333 Results for "

Lignan

" in MedChemExpress (MCE) Product Catalog:
Products (333)

333 Results for "Lignan" in MCE Product Catalog:

17
Arctigenin
Arctigenin
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17 Publications Verification
Cat. No.: HY-N0035
CAS No.: 7770-78-7
Synonyms: (-)-Arctigenin
Category:  

Neurological Disease Anti-aging Lignans Metabolic Disease Plants Compositae Caesalpinia magnifoliolata Metc. Endogenous metabolite Infection Human Gut Microbiota Metabolites Phenylpropanoids Disease Research Fields Inflammation/Immunology Cancer

Target:  

MMP Influenza Virus Autophagy Apoptosis

Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions .
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12
Sesamin
Sesamin
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12 Cited Publications
Cat. No.: HY-N0121
CAS No.: 607-80-7
Category:  

Neurological Disease Anti-aging Sesamum indicum Linn. Lignans Pedaliaceae Phenylpropanoids Plants Disease Research Fields

Target:  

Stearoyl-CoA Desaturase (SCD)

Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .
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8
Magnolol
Magnolol
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8 Cited Publications
Cat. No.: HY-N0163
CAS No.: 528-43-8
Category:  

Cardiovascular Disease Neurological Disease Lignans Plants Magnolia officinalis. Rehd. et Wils. Magnoliaceae Phenols Polyphenols Phenylpropanoids Disease Research Fields Inflammation/Immunology

Target:  

RAR/RXR PPAR Autophagy Bacterial

Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 µM and 17.7 µM, respectively.
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7
Secoisolariciresinol diglucoside
Secoisolariciresinol diglucoside
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7 Cited Publications
Cat. No.: HY-105008
CAS No.: 257930-74-8
Purity:  99.74%
Synonyms: (S,S)-SDG; (S,S)-LGM2605
Category:  

Cardiovascular Disease Neurological Disease Lignans Plants Linum usitatissimum Linn. Linaceae Phenols Polyphenols Phenylpropanoids Disease Research Fields

Target:  

Free Radical Scavengers

Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects .
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6
Macelignan
Macelignan
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6 Cited Publications
Cat. No.: HY-N0064
CAS No.: 107534-93-0
Synonyms: (+)-AnwuLignan; Anwuligan
Category:  

Neurological Disease Lignans Metabolic Disease Plants Monophenols Phenols Phenylpropanoids Schisandraceae Disease Research Fields Inflammation/Immunology Schisandra chinensis (Turcz.) Baill.

Target:  

COX

Macelignan ((+)-Anwulignan; Anwuligan)?is an orally active lignan isolated from Myristica fragrans. Macelignan possesses many pharmacological activities, including anti-inflammatory, anti-cancer, anti-diabetes, and neuroprotective activities .
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5
Schisandrin C
Schisandrin C
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5 Cited Publications
Cat. No.: HY-N0690
CAS No.: 61301-33-5
Synonyms: Schizandrin-C; Wuweizisu-C
Category:  

Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer

Target:  

Apoptosis

Schisandrin C (Schizandrin-C) is a phytochemical lignan isolated from Schizandra chinensis . Schisandrin C has diverse biological activities, including anticancer, anti-inflammatory and antioxidant effects. Schisandrin C can be used for cancer, alzheimer’s disease, and liver diseases research . Schisandrin C induces cell apoptosis .
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4
Schisandrin
Schisandrin
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4 Cited Publications
Cat. No.: HY-N0691
CAS No.: 7432-28-2
Synonyms: Schizandrin; Schizandrol; Schizandrol-A
Category:  

Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer

Target:  

Autophagy

Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats .
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3
Schisantherin A
Schisantherin A
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3 Cited Publications
Cat. No.: HY-N0694
CAS No.: 58546-56-8
Synonyms: Gomisin-C; Schizantherin-A; Wuweizi ester-A
Category:  

Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Inflammation/Immunology Schisandra chinensis (Turcz.) Baill.

Target:  

NF-κB

Schisantherin A is a dibenzocyclooctadiene lignan. Schisantherin A inhibits p65-NF-κB translocation into the nucleus by IκBα degradation.
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3
Diphyllin
Diphyllin
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3 Cited Publications
Cat. No.: HY-N2532
CAS No.: 22055-22-7
Category:  

Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Plants Infection Monophenols Phenols Phenylpropanoids Berberidaceae Disease Research Fields Inflammation/Immunology

Target:  

VSV HIV Proton Pump Influenza Virus

Diphyllin is an orally active V-ATPase inhibitor (IC50=17 nM) and HIV-1 inhibitor (IC50=0.38 μM). Diphyllin blocks the acidification of osteoclast lysosomes and bone resorption lacunas (IC50=0.6 nM for acid influx inhibition)， thereby inhibiting bone resorption. Diphyllin can effectively inhibit osteoclast-mediated bone resorption and has no effect on osteoblastic bone formation. Diphyllin can be used in the research of bone metabolism-related diseases and has the potential to inhibit diseases related to excessive bone resorption .
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3
Gomisin J
Gomisin J
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3 Cited Publications
Cat. No.: HY-N0385
CAS No.: 66280-25-9
Category:  

Cardiovascular Disease Monophenols Lignans Phenols Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill.

Target:  

NO Synthase AMPK CaMK NF-κB Keap1-Nrf2

Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, AMPK (LKB1, CaMKIIβ), fetuin-A, NF-κB, Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the AMPK pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc .
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2
Schisandrol B
Schisandrol B
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2 Cited Publications
Cat. No.: HY-N0692
CAS No.: 58546-54-6
Synonyms: Gomisin-A; TJN-101; Wuweizi alcohol-B
Category:  

Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer

Target:  

Reactive Oxygen Species (ROS) Cytochrome P450 Autophagy

Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .
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1
Secoisolariciresinol
Secoisolariciresinol
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1 Cited Publications
Cat. No.: HY-N6071
CAS No.: 29388-59-8
Synonyms: (-)-Secoisolariciresinol
Category:  

Lignans Plants Endogenous metabolite Human Gut Microbiota Metabolites other families Other Diseases Phenols Polyphenols Phenylpropanoids Disease Research Fields

Target:  

Drug Intermediate

Secoisolariciresinol ((-)-Secoisolariciresinol) is a plant lignan and a precursor of enterolignans. Secoisolariciresinol can be converted into enterodiol and enterolactone by intestinal microflora. Secoisolariciresinol may reduce the risk of cancer and cardiovascular diseases .
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1
Sauchinone
Sauchinone
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1 Cited Publications
Cat. No.: HY-N0613
CAS No.: 177931-17-8
Category:  

Saururaceae Saururus chinensis (Lour.) Baill. Terpenoids Diterpenoids Plants Disease Research Fields Inflammation/Immunology

Target:  

NF-κB

Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity .
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1
(+)-Syringaresinol
(+)-Syringaresinol
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1 Cited Publications
Cat. No.: HY-126030
CAS No.: 21453-69-0
Purity:  98.69%
Category:  

Lignans Phenols Polyphenols Antheroporum pierrei Gagnep. Phenylpropanoids Plants Compositae Disease Research Fields Cancer

Target:  

Nuclear Factor of activated T Cells (NFAT)

(+)-Syringaresinol, a lignan, is a NFAT transcription factor inhibitor, with an IC50 of 329.4 μM. (+)-Syringaresinol also can be used for the research of lymphocytic leukemia .
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1
Matairesinoside
Matairesinoside
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1 Cited Publications
Cat. No.: HY-N7996
CAS No.: 23202-85-9
Category:  

Infection Monophenols Oleaceae Lignans Phenols Phenylpropanoids Plants Disease Research Fields Forsythia

Target:  

Free Radical Scavengers Bacterial Fungal

Matairesinoside is a lignan with antibacterial and antioxidant activities. Matairesinoside also shows virus-cell fusion inhibitory activity .
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1
Epimagnolin A
Epimagnolin A
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1 Cited Publications
Cat. No.: HY-N5107
CAS No.: 41689-51-4
Synonyms: (+)-epi-Magnolin
Category:  

Infection other families Lignans Phenylpropanoids Plants Disease Research Fields

Target:  

Parasite

Epimagnolin A, a furfuran lignan, shows mild antiplasmodial activities (IC50=5.7 μg/mL) without noticeable toxicity on mammalian normal cells .
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1
Obovatol
Obovatol
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1 Cited Publications
Cat. No.: HY-N8259
CAS No.: 83864-78-2
Category:  

Magnoliaceae Other Diseases Lignans Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Houpoea obovata (Thunberg) N. H. Xia & C. Y. Wu

Target:  

Others

Obovatol is a biphenyl ether lignan isolated from the leaves of Magnolia obovata Thunb .
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1
Aldumastat
Aldumastat
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1 Cited Publications
Cat. No.: HY-137430
CAS No.: 1957278-93-1
Purity:  99.36%
Synonyms: GLPG1972; S201086
Target:  

ADAMTS

Research Areas:  

Metabolic Disease

Aldumastat (GLPG1972; S201086) is a potent, seletive and orally active ADAMTS-5 (IC50=19 nM) inhibitor, and has 8-fold seletivity over ADAMTS-4 (IC50=156 nM). Aldumastat has anticatabolic activity and is used for osteoarthritis research .
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1
Chicanine
Chicanine
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1 Cited Publications
Cat. No.: HY-N2270
CAS No.: 78919-28-5
Category:  

Monophenols Lignans Phenols Phenylpropanoids Plants Schisandraceae Disease Research Fields Inflammation/Immunology Schisandra chinensis (Turcz.) Baill.

Target:  

p38 MAPK ERK IKK

Chicanine is a lignan compound of Schisandra chinesis, inhibits LPS-induced phosphorylation of p38 MAPK, ERK 1/2 and IκB-α, with anti-inflammatory activity .
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1
Pinoresinol 4-O-β-D-glucopyranoside
Pinoresinol 4-O-β-D-glucopyranoside
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1 Cited Publications
Cat. No.: HY-N2168
CAS No.: 69251-96-3
Synonyms: (+)-Pinoresinol 4-O-β-D-glucopyranoside
Category:  

Cardiovascular Disease other families Monophenols Lignans Phenols Phenylpropanoids Plants Disease Research Fields

Target:  

Glycosidase Free Radical Scavengers Estrogen Receptor/ERR Phosphodiesterase (PDE)

Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is an orally active α-glucosidase inhibitor, with an IC50 of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects .
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