Search Result

Isoforms Recommended:	IL-5

Results for "

IL5

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Interleukin Related (38) Amyloid-β (1) Apoptosis (5) Bacterial (3) c-Fms (1) CD28 (1) CD3 (1) Drug Derivative (1) Endogenous Metabolite (3) Fungal (2) Glucosylceramide Synthase (GCS) (1) GSNOR (1) IFNAR (2) Keap1-Nrf2 (2) Liposome (1) LPL Receptor (2) MMP (4) mRNA (2) Mucin (1) Nuclear Factor of activated T Cells (NFAT) (1) Phosphatase (2) Phosphodiesterase (PDE) (2) Proteasome (2) Reference Standards (3) Ser/Thr Protease (2) Small Interfering RNA (siRNA) (6) SOD (2) Src (2) TGF-beta/Smad (3) TNF Receptor (1) Tyrosinase (2)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (43) Metabolic Disease (3) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) mRNA (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (2) Cholesterol (1) Interleukin & Receptors (2) siRNAs (6)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: Interleukin Related IRAK Itk

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P9945

Mepolizumab SB 240563	Interleukin Related	Cardiovascular Disease Inflammation/Immunology
Mepolizumab (SB 240563) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5 (IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma .

HY-P9945A

*Mepolizumab (anti-IL5)*	Interleukin Related	Inflammation/Immunology
Mepolizumab (anti-IL5) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5 (IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma .

HY-P990774

Verekitug ASP-7266; TRAB-1; UPB-101	Interleukin Related	Inflammation/Immunology
Verekitug (ASP-7266; TRAB-1; UPB-101) is a human monoclonal antibody targeting the thymic stromal lymphopoietin receptor (TSLPR), with a mean half-life of approximately 20 days. At doses of Verekitug ≥100 mg, complete and sustained TSLPR-specific occupancy is achieved, and the antibody does not bind to IL-7Rα. By inhibiting TSLP-driven inflammatory responses, Verekitug blocks TSLP-induced cell proliferation and TARC expression, while reducing fractional exhaled NO levels, blood eosinophil counts, and levels of *IL-5* and IgE. Verekitug significantly improves scores for nasal polyps, nasal congestion and olfactory dysfunction, with favorable safety and good tolerability; potential adverse reactions include headache, upper respiratory tract infection, sinusitis and nasopharyngitis. Verekitug is used in relevant studies on asthma, chronic rhinosinusitis with nasal polyps and chronic obstructive pulmonary disease .

HY-19969

YM-90709 1 Publications Verification	Interleukin Related	Inflammation/Immunology
YM-90709 is a novel *IL-5* inhibitor which selectively blocks the binding of IL-5 to the IL-5 receptor (IL-5R).YM-90709 potently inhibits the binding of [ ¹²⁵I]-IL-5 to IL-5R on human peripheral eosinophils and eosinophilic HL-60 clone 15 cells with IC₅₀ values of 1.0 and 0.57 μM .

HY-N1938

D(+)-Raffinose pentahydrate D-Raffinose pentahydrate	Endogenous Metabolite Glucosylceramide Synthase (GCS) Bacterial Phosphodiesterase (PDE) Interleukin Related	Infection Inflammation/Immunology
D(+)-Raffinose pentahydrate is an orally active inhibitor of LecA (K_d = 32 μM) and GtfC. D(+)-Raffinose pentahydrate reduces cyclic diguanylate (c-di-GMP) by increased activity of a c-di-GMP specific phosphodiesterase. D(+)-Raffinose pentahydrate interferes with GTF function. D(+)-Raffinose pentahydrate decreases IL-4 and *IL-5* mRNA. D(+)-Raffinose pentahydrate exhibits biofilm-inhibitory activity against Pseudomonas aeruginosa and Streptococcus mutans and inhibits allergic airway eosinophilia .

HY-137131

DC-Chol hydrochloride DC-Cholesterol hydrochloride	Amyloid-β Liposome IFNAR Interleukin Related	Neurological Disease Inflammation/Immunology
DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity .

HY-P9923A

*Benralizumab (anti-IL5RA )* 1 Publications Verification MEDI-563 (anti-IL5RA ); BIW-8405 (anti-IL5RA )	Interleukin Related Apoptosis	Inflammation/Immunology
Benralizumab (anti-IL5RA ) (MEDI-563 (anti-IL5RA ); BIW-8405 (anti-IL5RA)) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma study .

HY-N0646

Silydianin 1 Publications Verification	Phosphatase Endogenous Metabolite Tyrosinase Apoptosis Interleukin Related	Inflammation/Immunology Cancer
Silydianin is a flavonolignan. Silydianin can be obtained from Silybum marianum. Silydianin inhibits PTP1B with an IC₅₀ of 17.38 μM. Silydianin inhibits both monophenolase and diphenolase of tyrosinase significantly, with IC₅₀s of 2.6 μM and 16.5 μM, respectively. Silydianin induces Apoptosis and reduces cytokines (IL-4 and *IL-5*). Silymarin has antioxidant, cytoprotective and immunomodulatory effects. Silydianin has antitumor activity against prostate cancer. Silymarin can be used in allergic asthma research ^[5] .

HY-P990748

Lunsekimig SAR443765	Interleukin Related	Inflammation/Immunology
Lunsekimig (SAR443765) is an anti-TSLP/IL13/ALB nonobody composed of 5 sequentially linked variable region heavy chains. Lunsekimig decreases blood eosinophils and lowers plasma levels of IL-5, eotaxin-3, and IgE. Lunsekimig also improves lung function. Lunsekimig can be used for the study and treatment of type 2 inflammatory asthma .

HY-P990213

*Anti-Mouse/Human IL-5* Antibody (TRFK5)**	Interleukin Related	Inflammation/Immunology
Anti-Mouse/Human IL-5 Antibody (TRFK5) is a rat-derived anti-mouse *IL-5* IgG1 κ type antibody inhibitor. Anti-Mouse/Human IL-5 Antibody (TRFK5) can significantly decrease eosinophils. Anti-Mouse/Human IL-5 Antibody (TRFK5) shows potent anti- inflammation effect on pulmonary inflammation and asthma .

HY-NP159

House Dust Mite Extract, from D.farinae	Mucin Interleukin Related	Inflammation/Immunology
House Dust Mite Extract, from D.farinae is a house dust mite allergen extract derived from Dermatophagoides farinae. House Dust Mite Extract, from D.farinae significantly increases the levels of cytokines (IL-4, *IL-5, IL-6) in bronchoalveolar lavage fluid. House Dust Mite Extract, from D.farinae upregulates the overexpression of MUC5AC*. House Dust Mite Extract, from D.farinae induces allergic asthma and pulmonary inflammation .

