Search Result

Isoforms Recommended:	PI3Kγ

Results for "

PI3Kγ

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (11) Apoptosis (33) ATM/ATR (1) Autophagy (16) c-Myc (1) Casein Kinase (1) Caspase (1) CD3 (1) CDK (6) DNA-PK (5) Drug Derivative (1) EGFR (1) Epigenetic Reader Domain (4) GSK-3 (1) HDAC (2) HIF/HIF Prolyl-Hydroxylase (1) Histone Methyltransferase (1) Interleukin Related (1) Isotope-Labeled Compounds (3) Ligands for Target Protein for PROTAC (1) MEK (1) Mitochondrial Metabolism (1) Mitophagy (7) MMP (1) mTOR (31) NF-κB (1) P-glycoprotein (1) p38 MAPK (1) Paraptosis (1) PARP (1) PD-1/PD-L1 (1) PI3K (127) PI4K (2) PPAR (1) PROTACs (3) Reactive Oxygen Species (ROS) (6) Reference Standards (13) SARS-CoV (1) STING (1) VEGFR (1) Virus Protease (1)
By Research Areas:	Cancer (116) Infection (2) Inflammation/Immunology (26) Metabolic Disease (5) Neurological Disease (6)

By Targets:

Akt (11)

Apoptosis (33)

ATM/ATR (1)

Autophagy (16)

c-Myc (1)

Casein Kinase (1)

Caspase (1)

CD3 (1)

CDK (6)

DNA-PK (5)

Drug Derivative (1)

EGFR (1)

Epigenetic Reader Domain (4)

GSK-3 (1)

HDAC (2)

HIF/HIF Prolyl-Hydroxylase (1)

Histone Methyltransferase (1)

Interleukin Related (1)

Isotope-Labeled Compounds (3)

Ligands for Target Protein for PROTAC (1)

MEK (1)

Mitochondrial Metabolism (1)

Mitophagy (7)

MMP (1)

mTOR (31)

NF-κB (1)

P-glycoprotein (1)

p38 MAPK (1)

Paraptosis (1)

PARP (1)

PD-1/PD-L1 (1)

PI3K (127)

PI4K (2)

PPAR (1)

PROTACs (3)

Reactive Oxygen Species (ROS) (6)

Reference Standards (13)

SARS-CoV (1)

STING (1)

VEGFR (1)

Virus Protease (1)

By Research Areas:

Cancer (116)

Infection (2)

Inflammation/Immunology (26)

Metabolic Disease (5)

Neurological Disease (6)

132

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18085

Quercetin Maximum Cited Publications 199 Publications Verification	Reactive Oxygen Species (ROS) PI3K Autophagy Mitophagy Apoptosis	Cancer
Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a *PI3K* inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-10681

Gedatolisib 5 Publications Verification PKI-587; PF-05212384	PI3K mTOR	Cancer
Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, *PI3Kγ, and mTOR* with IC₅₀s of 0.4 nM, 5.4 nM and 1.6 nM, respectively . Gedatolisib is equally effective in both complexes of mTOR, mTORC1 and mTORC2 .

HY-N0451

Acacetin 10+ Cited Publications 5,7-Dihydroxy-4'-methoxyflavone	Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Cancer
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research .

HY-100716

Eganelisib 15+ Cited Publications IPI-549	PI3K	Cancer
Eganelisib (IPI549) is a potent and selective *PI3Kγ* inhibitor with an IC₅₀ of 16 nM. Eganelisib shows >100-fold selectivity over other lipid and protein kinases .

HY-D0254

Gallein 5+ Cited Publications Pyrogallol phthalein	PI3K	Cancer
Gallein is a Gβγ subunit signaling inhibitor that can interfere with the interaction between Gβγ subunit and PI3Kγ, regulate platelet function, and exhibit anti-tumor activity ^[1][3].

HY-18085A

Quercetin hydrate 195+ Cited Publications	PI3K Autophagy Mitophagy Apoptosis Reactive Oxygen Species (ROS)	Cancer
Quercetin hydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a *PI3K* inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-15346

Copanlisib 30+ Cited Publications BAY 80-6946	PI3K Apoptosis	Cancer
Copanlisib (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I *PI3K* inhibitor, with IC₅₀s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and *PI3Kγ*, respectively. Copanlisib has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib has superior antitumor activity .

