalsomatropin alfa extends its half-life through fusion with modified serum albumin. Redalsomatropin alfa is well-tolerated and can maintain *IGF-1* levels. Redalsomatropin alfa can be used in research related to growth hormone deficiency .

HY-P990440

*Anti-IGF1R/CD221 Antibody*	Inhibitory Antibodies	Inflammation/Immunology
Anti-IGF1R/CD221 Antibody is a CHO-expressed human antibody that targets *IGF1R/CD221. Anti-IGF1R/CD221 Antibody contains huIgG1 heavy chains and huκ light chains, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-IGF*1R/CD221 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15494

Picropodophyllin Maximum Cited Publications 30 Publications Verification AXL1717; Picropodophyllotoxin; PPP	Classification of Application Fields Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Disease Research Fields Endocrinology Source Classification	IGF-1R Apoptosis
Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC₅₀ of 1 nM.

HY-113402

Gamma-glutamylcysteine 4 Publications Verification γ-Glu-Cys	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite Interleukin Related TNF Receptor AMPK Sirtuin STAT PI3K NF-κB JAK p38 MAPK JNK Akt Apoptosis Ferroptosis
Gamma-glutamylcysteine (γ-Glu-Cys) is an orally active, blood-brain barrier permeable dipeptide . Gamma-glutamylcysteine activates AMPK, SIRT1, IL-4/STAT6, AC/cAMP/PI3K, *IGF-1R/IRS1/PI3K*, and Nrf2 signaling pathways; it inhibits NF-κB, JAK1/STAT1/3, MAPKs, cadmium-induced p38 MAPK, JNK, and PI3K/Akt signaling pathways. Gamma-glutamylcysteine regulates macrophage polarization, modulates the trafficking of CD36 and GLUT4, induces glutathione synthesis, improves metabolic dysfunction, reduces lipid deposition, ameliorates glucose homeostasis, inhibits apoptosis (Apoptosis), stabilizes mitochondria, suppresses lipid peroxidation, iron accumulation and ferroptosis (Ferroptosis), reduces ds-HMGB1 levels, reverses mechanical hyperalgesia, and alleviates hepatic lipid droplet formation. Gamma-glutamylcysteine is applicable to research related to inflammatory bowel disease, type 2 diabetes, cadmium-induced neurotoxicity, Alzheimer's disease, cerebral ischemia/reperfusion injury, neuropathy, and alcoholic liver disease .

HY-N0908

Ginsenoside Rg5 3 Publications Verification	Panax ginseng C. A. Meyer Cardiovascular Disease Triterpenes Classification of Application Fields Terpenoids Plants Inflammation/Immunology Disease Research Fields Araliaceae Endocrinology Source Classification	IGF-1R NF-κB COX
Ginsenoside Rg5 is the main component of Red ginseng and *IGF-1R* agonist. Ginsenoside Rg5 compets for the binding site of IGF-1R and blocks the binding of *IGF-1* to IGF-1R (IC₅₀ about 90 nM). Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65.

HY-W015924

2-Hydroxyisobutyric acid	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
2-Hydroxyisobutyric acid (2-HIBA) is a selective modulator of the *Insulin/IGF-1* pathway and the p38 MAPK pathway, which reduces reactive oxygen species (ROS) and fat accumulation in Caenorhabditis elegans. 2-Hydroxyisobutyric acid promotes β-oxidation and inhibits fatty acid synthesis by upregulating SKN-1/NRF2 and downregulating SREBP-1c transcription factors. 2-Hydroxyisobutyric acid has anti-aging and lipid-lowering effects, and can be used to study metabolic diseases such as obesity and diabetes. 2-Hydroxyisobutyric acid is also a renewable precursor of methacrylate through 2-HIB-CoA mutase-mediated biosynthesis[1][2].

HY-113402A

Gamma-glutamylcysteine TFA 4 Publications Verification γ-Glu-Cys TFA	Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Interleukin Related TNF Receptor Endogenous Metabolite AMPK Sirtuin STAT PI3K NF-κB JAK p38 MAPK JNK Akt Apoptosis Ferroptosis
Gamma-glutamylcysteine TFA (γ-Glu-Cys TFA) is an orally active, blood-brain barrier permeable dipeptide . Gamma-glutamylcysteine TFA activates AMPK, SIRT1, IL-4/STAT6, AC/cAMP/PI3K, *IGF-1R/IRS1/PI3K*, and Nrf2 signaling pathways; it inhibits NF-κB, JAK1/STAT1/3, MAPKs, cadmium-induced p38 MAPK, JNK, and PI3K/Akt signaling pathways. Gamma-glutamylcysteine TFA regulates macrophage polarization, modulates the trafficking of CD36 and GLUT4, induces glutathione synthesis, improves metabolic dysfunction, reduces lipid deposition, ameliorates glucose homeostasis, inhibits apoptosis (Apoptosis), stabilizes mitochondria, suppresses lipid peroxidation, iron accumulation and ferroptosis (Ferroptosis), reduces ds-HMGB1 levels, reverses mechanical hyperalgesia, and alleviates hepatic lipid droplet formation. Gamma-glutamylcysteine TFA is applicable to research related to inflammatory bowel disease, type 2 diabetes, cadmium-induced neurotoxicity, Alzheimer's disease, cerebral ischemia/reperfusion injury, neuropathy, and alcoholic liver disease .

HY-N7922

Urolithin M5 1 Publications Verification Decarboxyellagic acid	Structural Classification Canarium album (Lour.) Rauesch. Phenols Polyphenols Plants Burseraceae Source Classification	Influenza Virus p38 MAPK EGFR Akt Reactive Oxygen Species (ROS) Apoptosis
Urolithin M5 (Decarboxyellagic acid) is an orally active influenza virus neuraminidase inhibitor and neuroprotective agent, with IC₅₀ values of 174.8 μM (HK68), 191.5 μM (pdm09), 243.2 μM (WSN) and 257.1 μM (PR8) against four influenza virus neuraminidases, respectively. Urolithin M5 inhibits viral neuraminidase activity, thereby blocking influenza virus replication (including oseltamivir (HY-13317)-resistant strains), protecting infected mammals from death and improving pulmonary edema. Urolithin M5 forms a hydrogen-bond stabilized complex with *IGF1R, and binds to MAPK14, AKT1, NFKB1* and EGFR. Urolithin M5 reduces reactive oxygen species production, inhibits neuronal apoptosis, restores mitochondrial transmembrane potential, and promotes neurite outgrowth of damaged neuronal cells. Urolithin M5 can be used in research related to influenza virus infection and Alzheimer's disease .

HY-B0025

Voglibose 1 Publications Verification	Structural Classification Microorganisms Classification of Application Fields Metabolic Disease Disease Research Fields Saccharides Source Classification	Glycosidase
Voglibose is an orally active alpha-glucosidase inhibitor that prevents the development of colorectal precancerous lesions induced by obesity and diabetes. Voglibose reduces oxidative stress in an inflammatory environment and inhibits the insulin-like growth factor/insulin-like growth factor-1 receptor (IGF/IGF-1R) functional axis .

HY-W074890

Palmitoylglycine 1 Publications Verification N-palmitoyl glycine	Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Calcium Channel NO Synthase
Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA .

HY-N1990

Gypenoside XLIX 2 Publications Verification	Cardiovascular Disease Triterpenes Structural Classification Classification of Application Fields Terpenoids Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino Disease Research Fields Source Classification	PPAR Sirtuin Keap1-Nrf2 Toll-like Receptor (TLR) NF-κB Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) Apoptosis Pyroptosis Autophagy
Gypenoside XLIX is a multifunctional bioactive compound that can be isolated from Gynostemma pentaphyllum, with a K_a value of 1.58 μM for its binding to SIRT1. Gypenoside XLIX acts as a PPAR-α agonist. It inhibits the activation of TLR4-mediated NF-κB signaling pathway by activating the Sirt1/Nrf2 signaling pathway, reduces ROS accumulation, and alleviates hepatic inflammatory injury in mice with sepsis-induced liver disease. Gypenoside XLIX targets SIRT1 to block YAP-NLRP3 activation and improve sepsis-induced cardiomyopathy. Gypenoside XLIX inhibits apoptosis (Apoptosis), pyroptosis (Pyroptosis), autophagy (Autophagy), lipid peroxidation, pro-inflammatory cytokines and anti-inflammatory cytokines. Gypenoside XLIX alleviates sepsis-induced splenic injury by inhibiting inflammation and oxidative stress, and mitigates sepsis-associated encephalopathy by targeting PPAR-α. Gypenoside XLIX prevents acute kidney injury by inhibiting *IGFBP7/IGF1R*-mediated programmed cell death and inflammation. Gypenoside XLIX inhibits the expression and activity of vascular cell adhesion molecule-1 in cytokine-induced human endothelial cells. Gypenoside XLIX is applicable to research related to acute liver injury, lung injury, cardiomyopathy, acute splenic injury, sepsis-associated encephalopathy, acute kidney injury, atherosclerosis and chronic inflammation .

HY-15494R

Picropodophyllin (Standard) AXL1717 (Standard); Picropodophyllotoxin (Standard); PPP (Standard)	Structural Classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Source Classification	IGF-1R Apoptosis Reference Standards
Picropodophyllin (Standard) is the analytical standard of Picropodophyllin. This product is intended for research and analytical applications. Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM.

HY-N6611

Chimaphilin	Quinones Passifloraceae Passiflora incarnata L. Plants Naphthalene Quinones Source Classification	IGF-1R
Chimaphilin is an *IGF-1R* inhibitor (IC₅₀: 0.086 μM). Chimaphilin has antifungal, antioxidant and anticancer activities. Chimaphilin inhibits the growth of both drug-sensitive and drug-resistant osteosarcoma cell lines. Chimaphilin can induce cancer cell apoptosis. Chimaphilin is a main component of pyrola .

HY-113402R

Gamma-glutamylcysteine (Standard) γ-Glu-Cys (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Interleukin Related TNF Receptor AMPK Sirtuin STAT PI3K NF-κB JAK p38 MAPK JNK Akt Apoptosis Ferroptosis
Gamma-glutamylcysteine (Standard) is the analytical standard of Gamma-glutamylcysteine. This product is intended for research and analytical applications. Gamma-glutamylcysteine (γ-Glu-Cys) is an orally active, blood-brain barrier permeable dipeptide . Gamma-glutamylcysteine activates AMPK, SIRT1, IL-4/STAT6, AC/cAMP/PI3K, *IGF-1R/IRS1/PI3K*, and Nrf2 signaling pathways; it inhibits NF-κB, JAK1/STAT1/3, MAPKs, cadmium-induced p38 MAPK, JNK, and PI3K/Akt signaling pathways. Gamma-glutamylcysteine regulates macrophage polarization, modulates the trafficking of CD36 and GLUT4, induces glutathione synthesis, improves metabolic dysfunction, reduces lipid deposition, ameliorates glucose homeostasis, inhibits apoptosis (Apoptosis), stabilizes mitochondria, suppresses lipid peroxidation, iron accumulation and ferroptosis (Ferroptosis), reduces ds-HMGB1 levels, reverses mechanical hyperalgesia, and alleviates hepatic lipid droplet formation. Gamma-glutamylcysteine is applicable to research related to inflammatory bowel disease, type 2 diabetes, cadmium-induced neurotoxicity, Alzheimer's disease, cerebral ischemia/reperfusion injury, neuropathy, and alcoholic liver disease.

HY-W015924R

2-Hydroxyisobutyric acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
2-Hydroxyisobutyric acid (Standard) is the analytical standard of 2-Hydroxyisobutyric acid. This product is intended for research and analytical applications. 2-Hydroxyisobutyric acid (2-HIBA) is a selective modulator of the Insulin/IGF-1 pathway and the p38 MAPK pathway, which reduces reactive oxygen species (ROS) and fat accumulation in Caenorhabditis elegans. 2-Hydroxyisobutyric acid promotes β-oxidation and inhibits fatty acid synthesis by upregulating SKN-1/NRF2 and downregulating SREBP-1c transcription factors. 2-Hydroxyisobutyric acid has anti-aging and lipid-lowering effects, and can be used to study metabolic diseases such as obesity and diabetes. 2-Hydroxyisobutyric acid is also a renewable precursor of methacrylate through 2-HIB-CoA mutase-mediated biosynthesis[1][2].

HY-W074890R

Palmitoylglycine (Standard) N-palmitoyl glycine (Standard)	Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Calcium Channel NO Synthase
Palmitoylglycine (Standard) is the analytical standard of Palmitoylglycine. This product is intended for research and analytical applications. Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA[1][2][3].

HY-N0908R

Ginsenoside Rg5 (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Plants Araliaceae Source Classification	Reference Standards IGF-1R NF-κB COX
Ginsenoside Rg5 (Standard) is the analytical standard of Ginsenoside Rg5. This product is intended for research and analytical applications. Ginsenoside Rg5 is the main component of Red ginseng and IGF-1R agonist. Ginsenoside Rg5 compets for the binding site of IGF-1R and blocks the binding of IGF-1 to IGF-1R (IC50 about 90 nM). Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65.

HY-113402AR

Gamma-glutamylcysteine TFA (Standard) γ-Glu-Cys TFA (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Interleukin Related TNF Receptor Endogenous Metabolite Reference Standards AMPK Sirtuin STAT PI3K NF-κB JAK p38 MAPK JNK Akt Apoptosis Ferroptosis
Gamma-glutamylcysteine (TFA) (Standard) is the analytical standard of Gamma-glutamylcysteine (TFA). This product is intended for research and analytical applications. Gamma-glutamylcysteine TFA (γ-Glu-Cys TFA) is an orally active, blood-brain barrier permeable dipeptide . Gamma-glutamylcysteine TFA activates AMPK, SIRT1, IL-4/STAT6, AC/cAMP/PI3K, *IGF-1R/IRS1/PI3K*, and Nrf2 signaling pathways; it inhibits NF-κB, JAK1/STAT1/3, MAPKs, cadmium-induced p38 MAPK, JNK, and PI3K/Akt signaling pathways. Gamma-glutamylcysteine TFA regulates macrophage polarization, modulates the trafficking of CD36 and GLUT4, induces glutathione synthesis, improves metabolic dysfunction, reduces lipid deposition, ameliorates glucose homeostasis, inhibits apoptosis (Apoptosis), stabilizes mitochondria, suppresses lipid peroxidation, iron accumulation and ferroptosis (Ferroptosis), reduces ds-HMGB1 levels, reverses mechanical hyperalgesia, and alleviates hepatic lipid droplet formation. Gamma-glutamylcysteine TFA is applicable to research related to inflammatory bowel disease, type 2 diabetes, cadmium-induced neurotoxicity, Alzheimer's disease, cerebral ischemia/reperfusion injury, neuropathy, and alcoholic liver disease.

HY-B0025R

Voglibose (Standard)	Structural Classification Microorganisms Saccharides Source Classification	Reference Standards Glycosidase
Voglibose (Standard) is the analytical standard of Voglibose. This product is intended for research and analytical applications. Voglibose is an orally active alpha-glucosidase inhibitor that prevents the development of colorectal precancerous lesions induced by obesity and diabetes. Voglibose reduces oxidative stress in an inflammatory environment and inhibits the insulin-like growth factor/insulin-like growth factor-1 receptor (IGF/IGF-1R) functional axis[1].

