MMP14

Isoforms Recommended:	MMP-14

By Targets:	MMP (20) Claudin (1) Endogenous Metabolite (1) Fluorescent Dye (2) NO Synthase (1) Reference Standards (1) Small Interfering RNA (siRNA) (3) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (3) Endocrinology (1) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Targets Recommended: MMP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12169

Marimastat Maximum Cited Publications 19 Publications Verification BB2516; TA2516	MMP	Cancer
Marimastat (BB2516) is a broad spectrum and orally bioavailable inhibitor of *MMPs, with potent activity against MMP-9 (IC₅₀=3 nM), MMP-1 (IC₅₀=5 nM), MMP-2 (IC₅₀=6 nM), MMP-14* (IC₅₀=9 nM) and MMP-7 (IC₅₀=13 nM), used in the treatment of cancer. Marimastat (BB2516) is an angiogenesis and metastasis inhibitor, which limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes .

HY-110397

KP-457 3 Publications Verification	MMP	Cardiovascular Disease
KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC₅₀s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively.

HY-15827

NSC 405020 3 Publications Verification	MMP	Cardiovascular Disease Cancer
NSC 405020 is a specific *MMP14* inhibitor. NSC 405020 can directly interact with the hemopexin domain of MMP14. NSC 405020 reduces the expression of full length and active cleaved Notch3 (NICD3). NSC 405020 can be used to research vestibular schwannoma, hemostasis and thrombosis .

HY-107394

UK 356618 5+ Cited Publications	MMP	Inflammation/Immunology Cancer
UK 356618 (Compound 4j) is a potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) with an IC₅₀ of 5.9 nM. UK 356618 is less potent against MMP-1, MMP-2, MMP-9, MMP-13 and MMP-14 compared with *MMP-3* .

HY-P991316

KD014 DX-2400; DX-2410	MMP NO Synthase	Inflammation/Immunology Cancer
KD014 (DX-2400) is a human monoclonal antibody that selectively targets *MMP‑14*. KD014 inhibits collagen degradation and regulates the polarization of macrophages toward an anti-inflammatory/anti-tumor phenotype. KD014 alleviates joint damage in rheumatoid arthritis and suppresses tumor growth and invasion. KD014 can be used in studies related to breast cancer and rheumatoid arthritis .

HY-P990045

Lixudebart ALE.F02	Claudin	Endocrinology
Lixudebart (ALE.F02) is a humanized immunoglobulin G1-kappa, anti-CLDN1 monoclonal antibody. Lixudebart disrupts CLDN1 interactions with CD44 and MMP14, reduces renal macrophage infiltration, epithelial activation, and urinary albumin-to-creatinine ratio, and attenuates glomerulosclerosis. Lixudebart can be used for the research of focal segmental glomerulosclerosis .

HY-124373

ND-336	MMP	Metabolic Disease
ND-336 is a selective inhibitor of matrix metalloproteinase (MMP)-2, *MMP-9, and MMP-14, with K_i*s of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound .

HY-RS08528

MMP14 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) MMP	Others
MMP14 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MMP14 Human Pre-designed siRNA Set A MMP14 Human Pre-designed siRNA Set A

HY-107639

UK-370106	MMP	Inflammation/Immunology
UK-370106 is a potent and highly selective *MMP-3* (IC₅₀ of 23 nM) and *MMP-12* (IC₅₀ of 42 nM) inhibitor with >1200-fold higher potency than MMP-1, MMP-2, MMP-9, and MMP-14, and about 100-fold than MMP-13 and MMP-8. UK-370106 potently inhibits cleavage of [ ³H]-fibronectin by *MMP-3* (IC₅₀ of 320 nM) and has little effect on keratinocyte migration in vitro .

HY-162038

RXP03	MMP	Others
RXP03 is a *MMPs* inhibitor with the K_i of 20 nM, 2.5 nM, 10 nM, 5nM and 105 nM for MMP-2, MMP-8, MMP-9, MMP-11, MMP-14, respectively .