HY-15346A

Copanlisib dihydrochloride 30+ Cited Publications BAY 80-6946 dihydrochloride	PI3K Apoptosis	Cancer
Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is a potent, selective and ATP-competitive pan-class I *PI3K* inhibitor, with IC₅₀s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and *PI3Kγ*, respectively. Copanlisib dihydrochloride has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib dihydrochloride has superior antitumor activity .

HY-19962

Paxalisib 5 Publications Verification GDC-0084	PI3K mTOR	Cancer
Paxalisib (GDC-0084) is a brain penetrant inhibitor of *PI3K* and mTOR, with K_is of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively .

HY-13898

Taselisib 20+ Cited Publications GDC-0032; RG-7604	PI3K	Cancer
Taselisib (GDC-0032) is a potent *PI3K* inhibitor targets PIK3CA mutations, with K_is of 0.12 nM, 0.29 nM, 0.97 nM, and 9.1 nM for PI3Kδ, PI3Kα, PI3Kγ and PI3Kβ, respectively.

HY-12868

Bimiralisib 4 Publications Verification PQR309	PI3K mTOR	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Bimiralisib (PQR309) is a potent, brain-penetrant, orally bioavailable, pan-class I *PI3K/mTOR* inhibitor with IC₅₀s of 33 nM, 451 nM, 661 nM, 708 nM and 89 nM for PI3Kα, PI3Kδ, PI3Kβ, *PI3Kγ* and mTOR, respectively. Bimiralisib is an mTORC1 and mTORC2 inhibitor.

HY-13246

Apitolisib 10+ Cited Publications GDC-0980; GNE 390; RG 7422	PI3K mTOR Apoptosis	Cancer
Apitolisib (GDC-0980; GNE 390; RG 7422) is a selective, potent, orally bioavailable Class I *PI3* kinase and mTOR kinase (TORC1/2) inhibitor with IC₅₀s of 5 nM/27 nM/7 nM/14 nM for *PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ, and with a?K_i?of 17 nM for mTOR*.

HY-13532

AS-252424 5+ Cited Publications	PI3K	Cancer
AS-252424 is a potent and selective *PI3Kγ* inhibitor with an IC₅₀ of 30±10 nM.

HY-N0146

Quercetin dihydrate 190+ Cited Publications	PI3K Apoptosis	Inflammation/Immunology Cancer
Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a *PI3K* inhibitor with *IC₅₀s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K* δ and PI3K β, respectively .**

HY-18085R

Quercetin (Standard)	Reactive Oxygen Species (ROS) Reference Standards PI3K Autophagy Mitophagy Apoptosis	Cancer
Quercetin (Standard) is the analytical standard of Quercetin. This product is intended for research and analytical applications. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-12513

Samotolisib 5+ Cited Publications LY3023414	PI3K DNA-PK mTOR Autophagy	Cancer
Samotolisib (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC₅₀s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, DNA-PK and mTOR, respectively. Samotolisib potently inhibits mTORC1/2 at low nanomolar concentrations .

HY-10109

AS-605240 4 Publications Verification	PI3K Autophagy	Cancer
AS-605240 is a specific and orally active inhibitor of the *PI3Kγ, with an IC₅₀* of 8 nM, and a K_i of 7.8 nM.

HY-12046

PIK-93 5+ Cited Publications	PI4K PI3K Virus Protease	Cancer
PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC₅₀ of 19 nM, and also inhibits *PI3Kγ* and PI3Kα with IC₅₀ of 16 nM and 39 nM, respectively.

HY-50847

ZSTK474 15+ Cited Publications	PI3K Autophagy	Cancer
ZSTK474 is an ATP-competitive pan-class I *PI3K* inhibitor with IC₅₀s of 16 nM, 44 nM, 4.6 nM and 49 nM for PΙ3Κα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.

HY-12330

AZD8186 5+ Cited Publications	PI3K	Cancer
AZD8186 is a *PI3K* inhibitor, which potently inhibits PI3Kβ (IC₅₀=4 nM) and PI3Kδ (IC50₅₀=12 nM) with selectivity over PI3Kα (IC₅₀=35 nM) and PI3Kγ (IC₅₀=675 nM).

HY-111570

PI3Kγ inhibitor AZ2 2 Publications Verification	PI3K	Inflammation/Immunology
PI3Kγ inhibitor AZ2 is a highly selective *PI3Kγ* inhibitor (The pIC₅₀ value for *PI3Kγ* is 9.3). PI3Kγ inhibitor AZ2 can be used for the research of inflammatory and immune diseases .