HY-P9949

Reslizumab Sch 55700; CDP-835; JES1-39D10	Interleukin Related	Inflammation/Immunology
Reslizumab (Sch 55700) is humanized monoclonal antibodies that target **interleukin-5 (IL-5) for the treatment of eosinophilic asthma. Reslizumab is effective in neutralizing the function of IL-5. Reslizumab has high binding affinity for human IL-5, with K_D** values of 109 pM and 4.3 pM in the the Biacore surface plasmon resonance and Kinetic Exclusion Assay, respectively .

HY-17002

Suplatast (Tosilate) 1 Publications Verification IPD 1151T	Interleukin Related	Inflammation/Immunology
Suplatast Tosilate (IPD 1151T) is an orally active Th2 cytokine inhibitor which can inhibit both IL-4 and IL-5 production from Th2 cells and suppress IgE synthesis. Suplatast Tosilate is an anti-allergic agent. Suplatast Tosilate has antiasthmatic, anti-inflammatory and antifibrotic activity .

HY-P99371

Lirentelimab AK002; Antolimab	Apoptosis	Inflammation/Immunology
Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis .

HY-P1111

Lyn peptide inhibitor	Src Interleukin Related	Inflammation/Immunology
Lyn peptide inhibitor (YGYRLRRKWEEKIPNP-NH₂) is a potent, cell-permeable Lyn kinase inhibitor that inhibits Lyn-coupled signaling pathways associated with the *IL-5* receptor while preserving the integrity of other signals. Lyn peptide inhibitor blocks the activation of Lyn and inhibits the binding of Lyn tyrosine kinase to the βc subunit of the IL-3/GM-CSF/IL-5 receptor. Lyn peptide inhibitor can be used in the research of eosinophilic diseases such as asthma and allergy .

HY-N6013

Aloin (mixture of A&B)	MMP Proteasome Keap1-Nrf2 TGF-beta/Smad Interleukin Related SOD Bacterial Fungal	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Aloin (mixture of A&B) is an orally active anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) mitigates airway impairment and exerts neuroprotective, anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral and antitumor effects. Aloin (mixture of A&B) inhibits Clostridium histolyticum collagenase, granulocyte matrix metalloproteinases and human 20S proteasome. Aloin (mixture of A&B) upregulates the Nrf2/HO-1 pathway, suppresses the TGF-β/Smad2/3 pathway. Aloin (mixture of A&B) reduces *IL-4/IL-5/IL-13* levels, and reverses oxidative stress markers (MDA, SOD, GSH). Aloin (mixture of A&B) can be used for research on chronic ulcers, burns, wounds, inflammatory and degenerative disorders, asthma and neuroblastoma .

HY-P990094

Trabikibart CSL311	c-Fms	Inflammation/Immunology
Trabikibart (CSL311) is a specific inhibitor targeting the βc receptor (CSF2RB) that inhibits signal transduction mediated by GM-CSF, *IL-5, and IL-3*. Trabikibart exhibits significant anti-inflammatory and anti-edema effects, reduces myeloid cell infiltration, and inhibits inflammatory cell survival. Trabikibart also possesses antiviral immune functions, which alleviate pulmonary inflammation, reverse airway dysfunction and fibrosis, and thereby restore impaired pulmonary function. Trabikibart can be used in research on related diseases such as acute respiratory distress syndrome, viral pneumonia, asthma, and chronic rhinosinusitis with nasal polyps .

HY-P9923

Benralizumab 1 Publications Verification MEDI-563; BIW-8405; KHK4563	Interleukin Related Apoptosis	Inflammation/Immunology Cancer
Benralizumab (MEDI-563) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma .

HY-P99850

Depemokimab GSK-3511294	Interleukin Related	Inflammation/Immunology
Depemokimab (GSK-3511294) is a long-acting anti-IL-5 monoclonal antibody. Depemokimab can be used for research of asthma .

HY-N8309

Luteolin-4'-O-glucoside	Interleukin Related	Inflammation/Immunology Cancer
Luteolin-4'-O-glucoside is an *IL-5* inhibitor with an IC₅₀ of 3.7 μM. Luteolin-4'-O-glucoside resists hyperuricemia and acute gouty arthritis activity. Luteolin-4'-O-glucoside shows anticancer activity .

HY-110295

SPL-334	GSNOR	Inflammation/Immunology
SPL-334 is a potent and selective S-Nitrosoglutathione reductase (GSNOR) inhibitor. SPL-334 causes a significant reduction in the production of Th2 cytokines IL-5 and IL-13 and the levels of the chemokine CCL11 (eotaxin-1) in the airways. SPL-334 can be used in research of allergic airway inflammation .

HY-111167

AN-2898	Phosphodiesterase (PDE) Interleukin Related TNF Receptor IFNAR	Inflammation/Immunology
AN-2898 is a selective PDE4 inhibitor with IC₅₀ of 0.027 μM over other phosphodiesterase enzymes, such as PDE1A, PDE2A and PDE3A. AN-2898 also potently inhibits PDE4 subtypes (PDE4B1, PDE4A1A and PDE4D2). AN-2898 significantly inhibits the production of TNF-α, IL-2, IFN-γ, *IL-5* and IL-10. AN-2898 can be used for mild to moderate atopic dermatitis (AD) and psoriasis research .

HY-175876

ADAM17-IN-1	MMP Interleukin Related	Inflammation/Immunology
ADAM17-IN-1 is a selective inhibitor of ADAM17. ADAM17-IN-1 inhibits ADAM17 activity to reduce metabolic activity of dendritic cells (DCs), impair DC antigen-presenting function, suppress allergen-specific Th2 cell polarization, and reduce Th2 cytokine (*IL-4, IL-5, IL-13*) secretion. ADAM17-IN-1 demonstrates protective efficacy against house dust mite (HDM)-induced type 2/eosinophilic airway inflammation in mice. ADAM17-IN-1 can be used for the study of type 2-high allergic asthma .

HY-RS06771

Il5 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
Il5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il5 Mouse Pre-designed siRNA Set A Il5 Mouse Pre-designed siRNA Set A

HY-RS06770

IL5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
IL5 Human Pre-designed siRNA Set A contains three designed siRNAs for IL5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL5 Human Pre-designed siRNA Set A IL5 Human Pre-designed siRNA Set A

HY-P991712

Revbekitug	Interleukin Related	Inflammation/Immunology
Revbekitug is a humanized IgG1κ antibody targeting *IL-5*. The corresponding isotype control is: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-RS06772

Il5 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
Il5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il5 Rat Pre-designed siRNA Set A Il5 Rat Pre-designed siRNA Set A

HY-P991633

TQC2938	Interleukin Related	Inflammation/Immunology
TQC2938 is a humanized IgG2 monoclonal antibody inhibitor targeting Stimulation-2 (ST2). TQC2938 inhibits the ST2/IL-33 signaling pathway, reduces the level of downstream Th2 cytokines (such as IL-4, IL-5, and IL-13) and eosinophils as well as other inflammatory cells. TQC2938 can be used for inflammatory diseases like asthma research .