HY-114785

BPHA	MMP	Cancer
BPHA is a potent and orally active *MMP-2, MMP-9* and *MMP-14* inhibitor with IC₅₀s of 12 nM, 16 nM and 17 nM, respectively. BPHA does not inhibit MMP-1, -3, and -7 (the IC₅₀s are 974, >1000, and 795 nM, respectively). BPHA has antiangiogenic and antitumor effects .

HY-E70290

N-Acetylgalactosaminyltransferase 1 GALNT1	Endogenous Metabolite β-catenin Wnt	Cancer
N-Acetylgalactosaminyltransferase 1 (GALNT1) is a glycosyltransferase that initiates mucin-type O-glycosylation by transferring α-GalNAc from UDP-GalNAc to serine (Ser) or threonine (Thr) residues in proteins. Overexpression of N-Acetylgalactosaminyltransferase 1 in gastric cancer can promote abnormal O-glycosylation of CD44, thereby activating the Wnt/β-catenin signaling pathway and regulating the malignant behavior of gastric cancer cells. Additionally, N-Acetylgalactosaminyltransferase 1 plays a crucial role in cancer growth and metastasis by modifying the O-glycosylation of various glycoproteins, such as mucin (MUC1), osteopontin (OPN), matrix metalloproteinase-14 (MMP14), and integrin α3 .

HY-P3120

Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2	MMP Fluorescent Dye	Others
Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14). Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2, upon cleavage by MMP-14, releases 7-methoxycoumarin-4-acetyl (Mca) (Ex/Em = 328/420 nm).

HY-RS08530

Mmp14 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) MMP	Others
Mmp14 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mmp14 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mmp14 Rat Pre-designed siRNA Set A Mmp14 Rat Pre-designed siRNA Set A

HY-RS08529

Mmp14 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) MMP	Others
Mmp14 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mmp14 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mmp14 Mouse Pre-designed siRNA Set A Mmp14 Mouse Pre-designed siRNA Set A

HY-124373A

(R)-ND-336	MMP	Metabolic Disease
(R)-ND-336 is a potent and selective *MMP-9* inhibitor with a K_i of 19 nM. (R)-ND-336 inhibits MMP-2 (K_i=127 nM) and MMP-14 (K_i=119 nM). (R)-ND-336 has the potential for diabetic foot ulcers (DFUs) research .

HY-12169R

Marimastat (Standard) BB2516 (Standard); TA2516 (Standard)	MMP Reference Standards	Cancer
Marimastat (Standard) is the analytical standard of Marimastat. This product is intended for research and analytical applications. Marimastat (BB2516) is a broad spectrum and orally bioavailable inhibitor of MMPs, with potent activity against MMP-9 (IC50=3 nM), MMP-1 (IC50=5 nM), MMP-2 (IC50=6 nM), MMP-14 (IC50=9 nM) and MMP-7 (IC50=13 nM), used in the treatment of cancer. Marimastat (BB2516) is an angiogenesis and metastasis inhibitor, which limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes .

HY-110397G

KP-457	MMP	Cardiovascular Disease
KP-457 (GMP) is KP-457 (HY-110397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture.KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC₅₀s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively .

HY-35513

3-Aminobenzene-1,2-diol	MMP	Cancer
3-Aminobenzene-1,2-diol (compound C8) is a matrix metalloproteinase (MMP) inhibitor with IC₅₀ values of 20, 26, 16 and 16.3 μM for MMP-2, MMP-8, MMP-9 and MMP-14, respectively .

HY-P3120A

Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 TFA	MMP Fluorescent Dye	Others
Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 TFA is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14). Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 TFA, upon cleavage by MMP-14, releases 7-methoxycoumarin-4-acetyl (Mca) (Ex/Em = 328/420 nm).

HY-P991478

RLVT-14-02	MMP	Neurological Disease
RLVT-14-02 is a human monoclonal antibody (mAb) targeting *MMP14*. RLVT-14-02 can be used in neuropathic pain research.

HY-160720

ASPH-IN-1	MMP	Cancer
ASPH-IN-1 (Compound 14c) is an orally active ASPH inhibitor. ASPH-IN-1 down-regulates *MMP2* and *MMP14* protein expression. ASPH-IN-1 exhibits anti-cancer activity against cholangiocarcinoma .

Cat. No.	Product Name	Type

HY-P3120

Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2	Fluorescent Dye
Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14). Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2, upon cleavage by MMP-14, releases 7-methoxycoumarin-4-acetyl (Mca) (Ex/Em = 328/420 nm).

HY-110397G

KP-457	Fluorescent Dye
KP-457 (GMP) is KP-457 (HY-110397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture.KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC₅₀s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively .

KP-457

Fluorescent Dye

KP-457 (GMP) is KP-457 (HY-110397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture.KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC₅₀s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively .

HY-P3120A

Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 TFA	Fluorescent Dye
Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 TFA is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14). Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 TFA, upon cleavage by MMP-14, releases 7-methoxycoumarin-4-acetyl (Mca) (Ex/Em = 328/420 nm).

Cat. No.	Product Name	Type

HY-110397G

KP-457	Biochemical Assay Reagents
KP-457 (GMP) is KP-457 (HY-110397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture.KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC₅₀s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively .

KP-457

Biochemical Assay Reagents

KP-457 (GMP) is KP-457 (HY-110397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture.KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC₅₀s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively .

Cat. No.	Product Name	Target	Research Area

HY-P3120

Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2	MMP Fluorescent Dye	Others
Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14). Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2, upon cleavage by MMP-14, releases 7-methoxycoumarin-4-acetyl (Mca) (Ex/Em = 328/420 nm).

HY-P3120A

Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 TFA	MMP Fluorescent Dye	Others
Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 TFA is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14). Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 TFA, upon cleavage by MMP-14, releases 7-methoxycoumarin-4-acetyl (Mca) (Ex/Em = 328/420 nm).

Cat. No.	Product Name	Target	Research Area	Image

HY-P991316

KD014 DX-2400; DX-2410	MMP NO Synthase	Inflammation/Immunology Cancer
KD014 (DX-2400) is a human monoclonal antibody that selectively targets *MMP‑14*. KD014 inhibits collagen degradation and regulates the polarization of macrophages toward an anti-inflammatory/anti-tumor phenotype. KD014 alleviates joint damage in rheumatoid arthritis and suppresses tumor growth and invasion. KD014 can be used in studies related to breast cancer and rheumatoid arthritis .

HY-P990045

Lixudebart ALE.F02	Claudin	Endocrinology
Lixudebart (ALE.F02) is a humanized immunoglobulin G1-kappa, anti-CLDN1 monoclonal antibody. Lixudebart disrupts CLDN1 interactions with CD44 and MMP14, reduces renal macrophage infiltration, epithelial activation, and urinary albumin-to-creatinine ratio, and attenuates glomerulosclerosis. Lixudebart can be used for the research of focal segmental glomerulosclerosis .

HY-P991478

RLVT-14-02	MMP	Neurological Disease
RLVT-14-02 is a human monoclonal antibody (mAb) targeting *MMP14*. RLVT-14-02 can be used in neuropathic pain research.

Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (2) ICC/IF (2) IP (2) WB (2) FC (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81845

	MMP14 Antibody (YA1590) MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; WNCHRS; MT1-MMP; MT-MMP 1	WB, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat
	MMP14 Antibody (YA1590) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MMP14.

HY-P81845A

	MMP14 Antibody (YA1590)(PBS only) MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; WNCHRS; MT1-MMP; MT-MMP 1	WB, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat
	MMP14 Antibody (YA1590) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MMP14.

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Cat. No.	Product Name		Classification

HY-RS08528

MMP14 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
MMP14 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS08530

Mmp14 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Mmp14 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mmp14 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS08529

Mmp14 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Mmp14 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mmp14 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Targets Recommended: MMP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-110397G

KP-457	MMP	Cardiovascular Disease
KP-457 (GMP) is KP-457 (HY-110397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture.KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC₅₀s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Antibodies

Oligonucleotides

GMP Molecules