HY-101146

SF2523 2 Publications Verification	PI3K Epigenetic Reader Domain DNA-PK	Cancer
SF2523 is a highly selective and potent inhibitor of *PI3K* with IC₅₀s of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3Kα, *PI3Kγ, DNA-PK*, BRD4 and mTOR, respectively.

HY-16526

Pilaralisib 5 Publications Verification XL-147; SAR245408	PI3K	Cancer
Pilaralisib (XL147; SAR245408) is a potent and highly selective class I *PI3Ks inhibitor with IC₅₀s of 39 nM, 383 nM, 23 nM and 36 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3K*δ.

HY-10683

PKI-402 10+ Cited Publications	PI3K mTOR	Cancer
PKI-402 is a selective, reversible, ATP-competitive inhibitor of *PI3K, including PI3K-α* mutants, and mTOR (IC₅₀=2, 3, 7,14 and 16 nM for PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ).

HY-16585

VS-5584 5 Publications Verification SB2343	PI3K mTOR	Cancer
VS-5584 is a *pan-PI3K/mTOR* kinase inhibitor with IC₅₀s of 16 nM, 68 nM, 42 nM, 25 nM, and 37 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively. VS-5584 simultaneously blocks mTORC2 as well as mTORC1.

HY-111508

PI3K/mTOR Inhibitor-2 1 Publications Verification	PI3K mTOR	Cancer
PI3K/mTOR Inhibitor-2 is a potent dual pan-PI3K/mTOR inhibitor with IC₅₀s of 3.4/34/16/1 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ and 4.7 nM for mTOR . Antitumor activity .

HY-144806

PI3K/AKT-IN-1 10+ Cited Publications	PI3K Akt Apoptosis	Cancer
PI3K/AKT-IN-1 is an effective *PI3K/AKT* dual inhibitor (IC₅₀ of 6.99, 4.01 and 3.36 μM for PI3Kγ, PI3Kδ and AKT, respectively). PI3K/AKT-IN-1 has anticancer activity and acts by inhibiting PI3K/AKT axis and inducing caspase 3 dependent apoptosis .

HY-15294

CZC24832	PI3K	Inflammation/Immunology Cancer
CZC24832 is a highly selective and potent *PI3Kγ* inhibitor (IC₅₀=27 nM) with apparent dissociation constants (K_d ^app) of 19 nM.

HY-112897

IITZ-01	Autophagy PI3K Apoptosis	Cancer
IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC₅₀ of 2.62 μM for PI3Kγ.

HY-13531

AS-604850 1 Publications Verification	PI3K	Cancer
AS-604850 is a potent, selective and ATP-competitive *PI3Kγ* inhibitor with an IC₅₀ value of 0.25 μM and a K_i value of 0.18 μM. AS-604850 shows isoform selective inhibitor of *PI3Kγ* with over 30-fold selectivity for PI3Kδ and β, and 18-fold selectivity over PI3Kα, respectively .

HY-17645

Tenalisib 1 Publications Verification RP6530	PI3K	Cancer
Tenalisib (RP6530) is a novel, potent, and selective PI3Kδ and *PI3Kγ* inhibitor with IC₅₀ values of 25 and 33 nM, respectively.

HY-13431

KU-0060648 4 Publications Verification	DNA-PK PI3K mTOR	Cancer
KU-0060648 is a dual inhibitor of *PI3K* and DNA-PK with IC₅₀s of 4 nM, 0.5 nM, 0.1 nM, 0.594 nM and 8.6 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and DNA-PK, respectively .

HY-10811

GNE-493 2 Publications Verification	PI3K mTOR	Cancer
GNE-493 is a potent, selective, and orally available dual *pan-PI3-kinase/mTOR* inhibitor with IC₅₀s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR.

HY-13334

BGT226 maleate 5 Publications Verification NVP-BGT226 maleate	PI3K mTOR Autophagy Apoptosis	Cancer
BGT226 (NVP-BGT226 maleate) is a *PI3K* (with IC₅₀s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and *PI3Kγ) /mTOR* dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells .

HY-12034

WYE-354 5+ Cited Publications	mTOR Autophagy Apoptosis	Cancer
WYE-354 is an ATP-competitive mTOR inhibitor with an IC₅₀ of 5 nM. WYE-354 also inhibits PI3Kα and *PI3Kγ* with IC₅₀s of 1.89 μM and 7.37 μM, respectively. WYE-354 inhibits both mTORC1 and mTORC2. WYE-354 induces autophagy activation in vitro ^[3].