Species:	Human (40) Rhesus Macaque (2) Rat (3) Mouse (18) Cynomolgus (4) Pig (1)
Tag:	SUMO (1) T7 (1) His (45) Tag Free (13) Avi (9) GST (4) Flag (1) Fc (9)
Source:	HEK293 (39) Sf9 insect cells (2) P. pastoris (3) E. coli (25)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70698AF

	*Animal-Free IGF-I/IGF-1 Protein, Mouse (His)* rMuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I	Mouse	E. coli
	The IGF-I/IGF-1 protein is structurally similar to insulin and has potent growth-promoting activity. As a physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts, exceeding the efficacy of insulin at lower concentrations. Animal-Free IGF-I/IGF-1 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIGF-I/IGF-1 protein, expressed by E. coli , with C-His labeled tag.This product is for cell culture use only.

HY-P7070

	IGF-I/IGF-1 Protein, Mouse 10+ Cited Publications rMuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I	Mouse	E. coli
	IGF-I/IGF-1 Protein is an insulin-like growth factor that possesses both growth-promoting and metabolic-regulating functions. IGF-I/IGF-1 Protein is also a neurotrophic factor with neuroprotective and neuroplasticity-regulating activities. IGF-I/IGF-1 Protein plays a key role in growth and development, cell proliferation, metabolic regulation and other aspects. IGF-I/IGF-1 Protein, Mouse is a recombinant IGF-I/IGF-1 protein expressed by E. coli without a tag.

HY-P700094AF

	*Animal-Free IGF2 Protein, Human (His)* Somatamedin A; IGF-II	Human	E. coli
	The IGF2 protein is an important member of the insulin-like growth factor family and plays an important role in mammalian growth, fetoplacental development, and adult glucose metabolism. Regulated by placental prolactin, affecting tissue differentiation. Animal-Free IGF2 Protein, Human (His) is the recombinant human-derived animal-FreeIGF2 protein, expressed by E. coli , with N-His labeled tag.This product is for cell culture use only.

HY-P7019

	IGF2 Protein, Human 3 Publications Verification rHuIGF-2; Somatamedin A; IGF-II	Human	E. coli
	IGF2 Protein, Human is a mitogenic cytokine, binds to IGF type 1 receptor, and modulates growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone.

HY-P7018

	IGF-I/IGF-1 Protein, Human (70a.a) Maximum Cited Publications 24 Publications Verification rHuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I	Human	E. coli
	IGF-I/IGF-1 Protein is an insulin-like growth factor that possesses both growth-promoting and metabolic-regulating functions. IGF-I/IGF-1 Protein is also a neurotrophic factor with neuroprotective and neuroplasticity-regulating activities. IGF-I/IGF-1 Protein plays a key role in growth and development, cell proliferation, metabolic regulation and other aspects. IGF-I/IGF-1 protein, Human (70a.a) is a recombinant IGF-I/IGF-1 protein expressed by E. coli without a tag.

HY-P706010

	IGF-I/IGF-1 protein, Rat (GST) IGF1; IGF-1Insulin-like growth factor I; IGF-I; Somatomedin	Rat	E. coli

HY-P7018A

	*DES1-3 IGF-I/IGF-1 Protein, Human* rHuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I	Human	E. coli

HY-P704375

	IGF-I/IGF-1 Protein, Mouse (HEK293, hFc) rMuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I	Mouse	HEK293
	The IGF-I/IGF-1 protein is structurally similar to insulin and has potent growth-promoting activity. As a physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts, exceeding the efficacy of insulin at lower concentrations. IGF-I/IGF-1 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived IGF-I/IGF-1 protein, expressed by HEK293, with N-hFc labeled tag.

HY-P7203

	IGF-I/IGF-1 Protein, Rat 3 Publications Verification rRtIGF-I; Somatomedin C; IGF1; Mechano growth factor	Rat	E. coli
	IGF-I/IGF-1 Protein, Rat has somatomedin activity and ability to potently promote neuronal survival.

HY-P700185AF

	*Animal-Free IGF-II Protein, Mouse (His)* Insulin-like growth factor 2; Multiplication-stimulating polypeptide; IGF-II; IGF-2; IGF2	Mouse	E. coli
	The IGF-II protein plays a crucial role in glucose-mediated insulin secretion, acting together with insulin as a physiological amplifier. Furthermore, it exhibits osteogenic properties by enhancing osteoblast mitotic activity through phosphorylation of MAPK1 and MAPK3. Animal-Free IGF-II Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIGF-II protein, expressed by E. coli , with N-His labeled tag. This product is for cell culture use only.

HY-P700093AF

	*Animal-Free IGF-I/IGF-1 Protein, Human (His)* 1 Publications Verification Somatamedin C; IGF-IA; Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; MGF; Somatomedin-C; IGF1; IBP1	Human	E. coli
	The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. Animal-Free IGF-I/IGF-1 Protein, Human (His) is the recombinant human-derived animal-FreeIGF-I/IGF-1 protein, expressed by E. coli , with C-His labeled tag.This product is for cell culture use only.

HY-P704374

	IGF-I/IGF-1 Protein, Human (HEK293, N-His) 1 Publications Verification Somatamedin C; IGF-IA; Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; MGF; Somatomedin-C; IGF1; IBP1	Human	HEK293
	The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. IGF-I/IGF-1 Protein, Human (HEK293, N-His) is the recombinant human-derived IGF-I/IGF-1 protein, expressed by HEK293, with N-His labeled tag.

HY-P73906

	IGF2 Protein, Human (P.pastoris) Insulin-like growth factor II; IGF-II; Preptin; IGF2; PP1446	Human	P. pastoris
	The IGF2 protein is an important member of the insulin-like growth factor family and plays an important role in mammalian growth, fetoplacental development, and adult glucose metabolism. Regulated by placental prolactin, affecting tissue differentiation. IGF2 Protein, Human (P.pastoris) is the recombinant human-derived IGF2 protein, expressed by P. pastoris , with tag free.

HY-P78458

	IGF-I R Protein, Human (HEK293, His-Avi) CD221; IGF1R; IGF-1R; IGF-I R; IGF-I receptor; IGFIR; IGFR; JTK13; MGC142170; MGC142172; MGC18216	Human	HEK293
	IGF-I receptor (IGF1R) mediates insulin-like growth factor effects, binding strongly to IGF1. Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways, influencing cell survival, protein synthesis, and proliferation. IGF1R also signals through JAK/STAT, inhibiting JNK activation. Hybrid receptors show variable binding to IGF1 and insulin. IGF-I R Protein, Human (HEK293, His-Avi) is the recombinant human-derived IGF-I R protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P704373

	IGF2 Protein, Human (HEK293, hFc) Somatamedin A; IGF-II	Human	HEK293
	The IGF2 protein is an important member of the insulin-like growth factor family and plays an important role in mammalian growth, fetoplacental development, and adult glucose metabolism. Regulated by placental prolactin, affecting tissue differentiation. IGF2 Protein, Human (HEK293, hFc) is the recombinant human-derived IGF2 protein, expressed by HEK293, with N-hFc labeled tag.