HY-19486

UR-1505	Nuclear Factor of activated T Cells (NFAT) CD3 CD28 Interleukin Related	Inflammation/Immunology
UR-1505 is a nuclear factor of activated T cells (NF-AT) inhibitor. UR-1505 can suppress CD3/CD28 induced T cell proliferation, increase p27 ^KIP levels, and induce G1/S cell cycle arrest. UR-1505 can also inhibit the production of *IL-5* and IFN-γ in activated T cells. UR-1505 has immunomodulatory properties and can be used in the study of atopic dermatitis .

HY-174602

*Human IL5* mRNA**	mRNA	Inflammation/Immunology
Human IL5 mRNA encodes the human interleukin 5 (IL5) protein, a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. IL5 plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases.

HY-106979

Olcorolimus SAR-943	Drug Derivative Interleukin Related	Inflammation/Immunology
Olcorolimus (SAR-943) is a Rapamycin (HY-10219) derivative. Olcorolimus can reduce IL-4, IL-5, eosinophil, neutrophil, lymphocyte, cellular fibronectin; lung epithelial cell proliferation and mucus hypersecretory phenotype in Ovalbumin (HY-W250978)-sensitized BALB/c mice. Olcorolimus can be used for the researches of inflammation and immunology, such as asthma .

HY-P1111A

Lyn peptide inhibitor TFA	Src Interleukin Related	Inflammation/Immunology
Lyn peptide inhibitor TFA is a potent and cell-permeable inhibitor of *Lyn-coupled IL-5* receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor TFA blocks Lyn activation and inhibits the binding of Lyn tyrosine kinase** to βc subunit of IL-3/GM-CSF/IL-5 receptors. Lyn peptide inhibitor TFA can be used for study of asthma, allergic, and other eosinophilic disorders .

HY-147660

IMMH001	LPL Receptor	Inflammation/Immunology
IMMH001, also called SYL930, is an orally active, potent and selective S1P1 (sphingosine-1-phosphate receptor 1) agonist. IMMH001 decreased levels of both chemokines and proinflammatory cytokines, including IL-1β, IL-5, IL-18, IP10, CCL3, and CCL5. IMMH001 can be used for rheumatoid arthritis (RA) research .

HY-W585843

1,1′-Ethylidenebis[L-tryptophan]	Interleukin Related	Inflammation/Immunology
1,1′-Ethylidenebis[L-tryptophan] is an impurity in the synthesis of L-tryptophan. 1,1′-Ethylidenebis[L-tryptophan] promotes the proliferation of eosinophilic leukemia cells, induces the release of eosinophil cationic protein from eosinophils, and stimulates T cells to produce *IL-5*. 1,1′-Ethylidenebis[L-tryptophan] (40 µg/kg) can induce fascia thickening, mast cell infiltration, and fibrosis in adipose and subcutaneous muscle tissues in mice. 1,1′-Ethylidenebis[L-tryptophan] can be used in immunology and inflammation research .

HY-P991144

Lasrekibart	Interleukin Related	Inflammation/Immunology
Lasrekibart is a humanized monoclonal antibody targeting human interleukin 5 (IL-5). Lasrekibart specifically binds to *IL-5, blocking the interaction between IL-5* and its receptor, thus exerting immunosuppressive and anti-inflammatory activities. Lasrekibart is promising for research of allergic and inflammatory diseases, such as asthma .

HY-P990058

Varokibart	Interleukin Related	Inflammation/Immunology
Varokibart (TEV-53275) is a human IgG4λ antibody targeting *IL5* .

HY-19472

RWJ-58643	Ser/Thr Protease	Inflammation/Immunology
RWJ-58643 is a β-trypsin inhibitor that suppresses allergic inflammation. RWJ-58643 (100 mg) significantly reduced nasal allergy symptoms, eosinophil infiltration, and IL-5 levels at low doses. RWJ-58643 resulted in late eosinophilia and elevated IL-5 levels at high doses (300 mg and 600 mg). RWJ-58643 modulates allergic responses by inhibiting the release of β-trypsin from mast cells .

HY-19472A

RWJ-58643 hydrochloride	Ser/Thr Protease	Inflammation/Immunology
RWJ-58643 hydrochloride is a β-trypsin inhibitor that inhibits allergic inflammation. RWJ-58643 hydrochloride (100 mg) significantly reduces nasal allergy symptoms, eosinophil infiltration, and IL-5 levels at low doses. RWJ-58643 hydrochloride causes late eosinophilia and elevated IL-5 levels at high doses (300 mg and 600 mg). RWJ-58643 hydrochloride modulates allergic reactions by inhibiting the release of β-trypsin from mast cells.

HY-P991599

SHR-1703	Interleukin Related	Inflammation/Immunology
SHR-1703 is a long-acting humanized anti-IL-5 IgG1 monoclonal antibody. SHR-1703 can selectively recognize and bind to *IL-5, blocking the binding of IL-5* to the α chain of the receptor on the surface of eosinophils, thereby inhibiting the proliferation, activation, and migration of eosinophils, and ultimately reducing eosinophil-mediated inflammation and damage. SHR-1703 can be used in the research of eosinophil-related diseases, such as eosinophilic asthma. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-N8309R

Luteolin-4'-O-glucoside (Standard)	Reference Standards Interleukin Related	Inflammation/Immunology Cancer
Luteolin-4'-O-glucoside (Standard) is the analytical standard of Luteolin-4'-O-glucoside. This product is intended for research and analytical applications. Luteolin-4'-O-glucoside is an IL-5 inhibitor with an IC₅₀ of 3.7 μM. Luteolin-4'-O-glucoside resists hyperuricemia and acute gouty arthritis activity. Luteolin-4'-O-glucoside shows anticancer activity .

HY-N6013R

Aloin (mixture of A&B) (Standard)	Reference Standards Proteasome MMP Keap1-Nrf2 TGF-beta/Smad Interleukin Related SOD Fungal Bacterial	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Aloin (mixture of A&B) (Standard) is the analytical standard of Aloin (mixture of A&B) (HY-N6013). This product is intended for research and analytical applications. Aloin (mixture of A&B) is an orally active anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) mitigates airway impairment and exerts neuroprotective, anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral and antitumor effects. Aloin (mixture of A&B) inhibits Clostridium histolyticum collagenase, granulocyte matrix metalloproteinases and human 20S proteasome. Aloin (mixture of A&B) upregulates the Nrf2/HO-1 pathway, suppresses the TGF-β/Smad2/3 pathway. Aloin (mixture of A&B) reduces *IL-4/IL-5/IL-13* levels, and reverses oxidative stress markers (MDA, SOD, GSH). Aloin (mixture of A&B) can be used for research on chronic ulcers, burns, wounds, inflammatory and degenerative disorders, asthma and neuroblastoma .

HY-169864

KRO-105714	LPL Receptor	Inflammation/Immunology
KRO-105714 is the antagonist for sphingosine phosphocholine receptor (SPC Receptor) and sphingosine-1-phosphate receptor 1 (S1P1 Receptor) (IC₅₀=79.2 nM). KRO-105714 inhibits SPC-induced proliferation of NIH3T3 (IC₅₀=5.6 nM), inhibits SPC-induced cell migration (IC₅₀=0.59 μM) and tube formation in HUVECs. KRO-105714 inhibits SPC-induced generation of IL-4 and IL-5, exhibits anti-inflammtory efficacy in mouse atopic dermatitis models .

HY-165484

AVP-13358	Interleukin Related	Inflammation/Immunology
AVP-13358 is an orally active IgE inhibitor that effectively suppresses immunoglobulin E (IgE)-mediated immune responses, with IC₅₀ values of 8 and 3 nM for IgE inhibition in vivo and in vitro in BALB/c mice, respectively. AVP-13358 acts directly on T cells, inhibiting the production and release of IL-4, *IL-5, and IL-13. It also targets other markers critical for the development of allergic responses, including the B cell IgE* receptor (CD23) in human monocytes and the CD23 and IL-4 receptors in mouse B cells. AVP-13358 can be used in research related to anti-allergic responses .

HY-N0646R

Silydianin (Standard)	Reference Standards Phosphatase Endogenous Metabolite Tyrosinase Apoptosis Interleukin Related	Inflammation/Immunology Cancer
Silydianin (Standard) is the analytical standard of Silydianin (HY-N0646). This product is intended for research and analytical applications. Silydianin is a flavonolignan. Silydianin can be obtained from Silybum marianum. Silydianin inhibits PTP1B with an IC₅₀ of 17.38 μM. Silydianin inhibits both monophenolase and diphenolase of tyrosinase significantly, with IC₅₀s of 2.6 μM and 16.5 μM, respectively. Silydianin induces Apoptosis and reduces cytokines (IL-4 and *IL-5*). Silymarin has antioxidant, cytoprotective and immunomodulatory effects. Silydianin has antitumor activity against prostate cancer. Silymarin can be used in allergic asthma research ^[5] .

HY-174601

*Human IL5RA mRNA*	mRNA	Inflammation/Immunology
Human IL5RA mRNA encodes the human interleukin 5 receptor subunit alpha (IL5RA) protein, an interleukin 5 specific subunit of a heterodimeric cytokine receptor. IL5RA has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4.

HY-P990452

*Anti-IL-5* Antibody**	Interleukin Related	Inflammation/Immunology
Anti-IL-5 Antibody is a CHO-expressed humanized antibody that targets *IL-5. The Anti-IL-5* Antibody is composed of huIgG4 heavy chains and huκ light chains, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-IL-5 Antibody can be referenced as Human IgG4 kappa, Isotype Control (HY-P99003).

HY-RS06773

IL5RA Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL5RA Human Pre-designed siRNA Set A contains three designed siRNAs for IL5RA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL5RA Human Pre-designed siRNA Set A IL5RA Human Pre-designed siRNA Set A

HY-182795

Colchicine derivative-1	MMP Interleukin Related TGF-beta/Smad	Metabolic Disease
Colchicine derivative-1 is a colchicine derivative. Colchicine derivative-1 exhibits cytotoxicity against various cells. Colchicine derivative-1 arrests cancer cells at the G2/M phase of the cell cycle. Colchicine derivative-1 increases the levels of MMP-2, MMP-8, MMP-9, IL-2, IL-6, IL-17A, IL-22, IL-4, and *IL-5* in the blood, inhibits the gene expression of hepatic fibrinogen α, β, γ and TGF-β1, and alleviates hepatic fibrosis symptoms in mice. Colchicine derivative-1 has antifibrotic activity and can be used in studies related to hepatic fibrosis .

HY-RS26191

Il5ra Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il5ra Rat Pre-designed siRNA Set A contains three designed siRNAs for Il5ra gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il5ra Rat Pre-designed siRNA Set A Il5ra Rat Pre-designed siRNA Set A

HY-RS19696

Il5ra Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il5ra Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il5ra gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il5ra Mouse Pre-designed siRNA Set A Il5ra Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Type

HY-137131

DC-Chol hydrochloride

DC-Cholesterol hydrochloride

Biochemical Assay Reagents

DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity .

HY-NP159

House Dust Mite Extract, from D.farinae

Biochemical Assay Reagents

House Dust Mite Extract, from D.farinae is a house dust mite allergen extract derived from Dermatophagoides farinae. House Dust Mite Extract, from D.farinae significantly increases the levels of cytokines (IL-4, IL-5, IL-6) in bronchoalveolar lavage fluid. House Dust Mite Extract, from D.farinae upregulates the overexpression of MUC5AC. House Dust Mite Extract, from D.farinae induces allergic asthma and pulmonary inflammation .

Cat. No.	Product Name	Target	Research Area

HY-P1111

Lyn peptide inhibitor	Src Interleukin Related	Inflammation/Immunology
Lyn peptide inhibitor (YGYRLRRKWEEKIPNP-NH₂) is a potent, cell-permeable Lyn kinase inhibitor that inhibits Lyn-coupled signaling pathways associated with the *IL-5* receptor while preserving the integrity of other signals. Lyn peptide inhibitor blocks the activation of Lyn and inhibits the binding of Lyn tyrosine kinase to the βc subunit of the IL-3/GM-CSF/IL-5 receptor. Lyn peptide inhibitor can be used in the research of eosinophilic diseases such as asthma and allergy .

HY-P1111A

Lyn peptide inhibitor TFA	Src Interleukin Related	Inflammation/Immunology
Lyn peptide inhibitor TFA is a potent and cell-permeable inhibitor of *Lyn-coupled IL-5* receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor TFA blocks Lyn activation and inhibits the binding of Lyn tyrosine kinase** to βc subunit of IL-3/GM-CSF/IL-5 receptors. Lyn peptide inhibitor TFA can be used for study of asthma, allergic, and other eosinophilic disorders .

Cat. No.	Product Name	Target	Research Area	Image

HY-P9945

Mepolizumab SB 240563	Interleukin Related	Cardiovascular Disease Inflammation/Immunology
Mepolizumab (SB 240563) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5 (IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma .

HY-P9945A

*Mepolizumab (anti-IL5)*	Interleukin Related	Inflammation/Immunology
Mepolizumab (anti-IL5) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5 (IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma .

HY-P990774

Verekitug ASP-7266; TRAB-1; UPB-101	Interleukin Related	Inflammation/Immunology
Verekitug (ASP-7266; TRAB-1; UPB-101) is a human monoclonal antibody targeting the thymic stromal lymphopoietin receptor (TSLPR), with a mean half-life of approximately 20 days. At doses of Verekitug ≥100 mg, complete and sustained TSLPR-specific occupancy is achieved, and the antibody does not bind to IL-7Rα. By inhibiting TSLP-driven inflammatory responses, Verekitug blocks TSLP-induced cell proliferation and TARC expression, while reducing fractional exhaled NO levels, blood eosinophil counts, and levels of *IL-5* and IgE. Verekitug significantly improves scores for nasal polyps, nasal congestion and olfactory dysfunction, with favorable safety and good tolerability; potential adverse reactions include headache, upper respiratory tract infection, sinusitis and nasopharyngitis. Verekitug is used in relevant studies on asthma, chronic rhinosinusitis with nasal polyps and chronic obstructive pulmonary disease .

HY-P9923A

*Benralizumab (anti-IL5RA )* 1 Publications Verification MEDI-563 (anti-IL5RA ); BIW-8405 (anti-IL5RA )	Interleukin Related Apoptosis	Inflammation/Immunology
Benralizumab (anti-IL5RA ) (MEDI-563 (anti-IL5RA ); BIW-8405 (anti-IL5RA)) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma study .

HY-P990748

Lunsekimig SAR443765	Interleukin Related	Inflammation/Immunology
Lunsekimig (SAR443765) is an anti-TSLP/IL13/ALB nonobody composed of 5 sequentially linked variable region heavy chains. Lunsekimig decreases blood eosinophils and lowers plasma levels of IL-5, eotaxin-3, and IgE. Lunsekimig also improves lung function. Lunsekimig can be used for the study and treatment of type 2 inflammatory asthma .

HY-P990213

*Anti-Mouse/Human IL-5* Antibody (TRFK5)**	Interleukin Related	Inflammation/Immunology
Anti-Mouse/Human IL-5 Antibody (TRFK5) is a rat-derived anti-mouse *IL-5* IgG1 κ type antibody inhibitor. Anti-Mouse/Human IL-5 Antibody (TRFK5) can significantly decrease eosinophils. Anti-Mouse/Human IL-5 Antibody (TRFK5) shows potent anti- inflammation effect on pulmonary inflammation and asthma .

HY-P9949

Reslizumab Sch 55700; CDP-835; JES1-39D10	Interleukin Related	Inflammation/Immunology
Reslizumab (Sch 55700) is humanized monoclonal antibodies that target **interleukin-5 (IL-5) for the treatment of eosinophilic asthma. Reslizumab is effective in neutralizing the function of IL-5. Reslizumab has high binding affinity for human IL-5, with K_D** values of 109 pM and 4.3 pM in the the Biacore surface plasmon resonance and Kinetic Exclusion Assay, respectively .

HY-P99371

Lirentelimab AK002; Antolimab	Apoptosis	Inflammation/Immunology
Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis .

HY-P990094

Trabikibart CSL311	c-Fms	Inflammation/Immunology
Trabikibart (CSL311) is a specific inhibitor targeting the βc receptor (CSF2RB) that inhibits signal transduction mediated by GM-CSF, *IL-5, and IL-3*. Trabikibart exhibits significant anti-inflammatory and anti-edema effects, reduces myeloid cell infiltration, and inhibits inflammatory cell survival. Trabikibart also possesses antiviral immune functions, which alleviate pulmonary inflammation, reverse airway dysfunction and fibrosis, and thereby restore impaired pulmonary function. Trabikibart can be used in research on related diseases such as acute respiratory distress syndrome, viral pneumonia, asthma, and chronic rhinosinusitis with nasal polyps .

HY-P9923

Benralizumab 1 Publications Verification MEDI-563; BIW-8405; KHK4563	Interleukin Related Apoptosis	Inflammation/Immunology Cancer
Benralizumab (MEDI-563) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma .

HY-P99850

Depemokimab GSK-3511294	Interleukin Related	Inflammation/Immunology
Depemokimab (GSK-3511294) is a long-acting anti-IL-5 monoclonal antibody. Depemokimab can be used for research of asthma .

HY-P991712

Revbekitug	Interleukin Related	Inflammation/Immunology
Revbekitug is a humanized IgG1κ antibody targeting *IL-5*. The corresponding isotype control is: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991633

TQC2938	Interleukin Related	Inflammation/Immunology
TQC2938 is a humanized IgG2 monoclonal antibody inhibitor targeting Stimulation-2 (ST2). TQC2938 inhibits the ST2/IL-33 signaling pathway, reduces the level of downstream Th2 cytokines (such as IL-4, IL-5, and IL-13) and eosinophils as well as other inflammatory cells. TQC2938 can be used for inflammatory diseases like asthma research .

HY-P991144

Lasrekibart	Interleukin Related	Inflammation/Immunology
Lasrekibart is a humanized monoclonal antibody targeting human interleukin 5 (IL-5). Lasrekibart specifically binds to *IL-5, blocking the interaction between IL-5* and its receptor, thus exerting immunosuppressive and anti-inflammatory activities. Lasrekibart is promising for research of allergic and inflammatory diseases, such as asthma .

HY-P990058

Varokibart	Interleukin Related	Inflammation/Immunology
Varokibart (TEV-53275) is a human IgG4λ antibody targeting *IL5* .

HY-P991599

SHR-1703	Interleukin Related	Inflammation/Immunology
SHR-1703 is a long-acting humanized anti-IL-5 IgG1 monoclonal antibody. SHR-1703 can selectively recognize and bind to *IL-5, blocking the binding of IL-5* to the α chain of the receptor on the surface of eosinophils, thereby inhibiting the proliferation, activation, and migration of eosinophils, and ultimately reducing eosinophil-mediated inflammation and damage. SHR-1703 can be used in the research of eosinophil-related diseases, such as eosinophilic asthma. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990452

*Anti-IL-5* Antibody**	Interleukin Related	Inflammation/Immunology
Anti-IL-5 Antibody is a CHO-expressed humanized antibody that targets *IL-5. The Anti-IL-5* Antibody is composed of huIgG4 heavy chains and huκ light chains, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-IL-5 Antibody can be referenced as Human IgG4 kappa, Isotype Control (HY-P99003).

Recombinant Proteins Recommended:

IL-5

Species:	Human (14) Rat (3) Mouse (9) Cynomolgus (2) Rabbit (1) Canine (1) Pig (1)
Tag:	His (21) Tag Free (7) Avi (7) Fc (3)
Source:	HEK293 (18) CHO (3) Sf9 insect cells (4) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P78608

	IL-5 Protein, Rabbit (HEK293, His) IL-5; TRF; IL5; Interleukin-5	Rabbit	HEK293
	The IL5 protein is a cytokine that plays a key role in regulating the growth and differentiation of eosinophils, a type of white blood cell involved in allergic reactions and asthma. Dysregulation of IL5 protein is associated with a variety of allergic and inflammatory diseases. IL-5 Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived IL-5 protein, expressed by HEK293 , with N-6*His labeled tag.

HY-P71630

	IL-5 Protein, Pig (His) IL5; Interleukin-5; IL-5; EosinophIL differentiation factor; T-cell replacing factor; TRF	Pig	E. coli
	IL-5 Protein, expressed by T-lymphocytes and NK cells, is vital for eosinophil survival, differentiation, and chemotaxis. It also affects B-cells, inducing immunoglobulin production and growth. IL-5 Protein activates kinases LYN, SYK, and JAK2 through IL5RA and CSF2RB subunits, signaling via RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer. IL-5 Protein, Pig (His) is the recombinant pig-derived IL-5 protein, expressed by E. coli , with N-His labeled tag.

HY-P70612

	IL-5 Protein, Human (HEK293, His) 2 Publications Verification Interleukin-5; IL-5; B-cell differentiation factor I; EosinophIL differentiation factor; T-cell replacing factor; TRF; IL5	Human	HEK293
	The IL-5 Protein, predominantly expressed by T-lymphocytes and NK cells, is crucial for eosinophil survival, differentiation, and chemotaxis. It also affects B-cells, inducing immunoglobulin production, growth, and differentiation. IL-5 Protein activates kinases like LYN, SYK, and JAK2, which signal through RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer and interacts with IL5RA and CSF2RB subunits. IL-5 Protein, Human (HEK293, His) is the recombinant human-derived IL-5 protein, expressed by HEK293 , with C-His labeled tag.

HY-P700215AF

	*Animal-Free IL-5* Protein, Mouse (His)** 2 Publications Verification Interleukin-5; IL-5; B-cell differentiation factor I; EosinophIL differentiation factor; T-cell replacing factor; TRF; IL5	Mouse	E. coli
	IL-5 protein is expressed by T lymphocytes and NK cells and regulates eosinophils, affecting their survival, differentiation and chemotaxis.In addition, IL-5 stimulates immunoglobulin production, growth, and differentiation of activated and resting B cells.Animal-Free IL-5 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-5 protein, expressed by E.coli , with C-His labeled tag.This product is for cell culture use only.

HY-P700131AF

	*Animal-Free IL-5* Protein, Human (His)** Interleukin-5; B-cell differentiation factor I; EosinophIL differentiation factor; T-cell replacing factor; TRF; IL5	Human	E. coli
	The IL-5 Protein, predominantly expressed by T-lymphocytes and NK cells, is crucial for eosinophil survival, differentiation, and chemotaxis. It also affects B-cells, inducing immunoglobulin production, growth, and differentiation. IL-5 Protein activates kinases like LYN, SYK, and JAK2, which signal through RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer and interacts with IL5RA and CSF2RB subunits. Animal-Free IL-5 Protein, Human (His) is the recombinant human-derived animal-FreeIL-5 protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P73219

	IL-5 Protein, Mouse (sf9, His) Interleukin-5; IL-5; EDF; Eo-CSF; TRF	Mouse	Sf9 insect cells
	IL-5 protein is expressed by T lymphocytes and NK cells and regulates eosinophils, affecting their survival, differentiation and chemotaxis. In addition, IL-5 stimulates immunoglobulin production, growth, and differentiation of activated and resting B cells. IL-5 Protein, Mouse (sf9, His) is the recombinant mouse-derived IL-5 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P73218

	IL-5 Protein, Canine (sf9, His) Interleukin-5; IL-5; EDF; Eo-CSF; TRF	Canine	Sf9 insect cells
	IL-5 protein is expressed by T lymphocytes and NK cells and plays a crucial role in eosinophil survival, differentiation, and chemotaxis. It also promotes immunoglobulin production, growth and differentiation in B cells. IL-5 Protein, Canine (sf9, His) is the recombinant canine-derived IL-5 protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P73878

	IL-5 Protein, Cynomolgus (sf9, His) Interleukin-5; IL-5; EDF; Eo-CSF; TRF	Cynomolgus	Sf9 insect cells
	IL-5 Protein, produced by T-lymphocytes and NK cells, is crucial for eosinophil survival, differentiation, and chemotaxis. It stimulates immunoglobulin production and growth in B-cells. IL-5 Protein activates kinases (LYN, SYK, and JAK2) through a receptor (IL5RA and CSF2RB subunits), propagating signals via RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer. IL-5 Protein, Cynomolgus (sf9, His) is the recombinant cynomolgus-derived IL-5 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P704717

	IL-5 Protein, Cynomolgus (HEK293, His) Interleukin-5; IL-5; EDF; Eo-CSF; TRF	Cynomolgus	HEK293
	IL-5 Protein, produced by T-lymphocytes and NK cells, is crucial for eosinophil survival, differentiation, and chemotaxis. It stimulates immunoglobulin production and growth in B-cells. IL-5 Protein activates kinases (LYN, SYK, and JAK2) through a receptor (IL5RA and CSF2RB subunits), propagating signals via RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer. IL-5 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-5 protein, expressed by HEK293, with N-His labeled tag.

HY-P72387

	IL-5 Protein, Human (Biotinylated, HEK293, His-Avi) Interleukin-5; B-cell differentiation factor I; EosinophIL differentiation factor; T-cell replacing factor; TRF; IL5	Human	HEK293
	The IL-5 Protein, predominantly expressed by T-lymphocytes and NK cells, is crucial for eosinophil survival, differentiation, and chemotaxis. It also affects B-cells, inducing immunoglobulin production, growth, and differentiation. IL-5 Protein activates kinases like LYN, SYK, and JAK2, which signal through RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer and interacts with IL5RA and CSF2RB subunits. IL-5 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IL-5 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.

HY-P704394

	IL-5 Protein, Human (HEK293) Interleukin-5; B-cell differentiation factor I; EosinophIL differentiation factor; T-cell replacing factor; TRF; IL5	Human	HEK293
	The IL-5 Protein, predominantly expressed by T-lymphocytes and NK cells, is crucial for eosinophil survival, differentiation, and chemotaxis. It also affects B-cells, inducing immunoglobulin production, growth, and differentiation. IL-5 Protein activates kinases like LYN, SYK, and JAK2, which signal through RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer and interacts with IL5RA and CSF2RB subunits. IL-5 Protein, Human (HEK293) is the recombinant human-derived IL-5 protein, expressed by HEK293, with tag free.

HY-P78314

	IL-5 Protein, Mouse (HEK293, His-Avi) Interleukin-5; IL-5; T-cell replacing factor; TRF; EDF	Mouse	HEK293
	IL-5 protein is expressed by T lymphocytes and NK cells and regulates eosinophils, affecting their survival, differentiation and chemotaxis.In addition, IL-5 stimulates immunoglobulin production, growth, and differentiation of activated and resting B cells.IL-5 Protein, Mouse (HEK293, His-Avi) is the recombinant mouse-derived IL-5 protein, expressed by HEK293 , with N-His, N-Avi labeled tag.

HY-P78467

	IL-5 Protein, Human (HEK293, His-Avi) Interleukin-5; IL-5; T-cell replacing factor; TRF; EDF	Human	HEK293
	The IL-5 Protein, predominantly expressed by T-lymphocytes and NK cells, is crucial for eosinophil survival, differentiation, and chemotaxis. It also affects B-cells, inducing immunoglobulin production, growth, and differentiation. IL-5 Protein activates kinases like LYN, SYK, and JAK2, which signal through RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer and interacts with IL5RA and CSF2RB subunits. IL-5 Protein, Human (HEK293, His-Avi) is the recombinant human-derived IL-5 protein, expressed by HEK293 , with N-His, N-Avi labeled tag.

HY-P78155

	IL-5 Protein, Mouse (Biotinylated, HEK293, His-Avi) Interleukin-5; IL-5; T-cell replacing factor; TRF; EDF	Mouse	HEK293
	IL-5 protein is expressed by T lymphocytes and NK cells and regulates eosinophils, affecting their survival, differentiation and chemotaxis.In addition, IL-5 stimulates immunoglobulin production, growth, and differentiation of activated and resting B cells.IL-5 Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived IL-5 protein, expressed by HEK293 , with N-His, N-Avi labeled tag.

HY-P7081

	IL-5 Protein, Mouse rMuIL-5; EDF; BCDFII; TRF	Mouse	E. coli
	IL-5 Protein, Mouse is a hematopoietic growth factor expressed in Th2, mast cells and eosinophils.

HY-P7102

	IL-5 Protein, Rat 1 Publications Verification rRtIL-5; EDF; BCDFII; TRF	Rat	E. coli
	IL-5 Protein, Rat, a T-cell derived cytokine, stimulates B cell growth and increases immunoglobulin secretion.

HY-P7043

	IL-5 Protein, Human rHuIL-5; EDF; BCDFII; TRF	Human	E. coli
	IL-5 Protein, Human is a selective activator of human eosinophil function.

HY-P7102A

	IL-5 Protein, Rat (CHO) rRtIL-5; EDF; BCDFII; TRF	Rat	CHO
	IL-5 Protein, Rat (CHO), a CHO cell derived cytokine, stimulates B cell growth and increases immunoglobulin secretion.

HY-P7043A

	IL-5 Protein, Human (CHO) rHuIL-5; EDF; BCDFII; TRF	Human	CHO
	IL-5 Protein, Human (CHO) is a selective activator of human eosinophil function.

HY-P7081A

	IL-5 Protein, Mouse (CHO) rMuIL-5; EDF; BCDFII; TRF	Mouse	CHO
	IL-5 Protein, Mouse (CHO) is a CHO cell derived hematopoietic growth factor expressed in Th2, mast cells and eosinophils.

HY-P70746

	IL-5 Protein, Mouse (HEK293, His) Interleukin-5; IL-5; B-cell differentiation factor I; EosinophIL differentiation factor; T-cell replacing factor; TRF; IL5	Mouse	HEK293
	IL-5 protein is expressed by T lymphocytes and NK cells and regulates eosinophils, affecting their survival, differentiation and chemotaxis.In addition, IL-5 stimulates immunoglobulin production, growth, and differentiation of activated and resting B cells.IL-5 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IL-5 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P78162

	IL-5R alpha Protein, Human (Biotinylated, HEK293, His-Avi) CD125; CDw125CD125; HSIL5R3; IL-5 R alpha; IL-5R subunit alpha; IL5R; IL5RA; IL-5Ra; MGC26560	Human	HEK293
	IL-5R alpha protein is a cytokine receptor that is expressed on eosinophils, basophils and B cells and is involved in inflammation and immune regulation.IL-5R alpha Protein, Human (Biotinylated, HEK293, His-Avi) is expressed by HEK293 cells with His-Avi tags.

HY-P78471

	IL-5R alpha Protein, Human (HEK293, His-Avi) CD125; CDw125CD125; HSIL5R3; IL-5 R alpha; IL-5R subunit alpha; IL5R; IL5RA; IL-5Ra; MGC26560	Human	HEK293
	IL-5R alpha protein is a cytokine receptor that is expressed on eosinophils, basophils and B cells and is involved in inflammation and immune regulation.IL-5R alpha Protein, Human (HEK293, His-Avi) is expressed by HEK293 cells with His-Avi tags.

HY-P705047

	IL-5R alpha Protein, Human (Biotinylated, HEK293, Fc-Avi) CD125; CDw125CD125; HSIL5R3; IL-5 R alpha; IL-5R subunit alpha; IL5R; IL5RA; IL-5Ra; MGC26560	Human	HEK293

HY-P72539

	IL-5R alpha Protein, Human (HEK293, His) Interleukin-5 receptor subunit alpha; IL-5R-alpha; IL-5RA; CDw125; CD125; IL5R	Human	HEK293
	IL-5R alpha protein is a cytokine receptor that is expressed on eosinophils, basophils and B cells and is involved in inflammation and immune regulation.IL-5R alpha Protein, Human (HEK293, His) is expressed by HEK293 cells with a C-6*His tag.

HY-P72540

	IL-5R alpha Protein, Mouse (HEK293, His) Interleukin-5 receptor subunit alpha; IL-5R-alpha; IL-5RA; CDw125; CD125; IL5R	Mouse	HEK293
	IL-5R alpha protein is a cytokine receptor that is expressed on eosinophils, basophils and B cells and is involved in inflammation and immune regulation. IL-5R alpha Protein, Mouse (HEK293, His) is expressed by HEK293 cells and is a transmembrane protein with a C-6*His tag.

HY-P75864

	IL-5R alpha Protein, Mouse (sf9, His) Interleukin-5 receptor subunit alpha; IL-5R-alpha; IL-5RA; CDw125; CD125; IL5R	Mouse	Sf9 insect cells
	IL-5R alpha protein is a cytokine receptor that is expressed on eosinophils, basophils and B cells and is involved in inflammation and immune regulation. IL-5R alpha Protein, Mouse (sf9, His) is expressed by Sf9 insect cells and is a transmembrane protein (L340-C361) with a His tag.

HY-P74800

	IL-5R alpha Protein, Human (Q01344-2, HEK293, His) Interleukin-5 receptor subunit alpha; IL-5RA; CD125; IL5R	Human	HEK293
	IL-5R alpha protein is a cytokine receptor that is expressed on eosinophils, basophils and B cells and is involved in inflammation and immune regulation. IL-5R alpha Protein, Human (Q01344-2, HEK293, His) is expressed by HEK293 cells with a C-His tag.