HY-13530

CAY10505 5 Publications Verification	PI3K Apoptosis	Cancer
CAY10505 is a potent and selective *PI3Kγ* inhibitor with an IC₅₀ of 30 nM in neurons.

HY-13333

NVP-BAG956 BAG 956	PI3K	Cancer
NVP-BAG956 is an ATP-competitive *PI3K* inhibitor with IC50s of 34, 56, 112 and 444 nM for PI3Kδ, PI3Kα, PI3Kγ and PI3Kβ, respectively.

HY-15271

WYE-687 3 Publications Verification	mTOR PI3K	Cancer
WYE-687 is an ATP-competitive mTOR inhibitor with an IC₅₀ of 7 nM. WYE-687 concurrently inhibits activation of mTORC1 and mTORC2. WYE-687 also inhibits PI3Kα and *PI3Kγ* with IC₅₀s of 81 nM and 3.11 μM, respectively.

HY-19798

PI4KIIIbeta-IN-9 5 Publications Verification	PI4K PI3K	Cancer
PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC₅₀ of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and *PI3Kγ* with IC₅₀s of 152 nM and 1046 nM, respectively.

HY-18085S1

Quercetin-d3 1 Publications Verification	Isotope-Labeled Compounds PI3K Autophagy Mitophagy Reactive Oxygen Species (ROS) Apoptosis	Cancer
Quercetin-d₃ is the deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-162713

MTX-531	EGFR PI3K PPAR	Cancer
MTX-531 is an oral drug that inhibits EGFR (with an IC₅₀ of 14.7 nM) and *PI3K* (with IC₅₀ values of 6.4, 233, 8.3, and 1.1 nM for PI3Kα, PI3Kβ, *PI3Kγ, and PI3Kδ respectively), and it has anti-tumor effects. MTX-531 also acts as a weak agonist of PPARγ, with an IC₅₀* of 2.5 µM, helping to alleviate hyperglycemia induced by PI3K inhibitors .

HY-115870

AZD8154	PI3K	Inflammation/Immunology
AZD8154 is a selective PI3Kγδ dual inhibitor. AZD8154 can suppress PI3Kγ and PI3Kδ signaling pathway activation. AZD8154 can be used for the researches of inflammation and immunology, such as asthma .

HY-143404

PI3K-IN-30 3 Publications Verification	PI3K	Cancer
PI3K-IN-30 (compound 6d) is a potent *PI3K* inhibitor with IC₅₀s of 5.1, 136, 30.7 and 8.9 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively .

HY-112443

AZD3458	PI3K	Metabolic Disease Inflammation/Immunology Cancer
AZD3458 is a potent and remarkably selective *PI3Kγ* inhibitor with pIC₅₀s of 9.1, 5.1, <4.5, and 6.5 for *PI3Kγ, PI3Kα, PI3Kβ, and PI3K*δ, respectively .

HY-110109

ETP-45658	PI3K DNA-PK mTOR	Cancer
ETP-45658 is a potent *PI3K* inhibitor, with IC₅₀s of 22.0 nM, 39.8 nM, 129.0 nM and 717.3 nM for PI3Kα, PI3Kδ, PI3Kβ and *PI3Kγ, respectively. ETP-45658 also can inhibit DNA-PK* (IC₅₀=70.6 nM) and mTOR (IC₅₀=152.0 nM). ETP-45658 can be used for the research of cancer .

HY-148317

PI3Kγ inhibitor 6	PI3K	Inflammation/Immunology
PI3Kγ inhibitor 6 (compound 9) is a *PI3Kγ* inhibitor. PI3Kγ inhibitor 6 can be used for the research of inflammatory and autoimmune diseases .

HY-147419

Vulolisib	PI3K	Cancer
Vulolisib is a potent and orally active phosphatidylinositol 3-kinase (PI3K) inhibitor, with IC₅₀ values of 0.2 nM, 168 nM, 90 nM and 49 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively. Antiproliferative and antineoplastic activity .

HY-128333

PI3K/mTOR Inhibitor-4	PI3K mTOR	Cancer
PI3K/mTOR Inhibitor-4 is an orally active pan-class I *PI3K/mTOR* inhibitor. PI3K/mTOR Inhibitor-4 has enzymatic inhibition activity for PI3Kα, PI3Kγ, PI3Kδ and mTOR with IC₅₀ values of 0.63 nM, 22 nM, 9.2 nM and 13.85 nM, respectively. PI3K/mTOR Inhibitor-4 can be used for the research of cancer .