HY-P78142

	IGF-I R Protein, Human (Biotinylated, HEK293, His-Avi) CD221; IGF1R; IGF-1R; IGF-I R; IGF-I receptor; IGFIR; IGFR; JTK13; MGC142170; MGC142172; MGC18216	Human	HEK293
	IGF-I receptor (IGF1R) mediates insulin-like growth factor effects, binding strongly to IGF1. Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways, influencing cell survival, protein synthesis, and proliferation. IGF1R also signals through JAK/STAT, inhibiting JNK activation. Hybrid receptors show variable binding to IGF1 and insulin. IGF-I R Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IGF-I R protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P70788

	IGF-I/IGF-1 Protein, Human (G49-A118) 5+ Cited Publications Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; MGF; Somatomedin-C; IGF1; IBP1	Human	E. coli
	The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. IGF-I/IGF-1 Protein, Human (G49-A118) is the recombinant human-derived IGF-I/IGF-1 protein, expressed by E. coli , with tag free.

HY-P70698

	IGF-I/IGF-1 Protein, Mouse (His) 4 Publications Verification IGF1; IGF-1; insulin-like growth factor 1; Insulin-like growth factor I; Somatomedin C; somatomedin-C	Mouse	E. coli
	IGF-I/IGF-1 Protein, Mouse (His) is a mitogenic cytokine, binds to IGF type 1 receptor, and modulates growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone. IGF1 also mediates neuroprotective mechanism.

HY-P700478

	IGF-I/IGF-1 Protein, Human (P. pastoris, N-His) 1 Publications Verification Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; MGF; Somatomedin-C; IGF1; IBP1	Human	P. pastoris
	The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. IGF-I/IGF-1 Protein, Human (P. pastoris, N-His) is the recombinant human-derived IGF-I/IGF-1 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P70698A

	IGF-I/IGF-1 Protein, Mouse (N-His) IGF1; IGF-1; insulin-like growth factor 1; Insulin-like growth factor I; Somatomedin C; somatomedin-C	Mouse	E. coli
	The IGF-I/IGF-1 protein is structurally similar to insulin and has potent growth-promoting activity. As a physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts, exceeding the efficacy of insulin at lower concentrations. IGF-I/IGF-1 Protein, Mouse (N-His) is the recombinant mouse-derived IGF-I/IGF-1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P74843

	IGF-I/IGF-1 Protein, Mouse (P.pastoris) Insulin-like growth factor I; IGF-I; MGF; Somatomedin-C; IBP1	Mouse	P. pastoris
	IGF-I/IGF-1 Protein, part of the insulin family, is highlighted. IGF-I/IGF-1 Protein, Mouse (P.pastoris) is the recombinant mouse-derived IGF-I/IGF-1 protein, expressed by P. pastoris , with tag free.

HY-P73136

	IGF-I/IGF-1 Protein, Human (HEK293, hFc) Insulin-like growth factor I; IGF-I; MGF; Somatomedin-C; IBP1	Human	HEK293
	The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. IGF-I/IGF-1 Protein, Human (HEK293, hFc) is the recombinant human-derived IGF-I/IGF-1 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P78863

	IGF2 Protein, Human (Biotinylated, HEK293, Fc-Avi) IGF2; C11orf43; FLJ22066; FLJ44734; IGF-II; PP9974	Human	HEK293
	The IGF2 protein is an important member of the insulin-like growth factor family and plays an important role in mammalian growth, fetoplacental development, and adult glucose metabolism. Regulated by placental prolactin, affecting tissue differentiation. IGF2 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived IGF2 protein, expressed by HEK293 , with N-hFc, N-Avi labeled tag.

HY-P72256

	IGF-I R Protein, Human (His) CD221; CD221 antigen ; IGF 1 receptor; IGF 1R; IGF I receptor; IGF-I receptor; IGF1r; IGF1R_HUMAN; IGFIR; IGFIRC; IGFR; Insulin like growth factor 1 receptor; Insulin like growth factor 1 receptor precursor; Insulin-like growth factor 1 receptor beta chain; Insulin-like growth factor I receptor; JTK13; MGC142170; MGC142172; MGC18216; Soluble IGF1R variant 1; Soluble IGF1R variant 2	Human	E. coli
	IGF-I receptor (IGF1R) mediates insulin-like growth factor effects, binding strongly to IGF1. Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways, influencing cell survival, protein synthesis, and proliferation. IGF1R also signals through JAK/STAT, inhibiting JNK activation. Hybrid receptors show variable binding to IGF1 and insulin. IGF-I R Protein, Human (His) is the recombinant human-derived IGF-I R protein, expressed by E. coli , with N-6*His labeled tag.

HY-P72606

	IGF-I R Protein, Human (HEK293, His) Insulin-like growth factor 1 receptor; IGF-I receptor; IGF1R; CD221	Human	HEK293
	IGF-I receptor (IGF1R) mediates insulin-like growth factor effects, binding strongly to IGF1. Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways, influencing cell survival, protein synthesis, and proliferation. IGF1R also signals through JAK/STAT, inhibiting JNK activation. Hybrid receptors show variable binding to IGF1 and insulin. IGF-I R Protein, Human (HEK293, His) is the recombinant human-derived IGF-I R protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P701241

	IGF-I Protein, Salmon IGF1; IGF-1; insulin-like growth factor 1; Insulin-like growth factor I; Somatomedin C; somatomedin-C	Others	E. coli
	IGF-I protein is similar to insulin and exerts effective growth-promoting activity as a ligand of IGF1R. Binding to the α subunit of IGF1R activates intrinsic tyrosine kinase, triggering autophosphorylation of the β subunit. IGF-I Protein, Salmon is the recombinant IGF-I protein, expressed by E. coli , with tag free.

HY-P704676

	IGF-I R Protein, Human (HEK293, Fc) Insulin-like growth factor 1 receptor; IGF-I receptor; IGF1R; CD221	Human	HEK293
	IGF-I receptor (IGF1R) mediates insulin-like growth factor effects, binding strongly to IGF1. Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways, influencing cell survival, protein synthesis, and proliferation. IGF1R also signals through JAK/STAT, inhibiting JNK activation. Hybrid receptors show variable binding to IGF1 and insulin. IGF-I R Protein, Human (HEK293, Fc) is the recombinant human-derived IGF-I R protein, expressed by HEK293, with C-hFc labeled tag.

HY-P74442

	IGF-I R Protein, Human (HEK293, His, solution) Insulin-like growth factor 1 receptor; IGF-I receptor; CD221; IGF1R	Human	HEK293
	IGF-I receptor (IGF1R) mediates insulin-like growth factor effects, binding strongly to IGF1. Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways, influencing cell survival, protein synthesis, and proliferation. IGF1R also signals through JAK/STAT, inhibiting JNK activation. Hybrid receptors show variable binding to IGF1 and insulin. IGF-I R Protein, Human (HEK293, His, solution) is the recombinant human-derived IGF-I R protein, expressed by HEK293 , with C-His labeled tag.

HY-P73137

	IGF-I R Protein, Human (Active, sf9, His-GST) Insulin-like growth factor 1 receptor; IGF-I receptor; CD221; IGF1R	Human	Sf9 insect cells
	IGF-I receptor (IGF1R) mediates insulin-like growth factor effects, binding strongly to IGF1. Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways, influencing cell survival, protein synthesis, and proliferation. IGF1R also signals through JAK/STAT, inhibiting JNK activation. Hybrid receptors show variable binding to IGF1 and insulin. IGF-I R Protein, Human (sf9, His-GST) is the recombinant human-derived IGF-I R protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P70783

	*LR3 IGF-I/IGF-1 Protein, Human (83a.a, E51R)* 2 Publications Verification Long R3 IGF-I; Insulin-like growth factor I; MGF; Somatomedin-C; IBP1	Human	E. coli
	The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. LR3 IGF-I/IGF-1 Protein, Human (83a.a, E51R) is the recombinant human-derived LR3 IGF-I/IGF-1 protein, expressed by E. coli , with tag free and E51R mutation.

HY-P700870

	IGF2R Protein, Human (HEK293, His-Avi) CI-MPR; M6PR; MPR 300; IGF-II receptor; M6P/IGF2R; CD222; MPRI	Human	HEK293
	IGF2R proteins coordinate cellular processes by transporting phosphorylated lysosomal enzymes from the Golgi complex to lysosomes. Lysosomal enzymes with phosphomannosyl residues bind to mannose-6-phosphate receptors in the Golgi apparatus, form complexes, and transport to the acidic prelysosomal compartment. IGF2R Protein, Human (HEK293, His-Avi) is the recombinant human-derived IGF2R protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P70783G

	*GMP LR3 IGF-I/IGF-1 Protein, Human (83a.a, E51R)* Long R3 IGF-I; Insulin-like growth factor I; MGF; Somatomedin-C; IBP1	Human	E. coli
	The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. GMP LR3 IGF-I/IGF-1 Protein, Human (83a.a, E51R) is the recombinant human-derived LR3 IGF-I/IGF-1 protein, expressed by E. coli , with tag free.

HY-P700241AF

	*Animal-Free IGF-I Protein, Pig (His)* Insulin-like growth factor I; IGF-I; MGF; Somatomedin-C; IBP1	Pig	E. coli
	The IGF-I protein is structurally similar to insulin and has excellent growth-promoting activity. As a potential physiological regulator, it affects [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Animal-Free IGF-I Protein, Pig (His) is the recombinant pig-derived animal-FreeIGF-I protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P700869

	IGF2R Protein, Human (Biotinylated, HEK293, His-Avi) CI-MPR; M6PR; MPR 300; IGF-II receptor; M6P/IGF2R; CD222; MPRI	Human	HEK293
	IGF2R proteins coordinate cellular processes by transporting phosphorylated lysosomal enzymes from the Golgi complex to lysosomes. Lysosomal enzymes with phosphomannosyl residues bind to mannose-6-phosphate receptors in the Golgi apparatus, form complexes, and transport to the acidic prelysosomal compartment. IGF2R Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IGF2R protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P700871

	IGF2R Protein, Human (Domain 1-3, HEK293, His-Avi) CI-MPR; M6PR; MPR 300; IGF-II receptor; M6P/IGF2R; CD222; MPRI	Human	HEK293
	IGF2R proteins coordinate cellular processes by transporting phosphorylated lysosomal enzymes from the Golgi complex to lysosomes. Lysosomal enzymes with phosphomannosyl residues bind to mannose-6-phosphate receptors in the Golgi apparatus, form complexes, and transport to the acidic prelysosomal compartment. IGF2R Protein, Human (Domain 1-3, HEK293, His-Avi) is the recombinant human-derived IGF2R protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P701061

	IGF2R Protein, Human (Domain 1-7, HEK293, His-Avi) CI-MPR; M6PR; MPR 300; IGF-II receptor; M6P/IGF2R; CD222; MPRI	Human	HEK293
	IGF2R proteins coordinate cellular processes by transporting phosphorylated lysosomal enzymes from the Golgi complex to lysosomes. Lysosomal enzymes with phosphomannosyl residues bind to mannose-6-phosphate receptors in the Golgi apparatus, form complexes, and transport to the acidic prelysosomal compartment. IGF2R Protein, Human (Domain 1-7, HEK293, His-Avi) is the recombinant human-derived IGF2R protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P78723

	IGF-I R Protein, Mouse (HEK293, His) 2 Publications Verification IGF1R; IGFR; JTK13; CD221; MGC142170; MGC142172; MGC18216	Mouse	HEK293
	The IGF-I R protein is a receptor tyrosine kinase that mediates the effects of insulin-like growth factor 1 (IGF1) and has high affinity for IGF1. Upon ligand binding, IGF1R is activated, leading to autophosphorylation and tyrosine phosphorylation of substrates, including IRS1/2, Shc, and 14-3-3 proteins. IGF-I R Protein, Mouse (HEK293, His) is the recombinant mouse-derived IGF-I R protein, expressed by HEK293 , with C-His labeled tag.

HY-P78724

	IGF-I R Protein, Rat (HEK293, His) IGF1R; IGFR; JTK13; CD221; MGC142170; MGC142172; MGC18216	Rat	HEK293
	Igf1r Protein, a cell surface receptor, is involved in growth regulation and development. Dysregulation of Igf1r Protein has been linked to diseases like cancer and growth disorders. Targeting Igf1r Protein may offer potential therapeutic interventions in these conditions by modulating cell growth, inhibiting tumor progression, and managing growth-related disorders. IGF-I R Protein, Rat (HEK293, His) is the recombinant rat-derived IGF-I R protein, expressed by HEK293 , with C-His labeled tag.

HY-P78586

	IGF-I R Protein, Cynomolgus (HEK293, His) IGF1R; IGFR; JTK13; CD221; MGC142170; MGC142172; MGC18216	Cynomolgus	HEK293
	The IGF-I R protein is a receptor tyrosine kinase that mediates the effects of insulin-like growth factor 1 (IGF1) and has high affinity for IGF1. Upon ligand binding, IGF1R is activated, leading to autophosphorylation and tyrosine phosphorylation of substrates, including IRS1/2, Shc, and 14-3-3 proteins. IGF-I R Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IGF-I R protein, expressed by HEK293 , with C-His labeled tag.

HY-P703904

	IGF2R Protein, Human (HEK293, hFc) insulin like growth factor 2 receptor; CI-MPR; M6PR; MPR 300; IGF-II receptor; M6P/IGF2R; CD222; MPRI	Human	HEK293
	IGF2R proteins coordinate cellular processes by transporting phosphorylated lysosomal enzymes from the Golgi complex to lysosomes. Lysosomal enzymes with phosphomannosyl residues bind to mannose-6-phosphate receptors in the Golgi apparatus, form complexes, and transport to the acidic prelysosomal compartment. IGF2R Protein, Human (HEK293, hFc) is the recombinant human-derived IGF2R protein, expressed by HEK293, with C-hFc labeled tag.

HY-P70950

	IGF2BP2 Protein, Human (T7-His) Insulin-Like Growth Factor 2 mRNA-Binding Protein 2; IGF2 mRNA-Binding Protein 2; IMP-2; Hepatocellular Carcinoma Autoantigen p62; IGF-II mRNA-Binding Protein 2; VICKZ Family Member 2; IGF2BP2; IMP2; VICKZ2	Human	E. coli
	The IGF2BP2 protein is an RNA-binding factor that coordinates the recruitment of target transcripts into cytoplasmic mRNP, promoting mRNA transport and transient storage. It regulates the contact of target transcripts with the translation machinery and protects them from microRNA-mediated degradation. IGF2BP2 Protein, Human (T7-His) is the recombinant human-derived IGF2BP2 protein, expressed by E. coli , with N-T7, C-6*His labeled tag.

HY-P703525

	IGF2BP3 Protein, Human (His) Insulin-like growth factor 2 mRNA-binding protein 3; IGF2 mRNA-binding protein 3; IMP-3; IGF-II mRNA-binding protein 3; KH domain-containing protein overexpressed in cancer (hKOC); VICKZ family member 3; IGF2BP3; IMP3; KOC1; VICKZ3	Human	E. coli
	IGF2BP3 Protein, Human (His) is the recombinant human-derived IGF2BP3 protein, expressed by E. coli, with N-6*His tag.

HY-P74850

	IGF2BP2 Protein, Human (sf9, His-GST) Insulin-like growth factor 2 mRNA-binding protein 2; IMP-2; IGF2BP2; VICKZ2	Human	Sf9 insect cells
	The IGF2BP2 protein is an RNA-binding factor that coordinates the recruitment of target transcripts into cytoplasmic mRNP, promoting mRNA transport and transient storage. It regulates the contact of target transcripts with the translation machinery and protects them from microRNA-mediated degradation. IGF2BP2 Protein, Human (sf9, His-GST) is the recombinant human-derived IGF2BP2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P7S2794

	IGF2BP1 Protein, Human (His) Insulin-like growth factor 2 mRNA-binding protein 1; IGF2 mRNA-binding protein 1; IMP-1; IMP1; Coding region determinant-binding protein (CRD-BP); IGF-II mRNA-binding protein 1; VICKZ family member 1; Zipcode-binding protein 1 (ZBP-1); IGF2BP1; CRDBP; VICKZ1; ZBP1	Human	E. coli

HY-P7020

	IGFBP-3 Protein, Human rHuIGF-BP3; IBP-3; IGF-binding protein 3; IGFBP-3	Human	E. coli
	IGFBP-3 Protein, Human belongs to insulin-like growth factor-binding protein, prolongs the half-life of the insulin-like growth factors (IGFs), inhibits interaction of IGFs with their cell surface receptors, and functions in cancer reduction.

HY-P704674

	IGFBP-3 Protein, Human (HEK293, Fc) rHuIGF-BP3; IBP-3; IGF-binding protein 3; IGFBP-3	Human	HEK293
	IGFBP-3 protein is a part of IGFBP that significantly prolongs IGF half-life and modulates growth effects in cell culture. It inhibits or stimulates IGF-induced cellular responses by changing the kinetics of interaction with cell surface receptors. IGFBP-3 Protein, Human (HEK293, Fc) is the recombinant human-derived IGFBP-3 protein, expressed by HEK293, with C-hFc labeled tag.

HY-P703779

	IGFBP-2 Protein, Cynomolgus (HEK293, His) IBP-2; IGFBP-2; BP2; AI255832; mIGFBP-2; IGFBP2; IGF-BP53	Cynomolgus	HEK293
	IGFBP-2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IGFBP2 protein, expressed by HEK293, with C-His tag.

HY-P73138

	IGFBP-3 Protein, Human (HEK293, His) Insulin-like growth factor-binding protein 3; IGF-BP3; IBP-3; IGFBP-3	Human	HEK293
	IGFBP-3 protein is a part of IGFBP that significantly prolongs IGF half-life and modulates growth effects in cell culture. It inhibits or stimulates IGF-induced cellular responses by changing the kinetics of interaction with cell surface receptors. IGFBP-3 Protein, Human (HEK293, His) is the recombinant human-derived IGFBP-3 protein, expressed by HEK293 , with N-His labeled tag.

HY-P74846

	IGFBP-2 Protein, Mouse (HEK293, His) IBP-2; Insulin-like growth factor binding protein 2; IGFBP2; IGF-BP53	Mouse	HEK293
	IGFBP-2 protein, a member of the IGF-binding protein family, inhibits IGF-mediated growth and developmental rates. It can extend the half-life of IGF and exhibit dual functions by inhibiting or stimulating the growth-promoting effect of IGF in cell culture. IGFBP-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IGFBP-2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P74847

	IGFBP-2 Protein, Mouse (HEK293, Fc) IBP-2; Insulin-like growth factor binding protein 2; IGFBP2; IGF-BP53	Mouse	HEK293
	IGFBP-2 protein, a member of the IGF-binding protein family, inhibits IGF-mediated growth and developmental rates. It can extend the half-life of IGF and exhibit dual functions by inhibiting or stimulating the growth-promoting effect of IGF in cell culture. IGFBP-2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IGFBP-2 protein, expressed by HEK293 , with C-hFc labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-B0794S

AZ7550-d5
AZ7550-d₅ is the deuterium labeled AZ7550?(HY-B0794). AZ7550, an active metabolite of Osimtinib (AZD9291; HY-15772), inhibits the activity of?IGF1R?with an?IC₅₀?of 1.6 μM .

HY-P11431

Cyclo(Gly-Pro)
Cyclo(Gly-Pro) is a cyclic dipeptide. Cyclo(Gly-Pro) can be derived from the Nterminus of the *IGF-1*. Cyclo(Gly-Pro) attenuates nociceptive behaviour and inflammatory response in mice .

HY-15656S

Ceritinib-d7

Ceritinib (LDK378)-d₇ is a deuterium labeled Ceritinib (HY-15656). Ceritinib is a selective, orally bioavailable and ATP-competitive ALK tyrosine kinase inhibitor . Ceritinib is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC₅₀ of 200 pM. Ceritinib also inhibits IGF-1R, InsR, and STK22D with IC₅₀ values of 8, 7, and 23 nM, respectively. Ceritinib shows great antitumor potency .

HY-15494S1

Picropodophyllin-d6
Picropodophyllin-d₆ (AXL1717-d₆) is deuterium labeled Picropodophyllin. Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM.

HY-15494S

Picropodophyllin-d3
Picropodophyllin-d₃ (AXL1717-d₃; Picropodophyllotoxin-d₃; PPP-d₃) is the deuterium labeled Picropodophyllin (HY-15494). Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC₅₀ of 1 nM.

HY-W747751

Sorbic acid-13C2

Sorbic acid- ¹³C₂ is the ¹³C-labeled Sorbic acid (HY-N0626). Sorbic acid is an effective, safe, and non-toxic food preservative. It can effectively inhibit most molds, yeasts, and certain bacteria. Sorbic acid is orally active and can enhance the growth performance of economically important animals (Duroc × Landrace × Yorkshire piglets) by activating the insulin-like growth factor system (IGF), and it can also lead to lipid accumulation by disrupting lipid clearance pathways .

HY-W749516

Voglibose-13C3

Voglibose- ¹³C₃ is the ¹³C-labeled Voglibose (HY-B0025). Voglibose is an orally active alpha-glucosidase inhibitor that prevents the development of colorectal precancerous lesions induced by obesity and diabetes. Voglibose reduces oxidative stress in an inflammatory environment and inhibits the insulin-like growth factor/insulin-like growth factor-1 receptor (IGF/IGF-1R) functional axis.

Host:	Mouse (9) Rabbit (23)
Reactivity:	Human (31) Rat (13) Mouse (16) Dog (1)
Application:	IHC-P (23) ICC/IF (19) IF-Tissue (2) IP (10) IHC-F (4) WB (29) FC (7) ELISA (14)
Isotype:	IgG (23) IgG1 (4) IgG/Kappa (1) IgG2b (1)
Conjugation:	Non-conjugated (32) Biotin (5)
Clonality:	Polyclonal (3) Monoclonal (20) Monoclonal Antibody (1) Recombinant (12)
Modification:	Phosphorylated (2) Unmodified (23)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83447

	IGF-2 Antibody (YA3192) C11orf43; IGF 2; IGF II; IGF2; INSIGF; Somatomedin A	WB, ICC/IF	Human
	IGF-2 Antibody (YA3192) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IGF-2.

HY-P81112

	IGF1 Antibody IBP1; IGF 1; IGF I; IGF-1; IGF IA; IGF IB; IGF1; IGFI; IGFIA; Insulin like growth factor 1 (somatomedin C); Full=Insulin-like growth factor I; Insulin Like Growth Factor 1; Insulin like growth factor IA; Insulin like growth factor IB; Mechano growth factor; MGF; Mechano growth factor; MGF; Somatomedia C; Somatomedin C; IGF1_HUMAN. IGF-I;	WB, IHC-P, IHC-F, ICC/IF, ELISA	Human, Mouse, Rat, Dog
	IGF1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to IGF1.

HY-P86011

	IGF-2 Antibody (YA5703)	IHC-P, ICC/IF, ELISA	Human
	IGF-2 Antibody (YA5703) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to IGF-2.

HY-P88024

	IGF1 Antibody (YA7709)	WB	Human
	IGF1 Antibody (YA7709) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IGF1.

HY-P83906

	IGF-2 Antibody (YA3603) IGF-II; PP9974; C11orf43; FLJ22066; FLJ44734	IHC-P, ICC/IF, FC, ELISA	Human
	IGF-2 Antibody (YA3603) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IGF-2.

HY-P80717

	IGF1 Receptor Antibody (YA351) IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221	WB, IHC-P	Human
	IGF1 Receptor Antibody (YA351) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IGF1 Receptor.

HY-P85213

	IGF1 Receptor Antibody (YA4905) IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221	WB, IHC-P, ICC/IF, ELISA	Human
	IGF1 Receptor Antibody (YA4905) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IGF1 Receptor.

HY-P85214

	IGF1 Receptor Antibody (YA4906) IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221	WB, IHC-P, ICC/IF, ELISA	Human
	IGF1 Receptor Antibody (YA4906) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IGF1 Receptor.

HY-P86629

	IGF1 Receptor Antibody (YA6321) IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221	WB, IHC-P, ICC/IF, IP, ELISA	Human
	IGF1 Receptor Antibody (YA6321) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IGF1 Receptor.

HY-P83906A

	IGF-2 Antibody (YA3603)(PBS only) IGF-II; PP9974; C11orf43; FLJ22066; FLJ44734	IHC-P, ICC/IF, FC, ELISA	Human
	IGF-2 Antibody (YA3603) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IGF-2.

HY-P80717A

	IGF1 Receptor Antibody (YA351)(PBS only) IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221	WB, IHC-P	Human
	IGF1 Receptor Antibody (YA351) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IGF1 Receptor.

HY-P80825

	*Phospho-IGF1 Receptor (Tyr1166) Antibody (YA186)* IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221	WB, IP	Human, Mouse, Rat
	Phospho-IGF1 Receptor (Tyr1166) Antibody (YA186) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-IGF1 Receptor (Tyr1166).

HY-P80825A

	*Phospho-IGF1 Receptor (Tyr1166) Antibody (YA186)(PBS only)* IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221	WB, IP	Human, Mouse, Rat
	Phospho-IGF1 Receptor (Tyr1166) Antibody (YA186) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-IGF1 Receptor (Tyr1166).

HY-P81754

	IGF2R Antibody (YA1499) IGF2R; MPRI; Cation-independent mannose-6-phosphate receptor; CI Man-6-P receptor; CI-MPR; M6PR; 300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; IGF-II receptor; M6P/IGF2 receptor; M6P/IGF2R; CD222	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	IGF2R Antibody (YA1499) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IGF2R.

HY-P82288

	IGF2BP2 Antibody (YA2033) IGF2BP2; IMP2; VICKZ2; Insulin-like growth factor 2 mRNA-binding protein 2; IGF2 mRNA-binding protein 2; IMP-2; Hepatocellular carcinoma autoantigen p62; IGF-II mRNA-binding protein 2; VICKZ family member 2	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	IGF2BP2 Antibody (YA2033) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IGF2BP2.

HY-P82288A

	IGF2BP2 Antibody (YA2033)(PBS only) IGF2BP2; IMP2; VICKZ2; Insulin-like growth factor 2 mRNA-binding protein 2; IGF2 mRNA-binding protein 2; IMP-2; Hepatocellular carcinoma autoantigen p62; IGF-II mRNA-binding protein 2; VICKZ family member 2	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	IGF2BP2 Antibody (YA2033) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IGF2BP2.

HY-P80724

	IMP3 Antibody Cancer/testis antigen 98; CT98; DKFZp686F1078; hKOC; IF2B3_HUMAN; IGF II mRNA binding protein 3; IGF-II mRNA-binding protein 3; IGF2 mRNA binding protein 3; IGF2 mRNA-binding protein 3; IGF2BP3; IMP 3; IMP-3; Insulin like growth factor 2 mRNA binding prot	WB, ICC/IF, IP, FC	Human, Mouse, Rat
	IMP3 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to IMP3.

HY-P86076

	*Phospho-IGF1R(Tyr1135/1136)/Insulin Receptor β(Tyr1150/1151) Antibody (YA5768)* IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221; INSR; Insulin receptor; IR; CD antigen CD220	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-IGF1R(Tyr1135/1136)/Insulin Receptor β(Tyr1150/1151) Antibody (YA5768) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-IGF1R(Tyr1135/1136)/Insulin Receptor β(Tyr1150/1151).

HY-P85226

	IMP-3 Antibody (YA4918) IGF2BP3; IMP3; KOC1; VICKZ3; Insulin-like growth factor 2 mRNA-binding protein 3; IGF2 mRNA-binding protein 3; IMP-3; IGF-II mRNA-binding protein 3; KH domain-containing protein overexpressed in cancer; hKOC; VICKZ family member 3	WB, ICC/IF, IP, FC, IHC-P, IHC-F, IF-Tissue	Human
	IMP-3 Antibody (YA4918) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to IMP-3.

HY-P83793

	IGF2BP3 Antibody (YA3490) KOC; CT98; IMP3; KOC1; IMP-3; VICKZ3	WB, IHC-P, FC, ELISA	Human
	IGF2BP3 Antibody (YA3490) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IGF2BP3.

HY-P83793A

	IGF2BP3 Antibody (YA3490)(PBS only) KOC; CT98; IMP3; KOC1; IMP-3; VICKZ3	WB, IHC-P, FC, ELISA	Human
	IGF2BP3 Antibody (YA3490) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IGF2BP3.

HY-P85583

	IMP3 Antibody (YA5275) Cancer/testis antigen 98; CT98; DKFZp686F1078; hKOC; IF2B3_HUMAN; IGF II mRNA binding protein 3; IGF-II mRNA-binding protein 3; IGF2 mRNA binding protein 3; IGF2 mRNA-binding protein 3; IGF2BP3; IMP 3; IMP-3; Insulin like growth factor 2 mRNA binding protein 3; Insulin-like growth factor 2 mRNA-binding protein 3; KH domain containing protein overexpressed in cancer; KH domain-containing protein overexpressed in cancer; KOC 1; KOC1; VICKZ 3; VICKZ family member 3; VICKZ3.	IHC-P, WB, ICC/IF, ELISA	Human, Mouse
	IMP3 Antibody (YA5275) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to IMP3.

HY-P81844

	IGFBP2 Antibody (YA1589) IGFBP2; BP2; IBP2; Insulin-like growth factor-binding protein 2; IBP-2; IGF-binding protein 2; IGFBP-2	WB, IHC-P	Human
	IGFBP2 Antibody (YA1589) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IGFBP2.

HY-P85212

	IGFBP2 Antibody (YA4904) IGFBP2; BP2; IBP2; Insulin-like growth factor-binding protein 2; IBP-2; IGF-binding protein 2; IGFBP-2	WB, IHC-P, ICC/IF, ELISA	Human
	IGFBP2 Antibody (YA4904) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IGFBP2.

HY-P83326

	IGF2BP1 Antibody (YA3071) insulin-like growth factor 2 mRNA binding protein 1; IMP1; ZBP1; CRDBP; IMP-1; CRD-BP; VICKZ1	WB, IHC-P, IP	Human, Mouse
	IGF2BP1 Antibody (YA3071) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IGF2BP1.

HY-P83326A

	IGF2BP1 Antibody (YA3071)(PBS only) insulin-like growth factor 2 mRNA binding protein 1; IMP1; ZBP1; CRDBP; IMP-1; CRD-BP; VICKZ1	WB, IHC-P, IP	Human, Mouse
	IGF2BP1 Antibody (YA3071) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IGF2BP1.

HY-P82665

	IGFBP1 Antibody (YA2410) IGFBP1; IBP1; Insulin-like growth factor-binding protein 1; IBP-1; IGF-binding protein 1; IGFBP-1; Placental protein 12; PP12	WB	Human, Mouse, Rat
	IGFBP1 Antibody (YA2410) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IGFBP1.

HY-P86582

	CTGF Antibody (YA6274) Connective tissue growth factor; CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP-8;	WB, IP, ELISA	Human, Mouse, Rat
	CTGF Antibody (YA6274) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CTGF.

HY-P83334

	IGFBP7 Antibody (YA3079) IGFBP7; MAC25; PSF; Insulin-like growth factor-binding protein 7; IBP-7; IGF-binding protein 7; IGFBP-7; IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; Tumor-derived adhesion factor; TAF	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	IGFBP7 Antibody (YA3079) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IGFBP7.

HY-P83334A

	IGFBP7 Antibody (YA3079)(PBS only) IGFBP7; MAC25; PSF; Insulin-like growth factor-binding protein 7; IBP-7; IGF-binding protein 7; IGFBP-7; IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; Tumor-derived adhesion factor; TAF	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	IGFBP7 Antibody (YA3079) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IGFBP7.

HY-P81103

	CTGF Antibody CCN 2; CCN-2; CCN2; Connective Tissue Growth Factor; Hcs 24; Hcs24; Hypertrophic chondrocyte specific protein 24; Hypertrophic chondrocyte-specific gene product 24; Insulin-like Growth Factor-Binding Protein 8; MGC102839; NOV 2; NOV2; Connective tissue growth factor; CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP8; IGFBP-8; connective tissue growth factor precursor; CTGF_HUMAN.	WB, ELISA	Mouse, Rat
	CTGF Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to CTGF.

HY-P86830

	CYR61/CCN1 Antibody (YA6523) 3CH61 antibody; CCN 1 antibody; CCN family member 1 antibody; CCN1 antibody; CYR 61 antibody; Cyr61 antibody; CYR61 protein antibody; CYR61_HUMAN antibody; Cysteine rich angiogenic inducer 61 antibody; Cysteine rich heparin binding protein 61 antibody; 3CH61 antibody; CCN 1 antibody; CCN family member 1 antibody; CCN1 antibody; CYR 61 antibody; Cyr61 antibody; CYR61 protein antibody; CYR61_HUMAN antibody; Cysteine rich angiogenic inducer 61 antibody; Cysteine rich heparin binding protein 61 antibody; Cysteine-rich angiogenic inducer 61 antibody; GIG 1 antibody; GIG1 antibody; IBP-10 antibody; IGF-binding protein 10 antibody; IGFbp 10 antibody; IGFBP-10 antibody; IGFbp10 antibody; Insulin like growth factor binding protein 10 antibody; Insulin-like growth factor-binding protein 10 antibody; Protein CYR61 antibody; Protein GIG1 antibody;	WB, ICC/IF, IHC-P, IF-Tissue	Human
	CYR61/CCN1 Antibody (YA6523) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CYR61/CCN1.

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Cat. No.	Product Name		Classification

HY-RS06620

IGF2BP2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IGF2BP2 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2BP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-174655

*Human IGF1 mRNA*		mRNA
Human IGF1 mRNA encodes the human insulin like growth factor 1 (IGF1) protein which is involved in mediating growth and development.

HY-RS06618

IGF2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IGF2 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06619

IGF2BP1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IGF2BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06621

IGF2BP3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IGF2BP3 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2BP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-153485

Cimdelirsen ISIS 766720; IONIS-GHR-LRx		Antisense Oligonucleotides
Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor-1 (IGF-1) levels in acromegaly patients.

HY-153485A

Cimdelirsen sodium ISIS 766720 sodium; IONIS-GHR-LRx sodium		Antisense Oligonucleotides
Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor-1 (IGF-1) levels in acromegaly patients.

HY-RS17518

Igf2bp3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Igf2bp3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Igf2bp3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS22959

Igf1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Igf1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Igf1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-177622

Cibrigirsen		Antisense Oligonucleotides
Cibrigirsen is an antisense oligonucleotide targeted to the insulin-like growth factor I receptor(IGF-1R).

HY-RS06614

IGF1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IGF1 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16528

Igf1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Igf1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Igf1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16571

Igf2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Igf2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Igf2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06622

IGF2R Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IGF2R Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06617

Igf1r Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Igf1r Rat Pre-designed siRNA Set A contains three designed siRNAs for Igf1r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24452

Igf2r Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Igf2r Rat Pre-designed siRNA Set A contains three designed siRNAs for Igf2r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06615

IGF1R Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IGF1R Human Pre-designed siRNA Set A contains three designed siRNAs for IGF1R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17981

Igf2r Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Igf2r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Igf2r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06616

Igf1r Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Igf1r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Igf1r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06839

*INS-IGF2 Human Pre-designed siRNA Set A*		siRNAs Human Pre-designed siRNA Sets
INS-IGF2 Human Pre-designed siRNA Set A contains three designed siRNAs for INS-IGF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23290

Igf2bp1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Igf2bp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Igf2bp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23975

Igf2bp3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Igf2bp3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Igf2bp3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16822

Igf2bp2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Igf2bp2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Igf2bp2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23262

Igf2bp2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Igf2bp2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Igf2bp2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-174647

Human IGFBP6 mRNA		mRNA
Human IGFBP6 mRNA encodes the human insulin like growth factor binding protein 6 (IGFBP6) protein. IGFBP6 probably involves in prolong the half-life of the IGFs and either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.

HY-174648

Human IGFBP5 mRNA		mRNA
Human IGFBP5 mRNA encodes the human insulin like growth factor binding protein 5 (IGFBP5) protein. IGFBP5 probably involves in prolong the half-life of the IGFs and either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.

HY-177622A

Cibrigirsen sodium		Antisense Oligonucleotides
Cibrigirsen sodium is an antisense oligonucleotide targeted to the insulin-like growth factor I receptor(IGF-1R).

HY-174649

Human IGFBP4 mRNA		mRNA
Human IGFBP4 mRNA encodes the human insulin like growth factor binding protein 4 (IGFBP4) protein, a member of the insulin-like growth factor binding protein (IGFBP) family. IGFBP4 can bind both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.

HY-174650

Human IGFBP3 mRNA		mRNA
Human IGFBP3 mRNA encodes the human insulin like growth factor binding protein 3 (IGFBP3) protein, a member of the insulin-like growth factor binding protein (IGFBP) family. IGFBP3 can form a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors.

HY-174654

*Human IGF1R mRNA*		mRNA
Human IGF1R mRNA encodes the human insulin like growth factor 1 receptor (IGF1R) protein. IGF1R plays a critical role in transformation events.

HY-174653

*Human IGF2 mRNA*		mRNA
Human IGF2 mRNA encodes the human insulin like growth factor 2 (IGF2) protein, a member of the insulin family of polypeptide growth factors. IGF2 plays a key role in regulating fetoplacental development and also involves in tissue differentiation.

HY-RS23004

Igf2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Igf2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Igf2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16849

Igf2bp1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Igf2bp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Igf2bp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-174651

Human IGFBP2 mRNA		mRNA
Human IGFBP2 mRNA encodes the human insulin like growth factor binding protein 2 (IGFBP2) protein, is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II).

HY-174721

Human EGFR mRNA		mRNA
Human EGFR mRNA encodes the human epidermal growth factor receptor (EGFR) protein, a member of the protein kinase superfamily. IGF1R plays a critical role in transformation events. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation.

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