HY-P76195

	CD131 Protein, Rat (HEK293, Fc) Cytokine receptor common subunit beta; CD131; CSF2RB; IL3RB; IL5RB	Rat	HEK293
	The CD131 protein is a cell surface receptor that plays a critical role in the immune response and controls the generation and differentiation of hematopoietic progenitor cells. CD131 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD131 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P75608

	CD131 Protein, Human (HEK293, His) Cytokine receptor common subunit beta; CDw131; CD131; CSF2RB; IL3RB; IL5RB	Human	HEK293
	The CD131 protein is a cell surface receptor that plays a critical role in the immune response and controls the generation and differentiation of hematopoietic progenitor cells. CD131 Protein, Human (HEK293, His) is the recombinant human-derived CD131 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P704440

	CD131 Protein, Human (HEK293, hFc) Cytokine receptor common subunit beta; CDw131; CD131; CSF2RB; IL3RB; IL5RB	Human	HEK293
	The CD131 protein is a cell surface receptor that plays a critical role in the immune response and controls the generation and differentiation of hematopoietic progenitor cells. CD131 Protein, Human (HEK293, hFc) is the recombinant human-derived CD131 protein, expressed by HEK293, with C-hFc labeled tag.

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Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Mouse (4) Rabbit (3)
Reactivity:	Human (7) Rat (4) Mouse (4)
Application:	IHC-P (6) WB (4) FC (3) ELISA (4)
Isotype:	IgG (3) IgG1 (3)
Conjugation:	Non-conjugated (8) Biotin (4)
Clonality:	Monoclonal (5) Monoclonal Antibody (1) Recombinant (2)
Modification:	Unmodified (6)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85018

	IL-5 Antibody (YA4710) IL5; Interleukin-5; IL-5; B-cell differentiation factor I; EosinophIL differentiation factor; T-cell replacing factor; TRF; IL-5 nanobody;	ELISA	Human
	IL-5 Antibody (YA4710) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IL-5.

HY-P81483

	IL-5 Receptor alpha Antibody (YA1228) IL-5 Receptor alpha; interleukin 5 receptor; alpha; IL5R; CD125; CDw125; HSIL5R3	IHC-P	Human
	IL-5 Receptor alpha Antibody (YA1228) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IL-5 Receptor alpha.

HY-P81483A

	IL-5 Receptor alpha Antibody (YA1228)(PBS only) IL-5 Receptor alpha; interleukin 5 receptor; alpha; IL5R; CD125; CDw125; HSIL5R3	IHC-P	Human
	IL-5 Receptor alpha Antibody (YA1228) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IL-5 Receptor alpha.

HY-P87049

	REIIBP/NSD2 Antibody (YA6742) FLJ23286 antibody; IL5 promoter REII region binding protein antibody; KIAA1090 antibody; MGC176638 antibody; MMSET antibody; MMSET type II antibody; Multiple myeloma SET domain containing protein type III antibody; Multiple myeloma SET domain protein antibody; Multiple myeloma SET domain-containing protein antibody; NSD 2 antibody; FLJ23286 antibody; IL5 promoter REII region binding protein antibody; KIAA1090 antibody; MGC176638 antibody; MMSET antibody; MMSET type II antibody; Multiple myeloma SET domain containing protein type III antibody; Multiple myeloma SET domain protein antibody; Multiple myeloma SET domain-containing protein antibody; NSD 2 antibody; NSD2 antibody; NSD2_HUMAN antibody; Nuclear receptor binding SET domain protein 2 antibody; Nuclear SET domain-containing protein 2 antibody; Probable histone-lysine N-methyltransferase NSD2 antibody; Protein trithorax-5 antibody; REIIBP antibody; Trithorax/ash1 related protein 5 antibody; TRX5 antibody; TRX5 protein antibody; WHS antibody; Whsc1 antibody; Wolf Hirschhorn syndrome candidate 1 antibody; Wolf Hirschhorn syndrome candidate 1 protein antibody; Wolf-Hirschhorn syndrome candidate 1 protein antibody;	WB, IHC-P	Human, Mouse, Rat
	REIIBP/NSD2 Antibody (YA6742) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to REIIBP/NSD2.

HY-P84264

	IL-3RB Antibody (YA3961) CSF2RB; IL3RB; IL5RB; SMDP5; CDw131; betaGMR	WB, IHC-P, FC, ELISA	Human, Mouse, Rat
	IL-3RB Antibody (YA3961) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL-3RB.

HY-P83661

	IL-3RB Antibody(YA3396) CSF2RB; IL3RB; IL5RB; SMDP5; CDw131; CD131; betaGMR	WB, IHC-P, FC, ELISA	Human, Mouse, Rat
	IL-3RB Antibody(YA3396) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL-3RB.

HY-P84264A

	IL-3RB Antibody (YA3961)(PBS only) CSF2RB; IL3RB; IL5RB; SMDP5; CDw131; betaGMR	WB, IHC-P, FC, ELISA	Human, Mouse, Rat
	IL-3RB Antibody (YA3961) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL-3RB.

HY-P84960

	IL-3RB Antibody (YA7078) IL-3R common β chain; CDw131; Beta-C antibody; CD131 antibody; CDw131 antibody; Colony stimulating factor 2 receptor beta antibody; Colony stimulating factor 2 receptor beta low affinity; granulocyte macrophage; antibody; Common beta chain antibody; Csf2rb antibody; Cytokine receptor common beta chain antibody; Cytokine receptor common beta chain precursor; CDw131 antigen; antibody; Cytokine receptor common subunit beta antibody; GM CSF/IL 3/IL 5 receptor common beta chain antibody; GM-CSF/IL-3/IL-5 receptor common beta subunit antibody; granulocyte-macrophage colony-stimulating factor receptor; beta antibody; IL3RB antibody; IL3RB_HUMAN antibody; IL5RB antibody; Interleukin 3 receptor; beta antibody; Interleukin 3 receptor/granulocyte macrophage colony stimulating factor 3 receptor beta; high affinity; antibody; Interleukin 5 receptor; beta antibody; SMDP5 antibody; stimulating factor 3 receptor; beta; high affinity; antibody;
	IL-3RB Antibody is a non-conjugated antibody, targeting to CD131.

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Host
Reactivity
Application
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Clonality
Immunogen
Appearance
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Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-137131

DC-Chol hydrochloride DC-Cholesterol hydrochloride		Cholesterol
DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity .

HY-RS06771

Il5 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Il5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06770

IL5 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IL5 Human Pre-designed siRNA Set A contains three designed siRNAs for IL5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06772

Il5 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Il5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-174602

*Human IL5* mRNA**		mRNA Interleukin & Receptors
Human IL5 mRNA encodes the human interleukin 5 (IL5) protein, a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. IL5 plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases.

HY-174601

*Human IL5RA mRNA*		mRNA Interleukin & Receptors
Human IL5RA mRNA encodes the human interleukin 5 receptor subunit alpha (IL5RA) protein, an interleukin 5 specific subunit of a heterodimeric cytokine receptor. IL5RA has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4.

HY-RS06773

IL5RA Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IL5RA Human Pre-designed siRNA Set A contains three designed siRNAs for IL5RA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS26191

Il5ra Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Il5ra Rat Pre-designed siRNA Set A contains three designed siRNAs for Il5ra gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS19696

Il5ra Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Il5ra Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il5ra gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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