HY-10812

GNE-490	PI3K mTOR	Cancer
GNE-490, a (thienopyrimidin-2-yl)aminopyrimidine, is a potent pan-PI3K inhibitor with IC₅₀s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. GNE-490 has >200 fold selectivity for mTOR (IC₅₀=750 nM). GNE-490 shows potent suppression efficacy profile against MCF7.1 breast cancer xenograft model .

HY-10681R

Gedatolisib (Standard)	PI3K mTOR Reference Standards	Cancer
Gedatolisib (Standard) is the analytical standard of Gedatolisib. This product is intended for research and analytical applications. Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC50s of 0.4 nM, 5.4 nM and 1.6 nM, respectively . Gedatolisib is equally effective in both complexes of mTOR, mTORC1 and mTORC2 .

Cat. No.	Product Name	Target	Research Area

HY-P10093

*Penetratin-PI3Kγ(126-150)*	PI3K	Others
Penetratin-PI3Kγ(126-150) is a peptide inhibitor of *ΡI3Κ*γ that plays an important role in respiratory system diseases .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-18085

Quercetin Maximum Cited Publications 199 Publications Verification	Flavonols Classification of Application Fields Anti-aging Endocrine diseases Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Immune System Disorder Microorganisms other families Leguminosae Sunscreen Disease markers Cosmetic Research Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification Cancer	Reactive Oxygen Species (ROS) PI3K Autophagy Mitophagy Apoptosis
Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a *PI3K* inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-N0451

Acacetin 10+ Cited Publications 5,7-Dihydroxy-4'-methoxyflavone	Neurological Disease Classification of Application Fields Flavones Anti-aging Dendranthema morifolium (Ramat.) Tzvel. Plants Compositae Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Phenols Polyphenols Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis Autophagy
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research .

HY-N0146

Quercetin dihydrate 190+ Cited Publications	Flavonols Flavonoids other families Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	PI3K Apoptosis
Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a *PI3K* inhibitor with *IC₅₀s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K* δ and PI3K β, respectively .**

HY-18085R

Quercetin (Standard)	Flavonols Structural Classification Endocrine diseases Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Immune System Disorder Microorganisms other families Leguminosae Disease markers Glycyrrhiza uralensis Fisch. Source Classification	Reactive Oxygen Species (ROS) Reference Standards PI3K Autophagy Mitophagy Apoptosis
Quercetin (Standard) is the analytical standard of Quercetin. This product is intended for research and analytical applications. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-N0146R

Quercetin dihydrate (Standard)	Flavonols Structural Classification Flavonoids other families Phenols Polyphenols Plants Source Classification	Reference Standards PI3K Apoptosis
Quercetin (dihydrate) (Standard) is the analytical standard of Quercetin (dihydrate). This product is intended for research and analytical applications. Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC₅₀s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-N0451R

Acacetin (Standard) 10+ Cited Publications 5,7-Dihydroxy-4'-methoxyflavone (Standard)	Neurological Disease Classification of Application Fields Anti-aging Dendranthema morifolium (Ramat.) Tzvel. Plants Compositae Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Phenols Inflammation/Immunology Disease Research Fields Source Classification	Reference Standards Apoptosis Autophagy
Acacetin (Standard) is the analytical standard of Acacetin. This product is intended for research and analytical applications. Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research .

Cat. No.	Product Name	Chemical Structure

HY-18085S1

Quercetin-d3 1 Publications Verification
Quercetin-d₃ is the deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-18085S2

Quercetin-13C3
Quercetin- ¹³C₃ is the ¹³C-labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-18085S

Quercetin-d5
Quercetin-d₅ is a deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-18085AS

Quercetin-d3 hydrate 1 Publications Verification
Quercetin-d3 hydrate is a deuterium labeled Quercetin hydrate (HY-18085A), a flavonoid which can stimulate recombinant SIRT1 and also a *PI3K* inhibitor with IC₅₀s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-10681S

Gedatolisib-d8
Gedatolisib-d₈ (PKI-587-d₈) is the deuterium labeled Gedatolisib (HY-10681). Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC₅₀s of 0.4 nM, 5.4 nM and 1.6 nM, respectively. Gedatolisib is equally effective in both complexes of mTOR, mTORC1 and mTORC2 .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks